Histone H4

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Histone H4

Gene product:

histone H4

Species:

Leishmania braziliensis

UniProt:

A4HNL3_LEIBR

TriTrypDb:

LbrM.35.0130 , LBRM2903_150005100

Length:

196

Annotations

LeishMANIAdb annotations

Histone H4 protein, nuclear without any membrane association

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0000786	nucleosome	3	4
GO:0005634	nucleus	5	4
GO:0032991	protein-containing complex	1	4
GO:0032993	protein-DNA complex	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0044815	DNA packaging complex	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HNL3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNL3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003677	DNA binding	4	4
GO:0005198	structural molecule activity	1	4
GO:0005488	binding	1	4
GO:0005515	protein binding	2	4
GO:0030527	structural constituent of chromatin	2	4
GO:0046982	protein heterodimerization activity	4	4
GO:0046983	protein dimerization activity	3	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.561
CLV_NRD_NRD_1	134	136	PF00675	0.627
CLV_NRD_NRD_1	150	152	PF00675	0.330
CLV_NRD_NRD_1	171	173	PF00675	0.692
CLV_NRD_NRD_1	185	187	PF00675	0.440
CLV_NRD_NRD_1	72	74	PF00675	0.465
CLV_PCSK_KEX2_1	101	103	PF00082	0.822
CLV_PCSK_KEX2_1	111	113	PF00082	0.626
CLV_PCSK_KEX2_1	130	132	PF00082	0.394
CLV_PCSK_KEX2_1	134	136	PF00082	0.627
CLV_PCSK_KEX2_1	139	141	PF00082	0.544
CLV_PCSK_KEX2_1	150	152	PF00082	0.330
CLV_PCSK_KEX2_1	187	189	PF00082	0.465
CLV_PCSK_KEX2_1	72	74	PF00082	0.465
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.822
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.625
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.686
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.465
CLV_PCSK_PC7_1	126	132	PF00082	0.655
CLV_PCSK_PC7_1	135	141	PF00082	0.540
CLV_PCSK_SKI1_1	114	118	PF00082	0.738
CLV_PCSK_SKI1_1	122	126	PF00082	0.556
CLV_PCSK_SKI1_1	150	154	PF00082	0.646
CLV_PCSK_SKI1_1	174	178	PF00082	0.677
DEG_APCC_DBOX_1	75	83	PF00400	0.500
DEG_Nend_UBRbox_1	1	4	PF02207	0.499
DOC_MAPK_MEF2A_6	14	21	PF00069	0.454
DOC_USP7_MATH_1	106	110	PF00917	0.786
DOC_USP7_MATH_1	27	31	PF00917	0.528
DOC_USP7_MATH_1	85	89	PF00917	0.513
DOC_USP7_UBL2_3	107	111	PF12436	0.664
DOC_WW_Pin1_4	37	42	PF00397	0.519
DOC_WW_Pin1_4	48	53	PF00397	0.469
DOC_WW_Pin1_4	83	88	PF00397	0.503
LIG_14-3-3_CanoR_1	14	20	PF00244	0.452
LIG_14-3-3_CanoR_1	162	170	PF00244	0.649
LIG_14-3-3_CanoR_1	172	177	PF00244	0.526
LIG_14-3-3_CanoR_1	35	41	PF00244	0.512
LIG_14-3-3_CanoR_1	76	80	PF00244	0.493
LIG_BIR_III_4	105	109	PF00653	0.764
LIG_BRCT_BRCA1_1	17	21	PF00533	0.456
LIG_FHA_2	175	181	PF00498	0.661
LIG_LIR_Gen_1	144	153	PF02991	0.632
LIG_LIR_Gen_1	18	27	PF02991	0.478
LIG_LIR_Gen_1	62	71	PF02991	0.418
LIG_LIR_Nem_3	144	149	PF02991	0.639
LIG_LIR_Nem_3	164	170	PF02991	0.536
LIG_LIR_Nem_3	18	24	PF02991	0.474
LIG_LIR_Nem_3	62	66	PF02991	0.404
LIG_MYND_1	87	91	PF01753	0.491
LIG_SH2_CRK	10	14	PF00017	0.461
LIG_SH2_SRC	146	149	PF00017	0.626
LIG_SH2_STAP1	167	171	PF00017	0.659
LIG_SH2_STAT3	31	34	PF00017	0.534
LIG_SH2_STAT5	156	159	PF00017	0.639
LIG_SH2_STAT5	167	170	PF00017	0.496
LIG_SH3_1	81	87	PF00018	0.502
LIG_SH3_3	81	87	PF00018	0.502
LIG_SUMO_SIM_par_1	56	62	PF11976	0.418
LIG_TYR_ITIM	8	13	PF00017	0.448
LIG_UBA3_1	94	101	PF00899	0.514
LIG_WRC_WIRS_1	60	65	PF05994	0.407
MOD_CK1_1	12	18	PF00069	0.453
MOD_CK1_1	40	46	PF00069	0.505
MOD_CK1_1	48	54	PF00069	0.463
MOD_CK1_1	56	62	PF00069	0.412
MOD_CK1_1	75	81	PF00069	0.492
MOD_CK1_1	93	99	PF00069	0.525
MOD_Cter_Amidation	99	102	PF01082	0.817
MOD_GlcNHglycan	102	105	PF01048	0.720
MOD_GlcNHglycan	141	144	PF01048	0.478
MOD_GSK3_1	161	168	PF00069	0.624
MOD_GSK3_1	36	43	PF00069	0.509
MOD_LATS_1	70	76	PF00433	0.462
MOD_N-GLC_1	15	20	PF02516	0.444
MOD_N-GLC_1	37	42	PF02516	0.504
MOD_NEK2_1	53	58	PF00069	0.441
MOD_PIKK_1	106	112	PF00454	0.790
MOD_PKA_1	139	145	PF00069	0.683
MOD_PKA_1	172	178	PF00069	0.684
MOD_PKA_1	72	78	PF00069	0.476
MOD_PKA_2	139	145	PF00069	0.673
MOD_PKA_2	161	167	PF00069	0.632
MOD_PKA_2	72	78	PF00069	0.476
MOD_Plk_1	15	21	PF00069	0.450
MOD_Plk_4	53	59	PF00069	0.437
MOD_Plk_4	90	96	PF00069	0.508
MOD_ProDKin_1	37	43	PF00069	0.518
MOD_ProDKin_1	48	54	PF00069	0.466
MOD_ProDKin_1	83	89	PF00069	0.505
MOD_SUMO_rev_2	103	109	PF00179	0.803
TRG_ENDOCYTIC_2	10	13	PF00928	0.456
TRG_ENDOCYTIC_2	146	149	PF00928	0.638
TRG_ER_diArg_1	129	131	PF00400	0.661
TRG_ER_diArg_1	149	151	PF00400	0.316
TRG_ER_diArg_1	185	188	PF00400	0.456
TRG_ER_diArg_1	71	73	PF00400	0.457
TRG_NLS_Bipartite_1	101	115	PF00514	0.664
TRG_NLS_Bipartite_1	172	190	PF00514	0.496
TRG_NLS_MonoExtC_3	110	115	PF00514	0.640
TRG_NLS_MonoExtN_4	72	77	PF00514	0.474
TRG_Pf-PMV_PEXEL_1	20	25	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HHY8	Leishmania braziliensis	61%	100%
A4HNK8	Leishmania braziliensis	98%	100%