Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 5

Species:

Leishmania braziliensis

UniProt:

A4HNI9_LEIBR

TriTrypDb:

LbrM.34.5220 , LBRM2903_340063000

Length:

255

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNI9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNI9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	93	95	PF00675	0.629
CLV_PCSK_KEX2_1	93	95	PF00082	0.643
CLV_PCSK_SKI1_1	127	131	PF00082	0.612
CLV_PCSK_SKI1_1	204	208	PF00082	0.577
CLV_PCSK_SKI1_1	211	215	PF00082	0.542
CLV_PCSK_SKI1_1	230	234	PF00082	0.517
CLV_PCSK_SKI1_1	239	243	PF00082	0.503
DOC_CKS1_1	174	179	PF01111	0.679
DOC_CYCLIN_RxL_1	201	212	PF00134	0.666
DOC_MAPK_gen_1	202	210	PF00069	0.656
DOC_MAPK_JIP1_4	216	222	PF00069	0.436
DOC_MAPK_MEF2A_6	202	210	PF00069	0.669
DOC_MAPK_RevD_3	79	94	PF00069	0.701
DOC_PP1_RVXF_1	125	131	PF00149	0.717
DOC_PP1_RVXF_1	205	211	PF00149	0.661
DOC_PP1_RVXF_1	36	43	PF00149	0.576
DOC_USP7_MATH_1	102	106	PF00917	0.680
DOC_USP7_MATH_1	129	133	PF00917	0.684
DOC_USP7_MATH_1	163	167	PF00917	0.571
DOC_USP7_UBL2_3	127	131	PF12436	0.720
DOC_USP7_UBL2_3	145	149	PF12436	0.653
DOC_USP7_UBL2_3	207	211	PF12436	0.571
DOC_WW_Pin1_4	110	115	PF00397	0.502
DOC_WW_Pin1_4	173	178	PF00397	0.571
DOC_WW_Pin1_4	43	48	PF00397	0.570
LIG_14-3-3_CanoR_1	139	143	PF00244	0.644
LIG_14-3-3_CanoR_1	96	104	PF00244	0.558
LIG_BIR_II_1	1	5	PF00653	0.605
LIG_BRCT_BRCA1_1	38	42	PF00533	0.580
LIG_eIF4E_1	35	41	PF01652	0.583
LIG_FHA_1	139	145	PF00498	0.689
LIG_FHA_1	151	157	PF00498	0.668
LIG_FHA_1	222	228	PF00498	0.611
LIG_FHA_1	8	14	PF00498	0.591
LIG_FHA_2	196	202	PF00498	0.653
LIG_LIR_Gen_1	170	177	PF02991	0.706
LIG_LIR_Gen_1	250	255	PF02991	0.568
LIG_LIR_Gen_1	39	48	PF02991	0.558
LIG_LIR_Gen_1	73	81	PF02991	0.524
LIG_LIR_Gen_1	85	95	PF02991	0.574
LIG_LIR_Gen_1	99	107	PF02991	0.449
LIG_LIR_LC3C_4	10	13	PF02991	0.608
LIG_LIR_Nem_3	170	174	PF02991	0.718
LIG_LIR_Nem_3	250	254	PF02991	0.517
LIG_LIR_Nem_3	39	45	PF02991	0.569
LIG_LIR_Nem_3	73	78	PF02991	0.521
LIG_LIR_Nem_3	85	91	PF02991	0.575
LIG_MYND_1	61	65	PF01753	0.627
LIG_PCNA_yPIPBox_3	5	16	PF02747	0.595
LIG_Pex14_2	126	130	PF04695	0.730
LIG_Pex14_2	189	193	PF04695	0.582
LIG_PTB_Apo_2	26	33	PF02174	0.589
LIG_SH2_CRK	251	255	PF00017	0.621
LIG_SH2_CRK	88	92	PF00017	0.584
LIG_SH2_SRC	251	254	PF00017	0.631
LIG_SH3_1	59	65	PF00018	0.712
LIG_SH3_3	171	177	PF00018	0.445
LIG_SH3_3	59	65	PF00018	0.557
LIG_SUMO_SIM_par_1	68	74	PF11976	0.575
LIG_TRFH_1	88	92	PF08558	0.578
LIG_WRC_WIRS_1	168	173	PF05994	0.710
MOD_CK1_1	110	116	PF00069	0.528
MOD_CK2_1	110	116	PF00069	0.652
MOD_CK2_1	209	215	PF00069	0.641
MOD_CK2_1	71	77	PF00069	0.615
MOD_GlcNHglycan	104	107	PF01048	0.545
MOD_GlcNHglycan	109	112	PF01048	0.517
MOD_GlcNHglycan	165	168	PF01048	0.579
MOD_GlcNHglycan	17	21	PF01048	0.551
MOD_GlcNHglycan	98	101	PF01048	0.552
MOD_GSK3_1	16	23	PF00069	0.508
MOD_GSK3_1	163	170	PF00069	0.559
MOD_GSK3_1	175	182	PF00069	0.389
MOD_GSK3_1	3	10	PF00069	0.567
MOD_N-GLC_1	20	25	PF02516	0.604
MOD_N-GLC_1	4	9	PF02516	0.582
MOD_N-GLC_1	96	101	PF02516	0.468
MOD_NEK2_1	221	226	PF00069	0.554
MOD_NEK2_1	3	8	PF00069	0.582
MOD_NEK2_1	71	76	PF00069	0.615
MOD_NEK2_2	167	172	PF00069	0.573
MOD_PIKK_1	129	135	PF00454	0.731
MOD_PIKK_1	20	26	PF00454	0.604
MOD_PK_1	237	243	PF00069	0.580
MOD_PKA_2	138	144	PF00069	0.597
MOD_PKB_1	14	22	PF00069	0.596
MOD_PKB_1	94	102	PF00069	0.434
MOD_Plk_1	4	10	PF00069	0.582
MOD_Plk_1	96	102	PF00069	0.463
MOD_Plk_4	150	156	PF00069	0.594
MOD_Plk_4	209	215	PF00069	0.603
MOD_Plk_4	237	243	PF00069	0.580
MOD_Plk_4	36	42	PF00069	0.588
MOD_Plk_4	7	13	PF00069	0.568
MOD_ProDKin_1	110	116	PF00069	0.501
MOD_ProDKin_1	173	179	PF00069	0.569
MOD_ProDKin_1	43	49	PF00069	0.567
MOD_SUMO_rev_2	122	129	PF00179	0.605
MOD_SUMO_rev_2	33	40	PF00179	0.568
TRG_DiLeu_BaEn_1	36	41	PF01217	0.584
TRG_ENDOCYTIC_2	101	104	PF00928	0.517
TRG_ENDOCYTIC_2	251	254	PF00928	0.628
TRG_ENDOCYTIC_2	88	91	PF00928	0.589
TRG_ER_diArg_1	13	16	PF00400	0.604
TRG_ER_diArg_1	56	59	PF00400	0.720
TRG_ER_diArg_1	92	94	PF00400	0.630
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBX2	Leptomonas seymouri	73%	100%
A0A0S4JR49	Bodo saltans	61%	96%
A0A1X0NWC4	Trypanosomatidae	21%	93%
A0A1X0P5U7	Trypanosomatidae	66%	100%
A0A3S5IRL1	Trypanosoma rangeli	23%	92%
A0A3S7XA59	Leishmania donovani	91%	100%
A0A422N5Y6	Trypanosoma rangeli	66%	100%
A4IC46	Leishmania infantum	91%	100%
C9ZIA1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	94%
C9ZYC8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
E9AG01	Leishmania major	90%	100%
E9B754	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5BVF1	Trypanosoma cruzi	25%	93%
V5BYQ0	Trypanosoma cruzi	65%	100%