N-acetylglucosamine-6-phosphate deacetylase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

N-acetylglucosamine-6-phosphate deacetylase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HNK9_LEIBR

TriTrypDb:

LbrM.35.0080 , LBRM2903_350006200

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNK9

Function

Biological processes
Term	Name	Level	Count
GO:0006040	amino sugar metabolic process	4	1
GO:0006044	N-acetylglucosamine metabolic process	6	1
GO:0006046	N-acetylglucosamine catabolic process	7	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0046348	amino sugar catabolic process	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901071	glucosamine-containing compound metabolic process	5	1
GO:1901072	glucosamine-containing compound catabolic process	6	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901136	carbohydrate derivative catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016787	hydrolase activity	2	11
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	11
GO:0008448	N-acetylglucosamine-6-phosphate deacetylase activity	4	2
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	2
GO:0019213	deacetylase activity	3	2
GO:0047419	N-acetylgalactosamine-6-phosphate deacetylase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	126	132	PF00089	0.239
CLV_PCSK_KEX2_1	128	130	PF00082	0.278
CLV_PCSK_KEX2_1	169	171	PF00082	0.315
CLV_PCSK_KEX2_1	409	411	PF00082	0.323
CLV_PCSK_PC1ET2_1	128	130	PF00082	0.278
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.294
CLV_PCSK_PC1ET2_1	409	411	PF00082	0.323
CLV_PCSK_SKI1_1	179	183	PF00082	0.233
CLV_PCSK_SKI1_1	197	201	PF00082	0.322
CLV_PCSK_SKI1_1	205	209	PF00082	0.233
DOC_CKS1_1	11	16	PF01111	0.228
DOC_CYCLIN_RxL_1	194	201	PF00134	0.474
DOC_MAPK_gen_1	202	208	PF00069	0.492
DOC_MAPK_gen_1	393	400	PF00069	0.428
DOC_PP4_FxxP_1	64	67	PF00568	0.425
DOC_USP7_MATH_1	214	218	PF00917	0.494
DOC_USP7_MATH_1	38	42	PF00917	0.272
DOC_USP7_UBL2_3	42	46	PF12436	0.391
DOC_WW_Pin1_4	10	15	PF00397	0.222
DOC_WW_Pin1_4	181	186	PF00397	0.425
LIG_14-3-3_CanoR_1	339	345	PF00244	0.481
LIG_APCC_ABBA_1	183	188	PF00400	0.439
LIG_BIR_II_1	1	5	PF00653	0.304
LIG_BRCT_BRCA1_1	107	111	PF00533	0.425
LIG_Clathr_ClatBox_1	280	284	PF01394	0.481
LIG_Clathr_ClatBox_1	361	365	PF01394	0.377
LIG_Clathr_ClatBox_1	397	401	PF01394	0.494
LIG_FHA_1	118	124	PF00498	0.483
LIG_FHA_1	271	277	PF00498	0.471
LIG_FHA_1	302	308	PF00498	0.439
LIG_FHA_1	346	352	PF00498	0.447
LIG_FHA_1	371	377	PF00498	0.489
LIG_FHA_2	48	54	PF00498	0.322
LIG_FHA_2	56	62	PF00498	0.482
LIG_Integrin_isoDGR_2	319	321	PF01839	0.225
LIG_LIR_Apic_2	61	67	PF02991	0.266
LIG_LIR_Gen_1	353	362	PF02991	0.426
LIG_LIR_Nem_3	166	171	PF02991	0.435
LIG_LIR_Nem_3	353	358	PF02991	0.426
LIG_PTB_Apo_2	86	93	PF02174	0.439
LIG_PTB_Phospho_1	86	92	PF10480	0.457
LIG_SH2_CRK	422	426	PF00017	0.363
LIG_SH2_STAT3	92	95	PF00017	0.364
LIG_SH2_STAT5	133	136	PF00017	0.457
LIG_SH2_STAT5	198	201	PF00017	0.442
LIG_SH2_STAT5	332	335	PF00017	0.478
LIG_SH3_3	255	261	PF00018	0.494
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.312
LIG_SUMO_SIM_anti_2	273	279	PF11976	0.481
LIG_SUMO_SIM_anti_2	299	305	PF11976	0.438
LIG_SUMO_SIM_par_1	146	152	PF11976	0.364
LIG_SUMO_SIM_par_1	22	28	PF11976	0.372
LIG_TRAF2_1	227	230	PF00917	0.481
LIG_TRAF2_1	58	61	PF00917	0.393
LIG_TRAF2_1	93	96	PF00917	0.364
LIG_UBA3_1	219	224	PF00899	0.425
LIG_UBA3_1	361	368	PF00899	0.468
LIG_WRC_WIRS_1	241	246	PF05994	0.439
MOD_CDK_SPxK_1	10	16	PF00069	0.325
MOD_CK1_1	161	167	PF00069	0.524
MOD_CK1_1	174	180	PF00069	0.494
MOD_CK1_1	2	8	PF00069	0.315
MOD_CK2_1	111	117	PF00069	0.487
MOD_CK2_1	212	218	PF00069	0.477
MOD_CK2_1	225	231	PF00069	0.406
MOD_CK2_1	55	61	PF00069	0.483
MOD_CK2_1	85	91	PF00069	0.445
MOD_Cter_Amidation	391	394	PF01082	0.213
MOD_GlcNHglycan	307	310	PF01048	0.297
MOD_GSK3_1	101	108	PF00069	0.449
MOD_GSK3_1	287	294	PF00069	0.476
MOD_GSK3_1	29	36	PF00069	0.324
MOD_GSK3_1	301	308	PF00069	0.394
MOD_GSK3_1	399	406	PF00069	0.377
MOD_LATS_1	210	216	PF00433	0.425
MOD_LATS_1	245	251	PF00433	0.366
MOD_N-GLC_1	239	244	PF02516	0.322
MOD_NEK2_1	111	116	PF00069	0.517
MOD_NEK2_1	171	176	PF00069	0.425
MOD_NEK2_1	233	238	PF00069	0.425
MOD_NEK2_1	293	298	PF00069	0.466
MOD_NEK2_1	333	338	PF00069	0.526
MOD_NEK2_1	47	52	PF00069	0.493
MOD_PKA_2	246	252	PF00069	0.516
MOD_PKA_2	338	344	PF00069	0.377
MOD_PKA_2	425	431	PF00069	0.361
MOD_Plk_1	161	167	PF00069	0.494
MOD_Plk_1	239	245	PF00069	0.560
MOD_Plk_1	247	253	PF00069	0.436
MOD_Plk_1	90	96	PF00069	0.439
MOD_Plk_2-3	403	409	PF00069	0.494
MOD_Plk_4	105	111	PF00069	0.425
MOD_Plk_4	2	8	PF00069	0.417
MOD_Plk_4	247	253	PF00069	0.425
MOD_Plk_4	287	293	PF00069	0.481
MOD_Plk_4	346	352	PF00069	0.472
MOD_ProDKin_1	10	16	PF00069	0.227
MOD_ProDKin_1	181	187	PF00069	0.425
MOD_SUMO_rev_2	152	161	PF00179	0.517
MOD_SUMO_rev_2	162	171	PF00179	0.324
MOD_SUMO_rev_2	228	233	PF00179	0.526
TRG_ENDOCYTIC_2	19	22	PF00928	0.225
TRG_ENDOCYTIC_2	193	196	PF00928	0.428
TRG_ENDOCYTIC_2	422	425	PF00928	0.349
TRG_NES_CRM1_1	279	289	PF08389	0.517
TRG_NES_CRM1_1	353	365	PF08389	0.378
TRG_Pf-PMV_PEXEL_1	197	201	PF00026	0.311
TRG_PTS1	429	432	PF00515	0.415

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAM2	Leptomonas seymouri	78%	100%
A0A0S4JIK6	Bodo saltans	53%	98%
A0A1X0NNC6	Trypanosomatidae	59%	100%
A0A3R7KWA9	Trypanosoma rangeli	58%	100%
A0A3S7XA87	Leishmania donovani	88%	100%
A4ICY4	Leishmania infantum	88%	100%
E9ASC1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
O34450	Bacillus subtilis (strain 168)	26%	100%
Q4Q275	Leishmania major	87%	100%
Q8XAC3	Escherichia coli O157:H7	25%	100%
Q9VR81	Drosophila melanogaster	25%	100%
V5C012	Trypanosoma cruzi	59%	100%