Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNM3_LEIBR

TriTrypDb:

LbrM.35.0230 , LBRM2903_350007800

Length:

285

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 1
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HNM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNM3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	137	139	PF00675	0.662
CLV_NRD_NRD_1	235	237	PF00675	0.531
CLV_PCSK_KEX2_1	137	139	PF00082	0.683
CLV_PCSK_KEX2_1	235	237	PF00082	0.489
CLV_PCSK_SKI1_1	230	234	PF00082	0.439
CLV_PCSK_SKI1_1	35	39	PF00082	0.628
DEG_Nend_Nbox_1	1	3	PF02207	0.610
DOC_CKS1_1	154	159	PF01111	0.472
DOC_CYCLIN_yCln2_LP_2	154	160	PF00134	0.511
DOC_MAPK_MEF2A_6	187	196	PF00069	0.341
DOC_MAPK_MEF2A_6	94	103	PF00069	0.501
DOC_MAPK_RevD_3	220	236	PF00069	0.622
DOC_USP7_MATH_1	200	204	PF00917	0.561
DOC_WW_Pin1_4	153	158	PF00397	0.464
DOC_WW_Pin1_4	250	255	PF00397	0.750
LIG_14-3-3_CanoR_1	199	207	PF00244	0.386
LIG_Actin_WH2_2	88	104	PF00022	0.566
LIG_Clathr_ClatBox_1	126	130	PF01394	0.313
LIG_CtBP_PxDLS_1	96	100	PF00389	0.391
LIG_EH1_1	128	136	PF00400	0.486
LIG_FHA_1	174	180	PF00498	0.480
LIG_FHA_1	215	221	PF00498	0.320
LIG_FHA_1	29	35	PF00498	0.481
LIG_FHA_2	56	62	PF00498	0.537
LIG_LIR_Gen_1	118	129	PF02991	0.425
LIG_LIR_LC3C_4	217	222	PF02991	0.249
LIG_LIR_Nem_3	118	124	PF02991	0.436
LIG_LYPXL_SIV_4	212	220	PF13949	0.249
LIG_PDZ_Class_1	280	285	PF00595	0.776
LIG_Pex14_1	120	124	PF04695	0.334
LIG_SH2_CRK	213	217	PF00017	0.336
LIG_SH2_CRK	82	86	PF00017	0.489
LIG_SH2_NCK_1	213	217	PF00017	0.311
LIG_SH2_SRC	193	196	PF00017	0.321
LIG_SH2_SRC	213	216	PF00017	0.249
LIG_SH2_STAP1	48	52	PF00017	0.514
LIG_SH2_STAT5	193	196	PF00017	0.365
LIG_SH2_STAT5	231	234	PF00017	0.627
LIG_SH3_1	138	144	PF00018	0.500
LIG_SH3_3	138	144	PF00018	0.427
LIG_SUMO_SIM_anti_2	170	176	PF11976	0.357
LIG_SUMO_SIM_anti_2	217	223	PF11976	0.320
LIG_SUMO_SIM_par_1	170	176	PF11976	0.397
LIG_TYR_ITIM	80	85	PF00017	0.621
LIG_UBA3_1	267	272	PF00899	0.467
LIG_WRC_WIRS_1	126	131	PF05994	0.630
LIG_WW_1	45	48	PF00397	0.674
MOD_CDK_SPxK_1	153	159	PF00069	0.661
MOD_CDK_SPxxK_3	250	257	PF00069	0.697
MOD_CK1_1	152	158	PF00069	0.492
MOD_CK2_1	55	61	PF00069	0.640
MOD_GlcNHglycan	121	124	PF01048	0.631
MOD_GlcNHglycan	146	149	PF01048	0.699
MOD_GlcNHglycan	202	205	PF01048	0.721
MOD_GlcNHglycan	208	211	PF01048	0.646
MOD_GlcNHglycan	6	9	PF01048	0.625
MOD_GSK3_1	115	122	PF00069	0.647
MOD_GSK3_1	149	156	PF00069	0.492
MOD_N-GLC_1	149	154	PF02516	0.523
MOD_N-GLC_1	250	255	PF02516	0.488
MOD_NEK2_1	16	21	PF00069	0.484
MOD_NEK2_1	173	178	PF00069	0.544
MOD_NEK2_1	239	244	PF00069	0.628
MOD_NEK2_1	4	9	PF00069	0.599
MOD_NEK2_2	17	22	PF00069	0.647
MOD_PKA_2	186	192	PF00069	0.570
MOD_PKB_1	197	205	PF00069	0.483
MOD_Plk_1	239	245	PF00069	0.612
MOD_Plk_1	48	54	PF00069	0.605
MOD_Plk_2-3	55	61	PF00069	0.441
MOD_Plk_4	115	121	PF00069	0.661
MOD_Plk_4	214	220	PF00069	0.439
MOD_ProDKin_1	153	159	PF00069	0.577
MOD_ProDKin_1	250	256	PF00069	0.697
MOD_SUMO_for_1	271	274	PF00179	0.539
TRG_DiLeu_BaEn_1	130	135	PF01217	0.581
TRG_DiLeu_BaEn_1	170	175	PF01217	0.469
TRG_DiLeu_BaLyEn_6	223	228	PF01217	0.501
TRG_ENDOCYTIC_2	193	196	PF00928	0.516
TRG_ENDOCYTIC_2	213	216	PF00928	0.336
TRG_ENDOCYTIC_2	82	85	PF00928	0.609
TRG_ER_diArg_1	137	139	PF00400	0.602
TRG_ER_diArg_1	196	199	PF00400	0.532
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.447

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3B3	Leptomonas seymouri	44%	99%
A0A1X0P8Q0	Trypanosomatidae	25%	100%
A0A3Q8IN72	Leishmania donovani	79%	100%
A4ICX1	Leishmania infantum	79%	100%
E9ASD4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q262	Leishmania major	76%	100%