Leucine carboxyl methyltransferase 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine carboxyl methyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HNL5_LEIBR

TriTrypDb:

LbrM.35.0150 , LBRM2903_350007000

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNL5

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	12
GO:0032259	methylation	2	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.276
CLV_NRD_NRD_1	12	14	PF00675	0.317
CLV_NRD_NRD_1	18	20	PF00675	0.341
CLV_PCSK_KEX2_1	114	116	PF00082	0.343
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.368
CLV_PCSK_SKI1_1	135	139	PF00082	0.321
CLV_PCSK_SKI1_1	142	146	PF00082	0.327
CLV_PCSK_SKI1_1	187	191	PF00082	0.419
CLV_PCSK_SKI1_1	239	243	PF00082	0.390
DOC_CKS1_1	223	228	PF01111	0.367
DOC_CYCLIN_RxL_1	242	252	PF00134	0.321
DOC_MAPK_MEF2A_6	149	157	PF00069	0.242
DOC_MAPK_MEF2A_6	86	94	PF00069	0.224
DOC_PP2B_LxvP_1	251	254	PF13499	0.332
DOC_PP2B_PxIxI_1	152	158	PF00149	0.381
DOC_PP4_FxxP_1	223	226	PF00568	0.459
DOC_USP7_MATH_1	26	30	PF00917	0.373
DOC_USP7_UBL2_3	110	114	PF12436	0.168
DOC_USP7_UBL2_3	138	142	PF12436	0.274
DOC_WW_Pin1_4	149	154	PF00397	0.381
DOC_WW_Pin1_4	222	227	PF00397	0.373
DOC_WW_Pin1_4	37	42	PF00397	0.271
LIG_14-3-3_CanoR_1	115	123	PF00244	0.383
LIG_14-3-3_CanoR_1	232	238	PF00244	0.478
LIG_14-3-3_CanoR_1	50	58	PF00244	0.388
LIG_14-3-3_CanoR_1	59	69	PF00244	0.328
LIG_14-3-3_CanoR_1	84	90	PF00244	0.426
LIG_Actin_WH2_2	136	151	PF00022	0.292
LIG_Actin_WH2_2	162	177	PF00022	0.408
LIG_Actin_WH2_2	71	88	PF00022	0.408
LIG_AP2alpha_2	25	27	PF02296	0.271
LIG_APCC_ABBA_1	161	166	PF00400	0.287
LIG_BIR_II_1	1	5	PF00653	0.380
LIG_BIR_III_4	136	140	PF00653	0.381
LIG_deltaCOP1_diTrp_1	268	273	PF00928	0.356
LIG_FHA_1	150	156	PF00498	0.300
LIG_FHA_1	168	174	PF00498	0.216
LIG_FHA_2	4	10	PF00498	0.421
LIG_FHA_2	50	56	PF00498	0.381
LIG_FHA_2	62	68	PF00498	0.226
LIG_FXI_DFP_1	220	224	PF00024	0.472
LIG_GBD_Chelix_1	140	148	PF00786	0.461
LIG_LIR_Apic_2	222	226	PF02991	0.467
LIG_LIR_Gen_1	125	134	PF02991	0.290
LIG_LIR_Gen_1	159	169	PF02991	0.271
LIG_LIR_Gen_1	25	31	PF02991	0.311
LIG_LIR_Gen_1	271	280	PF02991	0.323
LIG_LIR_Gen_1	99	107	PF02991	0.260
LIG_LIR_Nem_3	125	130	PF02991	0.290
LIG_LIR_Nem_3	159	165	PF02991	0.291
LIG_LIR_Nem_3	200	205	PF02991	0.340
LIG_LIR_Nem_3	216	220	PF02991	0.344
LIG_LIR_Nem_3	235	241	PF02991	0.481
LIG_LIR_Nem_3	25	30	PF02991	0.299
LIG_LIR_Nem_3	278	283	PF02991	0.302
LIG_LIR_Nem_3	79	85	PF02991	0.271
LIG_LIR_Nem_3	99	105	PF02991	0.122
LIG_PCNA_yPIPBox_3	84	98	PF02747	0.401
LIG_Pex14_2	213	217	PF04695	0.478
LIG_Pex14_2	27	31	PF04695	0.271
LIG_PTB_Apo_2	21	28	PF02174	0.408
LIG_REV1ctd_RIR_1	28	37	PF16727	0.331
LIG_REV1ctd_RIR_1	80	89	PF16727	0.242
LIG_SH2_CRK	193	197	PF00017	0.309
LIG_SH2_CRK	280	284	PF00017	0.290
LIG_SH2_GRB2like	22	25	PF00017	0.408
LIG_SH2_NCK_1	127	131	PF00017	0.194
LIG_SH2_NCK_1	193	197	PF00017	0.385
LIG_SH2_SRC	164	167	PF00017	0.363
LIG_SH2_STAT5	164	167	PF00017	0.275
LIG_SH2_STAT5	22	25	PF00017	0.271
LIG_SH2_STAT5	250	253	PF00017	0.321
LIG_SH2_STAT5	280	283	PF00017	0.326
LIG_SH3_3	35	41	PF00018	0.331
LIG_SH3_3	87	93	PF00018	0.407
LIG_Sin3_3	188	195	PF02671	0.197
LIG_SUMO_SIM_par_1	152	159	PF11976	0.275
LIG_SUMO_SIM_par_1	188	194	PF11976	0.398
LIG_TYR_ITIM	191	196	PF00017	0.284
LIG_UBA3_1	81	86	PF00899	0.301
LIG_WRC_WIRS_1	27	32	PF05994	0.408
MOD_CK1_1	168	174	PF00069	0.358
MOD_CK1_1	286	292	PF00069	0.251
MOD_CK2_1	122	128	PF00069	0.272
MOD_CK2_1	26	32	PF00069	0.381
MOD_CK2_1	49	55	PF00069	0.430
MOD_CK2_1	61	67	PF00069	0.363
MOD_CMANNOS	270	273	PF00535	0.346
MOD_GlcNHglycan	288	291	PF01048	0.414
MOD_GSK3_1	114	121	PF00069	0.366
MOD_GSK3_1	33	40	PF00069	0.274
MOD_GSK3_1	44	51	PF00069	0.277
MOD_NEK2_1	122	127	PF00069	0.446
MOD_NEK2_1	173	178	PF00069	0.297
MOD_NEK2_1	249	254	PF00069	0.253
MOD_NEK2_1	3	8	PF00069	0.343
MOD_NEK2_1	49	54	PF00069	0.430
MOD_NEK2_1	61	66	PF00069	0.346
MOD_NEK2_2	237	242	PF00069	0.313
MOD_NEK2_2	26	31	PF00069	0.363
MOD_NEK2_2	77	82	PF00069	0.271
MOD_PIKK_1	122	128	PF00454	0.381
MOD_PKA_1	114	120	PF00069	0.312
MOD_PKA_2	114	120	PF00069	0.355
MOD_PKA_2	231	237	PF00069	0.462
MOD_PKA_2	44	50	PF00069	0.271
MOD_Plk_1	33	39	PF00069	0.271
MOD_Plk_4	118	124	PF00069	0.363
MOD_Plk_4	151	157	PF00069	0.280
MOD_Plk_4	26	32	PF00069	0.302
MOD_Plk_4	33	39	PF00069	0.252
MOD_Plk_4	44	50	PF00069	0.178
MOD_Plk_4	77	83	PF00069	0.271
MOD_ProDKin_1	149	155	PF00069	0.381
MOD_ProDKin_1	222	228	PF00069	0.371
MOD_ProDKin_1	37	43	PF00069	0.271
MOD_SUMO_rev_2	104	112	PF00179	0.336
MOD_SUMO_rev_2	131	140	PF00179	0.460
TRG_DiLeu_BaEn_1	118	123	PF01217	0.293
TRG_DiLeu_BaEn_1	271	276	PF01217	0.446
TRG_DiLeu_BaEn_2	277	283	PF01217	0.388
TRG_ENDOCYTIC_2	127	130	PF00928	0.285
TRG_ENDOCYTIC_2	193	196	PF00928	0.285
TRG_ENDOCYTIC_2	250	253	PF00928	0.321
TRG_ENDOCYTIC_2	280	283	PF00928	0.291
TRG_NES_CRM1_1	256	269	PF08389	0.528
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	218	222	PF00026	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBZ8	Leptomonas seymouri	75%	100%
A0A0S4JL13	Bodo saltans	54%	97%
A0A1X0P9A8	Trypanosomatidae	52%	99%
A0A3Q8IGT9	Leishmania donovani	89%	100%
A0A422NB24	Trypanosoma rangeli	53%	99%
A4ICX9	Leishmania infantum	89%	100%
D0A2H0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	99%
E9ASC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O94257	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	95%
P0CO56	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	28%	74%
P0CO57	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	28%	75%
P46554	Caenorhabditis elegans	31%	89%
Q04081	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	90%
Q3T0H0	Bos taurus	29%	89%
Q4ICG8	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	30%	79%
Q4Q270	Leishmania major	90%	100%
Q4WS57	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	27%	74%
Q5A387	Candida albicans (strain SC5314 / ATCC MYA-2876)	26%	81%
Q5AQJ2	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	27%	77%
Q60YU0	Caenorhabditis briggsae	30%	89%
Q6BQD2	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	25%	80%
Q6C997	Yarrowia lipolytica (strain CLIB 122 / E 150)	32%	91%
Q6CWW0	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	23%	89%
Q6FUI5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	28%	93%
Q6P4Z6	Rattus norvegicus	29%	89%
Q759U5	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	26%	91%
Q8VY08	Arabidopsis thaliana	30%	89%
Q9UIC8	Homo sapiens	30%	89%
V5BQK9	Trypanosoma cruzi	53%	89%