Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNI4_LEIBR

TriTrypDb:

LbrM.34.5170 , LBRM2903_340062400

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNI4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	220	222	PF00675	0.450
CLV_PCSK_KEX2_1	213	215	PF00082	0.412
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.412
CLV_PCSK_SKI1_1	214	218	PF00082	0.355
CLV_PCSK_SKI1_1	76	80	PF00082	0.473
DEG_APCC_DBOX_1	251	259	PF00400	0.347
DOC_MAPK_DCC_7	65	74	PF00069	0.474
DOC_MAPK_MEF2A_6	65	74	PF00069	0.489
DOC_USP7_MATH_1	146	150	PF00917	0.618
DOC_USP7_MATH_1	18	22	PF00917	0.416
DOC_USP7_MATH_1	70	74	PF00917	0.637
DOC_WW_Pin1_4	163	168	PF00397	0.511
LIG_14-3-3_CanoR_1	236	240	PF00244	0.396
LIG_Actin_WH2_2	127	145	PF00022	0.471
LIG_BIR_II_1	1	5	PF00653	0.450
LIG_FHA_1	101	107	PF00498	0.523
LIG_FHA_2	1	7	PF00498	0.586
LIG_FHA_2	111	117	PF00498	0.395
LIG_FHA_2	17	23	PF00498	0.412
LIG_FHA_2	226	232	PF00498	0.334
LIG_HP1_1	70	74	PF01393	0.466
LIG_LIR_Gen_1	196	206	PF02991	0.381
LIG_LIR_Nem_3	196	201	PF02991	0.378
LIG_PTAP_UEV_1	147	152	PF05743	0.474
LIG_SH2_CRK	198	202	PF00017	0.374
LIG_SH2_STAP1	180	184	PF00017	0.468
LIG_SH3_3	145	151	PF00018	0.476
LIG_SUMO_SIM_anti_2	190	196	PF11976	0.410
LIG_SUMO_SIM_par_1	70	75	PF11976	0.462
LIG_SxIP_EBH_1	9	20	PF03271	0.409
LIG_TRAF2_1	160	163	PF00917	0.482
MOD_CK1_1	118	124	PF00069	0.382
MOD_CK1_1	61	67	PF00069	0.640
MOD_CK2_1	110	116	PF00069	0.398
MOD_CK2_1	16	22	PF00069	0.435
MOD_GlcNHglycan	135	138	PF01048	0.503
MOD_GlcNHglycan	148	151	PF01048	0.517
MOD_GlcNHglycan	30	33	PF01048	0.422
MOD_GlcNHglycan	61	64	PF01048	0.636
MOD_GSK3_1	106	113	PF00069	0.401
MOD_GSK3_1	163	170	PF00069	0.459
MOD_GSK3_1	8	15	PF00069	0.482
MOD_NEK2_1	12	17	PF00069	0.551
MOD_NEK2_1	133	138	PF00069	0.530
MOD_NEK2_1	141	146	PF00069	0.584
MOD_PKA_2	100	106	PF00069	0.508
MOD_PKA_2	235	241	PF00069	0.398
MOD_PKA_2	33	39	PF00069	0.406
MOD_Plk_1	118	124	PF00069	0.479
MOD_Plk_1	128	134	PF00069	0.432
MOD_Plk_1	180	186	PF00069	0.443
MOD_Plk_2-3	225	231	PF00069	0.338
MOD_Plk_4	33	39	PF00069	0.418
MOD_Plk_4	8	14	PF00069	0.502
MOD_ProDKin_1	163	169	PF00069	0.502
TRG_DiLeu_BaEn_1	129	134	PF01217	0.354
TRG_DiLeu_BaEn_1	22	27	PF01217	0.392
TRG_DiLeu_BaEn_1	240	245	PF01217	0.391
TRG_DiLeu_BaEn_1	49	54	PF01217	0.557
TRG_ENDOCYTIC_2	198	201	PF00928	0.374
TRG_ER_diArg_1	123	126	PF00400	0.445
TRG_ER_diArg_1	38	41	PF00400	0.562
TRG_Pf-PMV_PEXEL_1	24	28	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXE8	Leptomonas seymouri	45%	79%
A0A3S7XA65	Leishmania donovani	62%	82%
A4IC40	Leishmania infantum	62%	82%
E9AFZ5	Leishmania major	60%	100%
E9B748	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	82%