Histone H4

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Histone H4

Gene product:

histone H4

Species:

Leishmania braziliensis

UniProt:

A4HNK4_LEIBR

TriTrypDb:

LbrM.35.0020 , LBRM2903_150005100

Length:

186

Annotations

LeishMANIAdb annotations

Histone H4 protein, nuclear without any membrane association

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0000786	nucleosome	3	4
GO:0005634	nucleus	5	4
GO:0032991	protein-containing complex	1	4
GO:0032993	protein-DNA complex	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0044815	DNA packaging complex	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HNK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNK4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	4
GO:0003677	DNA binding	4	4
GO:0005198	structural molecule activity	1	4
GO:0005488	binding	1	4
GO:0005515	protein binding	2	4
GO:0030527	structural constituent of chromatin	2	4
GO:0046982	protein heterodimerization activity	4	4
GO:0046983	protein dimerization activity	3	4
GO:0097159	organic cyclic compound binding	2	4
GO:1901363	heterocyclic compound binding	2	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.721
CLV_NRD_NRD_1	124	126	PF00675	0.657
CLV_NRD_NRD_1	140	142	PF00675	0.679
CLV_NRD_NRD_1	161	163	PF00675	0.718
CLV_NRD_NRD_1	175	177	PF00675	0.450
CLV_PCSK_KEX2_1	101	103	PF00082	0.596
CLV_PCSK_KEX2_1	120	122	PF00082	0.488
CLV_PCSK_KEX2_1	124	126	PF00082	0.657
CLV_PCSK_KEX2_1	129	131	PF00082	0.562
CLV_PCSK_KEX2_1	140	142	PF00082	0.679
CLV_PCSK_KEX2_1	177	179	PF00082	0.650
CLV_PCSK_KEX2_1	91	93	PF00082	0.783
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.590
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.720
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.650
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.783
CLV_PCSK_PC7_1	116	122	PF00082	0.601
CLV_PCSK_PC7_1	125	131	PF00082	0.507
CLV_PCSK_SKI1_1	104	108	PF00082	0.626
CLV_PCSK_SKI1_1	112	116	PF00082	0.595
CLV_PCSK_SKI1_1	140	144	PF00082	0.597
CLV_PCSK_SKI1_1	164	168	PF00082	0.719
CLV_PCSK_SKI1_1	55	59	PF00082	0.654
CLV_PCSK_SKI1_1	68	72	PF00082	0.689
DOC_CDC14_PxL_1	69	77	PF14671	0.545
DOC_CYCLIN_RxL_1	50	62	PF00134	0.604
DOC_CYCLIN_yCln2_LP_2	38	44	PF00134	0.553
DOC_USP7_MATH_1	82	86	PF00917	0.659
DOC_USP7_MATH_1	96	100	PF00917	0.667
DOC_USP7_UBL2_3	97	101	PF12436	0.733
DOC_WW_Pin1_4	37	42	PF00397	0.549
DOC_WW_Pin1_4	6	11	PF00397	0.533
LIG_14-3-3_CanoR_1	15	19	PF00244	0.562
LIG_14-3-3_CanoR_1	152	160	PF00244	0.684
LIG_14-3-3_CanoR_1	162	167	PF00244	0.723
LIG_14-3-3_CanoR_1	43	47	PF00244	0.571
LIG_14-3-3_CanoR_1	55	64	PF00244	0.605
LIG_14-3-3_CanoR_1	68	73	PF00244	0.686
LIG_14-3-3_CanoR_1	77	87	PF00244	0.620
LIG_BIR_III_4	95	99	PF00653	0.751
LIG_FHA_1	7	13	PF00498	0.537
LIG_FHA_2	165	171	PF00498	0.701
LIG_LIR_Gen_1	134	143	PF02991	0.682
LIG_LIR_Nem_3	134	139	PF02991	0.687
LIG_LIR_Nem_3	154	160	PF02991	0.580
LIG_LIR_Nem_3	27	32	PF02991	0.648
LIG_NRBOX	53	59	PF00104	0.551
LIG_SH2_SRC	136	139	PF00017	0.672
LIG_SH2_STAP1	157	161	PF00017	0.594
LIG_SH2_STAT5	146	149	PF00017	0.678
LIG_SH2_STAT5	157	160	PF00017	0.594
LIG_SH2_STAT5	56	59	PF00017	0.547
LIG_SH3_2	10	15	PF14604	0.550
LIG_SH3_3	67	73	PF00018	0.546
LIG_SH3_3	7	13	PF00018	0.537
MOD_CDC14_SPxK_1	40	43	PF00782	0.552
MOD_CDK_SPxK_1	37	43	PF00069	0.552
MOD_CK1_1	24	30	PF00069	0.574
MOD_CK1_1	45	51	PF00069	0.529
MOD_CK1_1	60	66	PF00069	0.606
MOD_CK1_1	81	87	PF00069	0.747
MOD_Cter_Amidation	89	92	PF01082	0.776
MOD_GlcNHglycan	131	134	PF01048	0.544
MOD_GlcNHglycan	34	37	PF01048	0.547
MOD_GlcNHglycan	80	83	PF01048	0.800
MOD_GlcNHglycan	92	95	PF01048	0.670
MOD_GSK3_1	151	158	PF00069	0.610
MOD_GSK3_1	21	28	PF00069	0.574
MOD_GSK3_1	42	49	PF00069	0.566
MOD_GSK3_1	56	63	PF00069	0.540
MOD_GSK3_1	78	85	PF00069	0.655
MOD_N-GLC_1	82	87	PF02516	0.717
MOD_NEK2_1	25	30	PF00069	0.574
MOD_NEK2_1	32	37	PF00069	0.575
MOD_NEK2_1	42	47	PF00069	0.709
MOD_NEK2_1	57	62	PF00069	0.575
MOD_NEK2_1	78	83	PF00069	0.746
MOD_PIKK_1	62	68	PF00454	0.578
MOD_PIKK_1	96	102	PF00454	0.735
MOD_PKA_1	129	135	PF00069	0.718
MOD_PKA_1	162	168	PF00069	0.721
MOD_PKA_2	129	135	PF00069	0.718
MOD_PKA_2	14	20	PF00069	0.565
MOD_PKA_2	151	157	PF00069	0.676
MOD_PKA_2	32	38	PF00069	0.557
MOD_PKA_2	42	48	PF00069	0.646
MOD_Plk_4	42	48	PF00069	0.550
MOD_ProDKin_1	37	43	PF00069	0.552
MOD_ProDKin_1	6	12	PF00069	0.534
MOD_SUMO_rev_2	93	99	PF00179	0.757
TRG_ENDOCYTIC_2	136	139	PF00928	0.672
TRG_ER_diArg_1	119	121	PF00400	0.701
TRG_ER_diArg_1	139	141	PF00400	0.667
TRG_ER_diArg_1	175	178	PF00400	0.655
TRG_NLS_Bipartite_1	162	180	PF00514	0.596
TRG_NLS_Bipartite_1	91	105	PF00514	0.742
TRG_NLS_MonoExtC_3	100	105	PF00514	0.710

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A4HHY8	Leishmania braziliensis	65%	100%
A4HNK8	Leishmania braziliensis	95%	100%