Stress-inducible protein STI1 homolog

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

stress-inducible protein STI1 homolog

Species:

Leishmania braziliensis

UniProt:

A4HNL2_LEIBR

TriTrypDb:

LbrM.35.0120 , LBRM2903_350006700

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNL2

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	12
GO:0009987	cellular process	1	12

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0030544	Hsp70 protein binding	4	12
GO:0031072	heat shock protein binding	3	12
GO:0051879	Hsp90 protein binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	211	213	PF00675	0.411
CLV_NRD_NRD_1	76	78	PF00675	0.244
CLV_PCSK_KEX2_1	211	213	PF00082	0.411
CLV_PCSK_SKI1_1	223	227	PF00082	0.550
DEG_Nend_UBRbox_2	1	3	PF02207	0.647
DOC_CYCLIN_RxL_1	93	102	PF00134	0.503
DOC_MAPK_gen_1	146	156	PF00069	0.250
DOC_USP7_MATH_1	200	204	PF00917	0.572
DOC_USP7_MATH_1	240	244	PF00917	0.458
DOC_USP7_MATH_1	81	85	PF00917	0.361
DOC_USP7_UBL2_3	125	129	PF12436	0.407
DOC_USP7_UBL2_3	165	169	PF12436	0.495
DOC_USP7_UBL2_3	93	97	PF12436	0.503
DOC_WW_Pin1_4	130	135	PF00397	0.506
DOC_WW_Pin1_4	99	104	PF00397	0.476
LIG_deltaCOP1_diTrp_1	70	76	PF00928	0.502
LIG_FHA_1	156	162	PF00498	0.476
LIG_FHA_1	23	29	PF00498	0.356
LIG_FHA_2	131	137	PF00498	0.466
LIG_LIR_Gen_1	185	192	PF02991	0.450
LIG_LIR_Gen_1	47	56	PF02991	0.562
LIG_LIR_Nem_3	47	51	PF02991	0.534
LIG_Pex14_1	71	75	PF04695	0.495
LIG_PTB_Apo_2	139	146	PF02174	0.371
LIG_SH2_GRB2like	175	178	PF00017	0.435
LIG_SH2_GRB2like	41	44	PF00017	0.430
LIG_SH2_STAP1	150	154	PF00017	0.367
LIG_SH2_STAP1	157	161	PF00017	0.341
LIG_SH2_STAP1	175	179	PF00017	0.303
LIG_SH2_STAP1	188	192	PF00017	0.438
LIG_SH2_STAP1	24	28	PF00017	0.378
LIG_SH2_STAP1	41	45	PF00017	0.424
LIG_SH2_STAT5	157	160	PF00017	0.476
LIG_SH2_STAT5	209	212	PF00017	0.535
LIG_SH2_STAT5	24	27	PF00017	0.356
LIG_SH2_STAT5	75	78	PF00017	0.454
MOD_CK1_1	34	40	PF00069	0.384
MOD_CK2_1	130	136	PF00069	0.484
MOD_GlcNHglycan	202	205	PF01048	0.502
MOD_GlcNHglycan	35	39	PF01048	0.506
MOD_GSK3_1	182	189	PF00069	0.523
MOD_NEK2_1	140	145	PF00069	0.468
MOD_PIKK_1	240	246	PF00454	0.440
MOD_PK_1	111	117	PF00069	0.363
MOD_Plk_4	140	146	PF00069	0.356
MOD_Plk_4	186	192	PF00069	0.551
MOD_ProDKin_1	130	136	PF00069	0.504
MOD_ProDKin_1	99	105	PF00069	0.476
MOD_SUMO_rev_2	135	140	PF00179	0.489
MOD_SUMO_rev_2	2	6	PF00179	0.395
TRG_ENDOCYTIC_2	188	191	PF00928	0.429
TRG_ER_diArg_1	210	212	PF00400	0.418
TRG_ER_diArg_1	65	68	PF00400	0.506
TRG_NES_CRM1_1	70	83	PF08389	0.441

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTR8	Leptomonas seymouri	84%	100%
A0A0N1IBD2	Leptomonas seymouri	26%	76%
A0A0S4JPS0	Bodo saltans	61%	99%
A0A0S4JRK3	Bodo saltans	24%	73%
A0A1X0P8F0	Trypanosomatidae	57%	99%
A0A3Q8IJP8	Leishmania donovani	84%	100%
A0A3S7WZC1	Leishmania donovani	24%	76%
A0A422NB01	Trypanosoma rangeli	58%	99%
A4I1Q9	Leishmania infantum	24%	76%
A4ICY0	Leishmania infantum	85%	100%
A4K2V0	Pongo abelii	25%	83%
D0A2G9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	99%
E9ASC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
O16259	Caenorhabditis elegans	29%	80%
Q15785	Homo sapiens	24%	83%
Q3KRD5	Rattus norvegicus	24%	83%
Q4Q271	Leishmania major	85%	100%
Q9CYG7	Mus musculus	23%	83%
V5BA34	Trypanosoma cruzi	57%	99%