LeishMANIAdb
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Phosphoglycan beta 1,3 galactosyltransferase 4

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphoglycan beta 1,3 galactosyltransferase 4
Gene product:
phosphoglycan beta 1,3 galactosyltransferase 4
Species:
Leishmania braziliensis
UniProt:
A4HNK6_LEIBR
TriTrypDb:
LbrM.35.0040 , LBRM2903_020007700 , LBRM2903_350005100
Length:
792

Annotations

LeishMANIAdb annotations

Phosphoglycan beta 1,3 galactosyltransferase (required for proper protective coat formation). Probably part of a much larger group. Expanded in Leishmaniids. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 60
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 53
NetGPI no yes: 0, no: 53
Cellular components
TermNameLevelCount
GO:0000139 Golgi membrane 5 14
GO:0016020 membrane 2 54
GO:0031090 organelle membrane 3 14
GO:0098588 bounding membrane of organelle 4 14
GO:0110165 cellular anatomical entity 1 54
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Expansion

Sequence features

A4HNK6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNK6

Function

Biological processes
TermNameLevelCount
GO:0006486 protein glycosylation 4 54
GO:0006807 nitrogen compound metabolic process 2 54
GO:0008152 metabolic process 1 54
GO:0019538 protein metabolic process 3 54
GO:0036211 protein modification process 4 54
GO:0043170 macromolecule metabolic process 3 54
GO:0043412 macromolecule modification 4 54
GO:0043413 macromolecule glycosylation 3 54
GO:0044238 primary metabolic process 2 54
GO:0070085 glycosylation 2 54
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Molecular functions
TermNameLevelCount
GO:0003824 catalytic activity 1 54
GO:0008194 UDP-glycosyltransferase activity 4 14
GO:0016740 transferase activity 2 54
GO:0016757 glycosyltransferase activity 3 54
GO:0016758 hexosyltransferase activity 4 54
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 390 394 PF00656 0.308
CLV_NRD_NRD_1 123 125 PF00675 0.673
CLV_NRD_NRD_1 332 334 PF00675 0.563
CLV_NRD_NRD_1 378 380 PF00675 0.678
CLV_NRD_NRD_1 591 593 PF00675 0.589
CLV_NRD_NRD_1 654 656 PF00675 0.541
CLV_NRD_NRD_1 86 88 PF00675 0.442
CLV_PCSK_FUR_1 776 780 PF00082 0.478
CLV_PCSK_KEX2_1 332 334 PF00082 0.558
CLV_PCSK_KEX2_1 378 380 PF00082 0.663
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Homologs

ProteinTaxonomySequence identityCoverage
A0A3Q8IGN9 Leishmania donovani 64% 97%
A0A3S5H4Y6 Leishmania donovani 37% 98%
A0A3S5H4Y9 Leishmania donovani 33% 80%
A0A3S7WT86 Leishmania donovani 37% 77%
A0A3S7WWA6 Leishmania donovani 64% 97%
A0A451EJD9 Leishmania donovani 57% 97%
A0A451EJF4 Leishmania donovani 37% 97%
A0A451EJF6 Leishmania donovani 40% 100%
A0A451EJF8 Leishmania donovani 37% 100%
A0A451EJF9 Leishmania donovani 40% 92%
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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS