LeishMANIAdb
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Histone H4

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Histone H4
Gene product:
histone H4
Species:
Leishmania braziliensis
UniProt:
A4HNK8_LEIBR
TriTrypDb:
LbrM.35.0070 , LBRM2903_150005100
Length:
145

Annotations

LeishMANIAdb annotations

Histone H4 protein, nuclear without any membrane association

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 1
Forrest at al. (metacyclic) no yes: 4
Forrest at al. (procyclic) no yes: 2
Silverman et al. no yes: 0
Pissara et al. yes yes: 46
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 8
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 4
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 34
NetGPI no yes: 0, no: 34
Cellular components
Term Name Level Count
GO:0000786 nucleosome 3 35
GO:0005634 nucleus 5 35
GO:0032991 protein-containing complex 1 35
GO:0032993 protein-DNA complex 2 35
GO:0043226 organelle 2 35
GO:0043227 membrane-bounded organelle 3 35
GO:0043229 intracellular organelle 3 35
GO:0043231 intracellular membrane-bounded organelle 4 35
GO:0044815 DNA packaging complex 2 35
GO:0110165 cellular anatomical entity 1 35

Expansion

Sequence features

A4HNK8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNK8

Function

Biological processes
Term Name Level Count
GO:0006325 chromatin organization 4 3
GO:0006334 nucleosome assembly 7 3
GO:0006338 chromatin remodeling 5 3
GO:0009987 cellular process 1 3
GO:0016043 cellular component organization 3 3
GO:0022607 cellular component assembly 4 3
GO:0034728 nucleosome organization 6 3
GO:0043933 protein-containing complex organization 4 3
GO:0065003 protein-containing complex assembly 5 3
GO:0065004 protein-DNA complex assembly 6 3
GO:0071824 protein-DNA complex subunit organization 5 3
GO:0071840 cellular component organization or biogenesis 2 3
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 35
GO:0003677 DNA binding 4 35
GO:0005198 structural molecule activity 1 35
GO:0005488 binding 1 35
GO:0005515 protein binding 2 35
GO:0030527 structural constituent of chromatin 2 35
GO:0046982 protein heterodimerization activity 4 35
GO:0046983 protein dimerization activity 3 35
GO:0097159 organic cyclic compound binding 2 35
GO:1901363 heterocyclic compound binding 2 35

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 120 122 PF00675 0.479
CLV_NRD_NRD_1 134 136 PF00675 0.458
CLV_NRD_NRD_1 79 81 PF00675 0.449
CLV_NRD_NRD_1 83 85 PF00675 0.491
CLV_NRD_NRD_1 99 101 PF00675 0.275
CLV_PCSK_KEX2_1 136 138 PF00082 0.388
CLV_PCSK_KEX2_1 50 52 PF00082 0.696
CLV_PCSK_KEX2_1 60 62 PF00082 0.529
CLV_PCSK_KEX2_1 79 81 PF00082 0.541
CLV_PCSK_KEX2_1 83 85 PF00082 0.491
CLV_PCSK_KEX2_1 88 90 PF00082 0.483
CLV_PCSK_KEX2_1 99 101 PF00082 0.275
CLV_PCSK_PC1ET2_1 136 138 PF00082 0.388
CLV_PCSK_PC1ET2_1 50 52 PF00082 0.696
CLV_PCSK_PC1ET2_1 60 62 PF00082 0.528
CLV_PCSK_PC1ET2_1 88 90 PF00082 0.483
CLV_PCSK_PC7_1 75 81 PF00082 0.466
CLV_PCSK_PC7_1 84 90 PF00082 0.485
CLV_PCSK_SKI1_1 123 127 PF00082 0.546
CLV_PCSK_SKI1_1 27 31 PF00082 0.452
CLV_PCSK_SKI1_1 63 67 PF00082 0.554
CLV_PCSK_SKI1_1 99 103 PF00082 0.477
DEG_Nend_UBRbox_3 1 3 PF02207 0.470
DOC_MAPK_DCC_7 18 28 PF00069 0.434
DOC_USP7_MATH_1 41 45 PF00917 0.717
DOC_USP7_MATH_1 55 59 PF00917 0.691
DOC_USP7_MATH_1 8 12 PF00917 0.518
DOC_USP7_UBL2_3 56 60 PF12436 0.554
DOC_WW_Pin1_4 17 22 PF00397 0.492
LIG_14-3-3_CanoR_1 111 119 PF00244 0.504
LIG_14-3-3_CanoR_1 121 126 PF00244 0.430
LIG_14-3-3_CanoR_1 27 32 PF00244 0.501
LIG_14-3-3_CanoR_1 36 46 PF00244 0.467
LIG_Actin_WH2_2 12 29 PF00022 0.441
LIG_BIR_III_4 54 58 PF00653 0.715
LIG_BRCT_BRCA1_1 10 14 PF00533 0.435
LIG_FHA_2 124 130 PF00498 0.473
LIG_LIR_Gen_1 93 102 PF02991 0.576
LIG_LIR_Nem_3 11 17 PF02991 0.439
LIG_LIR_Nem_3 113 119 PF02991 0.421
LIG_LIR_Nem_3 93 98 PF02991 0.589
LIG_OCRL_FandH_1 27 39 PF00620 0.453
LIG_SH2_SRC 95 98 PF00017 0.429
LIG_SH2_STAP1 116 120 PF00017 0.549
LIG_SH2_STAT5 105 108 PF00017 0.507
LIG_SH2_STAT5 116 119 PF00017 0.396
LIG_SH3_1 18 24 PF00018 0.426
LIG_SH3_3 18 24 PF00018 0.429
MOD_CK1_1 40 46 PF00069 0.562
MOD_Cter_Amidation 48 51 PF01082 0.635
MOD_GlcNHglycan 39 42 PF01048 0.607
MOD_GlcNHglycan 51 54 PF01048 0.614
MOD_GlcNHglycan 90 93 PF01048 0.398
MOD_GSK3_1 110 117 PF00069 0.504
MOD_GSK3_1 37 44 PF00069 0.511
MOD_N-GLC_1 41 46 PF02516 0.568
MOD_NEK2_1 37 42 PF00069 0.639
MOD_PIKK_1 55 61 PF00454 0.608
MOD_PKA_1 121 127 PF00069 0.484
MOD_PKA_1 88 94 PF00069 0.480
MOD_PKA_2 110 116 PF00069 0.593
MOD_PKA_2 88 94 PF00069 0.574
MOD_ProDKin_1 17 23 PF00069 0.486
MOD_SUMO_rev_2 52 58 PF00179 0.628
TRG_DiLeu_BaLyEn_6 12 17 PF01217 0.442
TRG_ENDOCYTIC_2 95 98 PF00928 0.435
TRG_ER_diArg_1 134 137 PF00400 0.374
TRG_ER_diArg_1 78 80 PF00400 0.464
TRG_ER_diArg_1 98 100 PF00400 0.263
TRG_NLS_Bipartite_1 121 139 PF00514 0.408
TRG_NLS_Bipartite_1 50 64 PF00514 0.563
TRG_NLS_MonoExtC_3 59 64 PF00514 0.534

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0NJN5 Trypanosomatidae 77% 100%
A0A1X0P2G0 Trypanosomatidae 75% 100%
A0A3Q8IFP7 Leishmania donovani 93% 100%
A0A3R7MKW7 Trypanosoma rangeli 76% 100%
A0A3S7WPA9 Leishmania donovani 93% 100%
A0A3S7WTF1 Leishmania donovani 92% 100%
A0A3S7X8Y8 Leishmania donovani 94% 100%
A0A451EJE0 Leishmania donovani 92% 100%
A4H399 Leishmania braziliensis 98% 100%
A4H3A0 Leishmania braziliensis 98% 100%
A4H7X1 Leishmania braziliensis 99% 100%
A4HD43 Leishmania braziliensis 88% 100%
A4HHY8 Leishmania braziliensis 65% 100%
A4HMF3 Leishmania braziliensis 98% 100%
A4HNK4 Leishmania braziliensis 95% 100%
A4HNL3 Leishmania braziliensis 98% 74%
A4HSP4 Leishmania infantum 93% 100%
A4HW98 Leishmania infantum 93% 100%
A4IB25 Leishmania infantum 94% 100%
C9ZJ36 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 74% 100%
C9ZPV3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 75% 95%
C9ZPV5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 77% 95%
C9ZPV8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 75% 100%
E9AKM9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9APZ8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9ASB9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
E9AUW4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%
P40287 Entamoeba histolytica 49% 100%
Q4JHM5 Leishmania donovani 93% 100%
Q4Q277 Leishmania major 91% 100%
Q4QFI3 Leishmania major 91% 100%
Q4QJ78 Leishmania major 90% 100%
Q8SQP4 Encephalitozoon cuniculi (strain GB-M1) 32% 100%
R9TL77 Trypanosoma rangeli 76% 100%
V5BAE8 Trypanosoma cruzi 75% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS