Putative DNA damage repair protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA damage repair protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HNL7_LEIBR

TriTrypDb:

LbrM.35.0170 , LBRM2903_350007200

Length:

624

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNL7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006281	DNA repair	5	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0006950	response to stress	2	12
GO:0006974	DNA damage response	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0033554	cellular response to stress	3	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0050896	response to stimulus	1	12
GO:0051716	cellular response to stimulus	2	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0000731	DNA synthesis involved in DNA repair	6	1
GO:0006301	postreplication repair	6	1
GO:0009058	biosynthetic process	2	1
GO:0009059	macromolecule biosynthetic process	4	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019985	translesion synthesis	7	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0042276	error-prone translesion synthesis	8	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0070987	error-free translesion synthesis	8	1
GO:0071897	DNA biosynthetic process	5	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003684	damaged DNA binding	5	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003824	catalytic activity	1	2
GO:0003887	DNA-directed DNA polymerase activity	5	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016779	nucleotidyltransferase activity	4	2
GO:0017125	deoxycytidyl transferase activity	5	1
GO:0034061	DNA polymerase activity	4	2
GO:0140097	catalytic activity, acting on DNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	267	271	PF00656	0.551
CLV_NRD_NRD_1	189	191	PF00675	0.299
CLV_NRD_NRD_1	283	285	PF00675	0.293
CLV_NRD_NRD_1	422	424	PF00675	0.406
CLV_PCSK_FUR_1	281	285	PF00082	0.281
CLV_PCSK_KEX2_1	283	285	PF00082	0.435
CLV_PCSK_KEX2_1	293	295	PF00082	0.608
CLV_PCSK_KEX2_1	325	327	PF00082	0.543
CLV_PCSK_KEX2_1	422	424	PF00082	0.437
CLV_PCSK_KEX2_1	509	511	PF00082	0.574
CLV_PCSK_KEX2_1	571	573	PF00082	0.464
CLV_PCSK_PC1ET2_1	293	295	PF00082	0.610
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.567
CLV_PCSK_PC1ET2_1	509	511	PF00082	0.574
CLV_PCSK_PC1ET2_1	571	573	PF00082	0.292
CLV_PCSK_PC7_1	289	295	PF00082	0.434
CLV_PCSK_PC7_1	321	327	PF00082	0.650
CLV_PCSK_SKI1_1	141	145	PF00082	0.262
CLV_PCSK_SKI1_1	148	152	PF00082	0.222
CLV_PCSK_SKI1_1	191	195	PF00082	0.335
CLV_PCSK_SKI1_1	213	217	PF00082	0.231
CLV_PCSK_SKI1_1	284	288	PF00082	0.404
CLV_PCSK_SKI1_1	309	313	PF00082	0.404
CLV_PCSK_SKI1_1	352	356	PF00082	0.352
CLV_PCSK_SKI1_1	472	476	PF00082	0.367
CLV_PCSK_SKI1_1	587	591	PF00082	0.381
CLV_PCSK_SKI1_1	61	65	PF00082	0.224
DEG_APCC_DBOX_1	283	291	PF00400	0.414
DEG_APCC_DBOX_1	351	359	PF00400	0.342
DEG_APCC_DBOX_1	586	594	PF00400	0.497
DOC_CYCLIN_RxL_1	188	197	PF00134	0.498
DOC_CYCLIN_RxL_1	349	356	PF00134	0.340
DOC_CYCLIN_yCln2_LP_2	617	623	PF00134	0.409
DOC_MAPK_DCC_7	422	430	PF00069	0.433
DOC_MAPK_gen_1	123	132	PF00069	0.535
DOC_MAPK_gen_1	141	151	PF00069	0.535
DOC_MAPK_gen_1	393	401	PF00069	0.468
DOC_MAPK_gen_1	422	430	PF00069	0.547
DOC_MAPK_gen_1	509	519	PF00069	0.658
DOC_MAPK_MEF2A_6	393	401	PF00069	0.475
DOC_MAPK_MEF2A_6	61	68	PF00069	0.392
DOC_PP1_RVXF_1	146	152	PF00149	0.384
DOC_PP1_RVXF_1	25	31	PF00149	0.347
DOC_PP2B_LxvP_1	617	620	PF13499	0.432
DOC_USP7_MATH_1	247	251	PF00917	0.489
DOC_USP7_MATH_1	602	606	PF00917	0.571
DOC_USP7_UBL2_3	385	389	PF12436	0.396
DOC_WW_Pin1_4	324	329	PF00397	0.511
DOC_WW_Pin1_4	520	525	PF00397	0.625
LIG_14-3-3_CanoR_1	141	147	PF00244	0.527
LIG_14-3-3_CanoR_1	2	12	PF00244	0.458
LIG_14-3-3_CanoR_1	213	221	PF00244	0.442
LIG_14-3-3_CanoR_1	364	369	PF00244	0.383
LIG_14-3-3_CanoR_1	373	377	PF00244	0.403
LIG_14-3-3_CanoR_1	472	477	PF00244	0.421
LIG_14-3-3_CanoR_1	510	515	PF00244	0.643
LIG_Actin_WH2_2	229	244	PF00022	0.498
LIG_Actin_WH2_2	448	466	PF00022	0.549
LIG_APCC_ABBA_1	46	51	PF00400	0.467
LIG_APCC_ABBAyCdc20_2	61	67	PF00400	0.441
LIG_CaM_IQ_9	19	35	PF13499	0.349
LIG_CaM_IQ_9	276	291	PF13499	0.354
LIG_deltaCOP1_diTrp_1	44	52	PF00928	0.411
LIG_FHA_1	325	331	PF00498	0.537
LIG_FHA_1	455	461	PF00498	0.452
LIG_FHA_1	520	526	PF00498	0.509
LIG_FHA_1	544	550	PF00498	0.639
LIG_FHA_1	85	91	PF00498	0.536
LIG_FHA_2	34	40	PF00498	0.510
LIG_FHA_2	373	379	PF00498	0.350
LIG_FHA_2	516	522	PF00498	0.750
LIG_GBD_Chelix_1	368	376	PF00786	0.470
LIG_LIR_Apic_2	594	599	PF02991	0.449
LIG_LIR_Gen_1	297	307	PF02991	0.445
LIG_LIR_Gen_1	604	613	PF02991	0.531
LIG_LIR_Gen_1	62	71	PF02991	0.350
LIG_LIR_Gen_1	81	90	PF02991	0.555
LIG_LIR_Nem_3	145	150	PF02991	0.520
LIG_LIR_Nem_3	176	182	PF02991	0.498
LIG_LIR_Nem_3	297	303	PF02991	0.370
LIG_LIR_Nem_3	345	351	PF02991	0.375
LIG_LIR_Nem_3	44	48	PF02991	0.367
LIG_LIR_Nem_3	578	582	PF02991	0.448
LIG_LIR_Nem_3	604	609	PF02991	0.447
LIG_LIR_Nem_3	62	66	PF02991	0.383
LIG_LIR_Nem_3	69	75	PF02991	0.437
LIG_LIR_Nem_3	81	85	PF02991	0.431
LIG_LYPXL_yS_3	579	582	PF13949	0.487
LIG_PDZ_Class_3	619	624	PF00595	0.530
LIG_Pex14_2	30	34	PF04695	0.339
LIG_Pex14_2	42	46	PF04695	0.336
LIG_SH2_CRK	147	151	PF00017	0.466
LIG_SH2_CRK	179	183	PF00017	0.535
LIG_SH2_CRK	300	304	PF00017	0.405
LIG_SH2_GRB2like	118	121	PF00017	0.442
LIG_SH2_SRC	118	121	PF00017	0.442
LIG_SH2_SRC	243	246	PF00017	0.465
LIG_SH2_STAT5	106	109	PF00017	0.447
LIG_SH2_STAT5	118	121	PF00017	0.497
LIG_SH2_STAT5	243	246	PF00017	0.508
LIG_SH2_STAT5	29	32	PF00017	0.540
LIG_SH2_STAT5	585	588	PF00017	0.372
LIG_SH3_3	378	384	PF00018	0.346
LIG_SH3_3	396	402	PF00018	0.340
LIG_SH3_3	421	427	PF00018	0.460
LIG_SUMO_SIM_anti_2	412	418	PF11976	0.301
LIG_SUMO_SIM_anti_2	515	523	PF11976	0.620
LIG_SUMO_SIM_par_1	426	432	PF11976	0.423
LIG_TRAF2_1	483	486	PF00917	0.358
LIG_TYR_ITIM	577	582	PF00017	0.483
LIG_TYR_ITSM	143	150	PF00017	0.535
LIG_TYR_ITSM	296	303	PF00017	0.401
LIG_WRC_WIRS_1	182	187	PF05994	0.518
LIG_WRC_WIRS_1	609	614	PF05994	0.464
MOD_CDK_SPxxK_3	520	527	PF00069	0.469
MOD_CK1_1	537	543	PF00069	0.530
MOD_CK1_1	611	617	PF00069	0.285
MOD_CK1_1	99	105	PF00069	0.453
MOD_CK2_1	118	124	PF00069	0.503
MOD_CK2_1	163	169	PF00069	0.442
MOD_CK2_1	181	187	PF00069	0.487
MOD_CK2_1	247	253	PF00069	0.570
MOD_CK2_1	33	39	PF00069	0.476
MOD_CK2_1	372	378	PF00069	0.330
MOD_CK2_1	433	439	PF00069	0.410
MOD_CK2_1	444	450	PF00069	0.440
MOD_Cter_Amidation	291	294	PF01082	0.432
MOD_Cter_Amidation	323	326	PF01082	0.521
MOD_GlcNHglycan	120	123	PF01048	0.359
MOD_GlcNHglycan	494	497	PF01048	0.677
MOD_GlcNHglycan	528	531	PF01048	0.554
MOD_GlcNHglycan	613	616	PF01048	0.391
MOD_GSK3_1	150	157	PF00069	0.474
MOD_GSK3_1	193	200	PF00069	0.477
MOD_GSK3_1	305	312	PF00069	0.398
MOD_GSK3_1	429	436	PF00069	0.467
MOD_GSK3_1	472	479	PF00069	0.391
MOD_GSK3_1	515	522	PF00069	0.657
MOD_GSK3_1	534	541	PF00069	0.558
MOD_GSK3_1	96	103	PF00069	0.451
MOD_NEK2_1	107	112	PF00069	0.447
MOD_NEK2_1	181	186	PF00069	0.492
MOD_NEK2_1	193	198	PF00069	0.472
MOD_NEK2_1	372	377	PF00069	0.341
MOD_NEK2_1	429	434	PF00069	0.447
MOD_NEK2_1	444	449	PF00069	0.445
MOD_NEK2_1	454	459	PF00069	0.542
MOD_NEK2_1	476	481	PF00069	0.470
MOD_NEK2_1	528	533	PF00069	0.579
MOD_NEK2_1	538	543	PF00069	0.605
MOD_NEK2_1	71	76	PF00069	0.442
MOD_NEK2_1	8	13	PF00069	0.625
MOD_PIKK_1	384	390	PF00454	0.432
MOD_PIKK_1	6	12	PF00454	0.409
MOD_PK_1	326	332	PF00069	0.454
MOD_PKA_2	3	9	PF00069	0.455
MOD_PKA_2	372	378	PF00069	0.285
MOD_PKA_2	526	532	PF00069	0.489
MOD_PKA_2	534	540	PF00069	0.448
MOD_Plk_1	248	254	PF00069	0.435
MOD_Plk_1	305	311	PF00069	0.351
MOD_Plk_2-3	163	169	PF00069	0.431
MOD_Plk_2-3	515	521	PF00069	0.622
MOD_Plk_4	142	148	PF00069	0.524
MOD_Plk_4	295	301	PF00069	0.490
MOD_Plk_4	326	332	PF00069	0.344
MOD_Plk_4	515	521	PF00069	0.685
MOD_ProDKin_1	324	330	PF00069	0.498
MOD_ProDKin_1	520	526	PF00069	0.626
MOD_SUMO_for_1	483	486	PF00179	0.358
MOD_SUMO_for_1	78	81	PF00179	0.456
TRG_DiLeu_BaLyEn_6	424	429	PF01217	0.471
TRG_ENDOCYTIC_2	147	150	PF00928	0.431
TRG_ENDOCYTIC_2	179	182	PF00928	0.498
TRG_ENDOCYTIC_2	300	303	PF00928	0.403
TRG_ENDOCYTIC_2	579	582	PF00928	0.425
TRG_ENDOCYTIC_2	82	85	PF00928	0.478
TRG_ER_diArg_1	1	4	PF00400	0.636
TRG_ER_diArg_1	281	284	PF00400	0.422
TRG_ER_diArg_1	421	423	PF00400	0.258
TRG_ER_diArg_1	532	535	PF00400	0.475
TRG_NES_CRM1_1	67	81	PF08389	0.431
TRG_NLS_MonoCore_2	508	513	PF00514	0.649
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.187
TRG_Pf-PMV_PEXEL_1	257	261	PF00026	0.533
TRG_Pf-PMV_PEXEL_1	352	356	PF00026	0.350

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA19	Leptomonas seymouri	69%	100%
A0A0S4JRX6	Bodo saltans	44%	87%
A0A1X0P8Q5	Trypanosomatidae	49%	99%
A0A3S7XA64	Leishmania donovani	82%	100%
A0A422NAZ8	Trypanosoma rangeli	48%	100%
A4ICX7	Leishmania infantum	82%	100%
D0A2H2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9ASC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q268	Leishmania major	82%	100%
V5BV86	Trypanosoma cruzi	49%	100%