Leucine carboxyl methyltransferase 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine carboxyl methyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HNL5_LEIBR

TriTrypDb:

LbrM.35.0150 , LBRM2903_350007000

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNL5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNL5

Function

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Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	12
GO:0032259	methylation	2	12

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.276
CLV_NRD_NRD_1	12	14	PF00675	0.317
CLV_NRD_NRD_1	18	20	PF00675	0.341
CLV_PCSK_KEX2_1	114	116	PF00082	0.343
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.368
CLV_PCSK_SKI1_1	135	139	PF00082	0.321
CLV_PCSK_SKI1_1	142	146	PF00082	0.327
CLV_PCSK_SKI1_1	187	191	PF00082	0.419
CLV_PCSK_SKI1_1	239	243	PF00082	0.390
DOC_CKS1_1	223	228	PF01111	0.367

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBZ8	Leptomonas seymouri	75%	100%
A0A0S4JL13	Bodo saltans	54%	97%
A0A1X0P9A8	Trypanosomatidae	52%	99%
A0A3Q8IGT9	Leishmania donovani	89%	100%
A0A422NB24	Trypanosoma rangeli	53%	99%
A4ICX9	Leishmania infantum	89%	100%
D0A2H0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	99%
E9ASC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
O94257	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	95%
P0CO56	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	28%	74%

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