LeishMANIAdb
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Phosphoglycan beta 1,3 galactosyltransferase 4

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphoglycan beta 1,3 galactosyltransferase 4
Gene product:
phosphoglycan beta 1,3 galactosyltransferase 4
Species:
Leishmania braziliensis
UniProt:
A4HNK6_LEIBR
TriTrypDb:
LbrM.35.0040 , LBRM2903_020007700 , LBRM2903_350005100
Length:
792

Annotations

LeishMANIAdb annotations

Phosphoglycan beta 1,3 galactosyltransferase (required for proper protective coat formation). Probably part of a much larger group. Expanded in Leishmaniids. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 60
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 16
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 53
NetGPI no yes: 0, no: 53
Cellular components
Term Name Level Count
GO:0016020 membrane 2 54
GO:0110165 cellular anatomical entity 1 54
GO:0000139 Golgi membrane 5 14
GO:0031090 organelle membrane 3 14
GO:0098588 bounding membrane of organelle 4 14

Expansion

Sequence features

A4HNK6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNK6

Function

Biological processes
Term Name Level Count
GO:0006486 protein glycosylation 4 54
GO:0006807 nitrogen compound metabolic process 2 54
GO:0008152 metabolic process 1 54
GO:0019538 protein metabolic process 3 54
GO:0036211 protein modification process 4 54
GO:0043170 macromolecule metabolic process 3 54
GO:0043412 macromolecule modification 4 54
GO:0043413 macromolecule glycosylation 3 54
GO:0044238 primary metabolic process 2 54
GO:0070085 glycosylation 2 54
GO:0071704 organic substance metabolic process 2 54
GO:1901564 organonitrogen compound metabolic process 3 54
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 54
GO:0016740 transferase activity 2 54
GO:0016757 glycosyltransferase activity 3 54
GO:0016758 hexosyltransferase activity 4 54
GO:0008194 UDP-glycosyltransferase activity 4 14

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 390 394 PF00656 0.308
CLV_NRD_NRD_1 123 125 PF00675 0.673
CLV_NRD_NRD_1 332 334 PF00675 0.563
CLV_NRD_NRD_1 378 380 PF00675 0.678
CLV_NRD_NRD_1 591 593 PF00675 0.589
CLV_NRD_NRD_1 654 656 PF00675 0.541
CLV_NRD_NRD_1 86 88 PF00675 0.442
CLV_PCSK_FUR_1 776 780 PF00082 0.478
CLV_PCSK_KEX2_1 332 334 PF00082 0.558
CLV_PCSK_KEX2_1 378 380 PF00082 0.663
CLV_PCSK_KEX2_1 591 593 PF00082 0.572
CLV_PCSK_KEX2_1 654 656 PF00082 0.599
CLV_PCSK_KEX2_1 710 712 PF00082 0.539
CLV_PCSK_KEX2_1 778 780 PF00082 0.519
CLV_PCSK_KEX2_1 85 87 PF00082 0.471
CLV_PCSK_PC1ET2_1 710 712 PF00082 0.539
CLV_PCSK_PC1ET2_1 778 780 PF00082 0.482
CLV_PCSK_PC7_1 82 88 PF00082 0.375
CLV_PCSK_SKI1_1 125 129 PF00082 0.594
CLV_PCSK_SKI1_1 361 365 PF00082 0.567
CLV_PCSK_SKI1_1 379 383 PF00082 0.597
CLV_PCSK_SKI1_1 610 614 PF00082 0.537
CLV_PCSK_SKI1_1 638 642 PF00082 0.495
CLV_PCSK_SKI1_1 778 782 PF00082 0.516
DEG_APCC_DBOX_1 84 92 PF00400 0.446
DEG_SCF_FBW7_1 430 437 PF00400 0.477
DOC_CDC14_PxL_1 506 514 PF14671 0.244
DOC_CDC14_PxL_1 91 99 PF14671 0.208
DOC_CKS1_1 431 436 PF01111 0.479
DOC_CYCLIN_yCln2_LP_2 227 233 PF00134 0.333
DOC_CYCLIN_yCln2_LP_2 428 434 PF00134 0.520
DOC_CYCLIN_yCln2_LP_2 61 67 PF00134 0.595
DOC_MAPK_gen_1 82 91 PF00069 0.641
DOC_MAPK_MEF2A_6 458 465 PF00069 0.430
DOC_MAPK_MEF2A_6 514 523 PF00069 0.295
DOC_MAPK_MEF2A_6 85 93 PF00069 0.550
DOC_MAPK_NFAT4_5 458 466 PF00069 0.338
DOC_PP1_RVXF_1 492 499 PF00149 0.419
DOC_PP1_RVXF_1 674 680 PF00149 0.314
DOC_PP2B_LxvP_1 428 431 PF13499 0.525
DOC_PP2B_LxvP_1 521 524 PF13499 0.311
DOC_PP2B_LxvP_1 61 64 PF13499 0.596
DOC_PP2B_PxIxI_1 399 405 PF00149 0.274
DOC_PP4_FxxP_1 686 689 PF00568 0.261
DOC_USP7_MATH_1 127 131 PF00917 0.391
DOC_USP7_MATH_1 18 22 PF00917 0.656
DOC_USP7_MATH_1 219 223 PF00917 0.481
DOC_USP7_MATH_1 234 238 PF00917 0.311
DOC_USP7_MATH_1 269 273 PF00917 0.466
DOC_USP7_MATH_1 355 359 PF00917 0.367
DOC_USP7_MATH_1 435 439 PF00917 0.325
DOC_USP7_MATH_1 600 604 PF00917 0.336
DOC_USP7_MATH_1 615 619 PF00917 0.295
DOC_USP7_MATH_1 672 676 PF00917 0.371
DOC_USP7_MATH_1 78 82 PF00917 0.624
DOC_USP7_UBL2_3 700 704 PF12436 0.305
DOC_WW_Pin1_4 265 270 PF00397 0.422
DOC_WW_Pin1_4 334 339 PF00397 0.416
DOC_WW_Pin1_4 396 401 PF00397 0.459
DOC_WW_Pin1_4 407 412 PF00397 0.374
DOC_WW_Pin1_4 430 435 PF00397 0.482
LIG_14-3-3_CanoR_1 114 122 PF00244 0.422
LIG_14-3-3_CanoR_1 124 130 PF00244 0.418
LIG_14-3-3_CanoR_1 147 155 PF00244 0.447
LIG_14-3-3_CanoR_1 165 174 PF00244 0.381
LIG_14-3-3_CanoR_1 189 196 PF00244 0.395
LIG_14-3-3_CanoR_1 3 8 PF00244 0.632
LIG_14-3-3_CanoR_1 301 305 PF00244 0.442
LIG_14-3-3_CanoR_1 332 338 PF00244 0.375
LIG_14-3-3_CanoR_1 458 462 PF00244 0.311
LIG_14-3-3_CanoR_1 531 538 PF00244 0.328
LIG_14-3-3_CanoR_1 540 545 PF00244 0.387
LIG_14-3-3_CanoR_1 610 615 PF00244 0.306
LIG_14-3-3_CanoR_1 676 680 PF00244 0.297
LIG_14-3-3_CanoR_1 759 763 PF00244 0.375
LIG_Actin_WH2_2 516 533 PF00022 0.292
LIG_Actin_WH2_2 688 706 PF00022 0.238
LIG_BRCT_BRCA1_1 61 65 PF00533 0.605
LIG_EH_1 598 602 PF12763 0.345
LIG_FHA_1 132 138 PF00498 0.433
LIG_FHA_1 173 179 PF00498 0.530
LIG_FHA_1 237 243 PF00498 0.463
LIG_FHA_1 316 322 PF00498 0.344
LIG_FHA_1 34 40 PF00498 0.643
LIG_FHA_1 342 348 PF00498 0.387
LIG_FHA_1 354 360 PF00498 0.358
LIG_FHA_1 555 561 PF00498 0.379
LIG_FHA_1 733 739 PF00498 0.273
LIG_FHA_1 758 764 PF00498 0.338
LIG_FHA_2 126 132 PF00498 0.388
LIG_FHA_2 348 354 PF00498 0.495
LIG_LIR_Apic_2 480 486 PF02991 0.444
LIG_LIR_Apic_2 537 541 PF02991 0.327
LIG_LIR_Apic_2 684 689 PF02991 0.245
LIG_LIR_Gen_1 133 139 PF02991 0.465
LIG_LIR_Gen_1 460 466 PF02991 0.392
LIG_LIR_Gen_1 517 527 PF02991 0.425
LIG_LIR_Gen_1 623 631 PF02991 0.369
LIG_LIR_Gen_1 678 686 PF02991 0.371
LIG_LIR_Nem_3 133 138 PF02991 0.470
LIG_LIR_Nem_3 303 307 PF02991 0.432
LIG_LIR_Nem_3 384 389 PF02991 0.363
LIG_LIR_Nem_3 460 465 PF02991 0.357
LIG_LIR_Nem_3 504 509 PF02991 0.389
LIG_LIR_Nem_3 517 523 PF02991 0.429
LIG_LIR_Nem_3 623 627 PF02991 0.383
LIG_LIR_Nem_3 678 682 PF02991 0.375
LIG_NRBOX 607 613 PF00104 0.342
LIG_Pex14_1 571 575 PF04695 0.269
LIG_SH2_NCK_1 354 358 PF00017 0.401
LIG_SH2_SRC 631 634 PF00017 0.254
LIG_SH2_STAP1 501 505 PF00017 0.440
LIG_SH2_STAP1 631 635 PF00017 0.288
LIG_SH2_STAP1 773 777 PF00017 0.370
LIG_SH2_STAT3 258 261 PF00017 0.376
LIG_SH2_STAT3 532 535 PF00017 0.279
LIG_SH2_STAT5 103 106 PF00017 0.256
LIG_SH2_STAT5 325 328 PF00017 0.436
LIG_SH2_STAT5 375 378 PF00017 0.364
LIG_SH2_STAT5 503 506 PF00017 0.333
LIG_SH2_STAT5 511 514 PF00017 0.285
LIG_SH2_STAT5 520 523 PF00017 0.329
LIG_SH2_STAT5 526 529 PF00017 0.375
LIG_SH2_STAT5 532 535 PF00017 0.371
LIG_SH2_STAT5 587 590 PF00017 0.256
LIG_SH2_STAT5 624 627 PF00017 0.341
LIG_SH2_STAT5 694 697 PF00017 0.423
LIG_SH2_STAT5 762 765 PF00017 0.369
LIG_SH3_3 405 411 PF00018 0.320
LIG_SH3_3 428 434 PF00018 0.495
LIG_SH3_3 504 510 PF00018 0.362
LIG_SH3_3 686 692 PF00018 0.292
LIG_SUMO_SIM_anti_2 603 610 PF11976 0.296
LIG_SUMO_SIM_anti_2 623 629 PF11976 0.266
LIG_SUMO_SIM_par_1 747 752 PF11976 0.270
LIG_TRAF2_1 208 211 PF00917 0.423
LIG_TYR_ITIM 305 310 PF00017 0.515
MOD_CDC14_SPxK_1 268 271 PF00782 0.486
MOD_CDK_SPK_2 334 339 PF00069 0.467
MOD_CDK_SPxK_1 265 271 PF00069 0.462
MOD_CK1_1 106 112 PF00069 0.529
MOD_CK1_1 252 258 PF00069 0.337
MOD_CK1_1 272 278 PF00069 0.510
MOD_CK1_1 334 340 PF00069 0.627
MOD_CK1_1 407 413 PF00069 0.458
MOD_CK1_1 419 425 PF00069 0.441
MOD_CK1_1 426 432 PF00069 0.450
MOD_CK1_1 6 12 PF00069 0.544
MOD_CK1_1 675 681 PF00069 0.342
MOD_CK2_1 115 121 PF00069 0.549
MOD_CK2_1 347 353 PF00069 0.643
MOD_Cter_Amidation 330 333 PF01082 0.351
MOD_Cter_Amidation 652 655 PF01082 0.361
MOD_GlcNHglycan 142 145 PF01048 0.511
MOD_GlcNHglycan 149 152 PF01048 0.510
MOD_GlcNHglycan 221 224 PF01048 0.615
MOD_GlcNHglycan 425 428 PF01048 0.556
MOD_GlcNHglycan 437 440 PF01048 0.481
MOD_GSK3_1 127 134 PF00069 0.568
MOD_GSK3_1 20 27 PF00069 0.542
MOD_GSK3_1 265 272 PF00069 0.544
MOD_GSK3_1 334 341 PF00069 0.625
MOD_GSK3_1 367 374 PF00069 0.388
MOD_GSK3_1 419 426 PF00069 0.414
MOD_GSK3_1 430 437 PF00069 0.388
MOD_GSK3_1 540 547 PF00069 0.365
MOD_GSK3_1 6 13 PF00069 0.551
MOD_N-GLC_1 10 15 PF02516 0.463
MOD_N-GLC_1 115 120 PF02516 0.520
MOD_N-GLC_1 24 29 PF02516 0.520
MOD_N-GLC_1 265 270 PF02516 0.469
MOD_N-GLC_1 315 320 PF02516 0.384
MOD_N-GLC_1 616 621 PF02516 0.324
MOD_N-GLC_1 724 729 PF02516 0.393
MOD_N-GLC_2 20 22 PF02516 0.469
MOD_NEK2_1 218 223 PF00069 0.539
MOD_NEK2_1 477 482 PF00069 0.465
MOD_NEK2_1 530 535 PF00069 0.363
MOD_NEK2_1 544 549 PF00069 0.438
MOD_NEK2_1 601 606 PF00069 0.416
MOD_NEK2_1 749 754 PF00069 0.289
MOD_NEK2_1 97 102 PF00069 0.344
MOD_NEK2_2 172 177 PF00069 0.663
MOD_NEK2_2 616 621 PF00069 0.322
MOD_OFUCOSY 17 24 PF10250 0.456
MOD_OFUCOSY 186 192 PF10250 0.384
MOD_PIKK_1 272 278 PF00454 0.506
MOD_PIKK_1 489 495 PF00454 0.528
MOD_PIKK_1 530 536 PF00454 0.320
MOD_PIKK_1 6 12 PF00454 0.537
MOD_PIKK_1 733 739 PF00454 0.365
MOD_PIKK_1 80 86 PF00454 0.487
MOD_PKA_2 131 137 PF00069 0.500
MOD_PKA_2 188 194 PF00069 0.469
MOD_PKA_2 300 306 PF00069 0.545
MOD_PKA_2 331 337 PF00069 0.499
MOD_PKA_2 338 344 PF00069 0.475
MOD_PKA_2 457 463 PF00069 0.432
MOD_PKA_2 530 536 PF00069 0.316
MOD_PKA_2 675 681 PF00069 0.294
MOD_PKA_2 758 764 PF00069 0.358
MOD_Plk_1 10 16 PF00069 0.446
MOD_Plk_1 115 121 PF00069 0.520
MOD_Plk_1 33 39 PF00069 0.531
MOD_Plk_1 616 622 PF00069 0.331
MOD_Plk_1 749 755 PF00069 0.327
MOD_Plk_2-3 45 51 PF00069 0.521
MOD_Plk_4 10 16 PF00069 0.478
MOD_Plk_4 3 9 PF00069 0.513
MOD_Plk_4 300 306 PF00069 0.468
MOD_Plk_4 371 377 PF00069 0.397
MOD_Plk_4 404 410 PF00069 0.442
MOD_Plk_4 457 463 PF00069 0.370
MOD_Plk_4 623 629 PF00069 0.341
MOD_Plk_4 678 684 PF00069 0.496
MOD_Plk_4 744 750 PF00069 0.336
MOD_Plk_4 758 764 PF00069 0.354
MOD_Plk_4 97 103 PF00069 0.315
MOD_ProDKin_1 265 271 PF00069 0.518
MOD_ProDKin_1 334 340 PF00069 0.504
MOD_ProDKin_1 396 402 PF00069 0.570
MOD_ProDKin_1 407 413 PF00069 0.454
MOD_ProDKin_1 430 436 PF00069 0.590
MOD_SUMO_rev_2 156 164 PF00179 0.475
MOD_SUMO_rev_2 209 215 PF00179 0.493
MOD_SUMO_rev_2 702 712 PF00179 0.330
TRG_DiLeu_BaEn_1 623 628 PF01217 0.287
TRG_DiLeu_BaEn_1 708 713 PF01217 0.344
TRG_DiLeu_BaLyEn_6 34 39 PF01217 0.564
TRG_DiLeu_BaLyEn_6 607 612 PF01217 0.295
TRG_DiLeu_LyEn_5 708 713 PF01217 0.342
TRG_ENDOCYTIC_2 200 203 PF00928 0.497
TRG_ENDOCYTIC_2 307 310 PF00928 0.549
TRG_ENDOCYTIC_2 503 506 PF00928 0.555
TRG_ENDOCYTIC_2 520 523 PF00928 0.522
TRG_ENDOCYTIC_2 624 627 PF00928 0.481
TRG_ENDOCYTIC_2 631 634 PF00928 0.385
TRG_ER_diArg_1 378 380 PF00400 0.561
TRG_ER_diArg_1 591 593 PF00400 0.441
TRG_ER_diArg_1 654 656 PF00400 0.409
TRG_ER_diArg_1 85 87 PF00400 0.531
TRG_NLS_MonoExtN_4 776 782 PF00514 0.320
TRG_Pf-PMV_PEXEL_1 591 595 PF00026 0.444
TRG_Pf-PMV_PEXEL_1 610 614 PF00026 0.328
TRG_Pf-PMV_PEXEL_1 710 714 PF00026 0.359

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IGN9 Leishmania donovani 64% 97%
A0A3S5H4Y6 Leishmania donovani 37% 98%
A0A3S5H4Y9 Leishmania donovani 33% 80%
A0A3S7WT86 Leishmania donovani 37% 77%
A0A3S7WWA6 Leishmania donovani 64% 97%
A0A451EJD9 Leishmania donovani 57% 97%
A0A451EJF4 Leishmania donovani 37% 97%
A0A451EJF6 Leishmania donovani 40% 100%
A0A451EJF8 Leishmania donovani 37% 100%
A0A451EJF9 Leishmania donovani 40% 92%
A4H3A9 Leishmania braziliensis 40% 100%
A4H3B4 Leishmania braziliensis 38% 100%
A4H3B5 Leishmania braziliensis 41% 99%
A4H3B6 Leishmania braziliensis 38% 98%
A4H3B8 Leishmania braziliensis 40% 100%
A4H3B9 Leishmania braziliensis 33% 100%
A4H4W8 Leishmania braziliensis 93% 100%
A4HJ20 Leishmania braziliensis 38% 100%
A4HNK3 Leishmania braziliensis 97% 100%
A4HRL9 Leishmania infantum 38% 97%
A4HRM0 Leishmania infantum 37% 100%
A4HRM1 Leishmania infantum 40% 100%
A4HRS1 Leishmania infantum 39% 92%
A4HRS3 Leishmania infantum 33% 80%
A4HRS5 Leishmania infantum 37% 100%
A4HZM0 Leishmania infantum 57% 97%
A4I7C7 Leishmania infantum 58% 97%
A4IAQ2 Leishmania infantum 55% 97%
E9AC91 Leishmania major 38% 100%
E9AC92 Leishmania major 38% 100%
E9AC94 Leishmania major 33% 67%
E9AC95 Leishmania major 37% 100%
E9AC96 Leishmania major 38% 100%
E9AC98 Leishmania major 33% 100%
E9AEH8 Leishmania major 58% 100%
E9AHA6 Leishmania infantum 57% 97%
E9AIP8 Leishmania braziliensis 94% 100%
E9AJI3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 40% 97%
E9AJI4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 99%
E9AJI5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9AJI6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 80%
E9ALD6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 66% 100%
E9ASB8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 59% 97%
E9AXX8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 59% 97%
E9B2C0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 64% 97%
Q4Q5T6 Leishmania major 58% 100%
Q4QCL8 Leishmania major 62% 100%
Q4QFJ3 Leishmania major 36% 77%
Q4QIG9 Leishmania major 62% 100%
Q7YXU9 Leishmania major 63% 100%
Q7YXV1 Leishmania major 62% 100%
Q7YXV2 Leishmania major 62% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS