Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNJ9_LEIBR

TriTrypDb:

LbrM.34.5320 , LBRM2903_340064100

Length:

260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNJ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNJ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	128	132	PF00656	0.431
CLV_NRD_NRD_1	165	167	PF00675	0.342
CLV_PCSK_KEX2_1	27	29	PF00082	0.461
CLV_PCSK_KEX2_1	87	89	PF00082	0.493
CLV_PCSK_PC1ET2_1	27	29	PF00082	0.409
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.493
CLV_PCSK_SKI1_1	15	19	PF00082	0.460
CLV_PCSK_SKI1_1	167	171	PF00082	0.607
CLV_PCSK_SKI1_1	225	229	PF00082	0.419
CLV_PCSK_SKI1_1	28	32	PF00082	0.420
DEG_Nend_UBRbox_1	1	4	PF02207	0.672
DEG_SCF_TRCP1_1	123	128	PF00400	0.466
DOC_CYCLIN_RxL_1	12	19	PF00134	0.510
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.470
DOC_CYCLIN_yCln2_LP_2	75	78	PF00134	0.515
DOC_PP2B_LxvP_1	54	57	PF13499	0.383
DOC_PP2B_LxvP_1	75	78	PF13499	0.457
DOC_USP7_MATH_1	132	136	PF00917	0.461
DOC_USP7_MATH_1	193	197	PF00917	0.540
DOC_USP7_MATH_1	247	251	PF00917	0.408
DOC_USP7_MATH_1	256	260	PF00917	0.543
DOC_WW_Pin1_4	16	21	PF00397	0.476
DOC_WW_Pin1_4	252	257	PF00397	0.392
DOC_WW_Pin1_4	48	53	PF00397	0.433
LIG_14-3-3_CanoR_1	166	176	PF00244	0.475
LIG_14-3-3_CanoR_1	195	204	PF00244	0.326
LIG_BRCT_BRCA1_1	102	106	PF00533	0.371
LIG_EVH1_1	175	179	PF00568	0.432
LIG_FHA_1	206	212	PF00498	0.545
LIG_FHA_1	37	43	PF00498	0.504
LIG_FHA_1	49	55	PF00498	0.323
LIG_FHA_1	88	94	PF00498	0.502
LIG_FHA_2	166	172	PF00498	0.475
LIG_HCF-1_HBM_1	94	97	PF13415	0.373
LIG_LIR_Gen_1	135	146	PF02991	0.515
LIG_LIR_Nem_3	135	141	PF02991	0.466
LIG_Pex14_1	161	165	PF04695	0.398
LIG_REV1ctd_RIR_1	104	114	PF16727	0.279
LIG_SH2_GRB2like	216	219	PF00017	0.342
LIG_SH2_SRC	216	219	PF00017	0.363
LIG_SH2_STAP1	235	239	PF00017	0.239
LIG_SH2_STAT5	145	148	PF00017	0.474
LIG_SH2_STAT5	159	162	PF00017	0.284
LIG_SH2_STAT5	216	219	PF00017	0.455
LIG_SH2_STAT5	97	100	PF00017	0.335
LIG_SH3_3	143	149	PF00018	0.501
LIG_SH3_3	173	179	PF00018	0.509
LIG_SH3_3	73	79	PF00018	0.515
LIG_UBA3_1	82	87	PF00899	0.541
MOD_CK1_1	124	130	PF00069	0.496
MOD_CK1_1	196	202	PF00069	0.517
MOD_CK1_1	250	256	PF00069	0.477
MOD_CK1_1	34	40	PF00069	0.355
MOD_CK2_1	165	171	PF00069	0.427
MOD_GlcNHglycan	123	126	PF01048	0.600
MOD_GlcNHglycan	33	36	PF01048	0.619
MOD_GSK3_1	105	112	PF00069	0.390
MOD_GSK3_1	121	128	PF00069	0.497
MOD_GSK3_1	193	200	PF00069	0.517
MOD_GSK3_1	252	259	PF00069	0.545
MOD_N-GLC_1	197	202	PF02516	0.402
MOD_NEK2_1	121	126	PF00069	0.469
MOD_NEK2_1	165	170	PF00069	0.360
MOD_NEK2_1	204	209	PF00069	0.427
MOD_NEK2_1	31	36	PF00069	0.488
MOD_PKA_1	87	93	PF00069	0.461
MOD_PKA_2	165	171	PF00069	0.391
MOD_PKA_2	196	202	PF00069	0.457
MOD_PKA_2	212	218	PF00069	0.404
MOD_PKA_2	87	93	PF00069	0.461
MOD_PKB_1	195	203	PF00069	0.341
MOD_Plk_1	200	206	PF00069	0.401
MOD_Plk_1	250	256	PF00069	0.575
MOD_Plk_4	109	115	PF00069	0.314
MOD_Plk_4	212	218	PF00069	0.503
MOD_ProDKin_1	16	22	PF00069	0.470
MOD_ProDKin_1	252	258	PF00069	0.411
MOD_ProDKin_1	48	54	PF00069	0.428
MOD_SUMO_for_1	86	89	PF00179	0.356
TRG_DiLeu_BaLyEn_6	49	54	PF01217	0.463
TRG_ENDOCYTIC_2	237	240	PF00928	0.389
TRG_ER_diArg_1	194	197	PF00400	0.335

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXE1	Leptomonas seymouri	51%	96%
A0A1X0NWL1	Trypanosomatidae	25%	93%
A0A3S7XA73	Leishmania donovani	80%	100%
A0A422N815	Trypanosoma rangeli	20%	97%
A4IC68	Leishmania infantum	80%	100%
E9AG11	Leishmania major	80%	100%
E9B764	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
V5DS95	Trypanosoma cruzi	22%	97%