SAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SAP domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HNL1_LEIBR

TriTrypDb:

LbrM.35.0110 , LBRM2903_350006600

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNL1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNL1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.547
CLV_NRD_NRD_1	234	236	PF00675	0.634
CLV_NRD_NRD_1	6	8	PF00675	0.553
CLV_PCSK_KEX2_1	208	210	PF00082	0.498
CLV_PCSK_KEX2_1	234	236	PF00082	0.634
CLV_PCSK_KEX2_1	317	319	PF00082	0.654
CLV_PCSK_KEX2_1	5	7	PF00082	0.555
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.498
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.543
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.555
CLV_PCSK_SKI1_1	105	109	PF00082	0.618
CLV_PCSK_SKI1_1	112	116	PF00082	0.593
CLV_PCSK_SKI1_1	163	167	PF00082	0.645
CLV_PCSK_SKI1_1	189	193	PF00082	0.332
CLV_PCSK_SKI1_1	195	199	PF00082	0.332
DEG_Nend_UBRbox_2	1	3	PF02207	0.666
DEG_SPOP_SBC_1	135	139	PF00917	0.720
DOC_CKS1_1	177	182	PF01111	0.446
DOC_CKS1_1	42	47	PF01111	0.523
DOC_CKS1_1	92	97	PF01111	0.651
DOC_CYCLIN_yCln2_LP_2	36	42	PF00134	0.704
DOC_MAPK_gen_1	29	38	PF00069	0.621
DOC_MAPK_gen_1	5	11	PF00069	0.567
DOC_MAPK_MEF2A_6	32	40	PF00069	0.656
DOC_PP2B_LxvP_1	36	39	PF13499	0.652
DOC_PP2B_LxvP_1	40	43	PF13499	0.664
DOC_PP4_FxxP_1	92	95	PF00568	0.652
DOC_PP4_MxPP_1	253	256	PF00568	0.542
DOC_USP7_MATH_1	107	111	PF00917	0.611
DOC_USP7_MATH_1	12	16	PF00917	0.475
DOC_USP7_MATH_1	135	139	PF00917	0.720
DOC_USP7_MATH_1	216	220	PF00917	0.693
DOC_USP7_MATH_1	296	300	PF00917	0.684
DOC_USP7_MATH_1	43	47	PF00917	0.724
DOC_USP7_UBL2_3	208	212	PF12436	0.457
DOC_WW_Pin1_4	154	159	PF00397	0.735
DOC_WW_Pin1_4	176	181	PF00397	0.596
DOC_WW_Pin1_4	22	27	PF00397	0.620
DOC_WW_Pin1_4	251	256	PF00397	0.718
DOC_WW_Pin1_4	264	269	PF00397	0.823
DOC_WW_Pin1_4	38	43	PF00397	0.683
DOC_WW_Pin1_4	51	56	PF00397	0.574
DOC_WW_Pin1_4	91	96	PF00397	0.659
LIG_14-3-3_CanoR_1	126	132	PF00244	0.484
LIG_14-3-3_CanoR_1	163	172	PF00244	0.764
LIG_14-3-3_CanoR_1	215	221	PF00244	0.625
LIG_14-3-3_CanoR_1	234	238	PF00244	0.661
LIG_14-3-3_CanoR_1	297	301	PF00244	0.652
LIG_14-3-3_CanoR_1	91	95	PF00244	0.716
LIG_BRCT_BRCA1_1	288	292	PF00533	0.562
LIG_BRCT_BRCA1_1	298	302	PF00533	0.645
LIG_CaM_IQ_9	207	223	PF13499	0.426
LIG_FHA_1	32	38	PF00498	0.756
LIG_FHA_1	48	54	PF00498	0.804
LIG_FHA_1	72	78	PF00498	0.547
LIG_FHA_2	138	144	PF00498	0.658
LIG_FHA_2	182	188	PF00498	0.302
LIG_FHA_2	270	276	PF00498	0.733
LIG_FHA_2	92	98	PF00498	0.708
LIG_Integrin_isoDGR_2	89	91	PF01839	0.479
LIG_LIR_Gen_1	278	287	PF02991	0.476
LIG_LIR_Nem_3	278	284	PF02991	0.564
LIG_LIR_Nem_3	79	83	PF02991	0.555
LIG_PCNA_yPIPBox_3	276	284	PF02747	0.459
LIG_PCNA_yPIPBox_3	29	37	PF02747	0.506
LIG_Pex14_2	114	118	PF04695	0.590
LIG_RPA_C_Fungi	212	224	PF08784	0.456
LIG_SH2_GRB2like	271	274	PF00017	0.543
LIG_SH2_NCK_1	132	136	PF00017	0.518
LIG_SH2_STAP1	132	136	PF00017	0.656
LIG_SH2_STAT5	10	13	PF00017	0.545
LIG_SH2_STAT5	271	274	PF00017	0.667
LIG_SH3_3	156	162	PF00018	0.702
LIG_SH3_3	174	180	PF00018	0.424
LIG_SH3_3	260	266	PF00018	0.757
LIG_SH3_3	36	42	PF00018	0.704
LIG_SH3_CIN85_PxpxPR_1	158	163	PF14604	0.686
LIG_WW_3	158	162	PF00397	0.634
MOD_CDK_SPK_2	91	96	PF00069	0.718
MOD_CDK_SPxxK_3	154	161	PF00069	0.736
MOD_CDK_SPxxK_3	22	29	PF00069	0.620
MOD_CDK_SPxxK_3	41	48	PF00069	0.746
MOD_CDK_SPxxK_3	51	58	PF00069	0.727
MOD_CK1_1	128	134	PF00069	0.603
MOD_CK1_1	137	143	PF00069	0.602
MOD_CK1_1	154	160	PF00069	0.750
MOD_CK1_1	181	187	PF00069	0.410
MOD_CK1_1	233	239	PF00069	0.621
MOD_CK1_1	267	273	PF00069	0.609
MOD_CK1_1	31	37	PF00069	0.577
MOD_CK1_1	41	47	PF00069	0.593
MOD_CK1_1	49	55	PF00069	0.666
MOD_CK2_1	137	143	PF00069	0.637
MOD_CK2_1	144	150	PF00069	0.645
MOD_CK2_1	181	187	PF00069	0.302
MOD_CK2_1	269	275	PF00069	0.647
MOD_GlcNHglycan	133	136	PF01048	0.742
MOD_GlcNHglycan	21	25	PF01048	0.698
MOD_GlcNHglycan	241	244	PF01048	0.660
MOD_GlcNHglycan	277	280	PF01048	0.569
MOD_GSK3_1	126	133	PF00069	0.587
MOD_GSK3_1	150	157	PF00069	0.704
MOD_GSK3_1	233	240	PF00069	0.651
MOD_GSK3_1	43	50	PF00069	0.742
MOD_N-GLC_1	154	159	PF02516	0.800
MOD_NEK2_1	149	154	PF00069	0.812
MOD_NEK2_1	197	202	PF00069	0.371
MOD_NEK2_1	237	242	PF00069	0.702
MOD_NEK2_1	71	76	PF00069	0.491
MOD_NEK2_2	107	112	PF00069	0.570
MOD_NEK2_2	216	221	PF00069	0.462
MOD_PIKK_1	178	184	PF00454	0.433
MOD_PIKK_1	43	49	PF00454	0.708
MOD_PKA_2	125	131	PF00069	0.524
MOD_PKA_2	216	222	PF00069	0.548
MOD_PKA_2	233	239	PF00069	0.627
MOD_PKA_2	28	34	PF00069	0.634
MOD_PKA_2	296	302	PF00069	0.652
MOD_PKA_2	90	96	PF00069	0.719
MOD_PKB_1	161	169	PF00069	0.556
MOD_Plk_2-3	144	150	PF00069	0.718
MOD_Plk_4	137	143	PF00069	0.717
MOD_Plk_4	202	208	PF00069	0.318
MOD_ProDKin_1	154	160	PF00069	0.736
MOD_ProDKin_1	176	182	PF00069	0.592
MOD_ProDKin_1	22	28	PF00069	0.620
MOD_ProDKin_1	251	257	PF00069	0.717
MOD_ProDKin_1	264	270	PF00069	0.823
MOD_ProDKin_1	38	44	PF00069	0.685
MOD_ProDKin_1	51	57	PF00069	0.570
MOD_ProDKin_1	91	97	PF00069	0.653
MOD_SUMO_rev_2	181	191	PF00179	0.311
MOD_SUMO_rev_2	270	278	PF00179	0.629
TRG_DiLeu_BaEn_1	14	19	PF01217	0.551
TRG_DiLeu_BaEn_2	186	192	PF01217	0.326
TRG_DiLeu_BaEn_4	144	150	PF01217	0.793
TRG_DiLeu_BaLyEn_6	32	37	PF01217	0.641
TRG_ENDOCYTIC_2	80	83	PF00928	0.632
TRG_ER_diArg_1	160	163	PF00400	0.691
TRG_ER_diArg_1	318	321	PF00400	0.662
TRG_ER_diArg_1	6	8	PF00400	0.553
TRG_NLS_MonoExtN_4	3	9	PF00514	0.590
TRG_NLS_MonoExtN_4	314	321	PF00514	0.542

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II75	Leptomonas seymouri	50%	100%
A0A1X0P8R1	Trypanosomatidae	29%	100%
A0A3S7XA97	Leishmania donovani	67%	100%
A0A422NB21	Trypanosoma rangeli	29%	100%
A4ICY1	Leishmania infantum	68%	100%
E9ASC4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4Q272	Leishmania major	67%	100%