Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HNM1_LEIBR

TriTrypDb:

LbrM.35.0210 , LBRM2903_350007600

Length:

641

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNM1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNM1

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	2
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	2
GO:0004672	protein kinase activity	3	2
GO:0005488	binding	1	2
GO:0005524	ATP binding	5	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	2
GO:0017076	purine nucleotide binding	4	2
GO:0030554	adenyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032559	adenyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:0140096	catalytic activity, acting on a protein	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	314	318	PF00656	0.394
CLV_C14_Caspase3-7	354	358	PF00656	0.502
CLV_C14_Caspase3-7	76	80	PF00656	0.268
CLV_MEL_PAP_1	109	115	PF00089	0.475
CLV_MEL_PAP_1	349	355	PF00089	0.261
CLV_NRD_NRD_1	413	415	PF00675	0.478
CLV_PCSK_FUR_1	57	61	PF00082	0.444
CLV_PCSK_KEX2_1	251	253	PF00082	0.466
CLV_PCSK_KEX2_1	413	415	PF00082	0.498
CLV_PCSK_KEX2_1	59	61	PF00082	0.541
CLV_PCSK_PC1ET2_1	251	253	PF00082	0.466
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.541
CLV_PCSK_SKI1_1	220	224	PF00082	0.695
CLV_PCSK_SKI1_1	251	255	PF00082	0.466
CLV_PCSK_SKI1_1	3	7	PF00082	0.618
CLV_PCSK_SKI1_1	305	309	PF00082	0.492
CLV_PCSK_SKI1_1	323	327	PF00082	0.273
CLV_PCSK_SKI1_1	361	365	PF00082	0.357
CLV_PCSK_SKI1_1	456	460	PF00082	0.491
CLV_PCSK_SKI1_1	49	53	PF00082	0.447
CLV_PCSK_SKI1_1	497	501	PF00082	0.569
CLV_PCSK_SKI1_1	59	63	PF00082	0.452
CLV_PCSK_SKI1_1	75	79	PF00082	0.383
DEG_APCC_DBOX_1	360	368	PF00400	0.397
DEG_Nend_Nbox_1	1	3	PF02207	0.586
DOC_CDC14_PxL_1	394	402	PF14671	0.501
DOC_CDC14_PxL_1	551	559	PF14671	0.408
DOC_CKS1_1	116	121	PF01111	0.280
DOC_CKS1_1	299	304	PF01111	0.533
DOC_CKS1_1	460	465	PF01111	0.495
DOC_CYCLIN_RxL_1	494	505	PF00134	0.574
DOC_CYCLIN_yCln2_LP_2	556	562	PF00134	0.463
DOC_MAPK_DCC_7	361	369	PF00069	0.403
DOC_MAPK_DCC_7	427	436	PF00069	0.439
DOC_MAPK_DCC_7	552	562	PF00069	0.569
DOC_MAPK_gen_1	167	175	PF00069	0.338
DOC_MAPK_gen_1	352	362	PF00069	0.287
DOC_MAPK_gen_1	381	390	PF00069	0.470
DOC_MAPK_gen_1	75	83	PF00069	0.511
DOC_MAPK_HePTP_8	424	436	PF00069	0.448
DOC_MAPK_MEF2A_6	265	274	PF00069	0.281
DOC_MAPK_MEF2A_6	361	369	PF00069	0.340
DOC_MAPK_MEF2A_6	427	436	PF00069	0.411
DOC_MAPK_MEF2A_6	507	514	PF00069	0.372
DOC_MAPK_RevD_3	398	414	PF00069	0.473
DOC_PP1_RVXF_1	103	109	PF00149	0.426
DOC_PP2B_LxvP_1	182	185	PF13499	0.593
DOC_PP2B_LxvP_1	283	286	PF13499	0.507
DOC_PP2B_LxvP_1	467	470	PF13499	0.532
DOC_PP2B_LxvP_1	611	614	PF13499	0.672
DOC_PP4_FxxP_1	175	178	PF00568	0.449
DOC_PP4_FxxP_1	299	302	PF00568	0.546
DOC_PP4_FxxP_1	362	365	PF00568	0.397
DOC_PP4_FxxP_1	430	433	PF00568	0.398
DOC_USP7_MATH_1	12	16	PF00917	0.588
DOC_USP7_MATH_1	156	160	PF00917	0.433
DOC_USP7_MATH_1	191	195	PF00917	0.460
DOC_USP7_MATH_1	550	554	PF00917	0.515
DOC_USP7_MATH_1	572	576	PF00917	0.525
DOC_USP7_MATH_1	590	594	PF00917	0.689
DOC_USP7_MATH_1	596	600	PF00917	0.572
DOC_WW_Pin1_4	115	120	PF00397	0.279
DOC_WW_Pin1_4	185	190	PF00397	0.523
DOC_WW_Pin1_4	298	303	PF00397	0.541
DOC_WW_Pin1_4	459	464	PF00397	0.498
DOC_WW_Pin1_4	542	547	PF00397	0.543
DOC_WW_Pin1_4	585	590	PF00397	0.569
DOC_WW_Pin1_4	618	623	PF00397	0.611
LIG_14-3-3_CanoR_1	112	116	PF00244	0.429
LIG_14-3-3_CanoR_1	265	271	PF00244	0.508
LIG_14-3-3_CanoR_1	427	431	PF00244	0.429
LIG_Actin_WH2_2	339	354	PF00022	0.401
LIG_APCC_ABBA_1	403	408	PF00400	0.359
LIG_APCC_ABBAyCdc20_2	402	408	PF00400	0.283
LIG_BRCT_BRCA1_1	274	278	PF00533	0.479
LIG_BRCT_BRCA1_1	488	492	PF00533	0.276
LIG_Clathr_ClatBox_1	310	314	PF01394	0.388
LIG_deltaCOP1_diTrp_1	164	175	PF00928	0.464
LIG_DLG_GKlike_1	396	403	PF00625	0.308
LIG_EH1_1	570	578	PF00400	0.506
LIG_EVH1_1	285	289	PF00568	0.506
LIG_EVH1_2	186	190	PF00568	0.597
LIG_FHA_1	108	114	PF00498	0.283
LIG_FHA_1	203	209	PF00498	0.439
LIG_FHA_1	306	312	PF00498	0.400
LIG_FHA_1	390	396	PF00498	0.421
LIG_FHA_1	427	433	PF00498	0.415
LIG_FHA_1	460	466	PF00498	0.552
LIG_FHA_1	473	479	PF00498	0.506
LIG_FHA_1	513	519	PF00498	0.558
LIG_FHA_1	520	526	PF00498	0.563
LIG_FHA_1	53	59	PF00498	0.473
LIG_FHA_1	586	592	PF00498	0.521
LIG_FHA_1	610	616	PF00498	0.511
LIG_FHA_2	504	510	PF00498	0.552
LIG_FHA_2	74	80	PF00498	0.439
LIG_GSK3_LRP6_1	185	190	PF00069	0.350
LIG_LIR_Apic_2	172	178	PF02991	0.435
LIG_LIR_Apic_2	296	302	PF02991	0.554
LIG_LIR_Apic_2	429	433	PF02991	0.324
LIG_LIR_Gen_1	237	248	PF02991	0.363
LIG_LIR_Gen_1	312	319	PF02991	0.348
LIG_LIR_Gen_1	385	395	PF02991	0.410
LIG_LIR_Gen_1	489	499	PF02991	0.371
LIG_LIR_Gen_1	633	640	PF02991	0.623
LIG_LIR_Nem_3	205	210	PF02991	0.485
LIG_LIR_Nem_3	235	241	PF02991	0.356
LIG_LIR_Nem_3	312	316	PF02991	0.453
LIG_LIR_Nem_3	319	325	PF02991	0.426
LIG_LIR_Nem_3	385	390	PF02991	0.416
LIG_LIR_Nem_3	486	490	PF02991	0.463
LIG_LIR_Nem_3	633	639	PF02991	0.624
LIG_MLH1_MIPbox_1	274	278	PF16413	0.533
LIG_MYND_1	555	559	PF01753	0.466
LIG_NRBOX	306	312	PF00104	0.275
LIG_Pex14_2	153	157	PF04695	0.238
LIG_Pex14_2	488	492	PF04695	0.475
LIG_Pex14_2	636	640	PF04695	0.608
LIG_PTB_Apo_2	13	20	PF02174	0.353
LIG_PTB_Apo_2	151	158	PF02174	0.239
LIG_PTB_Phospho_1	13	19	PF10480	0.356
LIG_Rb_pABgroove_1	323	331	PF01858	0.470
LIG_SH2_CRK	238	242	PF00017	0.436
LIG_SH2_CRK	329	333	PF00017	0.420
LIG_SH2_CRK	579	583	PF00017	0.500
LIG_SH2_SRC	19	22	PF00017	0.403
LIG_SH2_STAP1	19	23	PF00017	0.401
LIG_SH2_STAP1	406	410	PF00017	0.457
LIG_SH2_STAP1	579	583	PF00017	0.616
LIG_SH2_STAT3	406	409	PF00017	0.462
LIG_SH2_STAT5	161	164	PF00017	0.424
LIG_SH2_STAT5	202	205	PF00017	0.363
LIG_SH2_STAT5	207	210	PF00017	0.404
LIG_SH2_STAT5	21	24	PF00017	0.487
LIG_SH2_STAT5	277	280	PF00017	0.498
LIG_SH2_STAT5	386	389	PF00017	0.404
LIG_SH2_STAT5	532	535	PF00017	0.403
LIG_SH3_3	113	119	PF00018	0.519
LIG_SH3_3	183	189	PF00018	0.604
LIG_SH3_3	192	198	PF00018	0.291
LIG_SH3_3	283	289	PF00018	0.499
LIG_SH3_3	584	590	PF00018	0.624
LIG_SH3_5	198	202	PF00018	0.368
LIG_SUMO_SIM_anti_2	268	275	PF11976	0.278
LIG_SUMO_SIM_anti_2	68	76	PF11976	0.516
LIG_SUMO_SIM_anti_2	79	85	PF11976	0.406
LIG_SUMO_SIM_par_1	241	246	PF11976	0.418
LIG_SUMO_SIM_par_1	496	506	PF11976	0.334
LIG_SUMO_SIM_par_1	521	527	PF11976	0.383
LIG_SUMO_SIM_par_1	558	564	PF11976	0.362
LIG_SUMO_SIM_par_1	607	612	PF11976	0.504
LIG_SUMO_SIM_par_1	91	96	PF11976	0.468
LIG_TRAF2_1	247	250	PF00917	0.263
LIG_TRAF2_1	539	542	PF00917	0.325
LIG_TYR_ITIM	577	582	PF00017	0.479
LIG_UBA3_1	1	6	PF00899	0.625
LIG_UBA3_1	53	59	PF00899	0.464
LIG_UBA3_1	533	538	PF00899	0.525
LIG_WRC_WIRS_1	310	315	PF05994	0.471
LIG_WW_2	589	592	PF00397	0.501
MOD_CDK_SPxxK_3	298	305	PF00069	0.537
MOD_CDK_SPxxK_3	542	549	PF00069	0.536
MOD_CK1_1	11	17	PF00069	0.539
MOD_CK1_1	26	32	PF00069	0.479
MOD_CK1_1	389	395	PF00069	0.401
MOD_CK1_1	519	525	PF00069	0.531
MOD_CK1_1	585	591	PF00069	0.636
MOD_CK1_1	597	603	PF00069	0.648
MOD_CK1_1	618	624	PF00069	0.653
MOD_CK2_1	265	271	PF00069	0.470
MOD_CK2_1	503	509	PF00069	0.554
MOD_CK2_1	536	542	PF00069	0.431
MOD_CK2_1	596	602	PF00069	0.525
MOD_CK2_1	63	69	PF00069	0.453
MOD_Cter_Amidation	47	50	PF01082	0.504
MOD_GlcNHglycan	10	13	PF01048	0.597
MOD_GlcNHglycan	223	226	PF01048	0.576
MOD_GlcNHglycan	24	28	PF01048	0.527
MOD_GlcNHglycan	256	259	PF01048	0.471
MOD_GlcNHglycan	334	337	PF01048	0.314
MOD_GlcNHglycan	46	49	PF01048	0.350
MOD_GlcNHglycan	584	587	PF01048	0.714
MOD_GlcNHglycan	604	607	PF01048	0.622
MOD_GlcNHglycan	622	625	PF01048	0.571
MOD_GlcNHglycan	65	68	PF01048	0.384
MOD_GSK3_1	107	114	PF00069	0.281
MOD_GSK3_1	22	29	PF00069	0.521
MOD_GSK3_1	289	296	PF00069	0.503
MOD_GSK3_1	305	312	PF00069	0.435
MOD_GSK3_1	497	504	PF00069	0.442
MOD_GSK3_1	512	519	PF00069	0.348
MOD_GSK3_1	590	597	PF00069	0.686
MOD_GSK3_1	598	605	PF00069	0.474
MOD_GSK3_1	609	616	PF00069	0.657
MOD_GSK3_1	73	80	PF00069	0.269
MOD_GSK3_1	8	15	PF00069	0.599
MOD_N-GLC_1	317	322	PF02516	0.296
MOD_N-GLC_1	377	382	PF02516	0.278
MOD_N-GLC_1	519	524	PF02516	0.569
MOD_N-GLC_1	564	569	PF02516	0.448
MOD_NEK2_1	155	160	PF00069	0.399
MOD_NEK2_1	23	28	PF00069	0.524
MOD_NEK2_1	254	259	PF00069	0.514
MOD_NEK2_1	332	337	PF00069	0.297
MOD_NEK2_1	351	356	PF00069	0.224
MOD_NEK2_1	5	10	PF00069	0.608
MOD_NEK2_1	523	528	PF00069	0.455
MOD_NEK2_1	536	541	PF00069	0.341
MOD_NEK2_1	561	566	PF00069	0.417
MOD_NEK2_1	582	587	PF00069	0.688
MOD_NEK2_1	609	614	PF00069	0.713
MOD_NEK2_1	615	620	PF00069	0.755
MOD_NEK2_1	99	104	PF00069	0.308
MOD_NEK2_2	156	161	PF00069	0.432
MOD_PIKK_1	330	336	PF00454	0.287
MOD_PIKK_1	616	622	PF00454	0.734
MOD_PK_1	413	419	PF00069	0.292
MOD_PKA_1	413	419	PF00069	0.292
MOD_PKA_1	49	55	PF00069	0.453
MOD_PKA_2	111	117	PF00069	0.413
MOD_PKA_2	351	357	PF00069	0.315
MOD_PKA_2	413	419	PF00069	0.445
MOD_PKA_2	426	432	PF00069	0.334
MOD_PKA_2	44	50	PF00069	0.432
MOD_PKA_2	616	622	PF00069	0.723
MOD_Plk_1	317	323	PF00069	0.299
MOD_Plk_1	510	516	PF00069	0.458
MOD_Plk_1	519	525	PF00069	0.533
MOD_Plk_4	111	117	PF00069	0.418
MOD_Plk_4	156	162	PF00069	0.401
MOD_Plk_4	289	295	PF00069	0.462
MOD_Plk_4	386	392	PF00069	0.401
MOD_Plk_4	426	432	PF00069	0.413
MOD_Plk_4	49	55	PF00069	0.405
MOD_Plk_4	572	578	PF00069	0.470
MOD_Plk_4	635	641	PF00069	0.620
MOD_ProDKin_1	115	121	PF00069	0.282
MOD_ProDKin_1	185	191	PF00069	0.520
MOD_ProDKin_1	298	304	PF00069	0.533
MOD_ProDKin_1	459	465	PF00069	0.510
MOD_ProDKin_1	542	548	PF00069	0.537
MOD_ProDKin_1	585	591	PF00069	0.573
MOD_ProDKin_1	618	624	PF00069	0.613
MOD_SUMO_rev_2	246	253	PF00179	0.331
MOD_SUMO_rev_2	96	104	PF00179	0.565
TRG_DiLeu_BaEn_2	138	144	PF01217	0.501
TRG_DiLeu_BaLyEn_6	195	200	PF01217	0.458
TRG_DiLeu_BaLyEn_6	320	325	PF01217	0.466
TRG_DiLeu_BaLyEn_6	430	435	PF01217	0.406
TRG_DiLeu_BaLyEn_6	473	478	PF01217	0.501
TRG_DiLeu_BaLyEn_6	552	557	PF01217	0.429
TRG_ENDOCYTIC_2	19	22	PF00928	0.316
TRG_ENDOCYTIC_2	207	210	PF00928	0.537
TRG_ENDOCYTIC_2	238	241	PF00928	0.436
TRG_ENDOCYTIC_2	329	332	PF00928	0.452
TRG_ENDOCYTIC_2	579	582	PF00928	0.552
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.462
TRG_Pf-PMV_PEXEL_1	381	385	PF00026	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P470	Leptomonas seymouri	64%	99%
A0A0S4JMZ8	Bodo saltans	24%	100%
A0A1X0P8C9	Trypanosomatidae	35%	100%
A0A3Q8IIL7	Leishmania donovani	76%	100%
A4ICX3	Leishmania infantum	76%	100%
E9ASD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	99%
F4I313	Arabidopsis thaliana	22%	70%
Q4Q264	Leishmania major	76%	100%
Q6P3W7	Homo sapiens	23%	69%