Fructose-6-phosphate2-kinase/fructose-2,6-bisph os phatase-likeprotein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatas, putative

Species:

Leishmania braziliensis

UniProt:

A4HNM2_LEIBR

TriTrypDb:

LbrM.35.0220 , LBRM2903_350007700

Length:

485

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNM2

Function

Biological processes
Term	Name	Level	Count
GO:0006003	fructose 2,6-bisphosphate metabolic process	4	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0019637	organophosphate metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:0016310	phosphorylation	5	6

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0003873	6-phosphofructo-2-kinase activity	6	6
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008443	phosphofructokinase activity	5	6
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	12
GO:0019200	carbohydrate kinase activity	5	6
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	8	4
GO:0016787	hydrolase activity	2	4
GO:0016788	hydrolase activity, acting on ester bonds	3	4
GO:0016791	phosphatase activity	5	4
GO:0019203	carbohydrate phosphatase activity	6	4
GO:0042578	phosphoric ester hydrolase activity	4	4
GO:0050308	sugar-phosphatase activity	7	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	163	167	PF00656	0.440
CLV_NRD_NRD_1	168	170	PF00675	0.277
CLV_NRD_NRD_1	329	331	PF00675	0.374
CLV_NRD_NRD_1	400	402	PF00675	0.300
CLV_NRD_NRD_1	412	414	PF00675	0.268
CLV_PCSK_KEX2_1	168	170	PF00082	0.277
CLV_PCSK_KEX2_1	329	331	PF00082	0.289
CLV_PCSK_KEX2_1	400	402	PF00082	0.310
CLV_PCSK_SKI1_1	179	183	PF00082	0.525
CLV_PCSK_SKI1_1	209	213	PF00082	0.567
CLV_PCSK_SKI1_1	348	352	PF00082	0.299
CLV_PCSK_SKI1_1	400	404	PF00082	0.372
CLV_PCSK_SKI1_1	426	430	PF00082	0.318
CLV_Separin_Metazoa	38	42	PF03568	0.655
DEG_SPOP_SBC_1	55	59	PF00917	0.747
DOC_CKS1_1	33	38	PF01111	0.556
DOC_MAPK_FxFP_2	387	390	PF00069	0.274
DOC_MAPK_gen_1	413	419	PF00069	0.257
DOC_MAPK_MEF2A_6	255	262	PF00069	0.521
DOC_MAPK_MEF2A_6	370	378	PF00069	0.247
DOC_PP1_RVXF_1	145	151	PF00149	0.530
DOC_PP1_RVXF_1	182	189	PF00149	0.345
DOC_PP1_RVXF_1	382	388	PF00149	0.289
DOC_PP4_FxxP_1	387	390	PF00568	0.274
DOC_USP7_MATH_1	167	171	PF00917	0.376
DOC_USP7_MATH_1	177	181	PF00917	0.347
DOC_USP7_MATH_1	214	218	PF00917	0.478
DOC_USP7_MATH_1	349	353	PF00917	0.404
DOC_USP7_MATH_1	470	474	PF00917	0.615
DOC_USP7_MATH_1	478	482	PF00917	0.640
DOC_USP7_MATH_1	55	59	PF00917	0.727
DOC_WW_Pin1_4	150	155	PF00397	0.518
DOC_WW_Pin1_4	32	37	PF00397	0.557
DOC_WW_Pin1_4	400	405	PF00397	0.417
DOC_WW_Pin1_4	466	471	PF00397	0.581
DOC_WW_Pin1_4	66	71	PF00397	0.477
LIG_14-3-3_CanoR_1	133	142	PF00244	0.482
LIG_14-3-3_CanoR_1	168	172	PF00244	0.430
LIG_14-3-3_CanoR_1	196	201	PF00244	0.589
LIG_14-3-3_CanoR_1	213	222	PF00244	0.472
LIG_14-3-3_CanoR_1	228	234	PF00244	0.308
LIG_14-3-3_CanoR_1	264	272	PF00244	0.293
LIG_14-3-3_CanoR_1	311	315	PF00244	0.421
LIG_14-3-3_CanoR_1	329	337	PF00244	0.292
LIG_14-3-3_CanoR_1	380	387	PF00244	0.302
LIG_14-3-3_CanoR_1	426	432	PF00244	0.274
LIG_14-3-3_CanoR_1	471	478	PF00244	0.613
LIG_14-3-3_CanoR_1	80	88	PF00244	0.387
LIG_Actin_WH2_2	198	215	PF00022	0.483
LIG_BRCT_BRCA1_1	108	112	PF00533	0.425
LIG_BRCT_BRCA1_1	198	202	PF00533	0.502
LIG_BRCT_BRCA1_1	83	87	PF00533	0.448
LIG_CtBP_PxDLS_1	43	47	PF00389	0.617
LIG_eIF4E_1	373	379	PF01652	0.193
LIG_EVH1_2	258	262	PF00568	0.368
LIG_FHA_1	18	24	PF00498	0.406
LIG_FHA_1	225	231	PF00498	0.373
LIG_FHA_1	283	289	PF00498	0.434
LIG_FHA_1	336	342	PF00498	0.391
LIG_FHA_1	380	386	PF00498	0.334
LIG_FHA_1	401	407	PF00498	0.417
LIG_FHA_1	447	453	PF00498	0.257
LIG_FHA_1	66	72	PF00498	0.399
LIG_FHA_1	88	94	PF00498	0.304
LIG_FHA_2	158	164	PF00498	0.483
LIG_FHA_2	33	39	PF00498	0.683
LIG_FHA_2	363	369	PF00498	0.295
LIG_FHA_2	45	51	PF00498	0.645
LIG_LIR_Apic_2	32	36	PF02991	0.489
LIG_LIR_Gen_1	199	207	PF02991	0.406
LIG_LIR_Gen_1	393	402	PF02991	0.334
LIG_LIR_Nem_3	199	205	PF02991	0.421
LIG_LIR_Nem_3	236	241	PF02991	0.481
LIG_LIR_Nem_3	256	260	PF02991	0.381
LIG_LIR_Nem_3	393	398	PF02991	0.274
LIG_LIR_Nem_3	90	95	PF02991	0.451
LIG_LYPXL_S_1	372	376	PF13949	0.308
LIG_LYPXL_yS_3	373	376	PF13949	0.289
LIG_PCNA_yPIPBox_3	422	435	PF02747	0.417
LIG_Pex14_2	188	192	PF04695	0.356
LIG_Pex14_2	257	261	PF04695	0.372
LIG_Pex14_2	375	379	PF04695	0.417
LIG_Pex14_2	88	92	PF04695	0.439
LIG_REV1ctd_RIR_1	259	268	PF16727	0.274
LIG_REV1ctd_RIR_1	429	435	PF16727	0.417
LIG_REV1ctd_RIR_1	85	95	PF16727	0.315
LIG_SH2_CRK	33	37	PF00017	0.411
LIG_SH2_PTP2	395	398	PF00017	0.350
LIG_SH2_STAT3	120	123	PF00017	0.483
LIG_SH2_STAT5	141	144	PF00017	0.406
LIG_SH2_STAT5	185	188	PF00017	0.294
LIG_SH2_STAT5	395	398	PF00017	0.417
LIG_SH2_STAT5	95	98	PF00017	0.333
LIG_SH3_3	343	349	PF00018	0.350
LIG_SH3_3	36	42	PF00018	0.534
LIG_SH3_3	438	444	PF00018	0.311
LIG_SUMO_SIM_anti_2	153	161	PF11976	0.493
LIG_SUMO_SIM_anti_2	393	400	PF11976	0.417
LIG_TRAF2_1	365	368	PF00917	0.298
LIG_TRAF2_1	436	439	PF00917	0.308
LIG_TRAF2_1	76	79	PF00917	0.432
LIG_TRAF2_2	470	475	PF00917	0.573
LIG_TYR_ITIM	371	376	PF00017	0.303
LIG_UBA3_1	405	414	PF00899	0.295
LIG_WRC_WIRS_1	428	433	PF05994	0.308
MOD_CDK_SPK_2	32	37	PF00069	0.411
MOD_CDK_SPK_2	466	471	PF00069	0.476
MOD_CK1_1	170	176	PF00069	0.395
MOD_CK1_1	215	221	PF00069	0.552
MOD_CK1_1	224	230	PF00069	0.366
MOD_CK1_1	65	71	PF00069	0.418
MOD_CK2_1	32	38	PF00069	0.650
MOD_CK2_1	349	355	PF00069	0.343
MOD_CK2_1	362	368	PF00069	0.238
MOD_CK2_1	44	50	PF00069	0.741
MOD_CK2_1	470	476	PF00069	0.562
MOD_CK2_1	73	79	PF00069	0.420
MOD_CMANNOS	482	485	PF00535	0.584
MOD_GlcNHglycan	135	138	PF01048	0.477
MOD_GlcNHglycan	172	175	PF01048	0.282
MOD_GlcNHglycan	217	220	PF01048	0.617
MOD_GlcNHglycan	83	86	PF01048	0.479
MOD_GSK3_1	217	224	PF00069	0.450
MOD_GSK3_1	229	236	PF00069	0.319
MOD_GSK3_1	331	338	PF00069	0.308
MOD_GSK3_1	42	49	PF00069	0.628
MOD_GSK3_1	466	473	PF00069	0.528
MOD_GSK3_1	62	69	PF00069	0.516
MOD_N-GLC_1	65	70	PF02516	0.490
MOD_N-GLC_2	10	12	PF02516	0.341
MOD_N-GLC_2	410	412	PF02516	0.417
MOD_NEK2_1	106	111	PF00069	0.533
MOD_NEK2_1	212	217	PF00069	0.453
MOD_NEK2_1	229	234	PF00069	0.430
MOD_NEK2_1	282	287	PF00069	0.417
MOD_NEK2_1	310	315	PF00069	0.293
MOD_NEK2_1	328	333	PF00069	0.295
MOD_NEK2_1	54	59	PF00069	0.620
MOD_NEK2_1	6	11	PF00069	0.517
MOD_NEK2_1	87	92	PF00069	0.383
MOD_NEK2_2	250	255	PF00069	0.414
MOD_PIKK_1	323	329	PF00454	0.274
MOD_PIKK_1	470	476	PF00454	0.598
MOD_PKA_2	167	173	PF00069	0.276
MOD_PKA_2	186	192	PF00069	0.401
MOD_PKA_2	212	218	PF00069	0.411
MOD_PKA_2	310	316	PF00069	0.364
MOD_PKA_2	328	334	PF00069	0.196
MOD_PKA_2	379	385	PF00069	0.308
MOD_PKA_2	470	476	PF00069	0.571
MOD_PKA_2	6	12	PF00069	0.651
MOD_PKA_2	62	68	PF00069	0.621
MOD_PKA_2	79	85	PF00069	0.402
MOD_Plk_1	177	183	PF00069	0.590
MOD_Plk_1	203	209	PF00069	0.409
MOD_Plk_2-3	19	25	PF00069	0.504
MOD_Plk_2-3	391	397	PF00069	0.350
MOD_Plk_4	217	223	PF00069	0.464
MOD_Plk_4	229	235	PF00069	0.366
MOD_Plk_4	310	316	PF00069	0.417
MOD_Plk_4	391	397	PF00069	0.417
MOD_Plk_4	427	433	PF00069	0.296
MOD_ProDKin_1	150	156	PF00069	0.507
MOD_ProDKin_1	32	38	PF00069	0.559
MOD_ProDKin_1	400	406	PF00069	0.417
MOD_ProDKin_1	466	472	PF00069	0.594
MOD_ProDKin_1	66	72	PF00069	0.470
MOD_SUMO_rev_2	13	20	PF00179	0.608
MOD_SUMO_rev_2	143	148	PF00179	0.461
MOD_SUMO_rev_2	362	372	PF00179	0.308
TRG_DiLeu_BaEn_1	367	372	PF01217	0.303
TRG_DiLeu_BaEn_4	367	373	PF01217	0.323
TRG_DiLeu_BaEn_4	78	84	PF01217	0.245
TRG_DiLeu_BaLyEn_6	401	406	PF01217	0.397
TRG_ENDOCYTIC_2	185	188	PF00928	0.447
TRG_ENDOCYTIC_2	200	203	PF00928	0.434
TRG_ENDOCYTIC_2	373	376	PF00928	0.289
TRG_ENDOCYTIC_2	395	398	PF00928	0.274
TRG_ER_diArg_1	328	330	PF00400	0.372
TRG_ER_diArg_1	399	401	PF00400	0.310
TRG_Pf-PMV_PEXEL_1	351	355	PF00026	0.301
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3S9	Leptomonas seymouri	67%	100%
A0A0S4JII5	Bodo saltans	46%	74%
A0A1X0P8D4	Trypanosomatidae	52%	100%
A0A3S7XA60	Leishmania donovani	88%	100%
A0A422NB33	Trypanosoma rangeli	52%	100%
A4ICX2	Leishmania infantum	88%	100%
D0A2H6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9ASD3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q263	Leishmania major	87%	100%
V5C004	Trypanosoma cruzi	51%	100%