Elongation factor 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Elongation factor 2

Gene product:

elongation factor 2

Species:

Leishmania braziliensis

UniProt:

A4HNM5_LEIBR

TriTrypDb:

LbrM.35.0250 , LBRM2903_350008100

Length:

187

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNM5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003676	nucleic acid binding	3	2
GO:0003746	translation elongation factor activity	4	2
GO:0005488	binding	1	2
GO:0005525	GTP binding	5	2
GO:0008135	translation factor activity, RNA binding	3	2
GO:0017076	purine nucleotide binding	4	2
GO:0019001	guanyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032561	guanyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0045182	translation regulator activity	1	2
GO:0090079	translation regulator activity, nucleic acid binding	2	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	3	7	PF00656	0.540
CLV_NRD_NRD_1	169	171	PF00675	0.681
CLV_NRD_NRD_1	55	57	PF00675	0.465
CLV_NRD_NRD_1	95	97	PF00675	0.465
CLV_PCSK_KEX2_1	55	57	PF00082	0.465
CLV_PCSK_KEX2_1	94	96	PF00082	0.465
CLV_PCSK_SKI1_1	171	175	PF00082	0.675
CLV_PCSK_SKI1_1	55	59	PF00082	0.465
DOC_CKS1_1	106	111	PF01111	0.665
DOC_CYCLIN_yCln2_LP_2	69	75	PF00134	0.665
DOC_MAPK_gen_1	94	100	PF00069	0.665
DOC_USP7_MATH_2	153	159	PF00917	0.684
DOC_WW_Pin1_4	105	110	PF00397	0.665
DOC_WW_Pin1_4	63	68	PF00397	0.665
LIG_APCC_ABBA_1	36	41	PF00400	0.540
LIG_BRCT_BRCA1_1	121	125	PF00533	0.665
LIG_FHA_1	124	130	PF00498	0.665
LIG_FHA_1	154	160	PF00498	0.727
LIG_FHA_1	162	168	PF00498	0.529
LIG_LIR_Nem_3	144	149	PF02991	0.665
LIG_PDZ_Class_3	182	187	PF00595	0.699
LIG_Pex14_2	8	12	PF04695	0.540
LIG_SH2_CRK	89	93	PF00017	0.665
LIG_SH2_SRC	116	119	PF00017	0.665
LIG_SH2_STAP1	59	63	PF00017	0.665
LIG_SH2_STAT5	116	119	PF00017	0.665
LIG_SH3_3	103	109	PF00018	0.665
LIG_SH3_3	147	153	PF00018	0.665
LIG_SH3_3	172	178	PF00018	0.669
LIG_SUMO_SIM_par_1	74	80	PF11976	0.665
MOD_CDK_SPK_2	63	68	PF00069	0.665
MOD_DYRK1A_RPxSP_1	105	109	PF00069	0.665
MOD_GSK3_1	119	126	PF00069	0.665
MOD_N-GLC_1	160	165	PF02516	0.637
MOD_NEK2_1	4	9	PF00069	0.540
MOD_Plk_1	160	166	PF00069	0.642
MOD_Plk_1	34	40	PF00069	0.540
MOD_Plk_2-3	77	83	PF00069	0.665
MOD_Plk_4	4	10	PF00069	0.540
MOD_ProDKin_1	105	111	PF00069	0.665
MOD_ProDKin_1	63	69	PF00069	0.665
MOD_SUMO_for_1	173	176	PF00179	0.593
MOD_SUMO_rev_2	152	159	PF00179	0.743
TRG_ENDOCYTIC_2	116	119	PF00928	0.665
TRG_ENDOCYTIC_2	89	92	PF00928	0.665
TRG_ER_diArg_1	167	170	PF00400	0.656
TRG_ER_diArg_1	55	57	PF00400	0.665
TRG_ER_diArg_1	94	96	PF00400	0.665

Homologs


Protein	Taxonomy	Sequence identity	Coverage
P48862	Neisseria gonorrhoeae	34%	83%