Dynein_heavy domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Dynein heavy chain and region D6 of dynein motor/Ankyrin repeats (3 copies), putative

Species:

Leishmania braziliensis

UniProt:

A4HNJ5_LEIBR

TriTrypDb:

LbrM.34.5280 , LBRM2903_340063600

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005875	microtubule associated complex	2	4
GO:0030286	dynein complex	3	4
GO:0032991	protein-containing complex	1	4
GO:1902494	catalytic complex	2	4
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNJ5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNJ5

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	4
GO:0007018	microtubule-based movement	3	4
GO:0009987	cellular process	1	4

Molecular functions
Term	Name	Level	Count
GO:0003774	cytoskeletal motor activity	1	4
GO:0003777	microtubule motor activity	2	4
GO:0008569	minus-end-directed microtubule motor activity	3	4
GO:0140657	ATP-dependent activity	1	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	116	118	PF00675	0.248
CLV_NRD_NRD_1	182	184	PF00675	0.550
CLV_NRD_NRD_1	241	243	PF00675	0.452
CLV_NRD_NRD_1	252	254	PF00675	0.351
CLV_NRD_NRD_1	342	344	PF00675	0.445
CLV_PCSK_KEX2_1	116	118	PF00082	0.268
CLV_PCSK_KEX2_1	182	184	PF00082	0.516
CLV_PCSK_KEX2_1	241	243	PF00082	0.411
CLV_PCSK_SKI1_1	117	121	PF00082	0.285
CLV_PCSK_SKI1_1	169	173	PF00082	0.691
CLV_PCSK_SKI1_1	21	25	PF00082	0.433
CLV_PCSK_SKI1_1	253	257	PF00082	0.313
CLV_PCSK_SKI1_1	268	272	PF00082	0.259
CLV_PCSK_SKI1_1	275	279	PF00082	0.279
DOC_CYCLIN_yCln2_LP_2	132	138	PF00134	0.474
DOC_MAPK_MEF2A_6	121	130	PF00069	0.489
DOC_PP2B_LxvP_1	132	135	PF13499	0.549
DOC_PP2B_PxIxI_1	30	36	PF00149	0.535
DOC_USP7_MATH_1	148	152	PF00917	0.423
DOC_USP7_MATH_1	41	45	PF00917	0.413
DOC_WW_Pin1_4	11	16	PF00397	0.563
DOC_WW_Pin1_4	257	262	PF00397	0.266
DOC_WW_Pin1_4	27	32	PF00397	0.266
LIG_14-3-3_CanoR_1	241	251	PF00244	0.414
LIG_AP2alpha_2	40	42	PF02296	0.442
LIG_FHA_1	145	151	PF00498	0.529
LIG_FHA_1	196	202	PF00498	0.532
LIG_FHA_1	269	275	PF00498	0.299
LIG_FHA_1	28	34	PF00498	0.442
LIG_FHA_2	325	331	PF00498	0.486
LIG_FHA_2	85	91	PF00498	0.456
LIG_GBD_Chelix_1	100	108	PF00786	0.335
LIG_LIR_Gen_1	103	111	PF02991	0.376
LIG_LIR_Gen_1	159	167	PF02991	0.625
LIG_LIR_Gen_1	40	49	PF02991	0.462
LIG_LIR_Gen_1	72	78	PF02991	0.456
LIG_LIR_Gen_1	82	91	PF02991	0.405
LIG_LIR_Nem_3	103	108	PF02991	0.518
LIG_LIR_Nem_3	118	123	PF02991	0.399
LIG_LIR_Nem_3	12	16	PF02991	0.434
LIG_LIR_Nem_3	159	164	PF02991	0.577
LIG_LIR_Nem_3	318	323	PF02991	0.446
LIG_LIR_Nem_3	40	45	PF02991	0.462
LIG_LIR_Nem_3	72	76	PF02991	0.432
LIG_LIR_Nem_3	82	86	PF02991	0.433
LIG_LIR_Nem_3	94	100	PF02991	0.431
LIG_Pex14_2	120	124	PF04695	0.445
LIG_Pex14_2	140	144	PF04695	0.509
LIG_SH2_CRK	105	109	PF00017	0.535
LIG_SH2_PTP2	73	76	PF00017	0.431
LIG_SH2_SRC	73	76	PF00017	0.431
LIG_SH2_STAT5	338	341	PF00017	0.439
LIG_SH2_STAT5	47	50	PF00017	0.530
LIG_SH2_STAT5	73	76	PF00017	0.439
LIG_SH2_STAT5	85	88	PF00017	0.431
LIG_SH2_STAT5	96	99	PF00017	0.535
LIG_SH3_3	123	129	PF00018	0.577
LIG_SH3_3	133	139	PF00018	0.420
LIG_SH3_3	147	153	PF00018	0.433
LIG_SH3_3	281	287	PF00018	0.285
LIG_SUMO_SIM_anti_2	276	281	PF11976	0.189
LIG_WRC_WIRS_1	56	61	PF05994	0.535
MOD_CK1_1	151	157	PF00069	0.432
MOD_CK1_1	159	165	PF00069	0.427
MOD_CK1_1	219	225	PF00069	0.463
MOD_CK1_1	273	279	PF00069	0.331
MOD_CK2_1	11	17	PF00069	0.540
MOD_CK2_1	186	192	PF00069	0.559
MOD_CK2_1	242	248	PF00069	0.432
MOD_CK2_1	315	321	PF00069	0.484
MOD_GlcNHglycan	201	204	PF01048	0.493
MOD_GlcNHglycan	245	248	PF01048	0.300
MOD_GlcNHglycan	53	56	PF01048	0.279
MOD_GlcNHglycan	65	68	PF01048	0.256
MOD_GSK3_1	144	151	PF00069	0.353
MOD_GSK3_1	186	193	PF00069	0.557
MOD_GSK3_1	195	202	PF00069	0.508
MOD_GSK3_1	23	30	PF00069	0.516
MOD_GSK3_1	324	331	PF00069	0.497
MOD_GSK3_1	51	58	PF00069	0.535
MOD_NEK2_1	124	129	PF00069	0.496
MOD_NEK2_1	144	149	PF00069	0.420
MOD_NEK2_1	270	275	PF00069	0.411
MOD_PKA_2	151	157	PF00069	0.594
MOD_PKA_2	186	192	PF00069	0.559
MOD_PKA_2	199	205	PF00069	0.486
MOD_Plk_1	92	98	PF00069	0.499
MOD_Plk_2-3	188	194	PF00069	0.558
MOD_Plk_4	216	222	PF00069	0.386
MOD_Plk_4	92	98	PF00069	0.510
MOD_ProDKin_1	11	17	PF00069	0.567
MOD_ProDKin_1	257	263	PF00069	0.266
MOD_ProDKin_1	27	33	PF00069	0.266
MOD_SUMO_rev_2	341	346	PF00179	0.455
TRG_DiLeu_BaLyEn_6	138	143	PF01217	0.299
TRG_ENDOCYTIC_2	105	108	PF00928	0.535
TRG_ENDOCYTIC_2	73	76	PF00928	0.439
TRG_ER_diArg_1	115	117	PF00400	0.431
TRG_ER_diArg_1	240	242	PF00400	0.331
TRG_NES_CRM1_1	269	283	PF08389	0.331
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.257
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.366
TRG_Pf-PMV_PEXEL_1	268	272	PF00026	0.309
TRG_Pf-PMV_PEXEL_1	307	311	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEG4	Leptomonas seymouri	76%	100%
A0A0S4JP67	Bodo saltans	45%	93%
A0A1X0P5J8	Trypanosomatidae	49%	100%
A0A3Q8IIK7	Leishmania donovani	84%	100%
A0A3R7N649	Trypanosoma rangeli	47%	100%
A4IC52	Leishmania infantum	84%	100%
C9ZYC2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AG07	Leishmania major	84%	100%
E9B760	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
V5BYP5	Trypanosoma cruzi	47%	92%