Diacylglycerol kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

diacylglycerol kinase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HNJ8_LEIBR

TriTrypDb:

LbrM.34.5310 , LBRM2903_340063900 , LBRM2903_340064000

Length:

387

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HNJ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNJ8

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0007165	signal transduction	2	9
GO:0007186	G protein-coupled receptor signaling pathway	3	9
GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	4	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016310	phosphorylation	5	9
GO:0044237	cellular metabolic process	2	9
GO:0050789	regulation of biological process	2	9
GO:0050794	regulation of cellular process	3	9
GO:0065007	biological regulation	1	9

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0004143	diacylglycerol kinase activity	5	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016301	kinase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	137	139	PF00675	0.244
CLV_NRD_NRD_1	35	37	PF00675	0.292
CLV_NRD_NRD_1	67	69	PF00675	0.279
CLV_PCSK_KEX2_1	137	139	PF00082	0.276
CLV_PCSK_KEX2_1	92	94	PF00082	0.306
CLV_PCSK_PC1ET2_1	92	94	PF00082	0.306
CLV_PCSK_SKI1_1	15	19	PF00082	0.349
CLV_PCSK_SKI1_1	221	225	PF00082	0.321
CLV_PCSK_SKI1_1	32	36	PF00082	0.313
DEG_MDM2_SWIB_1	289	297	PF02201	0.490
DEG_ODPH_VHL_1	368	381	PF01847	0.172
DOC_CYCLIN_RxL_1	218	226	PF00134	0.362
DOC_CYCLIN_yCln2_LP_2	367	373	PF00134	0.172
DOC_MAPK_gen_1	227	235	PF00069	0.454
DOC_MAPK_gen_1	9	18	PF00069	0.562
DOC_MAPK_MEF2A_6	228	237	PF00069	0.479
DOC_PP1_RVXF_1	13	19	PF00149	0.446
DOC_PP1_RVXF_1	297	303	PF00149	0.490
DOC_PP2B_LxvP_1	353	356	PF13499	0.531
DOC_PP2B_LxvP_1	367	370	PF13499	0.351
DOC_WW_Pin1_4	98	103	PF00397	0.427
LIG_14-3-3_CanoR_1	156	160	PF00244	0.525
LIG_BRCT_BRCA1_1	120	124	PF00533	0.362
LIG_BRCT_BRCA1_1	182	186	PF00533	0.423
LIG_Clathr_ClatBox_1	234	238	PF01394	0.467
LIG_deltaCOP1_diTrp_1	45	51	PF00928	0.467
LIG_FHA_1	146	152	PF00498	0.574
LIG_FHA_1	205	211	PF00498	0.511
LIG_FHA_1	311	317	PF00498	0.467
LIG_FHA_1	339	345	PF00498	0.491
LIG_FHA_2	112	118	PF00498	0.423
LIG_FHA_2	150	156	PF00498	0.534
LIG_FHA_2	267	273	PF00498	0.362
LIG_FHA_2	59	65	PF00498	0.552
LIG_GBD_Chelix_1	375	383	PF00786	0.243
LIG_LIR_Apic_2	272	277	PF02991	0.490
LIG_LIR_Gen_1	136	146	PF02991	0.628
LIG_LIR_Gen_1	361	372	PF02991	0.319
LIG_LIR_Gen_1	45	56	PF02991	0.490
LIG_LIR_Gen_1	73	78	PF02991	0.471
LIG_LIR_Nem_3	136	142	PF02991	0.534
LIG_LIR_Nem_3	361	367	PF02991	0.319
LIG_LIR_Nem_3	45	51	PF02991	0.484
LIG_LIR_Nem_3	73	77	PF02991	0.516
LIG_LYPXL_yS_3	201	204	PF13949	0.362
LIG_PCNA_TLS_4	60	67	PF02747	0.467
LIG_Pex14_1	214	218	PF04695	0.423
LIG_Pex14_2	124	128	PF04695	0.493
LIG_Pex14_2	178	182	PF04695	0.436
LIG_Pex14_2	289	293	PF04695	0.490
LIG_PTB_Apo_2	176	183	PF02174	0.490
LIG_SH2_CRK	274	278	PF00017	0.490
LIG_SH2_NCK_1	146	150	PF00017	0.554
LIG_SH2_PTP2	74	77	PF00017	0.467
LIG_SH2_SRC	74	77	PF00017	0.467
LIG_SH2_STAP1	215	219	PF00017	0.490
LIG_SH2_STAT5	176	179	PF00017	0.427
LIG_SH2_STAT5	181	184	PF00017	0.420
LIG_SH2_STAT5	33	36	PF00017	0.484
LIG_SH2_STAT5	382	385	PF00017	0.312
LIG_SH2_STAT5	74	77	PF00017	0.467
LIG_SH3_3	103	109	PF00018	0.453
LIG_SH3_3	239	245	PF00018	0.422
LIG_Sin3_3	364	371	PF02671	0.262
LIG_SUMO_SIM_par_1	231	238	PF11976	0.467
LIG_WW_3	355	359	PF00397	0.585
MOD_CDC14_SPxK_1	101	104	PF00782	0.427
MOD_CDK_SPxK_1	98	104	PF00069	0.427
MOD_CK1_1	247	253	PF00069	0.467
MOD_CK2_1	58	64	PF00069	0.535
MOD_Cter_Amidation	304	307	PF01082	0.290
MOD_GlcNHglycan	11	14	PF01048	0.401
MOD_GlcNHglycan	125	128	PF01048	0.331
MOD_GlcNHglycan	24	27	PF01048	0.216
MOD_GlcNHglycan	246	249	PF01048	0.283
MOD_GSK3_1	145	152	PF00069	0.581
MOD_GSK3_1	155	162	PF00069	0.527
MOD_GSK3_1	315	322	PF00069	0.490
MOD_GSK3_1	334	341	PF00069	0.429
MOD_N-GLC_1	266	271	PF02516	0.181
MOD_N-GLC_1	331	336	PF02516	0.281
MOD_NEK2_1	118	123	PF00069	0.444
MOD_NEK2_1	159	164	PF00069	0.547
MOD_NEK2_1	204	209	PF00069	0.474
MOD_NEK2_1	331	336	PF00069	0.612
MOD_NEK2_1	347	352	PF00069	0.490
MOD_NEK2_1	38	43	PF00069	0.559
MOD_NEK2_1	381	386	PF00069	0.273
MOD_NEK2_2	338	343	PF00069	0.514
MOD_PIKK_1	347	353	PF00454	0.440
MOD_PKA_2	155	161	PF00069	0.479
MOD_Plk_4	229	235	PF00069	0.483
MOD_ProDKin_1	98	104	PF00069	0.427
TRG_DiLeu_BaEn_2	359	365	PF01217	0.427
TRG_DiLeu_BaEn_2	61	67	PF01217	0.420
TRG_ENDOCYTIC_2	181	184	PF00928	0.428
TRG_ENDOCYTIC_2	201	204	PF00928	0.444
TRG_ENDOCYTIC_2	215	218	PF00928	0.415
TRG_ENDOCYTIC_2	74	77	PF00928	0.467
TRG_ER_diArg_1	137	139	PF00400	0.441
TRG_ER_diArg_1	197	200	PF00400	0.467
TRG_ER_diArg_1	8	11	PF00400	0.614

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKR4	Leptomonas seymouri	67%	100%
A0A0S4KIS7	Bodo saltans	25%	87%
A0A1X0NZZ0	Trypanosomatidae	36%	100%
A0A3Q8IIW3	Leishmania donovani	81%	100%
A4IC67	Leishmania infantum	81%	100%
C9ZVX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	67%
E9AG10	Leishmania major	80%	100%
E9B763	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
F4JQ95	Arabidopsis thaliana	24%	79%
P52429	Homo sapiens	34%	68%
Q1PDI2	Arabidopsis thaliana	25%	79%
Q8VZG1	Arabidopsis thaliana	26%	79%
Q9R1C6	Mus musculus	35%	69%
V5AWH3	Trypanosoma cruzi	37%	100%