PUB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PUB domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HNM0_LEIBR

TriTrypDb:

LbrM.35.0200 , LBRM2903_350007500

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNM0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	31	35	PF00656	0.718
CLV_C14_Caspase3-7	340	344	PF00656	0.223
CLV_NRD_NRD_1	120	122	PF00675	0.605
CLV_NRD_NRD_1	131	133	PF00675	0.472
CLV_NRD_NRD_1	142	144	PF00675	0.432
CLV_NRD_NRD_1	155	157	PF00675	0.470
CLV_NRD_NRD_1	175	177	PF00675	0.459
CLV_NRD_NRD_1	187	189	PF00675	0.496
CLV_NRD_NRD_1	274	276	PF00675	0.539
CLV_NRD_NRD_1	355	357	PF00675	0.531
CLV_PCSK_FUR_1	118	122	PF00082	0.614
CLV_PCSK_KEX2_1	100	102	PF00082	0.560
CLV_PCSK_KEX2_1	120	122	PF00082	0.281
CLV_PCSK_KEX2_1	142	144	PF00082	0.552
CLV_PCSK_KEX2_1	155	157	PF00082	0.550
CLV_PCSK_KEX2_1	174	176	PF00082	0.465
CLV_PCSK_KEX2_1	276	278	PF00082	0.656
CLV_PCSK_KEX2_1	306	308	PF00082	0.328
CLV_PCSK_KEX2_1	355	357	PF00082	0.556
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.560
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.486
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.656
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.328
CLV_PCSK_SKI1_1	100	104	PF00082	0.528
CLV_PCSK_SKI1_1	108	112	PF00082	0.487
CLV_PCSK_SKI1_1	175	179	PF00082	0.481
CLV_PCSK_SKI1_1	291	295	PF00082	0.344
CLV_PCSK_SKI1_1	358	362	PF00082	0.460
DEG_APCC_DBOX_1	290	298	PF00400	0.385
DEG_APCC_DBOX_1	357	365	PF00400	0.453
DOC_MAPK_gen_1	120	130	PF00069	0.593
DOC_MAPK_gen_1	174	181	PF00069	0.467
DOC_MAPK_gen_1	305	311	PF00069	0.449
DOC_MAPK_gen_1	314	323	PF00069	0.449
DOC_MAPK_gen_1	355	364	PF00069	0.529
DOC_MAPK_MEF2A_6	174	181	PF00069	0.457
DOC_USP7_MATH_1	11	15	PF00917	0.668
DOC_USP7_MATH_2	23	29	PF00917	0.611
DOC_USP7_UBL2_3	174	178	PF12436	0.483
DOC_USP7_UBL2_3	94	98	PF12436	0.385
DOC_WW_Pin1_4	275	280	PF00397	0.532
LIG_14-3-3_CanoR_1	231	240	PF00244	0.621
LIG_14-3-3_CanoR_1	310	316	PF00244	0.355
LIG_14-3-3_CanoR_1	51	58	PF00244	0.589
LIG_Actin_WH2_2	342	360	PF00022	0.384
LIG_AP2alpha_2	300	302	PF02296	0.449
LIG_BIR_II_1	1	5	PF00653	0.683
LIG_FHA_1	287	293	PF00498	0.449
LIG_FHA_1	306	312	PF00498	0.404
LIG_FHA_1	348	354	PF00498	0.333
LIG_FHA_1	35	41	PF00498	0.537
LIG_FHA_1	71	77	PF00498	0.446
LIG_FHA_2	102	108	PF00498	0.503
LIG_FHA_2	190	196	PF00498	0.568
LIG_FHA_2	267	273	PF00498	0.356
LIG_FHA_2	276	282	PF00498	0.352
LIG_FHA_2	85	91	PF00498	0.552
LIG_LIR_Gen_1	43	53	PF02991	0.463
LIG_LIR_Gen_1	73	83	PF02991	0.508
LIG_LIR_Nem_3	43	48	PF02991	0.448
LIG_PCNA_PIPBox_1	252	261	PF02747	0.625
LIG_PCNA_yPIPBox_3	250	259	PF02747	0.506
LIG_RPA_C_Fungi	207	219	PF08784	0.616
LIG_RPA_C_Fungi	46	58	PF08784	0.326
LIG_SH2_STAT5	38	41	PF00017	0.511
LIG_SH3_3	10	16	PF00018	0.756
LIG_SH3_3	17	23	PF00018	0.743
LIG_SH3_3	224	230	PF00018	0.469
LIG_TRAF2_1	2	5	PF00917	0.744
MOD_CDK_SPxxK_3	275	282	PF00069	0.407
MOD_CK1_1	243	249	PF00069	0.634
MOD_CK1_1	27	33	PF00069	0.639
MOD_CK1_1	338	344	PF00069	0.223
MOD_CK2_1	101	107	PF00069	0.425
MOD_CK2_1	189	195	PF00069	0.524
MOD_CK2_1	25	31	PF00069	0.649
MOD_CK2_1	84	90	PF00069	0.567
MOD_Cter_Amidation	140	143	PF01082	0.528
MOD_GlcNHglycan	242	245	PF01048	0.631
MOD_GSK3_1	26	33	PF00069	0.651
MOD_GSK3_1	301	308	PF00069	0.422
MOD_GSK3_1	36	43	PF00069	0.425
MOD_N-GLC_1	11	16	PF02516	0.657
MOD_N-GLC_1	240	245	PF02516	0.691
MOD_NEK2_1	222	227	PF00069	0.583
MOD_NEK2_1	309	314	PF00069	0.343
MOD_NEK2_1	316	321	PF00069	0.343
MOD_NEK2_1	347	352	PF00069	0.388
MOD_NEK2_2	286	291	PF00069	0.413
MOD_OFUCOSY	66	72	PF10250	0.447
MOD_PIKK_1	222	228	PF00454	0.652
MOD_PIKK_1	248	254	PF00454	0.387
MOD_PIKK_1	70	76	PF00454	0.458
MOD_PKA_1	305	311	PF00069	0.385
MOD_PKA_2	230	236	PF00069	0.636
MOD_PKA_2	309	315	PF00069	0.449
MOD_PKA_2	316	322	PF00069	0.449
MOD_PKA_2	5	11	PF00069	0.730
MOD_Plk_1	240	246	PF00069	0.663
MOD_Plk_4	266	272	PF00069	0.479
MOD_Plk_4	316	322	PF00069	0.433
MOD_Plk_4	348	354	PF00069	0.340
MOD_Plk_4	40	46	PF00069	0.430
MOD_Plk_4	58	64	PF00069	0.418
MOD_ProDKin_1	275	281	PF00069	0.533
MOD_SUMO_for_1	147	150	PF00179	0.557
MOD_SUMO_rev_2	105	113	PF00179	0.495
TRG_DiLeu_BaEn_1	15	20	PF01217	0.510
TRG_DiLeu_BaEn_1	325	330	PF01217	0.475
TRG_DiLeu_BaEn_4	125	131	PF01217	0.537
TRG_DiLeu_BaLyEn_6	288	293	PF01217	0.475
TRG_ER_diArg_1	118	121	PF00400	0.615
TRG_ER_diArg_1	142	144	PF00400	0.486
TRG_ER_diArg_1	154	156	PF00400	0.548
TRG_ER_diArg_1	175	177	PF00400	0.466
TRG_ER_diArg_1	274	277	PF00400	0.553
TRG_ER_diArg_1	354	356	PF00400	0.569
TRG_NES_CRM1_1	150	162	PF08389	0.541
TRG_NLS_Bipartite_1	156	178	PF00514	0.538
TRG_NLS_MonoExtC_3	173	178	PF00514	0.482
TRG_NLS_MonoExtC_3	274	279	PF00514	0.431
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.536
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I208	Leptomonas seymouri	62%	99%
A0A0S4JLL2	Bodo saltans	37%	94%
A0A1X0P8K7	Trypanosomatidae	48%	100%
A0A3S5IQV7	Trypanosoma rangeli	47%	100%
A0A3S7XA96	Leishmania donovani	78%	100%
A4ICX4	Leishmania infantum	77%	100%
D0A2H5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	89%
E9ASD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4Q265	Leishmania major	78%	100%
V5BQK6	Trypanosoma cruzi	43%	100%