C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNI2_LEIBR

TriTrypDb:

LbrM.34.5150 , LBRM2903_340062200

Length:

257

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNI2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	11	13	PF00675	0.519
CLV_PCSK_KEX2_1	11	13	PF00082	0.519
CLV_PCSK_SKI1_1	27	31	PF00082	0.427
DEG_SCF_FBW7_1	169	175	PF00400	0.479
DOC_CKS1_1	169	174	PF01111	0.498
DOC_CKS1_1	216	221	PF01111	0.468
DOC_CKS1_1	5	10	PF01111	0.469
DOC_MAPK_MEF2A_6	94	103	PF00069	0.450
DOC_USP7_MATH_1	111	115	PF00917	0.479
DOC_USP7_MATH_1	122	126	PF00917	0.523
DOC_USP7_MATH_1	136	140	PF00917	0.631
DOC_USP7_MATH_1	186	190	PF00917	0.573
DOC_USP7_MATH_1	192	196	PF00917	0.523
DOC_USP7_MATH_1	245	249	PF00917	0.626
DOC_WW_Pin1_4	124	129	PF00397	0.590
DOC_WW_Pin1_4	168	173	PF00397	0.733
DOC_WW_Pin1_4	182	187	PF00397	0.606
DOC_WW_Pin1_4	215	220	PF00397	0.673
DOC_WW_Pin1_4	35	40	PF00397	0.500
DOC_WW_Pin1_4	4	9	PF00397	0.527
LIG_14-3-3_CanoR_1	170	176	PF00244	0.527
LIG_BIR_II_1	1	5	PF00653	0.703
LIG_EH_1	144	148	PF12763	0.461
LIG_FHA_1	125	131	PF00498	0.596
LIG_FHA_1	194	200	PF00498	0.594
LIG_FHA_1	49	55	PF00498	0.423
LIG_LIR_Apic_2	107	111	PF02991	0.499
LIG_LIR_Gen_1	210	220	PF02991	0.463
LIG_LIR_Gen_1	97	106	PF02991	0.418
LIG_LIR_Nem_3	210	216	PF02991	0.463
LIG_LIR_Nem_3	248	254	PF02991	0.613
LIG_LIR_Nem_3	97	101	PF02991	0.398
LIG_SH2_CRK	213	217	PF00017	0.469
LIG_SH2_CRK	98	102	PF00017	0.389
LIG_SH2_GRB2like	108	111	PF00017	0.573
LIG_SH2_GRB2like	182	185	PF00017	0.625
LIG_SH2_SRC	108	111	PF00017	0.514
LIG_SH2_SRC	227	230	PF00017	0.497
LIG_SH2_STAT3	93	96	PF00017	0.357
LIG_SH2_STAT5	108	111	PF00017	0.469
LIG_SH2_STAT5	182	185	PF00017	0.619
LIG_SH2_STAT5	251	254	PF00017	0.644
LIG_SH3_3	130	136	PF00018	0.639
LIG_SH3_3	140	146	PF00018	0.580
LIG_SH3_3	196	202	PF00018	0.776
LIG_SH3_3	203	209	PF00018	0.590
LIG_SH3_3	36	42	PF00018	0.475
LIG_SH3_3	89	95	PF00018	0.445
LIG_SH3_3	98	104	PF00018	0.464
LIG_WRC_WIRS_1	58	63	PF05994	0.419
LIG_WW_1	105	108	PF00397	0.385
MOD_CDK_SPxxK_3	4	11	PF00069	0.535
MOD_CK1_1	114	120	PF00069	0.552
MOD_CK1_1	190	196	PF00069	0.718
MOD_CK1_1	57	63	PF00069	0.412
MOD_CK2_1	117	123	PF00069	0.445
MOD_GlcNHglycan	87	90	PF01048	0.475
MOD_GSK3_1	160	167	PF00069	0.598
MOD_GSK3_1	168	175	PF00069	0.565
MOD_GSK3_1	182	189	PF00069	0.664
MOD_GSK3_1	214	221	PF00069	0.493
MOD_GSK3_1	29	36	PF00069	0.479
MOD_N-GLC_1	172	177	PF02516	0.539
MOD_N-GLC_1	193	198	PF02516	0.739
MOD_N-GLC_1	233	238	PF02516	0.515
MOD_NEK2_1	152	157	PF00069	0.583
MOD_NEK2_1	220	225	PF00069	0.603
MOD_NEK2_1	233	238	PF00069	0.507
MOD_NEK2_1	29	34	PF00069	0.411
MOD_NEK2_1	85	90	PF00069	0.418
MOD_PIKK_1	136	142	PF00454	0.486
MOD_PIKK_1	154	160	PF00454	0.552
MOD_PIKK_1	164	170	PF00454	0.543
MOD_PIKK_1	218	224	PF00454	0.592
MOD_PIKK_1	233	239	PF00454	0.497
MOD_PIKK_1	60	66	PF00454	0.377
MOD_PIKK_1	77	83	PF00454	0.371
MOD_PKA_2	33	39	PF00069	0.485
MOD_Plk_1	122	128	PF00069	0.448
MOD_Plk_4	160	166	PF00069	0.612
MOD_Plk_4	195	201	PF00069	0.615
MOD_Plk_4	57	63	PF00069	0.412
MOD_Plk_4	70	76	PF00069	0.315
MOD_ProDKin_1	124	130	PF00069	0.593
MOD_ProDKin_1	168	174	PF00069	0.732
MOD_ProDKin_1	182	188	PF00069	0.605
MOD_ProDKin_1	215	221	PF00069	0.674
MOD_ProDKin_1	35	41	PF00069	0.494
MOD_ProDKin_1	4	10	PF00069	0.523
TRG_ENDOCYTIC_2	213	216	PF00928	0.564
TRG_ENDOCYTIC_2	251	254	PF00928	0.644
TRG_ENDOCYTIC_2	43	46	PF00928	0.367
TRG_ENDOCYTIC_2	98	101	PF00928	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL43	Leptomonas seymouri	56%	90%
A0A1X0P4Q8	Trypanosomatidae	46%	100%
A0A3S7XA28	Leishmania donovani	81%	100%
A4IC38	Leishmania infantum	81%	100%
E9AFZ3	Leishmania major	80%	100%
E9B746	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%