DDE Tnp4 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNJ1_LEIBR

TriTrypDb:

LbrM.34.5240 , LBRM2903_340063200

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNJ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	112	114	PF00675	0.514
CLV_NRD_NRD_1	232	234	PF00675	0.429
CLV_NRD_NRD_1	253	255	PF00675	0.458
CLV_PCSK_FUR_1	251	255	PF00082	0.494
CLV_PCSK_KEX2_1	114	116	PF00082	0.515
CLV_PCSK_KEX2_1	251	253	PF00082	0.388
CLV_PCSK_PC1ET2_1	114	116	PF00082	0.540
CLV_PCSK_SKI1_1	2	6	PF00082	0.582
CLV_PCSK_SKI1_1	308	312	PF00082	0.500
DEG_Nend_UBRbox_1	1	4	PF02207	0.550
DOC_PP2B_LxvP_1	311	314	PF13499	0.445
DOC_PP2B_LxvP_1	55	58	PF13499	0.347
DOC_USP7_MATH_1	116	120	PF00917	0.537
DOC_USP7_MATH_1	176	180	PF00917	0.558
DOC_USP7_MATH_1	205	209	PF00917	0.534
DOC_USP7_UBL2_3	287	291	PF12436	0.408
DOC_WW_Pin1_4	245	250	PF00397	0.342
LIG_14-3-3_CanoR_1	115	125	PF00244	0.575
LIG_14-3-3_CanoR_1	148	158	PF00244	0.352
LIG_14-3-3_CanoR_1	202	212	PF00244	0.663
LIG_14-3-3_CanoR_1	251	257	PF00244	0.452
LIG_BRCT_BRCA1_1	25	29	PF00533	0.405
LIG_BRCT_BRCA1_1	33	37	PF00533	0.461
LIG_CSL_BTD_1	246	249	PF09270	0.324
LIG_deltaCOP1_diTrp_1	156	160	PF00928	0.463
LIG_eIF4E_1	220	226	PF01652	0.351
LIG_FHA_1	134	140	PF00498	0.315
LIG_FHA_1	237	243	PF00498	0.562
LIG_FHA_1	305	311	PF00498	0.671
LIG_FHA_2	225	231	PF00498	0.479
LIG_FHA_2	257	263	PF00498	0.383
LIG_FHA_2	66	72	PF00498	0.343
LIG_IRF3_LxIS_1	42	49	PF10401	0.323
LIG_LIR_Gen_1	15	24	PF02991	0.302
LIG_LIR_Gen_1	223	231	PF02991	0.482
LIG_LIR_Gen_1	26	37	PF02991	0.388
LIG_LIR_Gen_1	89	99	PF02991	0.354
LIG_LIR_Nem_3	15	19	PF02991	0.300
LIG_LIR_Nem_3	156	161	PF02991	0.363
LIG_LIR_Nem_3	223	229	PF02991	0.473
LIG_LIR_Nem_3	246	250	PF02991	0.327
LIG_LIR_Nem_3	289	293	PF02991	0.446
LIG_LIR_Nem_3	294	299	PF02991	0.447
LIG_LIR_Nem_3	41	47	PF02991	0.326
LIG_LIR_Nem_3	89	94	PF02991	0.357
LIG_NRBOX	224	230	PF00104	0.326
LIG_Pex14_2	91	95	PF04695	0.354
LIG_SH2_CRK	126	130	PF00017	0.456
LIG_SH2_GRB2like	161	164	PF00017	0.246
LIG_SH2_PTP2	128	131	PF00017	0.443
LIG_SH2_SRC	128	131	PF00017	0.297
LIG_SH2_STAP1	135	139	PF00017	0.293
LIG_SH2_STAT3	258	261	PF00017	0.531
LIG_SH2_STAT5	128	131	PF00017	0.323
LIG_SH2_STAT5	135	138	PF00017	0.294
LIG_SH2_STAT5	161	164	PF00017	0.371
LIG_SH2_STAT5	220	223	PF00017	0.360
LIG_SH2_STAT5	258	261	PF00017	0.477
LIG_SH2_STAT5	44	47	PF00017	0.308
LIG_SH2_STAT5	77	80	PF00017	0.388
LIG_SH3_2	58	63	PF14604	0.404
LIG_SH3_3	55	61	PF00018	0.342
LIG_SUMO_SIM_par_1	134	141	PF11976	0.367
LIG_TRAF2_1	259	262	PF00917	0.398
LIG_UBA3_1	105	114	PF00899	0.511
LIG_UBA3_1	225	234	PF00899	0.438
MOD_CDK_SPxK_1	245	251	PF00069	0.342
MOD_CDK_SPxxK_3	245	252	PF00069	0.330
MOD_CK1_1	138	144	PF00069	0.329
MOD_CK1_1	165	171	PF00069	0.383
MOD_CK1_1	17	23	PF00069	0.448
MOD_CK1_1	179	185	PF00069	0.365
MOD_CK1_1	200	206	PF00069	0.650
MOD_CK1_1	277	283	PF00069	0.382
MOD_CK1_1	38	44	PF00069	0.396
MOD_CK2_1	224	230	PF00069	0.473
MOD_CK2_1	256	262	PF00069	0.398
MOD_GlcNHglycan	131	134	PF01048	0.341
MOD_GlcNHglycan	178	181	PF01048	0.469
MOD_GlcNHglycan	19	22	PF01048	0.392
MOD_GlcNHglycan	202	205	PF01048	0.584
MOD_GlcNHglycan	207	210	PF01048	0.511
MOD_GlcNHglycan	48	51	PF01048	0.328
MOD_GSK3_1	129	136	PF00069	0.316
MOD_GSK3_1	165	172	PF00069	0.473
MOD_GSK3_1	200	207	PF00069	0.642
MOD_GSK3_1	220	227	PF00069	0.420
MOD_GSK3_1	252	259	PF00069	0.589
MOD_GSK3_1	31	38	PF00069	0.466
MOD_N-GLC_1	162	167	PF02516	0.264
MOD_N-GLC_2	73	75	PF02516	0.360
MOD_NEK2_1	109	114	PF00069	0.476
MOD_NEK2_1	23	28	PF00069	0.365
MOD_NEK2_1	256	261	PF00069	0.495
MOD_NEK2_1	37	42	PF00069	0.318
MOD_NEK2_1	46	51	PF00069	0.358
MOD_NEK2_2	135	140	PF00069	0.295
MOD_PIKK_1	165	171	PF00454	0.397
MOD_PIKK_1	237	243	PF00454	0.556
MOD_PKA_1	252	258	PF00069	0.564
MOD_PKA_1	286	292	PF00069	0.451
MOD_PKA_2	116	122	PF00069	0.537
MOD_PKA_2	147	153	PF00069	0.388
MOD_PKA_2	252	258	PF00069	0.388
MOD_PKA_2	65	71	PF00069	0.356
MOD_PKB_1	113	121	PF00069	0.610
MOD_Plk_1	133	139	PF00069	0.343
MOD_Plk_4	135	141	PF00069	0.318
MOD_Plk_4	220	226	PF00069	0.462
MOD_ProDKin_1	245	251	PF00069	0.346
MOD_SUMO_rev_2	172	177	PF00179	0.552
MOD_SUMO_rev_2	187	196	PF00179	0.628
TRG_ENDOCYTIC_2	126	129	PF00928	0.412
TRG_ER_diArg_1	250	253	PF00400	0.374
TRG_NLS_MonoExtC_3	112	117	PF00514	0.561
TRG_NLS_MonoExtN_4	113	118	PF00514	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5L9	Leptomonas seymouri	77%	79%
A0A0S4JQD1	Bodo saltans	42%	72%
A0A1X0P4Q6	Trypanosomatidae	56%	78%
A0A3S7XA38	Leishmania donovani	87%	100%
A0A422N5V3	Trypanosoma rangeli	52%	79%
A4IC48	Leishmania infantum	87%	100%
C9ZYC6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	78%
E9AG03	Leishmania major	88%	100%
E9B756	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BTX9	Trypanosoma cruzi	53%	71%