GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

alpha-1,2-mannosyltransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HNI6_LEIBR

TriTrypDb:

LbrM.34.5190 , LBRM2903_340062700

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	5
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	5
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

A4HNI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNI6

Function

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Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	5
GO:0006487	protein N-linked glycosylation	5	1
GO:0006490	oligosaccharide-lipid intermediate biosynthetic process	4	1
GO:0006629	lipid metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0019538	protein metabolic process	3	5
GO:0036211	protein modification process	4	5

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Molecular functions
Term	Name	Level	Count
GO:0000026	alpha-1,2-mannosyltransferase activity	6	12
GO:0000030	mannosyltransferase activity	5	12
GO:0003824	catalytic activity	1	12
GO:0004376	glycolipid mannosyltransferase activity	6	12
GO:0004377	GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity	7	12
GO:0016740	transferase activity	2	12
GO:0016757	glycosyltransferase activity	3	12
GO:0016758	hexosyltransferase activity	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	18	20	PF00675	0.334
CLV_NRD_NRD_1	322	324	PF00675	0.337
CLV_NRD_NRD_1	437	439	PF00675	0.228
CLV_PCSK_KEX2_1	20	22	PF00082	0.352
CLV_PCSK_KEX2_1	324	326	PF00082	0.277
CLV_PCSK_KEX2_1	437	439	PF00082	0.297
CLV_PCSK_PC1ET2_1	20	22	PF00082	0.469
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.277
CLV_PCSK_SKI1_1	109	113	PF00082	0.338
CLV_PCSK_SKI1_1	209	213	PF00082	0.308

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6F7	Leptomonas seymouri	66%	100%
A0A0S4INF7	Bodo saltans	23%	92%
A0A0S4JLQ0	Bodo saltans	42%	99%
A0A1X0P5V7	Trypanosomatidae	50%	98%
A0A3R7K7Z3	Trypanosoma rangeli	49%	98%
A0A3S7XA76	Leishmania donovani	87%	100%
A4IC43	Leishmania infantum	87%	100%
C9ZYD9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	99%
E9AFZ8	Leishmania major	87%	100%
E9B751	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%

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