Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HNI8_LEIBR

TriTrypDb:

LbrM.34.5210 , LBRM2903_340062900

Length:

355

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	6
GO:0005840	ribosome	5	5
GO:0032991	protein-containing complex	1	5
GO:0043228	non-membrane-bounded organelle	3	5
GO:0043232	intracellular non-membrane-bounded organelle	4	5
GO:1990904	ribonucleoprotein complex	2	5

Expansion

Sequence features

A4HNI8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNI8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	257	261	PF00656	0.500
CLV_NRD_NRD_1	334	336	PF00675	0.521
CLV_PCSK_KEX2_1	137	139	PF00082	0.500
CLV_PCSK_KEX2_1	334	336	PF00082	0.521
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.507
CLV_PCSK_SKI1_1	137	141	PF00082	0.424
CLV_PCSK_SKI1_1	317	321	PF00082	0.517
CLV_PCSK_SKI1_1	79	83	PF00082	0.242
DEG_Nend_UBRbox_2	1	3	PF02207	0.646
DEG_SPOP_SBC_1	343	347	PF00917	0.473
DOC_CKS1_1	20	25	PF01111	0.536
DOC_MAPK_gen_1	48	56	PF00069	0.510
DOC_MAPK_JIP1_4	37	43	PF00069	0.526
DOC_PP1_RVXF_1	238	244	PF00149	0.325
DOC_PP1_RVXF_1	315	322	PF00149	0.506
DOC_PP1_RVXF_1	77	83	PF00149	0.354
DOC_PP4_FxxP_1	148	151	PF00568	0.428
DOC_USP7_MATH_1	151	155	PF00917	0.367
DOC_USP7_MATH_1	166	170	PF00917	0.350
DOC_USP7_MATH_1	199	203	PF00917	0.492
DOC_USP7_MATH_1	211	215	PF00917	0.391
DOC_USP7_MATH_1	42	46	PF00917	0.354
DOC_USP7_UBL2_3	133	137	PF12436	0.503
DOC_WW_Pin1_4	147	152	PF00397	0.493
DOC_WW_Pin1_4	19	24	PF00397	0.548
DOC_WW_Pin1_4	233	238	PF00397	0.393
DOC_WW_Pin1_4	255	260	PF00397	0.506
DOC_WW_Pin1_4	287	292	PF00397	0.479
LIG_14-3-3_CanoR_1	40	50	PF00244	0.377
LIG_14-3-3_CanoR_1	68	72	PF00244	0.350
LIG_BRCT_BRCA1_1	213	217	PF00533	0.531
LIG_CSL_BTD_1	288	291	PF09270	0.475
LIG_FHA_1	171	177	PF00498	0.337
LIG_FHA_1	184	190	PF00498	0.299
LIG_FHA_1	20	26	PF00498	0.387
LIG_FHA_1	251	257	PF00498	0.339
LIG_FHA_1	76	82	PF00498	0.341
LIG_FHA_2	115	121	PF00498	0.704
LIG_FHA_2	151	157	PF00498	0.393
LIG_FHA_2	173	179	PF00498	0.353
LIG_FHA_2	297	303	PF00498	0.453
LIG_FHA_2	92	98	PF00498	0.367
LIG_HCF-1_HBM_1	72	75	PF13415	0.390
LIG_IRF3_LxIS_1	38	44	PF10401	0.516
LIG_LIR_Apic_2	147	151	PF02991	0.436
LIG_LIR_Apic_2	19	23	PF02991	0.525
LIG_LIR_Gen_1	95	104	PF02991	0.339
LIG_LIR_Nem_3	214	220	PF02991	0.531
LIG_LIR_Nem_3	265	271	PF02991	0.430
LIG_LIR_Nem_3	339	344	PF02991	0.382
LIG_LIR_Nem_3	47	53	PF02991	0.464
LIG_LIR_Nem_3	95	101	PF02991	0.332
LIG_LYPXL_yS_3	268	271	PF13949	0.530
LIG_PDZ_Class_2	350	355	PF00595	0.368
LIG_Pex14_1	71	75	PF04695	0.370
LIG_Pex14_2	246	250	PF04695	0.494
LIG_REV1ctd_RIR_1	215	225	PF16727	0.577
LIG_SH2_NCK_1	196	200	PF00017	0.458
LIG_SH2_PTP2	20	23	PF00017	0.292
LIG_SH2_PTP2	53	56	PF00017	0.446
LIG_SH2_SRC	196	199	PF00017	0.458
LIG_SH2_SRC	53	56	PF00017	0.418
LIG_SH2_STAP1	196	200	PF00017	0.458
LIG_SH2_STAP1	46	50	PF00017	0.534
LIG_SH2_STAT3	230	233	PF00017	0.484
LIG_SH2_STAT5	20	23	PF00017	0.427
LIG_SH2_STAT5	249	252	PF00017	0.335
LIG_SH2_STAT5	46	49	PF00017	0.403
LIG_SH2_STAT5	53	56	PF00017	0.341
LIG_SH2_STAT5	98	101	PF00017	0.360
LIG_SH3_2	35	40	PF14604	0.547
LIG_SH3_3	266	272	PF00018	0.417
LIG_SH3_3	32	38	PF00018	0.552
LIG_SH3_3	77	83	PF00018	0.445
LIG_SUMO_SIM_par_1	171	178	PF11976	0.340
LIG_TRAF2_1	6	9	PF00917	0.728
LIG_WRC_WIRS_1	251	256	PF05994	0.340
LIG_WW_3	82	86	PF00397	0.506
MOD_CDK_SPxxK_3	233	240	PF00069	0.399
MOD_CK1_1	132	138	PF00069	0.461
MOD_CK1_1	150	156	PF00069	0.357
MOD_CK1_1	16	22	PF00069	0.423
MOD_CK1_1	169	175	PF00069	0.186
MOD_CK1_1	202	208	PF00069	0.533
MOD_CK1_1	274	280	PF00069	0.456
MOD_CK1_1	44	50	PF00069	0.462
MOD_CK2_1	296	302	PF00069	0.335
MOD_GlcNHglycan	141	144	PF01048	0.463
MOD_GlcNHglycan	201	204	PF01048	0.322
MOD_GSK3_1	12	19	PF00069	0.579
MOD_GSK3_1	147	154	PF00069	0.473
MOD_GSK3_1	166	173	PF00069	0.177
MOD_GSK3_1	229	236	PF00069	0.397
MOD_GSK3_1	267	274	PF00069	0.483
MOD_N-GLC_1	16	21	PF02516	0.546
MOD_N-GLC_1	285	290	PF02516	0.482
MOD_N-GLC_2	296	298	PF02516	0.353
MOD_NEK2_1	229	234	PF00069	0.391
MOD_NEK2_1	250	255	PF00069	0.346
MOD_NEK2_1	342	347	PF00069	0.455
MOD_NEK2_1	41	46	PF00069	0.378
MOD_NEK2_2	211	216	PF00069	0.458
MOD_OFUCOSY	149	155	PF10250	0.379
MOD_PIKK_1	229	235	PF00454	0.485
MOD_PIKK_1	271	277	PF00454	0.497
MOD_PK_1	315	321	PF00069	0.525
MOD_PKA_1	12	18	PF00069	0.647
MOD_PKA_2	67	73	PF00069	0.338
MOD_Plk_1	16	22	PF00069	0.534
MOD_Plk_1	170	176	PF00069	0.343
MOD_Plk_1	285	291	PF00069	0.500
MOD_Plk_2-3	156	162	PF00069	0.417
MOD_Plk_4	172	178	PF00069	0.372
MOD_Plk_4	224	230	PF00069	0.368
MOD_ProDKin_1	147	153	PF00069	0.486
MOD_ProDKin_1	19	25	PF00069	0.548
MOD_ProDKin_1	233	239	PF00069	0.390
MOD_ProDKin_1	255	261	PF00069	0.501
MOD_ProDKin_1	287	293	PF00069	0.485
MOD_SUMO_for_1	109	112	PF00179	0.696
MOD_SUMO_rev_2	8	15	PF00179	0.691
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.358
TRG_ENDOCYTIC_2	268	271	PF00928	0.530
TRG_ENDOCYTIC_2	53	56	PF00928	0.446
TRG_ENDOCYTIC_2	98	101	PF00928	0.335
TRG_ER_diArg_1	333	335	PF00400	0.498
TRG_Pf-PMV_PEXEL_1	85	90	PF00026	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4A4	Leptomonas seymouri	82%	100%
A0A0S4JQ50	Bodo saltans	50%	100%
A0A1X0P672	Trypanosomatidae	53%	96%
A0A3R7LPD7	Trypanosoma rangeli	55%	99%
A0A3S7XA48	Leishmania donovani	94%	100%
A4IC45	Leishmania infantum	94%	100%
C9ZYC9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	98%
E9AG00	Leishmania major	94%	100%
E9B753	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
O74763	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	82%
P61962	Homo sapiens	36%	100%
P61963	Mus musculus	36%	100%
Q12523	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	68%
Q38960	Arabidopsis thaliana	37%	100%
Q552R1	Dictyostelium discoideum	40%	100%
Q9LPV9	Arabidopsis thaliana	38%	100%
Q9XGN1	Arabidopsis thaliana	37%	100%
V5BPC8	Trypanosoma cruzi	54%	99%