SAC3_GANP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SAC3/GANP/Nin1/mts3/eIF-3 p25 family, putative

Species:

Leishmania braziliensis

UniProt:

A4HNJ3_LEIBR

TriTrypDb:

LbrM.34.5260 , LBRM2903_340063400

Length:

505

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNJ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	498	502	PF00656	0.564
CLV_NRD_NRD_1	17	19	PF00675	0.746
CLV_NRD_NRD_1	45	47	PF00675	0.482
CLV_NRD_NRD_1	465	467	PF00675	0.538
CLV_NRD_NRD_1	498	500	PF00675	0.539
CLV_NRD_NRD_1	71	73	PF00675	0.510
CLV_PCSK_KEX2_1	135	137	PF00082	0.656
CLV_PCSK_KEX2_1	149	151	PF00082	0.653
CLV_PCSK_KEX2_1	17	19	PF00082	0.746
CLV_PCSK_KEX2_1	425	427	PF00082	0.665
CLV_PCSK_KEX2_1	45	47	PF00082	0.462
CLV_PCSK_KEX2_1	464	466	PF00082	0.434
CLV_PCSK_KEX2_1	70	72	PF00082	0.514
CLV_PCSK_PC1ET2_1	135	137	PF00082	0.743
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.744
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.665
CLV_PCSK_PC1ET2_1	464	466	PF00082	0.441
CLV_PCSK_SKI1_1	150	154	PF00082	0.747
CLV_PCSK_SKI1_1	164	168	PF00082	0.539
CLV_PCSK_SKI1_1	303	307	PF00082	0.475
CLV_PCSK_SKI1_1	36	40	PF00082	0.469
CLV_PCSK_SKI1_1	395	399	PF00082	0.348
CLV_PCSK_SKI1_1	426	430	PF00082	0.559
DEG_APCC_DBOX_1	382	390	PF00400	0.396
DEG_SPOP_SBC_1	154	158	PF00917	0.499
DEG_SPOP_SBC_1	185	189	PF00917	0.336
DOC_CYCLIN_RxL_1	421	433	PF00134	0.613
DOC_MAPK_gen_1	243	251	PF00069	0.328
DOC_MAPK_gen_1	70	78	PF00069	0.474
DOC_MAPK_MEF2A_6	402	409	PF00069	0.413
DOC_MAPK_NFAT4_5	402	410	PF00069	0.475
DOC_PP1_RVXF_1	388	394	PF00149	0.344
DOC_PP1_RVXF_1	424	431	PF00149	0.614
DOC_USP7_MATH_1	100	104	PF00917	0.708
DOC_USP7_MATH_1	434	438	PF00917	0.495
DOC_USP7_UBL2_3	227	231	PF12436	0.370
DOC_USP7_UBL2_3	232	236	PF12436	0.371
DOC_WW_Pin1_4	102	107	PF00397	0.710
DOC_WW_Pin1_4	26	31	PF00397	0.653
DOC_WW_Pin1_4	414	419	PF00397	0.349
DOC_WW_Pin1_4	96	101	PF00397	0.735
LIG_14-3-3_CanoR_1	408	418	PF00244	0.267
LIG_14-3-3_CanoR_1	441	449	PF00244	0.470
LIG_Actin_WH2_2	198	214	PF00022	0.413
LIG_Actin_WH2_2	379	397	PF00022	0.383
LIG_BRCT_BRCA1_1	412	416	PF00533	0.387
LIG_Clathr_ClatBox_1	371	375	PF01394	0.475
LIG_Clathr_ClatBox_1	428	432	PF01394	0.540
LIG_deltaCOP1_diTrp_1	435	446	PF00928	0.272
LIG_FHA_1	124	130	PF00498	0.610
LIG_FHA_1	154	160	PF00498	0.721
LIG_FHA_1	257	263	PF00498	0.443
LIG_FHA_1	271	277	PF00498	0.449
LIG_FHA_1	322	328	PF00498	0.344
LIG_FHA_1	335	341	PF00498	0.344
LIG_FHA_1	350	356	PF00498	0.273
LIG_FHA_1	362	368	PF00498	0.321
LIG_FHA_1	377	383	PF00498	0.449
LIG_FHA_1	446	452	PF00498	0.508
LIG_FHA_2	172	178	PF00498	0.670
LIG_FHA_2	185	191	PF00498	0.425
LIG_FHA_2	194	200	PF00498	0.449
LIG_FHA_2	221	227	PF00498	0.475
LIG_FHA_2	27	33	PF00498	0.555
LIG_FHA_2	496	502	PF00498	0.541
LIG_FHA_2	75	81	PF00498	0.455
LIG_LIR_Gen_1	213	222	PF02991	0.475
LIG_LIR_Gen_1	256	265	PF02991	0.475
LIG_LIR_Gen_1	316	327	PF02991	0.449
LIG_LIR_Gen_1	436	446	PF02991	0.430
LIG_LIR_Gen_1	491	496	PF02991	0.505
LIG_LIR_Gen_1	77	85	PF02991	0.427
LIG_LIR_Nem_3	192	198	PF02991	0.484
LIG_LIR_Nem_3	213	218	PF02991	0.449
LIG_LIR_Nem_3	316	322	PF02991	0.410
LIG_LIR_Nem_3	436	442	PF02991	0.427
LIG_LIR_Nem_3	443	449	PF02991	0.430
LIG_LIR_Nem_3	491	495	PF02991	0.441
LIG_LYPXL_yS_3	477	480	PF13949	0.561
LIG_NRBOX	366	372	PF00104	0.475
LIG_PCNA_PIPBox_1	283	292	PF02747	0.363
LIG_PCNA_PIPBox_1	299	308	PF02747	0.363
LIG_PCNA_yPIPBox_3	298	306	PF02747	0.469
LIG_Pex14_2	442	446	PF04695	0.480
LIG_REV1ctd_RIR_1	303	313	PF16727	0.344
LIG_SH2_CRK	308	312	PF00017	0.410
LIG_SH2_CRK	319	323	PF00017	0.358
LIG_SH2_GRB2like	31	34	PF00017	0.715
LIG_SH2_NCK_1	215	219	PF00017	0.487
LIG_SH2_NCK_1	73	77	PF00017	0.449
LIG_SH2_SRC	215	218	PF00017	0.487
LIG_SH2_SRC	31	34	PF00017	0.708
LIG_SH2_STAP1	263	267	PF00017	0.328
LIG_SH2_STAP1	290	294	PF00017	0.475
LIG_SH2_STAP1	62	66	PF00017	0.551
LIG_SH2_STAT5	195	198	PF00017	0.589
LIG_SH2_STAT5	237	240	PF00017	0.344
LIG_SH2_STAT5	312	315	PF00017	0.317
LIG_SH2_STAT5	380	383	PF00017	0.363
LIG_SH2_STAT5	385	388	PF00017	0.323
LIG_SH2_STAT5	492	495	PF00017	0.432
LIG_SH3_3	103	109	PF00018	0.726
LIG_SH3_3	140	146	PF00018	0.790
LIG_SH3_3	448	454	PF00018	0.519
LIG_SH3_3	47	53	PF00018	0.560
LIG_SH3_3	90	96	PF00018	0.693
LIG_Sin3_3	37	44	PF02671	0.348
LIG_SUMO_SIM_par_1	258	264	PF11976	0.428
LIG_TYR_ITIM	310	315	PF00017	0.344
LIG_UBA3_1	391	395	PF00899	0.389
LIG_UBA3_1	397	402	PF00899	0.416
LIG_UBA3_1	445	450	PF00899	0.469
LIG_UBA3_1	81	86	PF00899	0.544
LIG_WRC_WIRS_1	371	376	PF05994	0.475
MOD_CK1_1	16	22	PF00069	0.717
MOD_CK1_1	23	29	PF00069	0.715
MOD_CK1_1	321	327	PF00069	0.428
MOD_CK1_1	373	379	PF00069	0.223
MOD_CK1_1	99	105	PF00069	0.673
MOD_CK2_1	171	177	PF00069	0.665
MOD_CK2_1	184	190	PF00069	0.381
MOD_CK2_1	193	199	PF00069	0.424
MOD_CK2_1	220	226	PF00069	0.475
MOD_CK2_1	26	32	PF00069	0.711
MOD_CK2_1	455	461	PF00069	0.372
MOD_CK2_1	74	80	PF00069	0.473
MOD_Cter_Amidation	229	232	PF01082	0.475
MOD_Cter_Amidation	421	424	PF01082	0.658
MOD_Cter_Amidation	68	71	PF01082	0.404
MOD_GlcNHglycan	315	318	PF01048	0.475
MOD_GlcNHglycan	435	439	PF01048	0.453
MOD_GSK3_1	117	124	PF00069	0.682
MOD_GSK3_1	16	23	PF00069	0.621
MOD_GSK3_1	216	223	PF00069	0.451
MOD_GSK3_1	410	417	PF00069	0.372
MOD_GSK3_1	96	103	PF00069	0.662
MOD_N-GLC_1	193	198	PF02516	0.602
MOD_N-GLC_1	21	26	PF02516	0.687
MOD_N-GLC_1	256	261	PF02516	0.475
MOD_N-GLC_1	32	37	PF02516	0.368
MOD_N-GLC_1	349	354	PF02516	0.453
MOD_N-GLC_2	280	282	PF02516	0.328
MOD_NEK2_1	153	158	PF00069	0.649
MOD_NEK2_1	184	189	PF00069	0.475
MOD_NEK2_1	313	318	PF00069	0.475
MOD_NEK2_1	40	45	PF00069	0.567
MOD_NEK2_1	401	406	PF00069	0.427
MOD_NEK2_1	409	414	PF00069	0.394
MOD_NEK2_1	445	450	PF00069	0.493
MOD_NEK2_1	495	500	PF00069	0.508
MOD_NEK2_2	403	408	PF00069	0.363
MOD_NEK2_2	455	460	PF00069	0.581
MOD_PKA_1	466	472	PF00069	0.417
MOD_PKA_2	16	22	PF00069	0.754
MOD_PKA_2	220	226	PF00069	0.223
MOD_PKA_2	440	446	PF00069	0.468
MOD_Plk_1	193	199	PF00069	0.358
MOD_Plk_1	256	262	PF00069	0.475
MOD_Plk_1	349	355	PF00069	0.475
MOD_Plk_1	362	368	PF00069	0.260
MOD_Plk_1	376	382	PF00069	0.417
MOD_Plk_1	434	440	PF00069	0.399
MOD_Plk_1	455	461	PF00069	0.509
MOD_Plk_2-3	74	80	PF00069	0.500
MOD_Plk_4	376	382	PF00069	0.451
MOD_Plk_4	74	80	PF00069	0.459
MOD_ProDKin_1	107	113	PF00069	0.715
MOD_ProDKin_1	26	32	PF00069	0.647
MOD_ProDKin_1	414	420	PF00069	0.349
MOD_ProDKin_1	96	102	PF00069	0.738
MOD_SUMO_for_1	449	452	PF00179	0.523
MOD_SUMO_rev_2	226	233	PF00179	0.475
MOD_SUMO_rev_2	296	305	PF00179	0.459
TRG_DiLeu_BaEn_1	377	382	PF01217	0.449
TRG_DiLeu_BaEn_2	73	79	PF01217	0.554
TRG_DiLeu_BaEn_4	435	441	PF01217	0.537
TRG_ENDOCYTIC_2	198	201	PF00928	0.449
TRG_ENDOCYTIC_2	215	218	PF00928	0.449
TRG_ENDOCYTIC_2	308	311	PF00928	0.391
TRG_ENDOCYTIC_2	312	315	PF00928	0.303
TRG_ENDOCYTIC_2	319	322	PF00928	0.287
TRG_ENDOCYTIC_2	477	480	PF00928	0.545
TRG_ENDOCYTIC_2	492	495	PF00928	0.357
TRG_ENDOCYTIC_2	73	76	PF00928	0.431
TRG_ER_diArg_1	44	46	PF00400	0.501
TRG_ER_diArg_1	70	72	PF00400	0.541
TRG_NES_CRM1_1	240	252	PF08389	0.328
TRG_NLS_MonoCore_2	422	427	PF00514	0.680
TRG_NLS_MonoCore_2	463	468	PF00514	0.381
TRG_NLS_MonoExtN_4	420	427	PF00514	0.662

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL40	Leptomonas seymouri	55%	83%
A0A0S4JV64	Bodo saltans	34%	89%
A0A1X0P4X7	Trypanosomatidae	40%	81%
A0A3S5IQK8	Trypanosoma rangeli	38%	83%
A0A3S7XA75	Leishmania donovani	86%	85%
A4IC50	Leishmania infantum	86%	85%
C9ZYC4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	86%
E9AG05	Leishmania major	85%	100%
E9B758	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	85%
V5B8T1	Trypanosoma cruzi	36%	83%