LeishMANIAdb
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Putative folate/biopterin transporter

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative folate/biopterin transporter
Gene product:
NIMA-related kinase, putative
Species:
Leishmania braziliensis
UniProt:
A4HNI1_LEIBR
TriTrypDb:
LbrM.34.5140 , LBRM2903_340062100
Length:
478

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 6
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 45
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 15
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 74
NetGPI no yes: 0, no: 74
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A4HNI1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNI1

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 75
GO:0006793 phosphorus metabolic process 3 75
GO:0006796 phosphate-containing compound metabolic process 4 75
GO:0006807 nitrogen compound metabolic process 2 75
GO:0008152 metabolic process 1 75
GO:0009987 cellular process 1 75
GO:0016310 phosphorylation 5 75
GO:0019538 protein metabolic process 3 75
GO:0036211 protein modification process 4 75
GO:0043170 macromolecule metabolic process 3 75
GO:0043412 macromolecule modification 4 75
GO:0044237 cellular metabolic process 2 75
GO:0044238 primary metabolic process 2 75
GO:0071704 organic substance metabolic process 2 75
GO:1901564 organonitrogen compound metabolic process 3 75
GO:0007165 signal transduction 2 1
GO:0035556 intracellular signal transduction 3 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
GO:0000281 mitotic cytokinesis 4 1
GO:0000910 cytokinesis 3 1
GO:0018105 peptidyl-serine phosphorylation 6 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018209 peptidyl-serine modification 6 1
GO:0022402 cell cycle process 2 1
GO:0061640 cytoskeleton-dependent cytokinesis 4 1
GO:1903047 mitotic cell cycle process 3 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 75
GO:0003824 catalytic activity 1 75
GO:0004672 protein kinase activity 3 75
GO:0005488 binding 1 75
GO:0005524 ATP binding 5 75
GO:0016301 kinase activity 4 75
GO:0016740 transferase activity 2 75
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 75
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 75
GO:0017076 purine nucleotide binding 4 75
GO:0030554 adenyl nucleotide binding 5 75
GO:0032553 ribonucleotide binding 3 75
GO:0032555 purine ribonucleotide binding 4 75
GO:0032559 adenyl ribonucleotide binding 5 75
GO:0035639 purine ribonucleoside triphosphate binding 4 75
GO:0036094 small molecule binding 2 75
GO:0043167 ion binding 2 75
GO:0043168 anion binding 3 75
GO:0097159 organic cyclic compound binding 2 75
GO:0097367 carbohydrate derivative binding 2 75
GO:0140096 catalytic activity, acting on a protein 2 75
GO:1901265 nucleoside phosphate binding 3 75
GO:1901363 heterocyclic compound binding 2 75
GO:0004674 protein serine/threonine kinase activity 4 55

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 426 430 PF00656 0.160
CLV_NRD_NRD_1 244 246 PF00675 0.264
CLV_PCSK_KEX2_1 246 248 PF00082 0.256
CLV_PCSK_KEX2_1 394 396 PF00082 0.292
CLV_PCSK_PC1ET2_1 246 248 PF00082 0.281
CLV_PCSK_PC1ET2_1 394 396 PF00082 0.311
CLV_PCSK_SKI1_1 139 143 PF00082 0.334
CLV_PCSK_SKI1_1 154 158 PF00082 0.292
CLV_PCSK_SKI1_1 193 197 PF00082 0.303
CLV_PCSK_SKI1_1 269 273 PF00082 0.327
CLV_PCSK_SKI1_1 277 281 PF00082 0.324
CLV_PCSK_SKI1_1 300 304 PF00082 0.285
DEG_APCC_DBOX_1 112 120 PF00400 0.428
DEG_APCC_DBOX_1 276 284 PF00400 0.214
DEG_COP1_1 425 436 PF00400 0.342
DEG_SPOP_SBC_1 294 298 PF00917 0.165
DOC_CYCLIN_RxL_1 297 304 PF00134 0.399
DOC_MAPK_gen_1 157 166 PF00069 0.346
DOC_MAPK_gen_1 193 202 PF00069 0.307
DOC_MAPK_MEF2A_6 135 144 PF00069 0.307
DOC_MAPK_MEF2A_6 21 28 PF00069 0.572
DOC_MAPK_MEF2A_6 440 449 PF00069 0.393
DOC_PP4_FxxP_1 201 204 PF00568 0.305
DOC_PP4_FxxP_1 271 274 PF00568 0.279
DOC_PP4_FxxP_1 291 294 PF00568 0.131
DOC_PP4_FxxP_1 431 434 PF00568 0.264
DOC_USP7_MATH_1 294 298 PF00917 0.459
DOC_USP7_MATH_1 363 367 PF00917 0.613
DOC_USP7_UBL2_3 135 139 PF12436 0.283
DOC_USP7_UBL2_3 157 161 PF12436 0.310
DOC_USP7_UBL2_3 246 250 PF12436 0.206
DOC_USP7_UBL2_3 32 36 PF12436 0.622
DOC_USP7_UBL2_3 95 99 PF12436 0.382
DOC_WW_Pin1_4 231 236 PF00397 0.305
DOC_WW_Pin1_4 341 346 PF00397 0.555
DOC_WW_Pin1_4 361 366 PF00397 0.638
LIG_14-3-3_CanoR_1 314 321 PF00244 0.270
LIG_14-3-3_CanoR_1 338 345 PF00244 0.410
LIG_14-3-3_CanoR_1 405 409 PF00244 0.273
LIG_14-3-3_CanoR_1 77 85 PF00244 0.465
LIG_14-3-3_CanoR_1 88 92 PF00244 0.475
LIG_AP2alpha_2 289 291 PF02296 0.273
LIG_APCC_ABBAyCdc20_2 188 194 PF00400 0.292
LIG_BIR_III_2 429 433 PF00653 0.169
LIG_BRCT_BRCA1_1 427 431 PF00533 0.399
LIG_Clathr_ClatBox_1 141 145 PF01394 0.275
LIG_deltaCOP1_diTrp_1 389 397 PF00928 0.281
LIG_deltaCOP1_diTrp_1 466 472 PF00928 0.366
LIG_eIF4E_1 169 175 PF01652 0.329
LIG_eIF4E_1 22 28 PF01652 0.456
LIG_eIF4E_1 69 75 PF01652 0.413
LIG_FHA_1 203 209 PF00498 0.289
LIG_FHA_1 315 321 PF00498 0.324
LIG_FHA_1 347 353 PF00498 0.499
LIG_FHA_1 372 378 PF00498 0.573
LIG_FHA_1 70 76 PF00498 0.470
LIG_FHA_2 424 430 PF00498 0.318
LIG_FHA_2 458 464 PF00498 0.294
LIG_HCF-1_HBM_1 66 69 PF13415 0.554
LIG_LIR_Apic_2 234 240 PF02991 0.304
LIG_LIR_Apic_2 289 294 PF02991 0.276
LIG_LIR_Apic_2 428 434 PF02991 0.288
LIG_LIR_Gen_1 367 377 PF02991 0.377
LIG_LIR_Nem_3 123 128 PF02991 0.269
LIG_LIR_Nem_3 323 328 PF02991 0.404
LIG_LIR_Nem_3 367 373 PF02991 0.524
LIG_NRBOX 260 266 PF00104 0.255
LIG_Pex14_1 392 396 PF04695 0.265
LIG_Pex14_1 468 472 PF04695 0.340
LIG_SH2_CRK 176 180 PF00017 0.343
LIG_SH2_CRK 370 374 PF00017 0.518
LIG_SH2_SRC 176 179 PF00017 0.303
LIG_SH2_STAP1 19 23 PF00017 0.427
LIG_SH2_STAP1 219 223 PF00017 0.281
LIG_SH2_STAP1 248 252 PF00017 0.321
LIG_SH2_STAP1 386 390 PF00017 0.256
LIG_SH2_STAT5 22 25 PF00017 0.454
LIG_SH2_STAT5 237 240 PF00017 0.310
LIG_SH2_STAT5 328 331 PF00017 0.368
LIG_SH2_STAT5 37 40 PF00017 0.477
LIG_SH2_STAT5 382 385 PF00017 0.332
LIG_SH2_STAT5 396 399 PF00017 0.285
LIG_SH2_STAT5 69 72 PF00017 0.398
LIG_SH3_3 47 53 PF00018 0.619
LIG_SUMO_SIM_anti_2 136 145 PF11976 0.307
LIG_SUMO_SIM_par_1 136 145 PF11976 0.354
LIG_SUMO_SIM_par_1 178 184 PF11976 0.250
LIG_TRAF2_1 165 168 PF00917 0.393
LIG_TRFH_1 236 240 PF08558 0.273
LIG_TYR_ITIM 174 179 PF00017 0.310
LIG_TYR_ITIM 260 265 PF00017 0.338
LIG_TYR_ITIM 368 373 PF00017 0.535
LIG_UBA3_1 264 272 PF00899 0.302
LIG_UBA3_1 302 309 PF00899 0.298
MOD_CDK_SPxxK_3 341 348 PF00069 0.299
MOD_CK1_1 364 370 PF00069 0.561
MOD_CK1_1 375 381 PF00069 0.363
MOD_CK1_1 58 64 PF00069 0.655
MOD_CK2_1 272 278 PF00069 0.366
MOD_CK2_1 404 410 PF00069 0.283
MOD_CK2_1 457 463 PF00069 0.240
MOD_DYRK1A_RPxSP_1 361 365 PF00069 0.414
MOD_GlcNHglycan 147 150 PF01048 0.259
MOD_GlcNHglycan 196 199 PF01048 0.322
MOD_GlcNHglycan 357 360 PF01048 0.688
MOD_GlcNHglycan 9 12 PF01048 0.629
MOD_GSK3_1 213 220 PF00069 0.230
MOD_GSK3_1 227 234 PF00069 0.306
MOD_GSK3_1 337 344 PF00069 0.471
MOD_GSK3_1 371 378 PF00069 0.561
MOD_N-GLC_2 47 49 PF02516 0.399
MOD_NEK2_1 213 218 PF00069 0.296
MOD_NEK2_1 27 32 PF00069 0.316
MOD_NEK2_1 404 409 PF00069 0.245
MOD_NEK2_1 84 89 PF00069 0.459
MOD_PIKK_1 272 278 PF00454 0.339
MOD_PIKK_1 314 320 PF00454 0.233
MOD_PIKK_1 435 441 PF00454 0.393
MOD_PKA_1 246 252 PF00069 0.315
MOD_PKA_2 246 252 PF00069 0.308
MOD_PKA_2 313 319 PF00069 0.302
MOD_PKA_2 337 343 PF00069 0.413
MOD_PKA_2 404 410 PF00069 0.324
MOD_PKA_2 87 93 PF00069 0.448
MOD_Plk_1 55 61 PF00069 0.568
MOD_Plk_2-3 133 139 PF00069 0.307
MOD_Plk_2-3 221 227 PF00069 0.305
MOD_Plk_4 70 76 PF00069 0.449
MOD_ProDKin_1 231 237 PF00069 0.305
MOD_ProDKin_1 341 347 PF00069 0.554
MOD_ProDKin_1 361 367 PF00069 0.620
MOD_SUMO_rev_2 132 141 PF00179 0.390
TRG_DiLeu_BaLyEn_6 302 307 PF01217 0.399
TRG_ENDOCYTIC_2 176 179 PF00928 0.313
TRG_ENDOCYTIC_2 262 265 PF00928 0.310
TRG_ENDOCYTIC_2 288 291 PF00928 0.289
TRG_ENDOCYTIC_2 370 373 PF00928 0.547
TRG_ENDOCYTIC_2 396 399 PF00928 0.274
TRG_ER_diArg_1 245 248 PF00400 0.286
TRG_NLS_MonoExtN_4 391 397 PF00514 0.307
TRG_Pf-PMV_PEXEL_1 277 281 PF00026 0.289

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3N5 Leptomonas seymouri 38% 100%
A0A0N0P953 Leptomonas seymouri 86% 100%
A0A0N1I5W3 Leptomonas seymouri 32% 67%
A0A0N1I9A0 Leptomonas seymouri 28% 74%
A0A0N1PD05 Leptomonas seymouri 35% 100%
A0A0S4IMB7 Bodo saltans 38% 100%
A0A0S4IQ75 Bodo saltans 30% 95%
A0A0S4IRZ7 Bodo saltans 34% 97%
A0A0S4IVW1 Bodo saltans 28% 76%
A0A0S4IX86 Bodo saltans 38% 100%
A0A0S4J804 Bodo saltans 62% 91%
A0A0S4JIJ6 Bodo saltans 30% 85%
A0A0S4JN19 Bodo saltans 30% 77%
A0A0S4JPZ1 Bodo saltans 32% 100%
A0A0S4JU73 Bodo saltans 27% 100%
A0A1X0NIA0 Trypanosomatidae 37% 100%
A0A1X0NIX2 Trypanosomatidae 33% 100%
A0A1X0NUB2 Trypanosomatidae 32% 82%
A0A1X0P527 Trypanosomatidae 36% 100%
A0A1X0P549 Trypanosomatidae 73% 100%
A0A1X0P863 Trypanosomatidae 36% 96%
A0A1X0P994 Trypanosomatidae 35% 96%
A0A3Q8IAQ1 Leishmania donovani 36% 100%
A0A3Q8IC87 Leishmania donovani 32% 100%
A0A3Q8IFK8 Leishmania donovani 33% 100%
A0A3Q8IFW0 Leishmania donovani 36% 100%
A0A3Q8IJM9 Leishmania donovani 90% 100%
A0A3Q8INQ4 Leishmania donovani 32% 100%
A0A3R7K109 Trypanosoma rangeli 29% 100%
A0A3R7KCZ4 Trypanosoma rangeli 39% 100%
A0A3R7MKG5 Trypanosoma rangeli 35% 100%
A0A3S5H5U5 Leishmania donovani 26% 100%
A0A3S7X5M4 Leishmania donovani 29% 73%
A0A3S7X6T8 Leishmania donovani 35% 100%
A0A3S7X7Y2 Leishmania donovani 28% 100%
A0A3S7XAL3 Leishmania donovani 36% 96%
A0A3S7XAT9 Leishmania donovani 35% 95%
A0A422NCP0 Trypanosoma rangeli 36% 96%
A0A422NH41 Trypanosoma rangeli 32% 83%
A4H4S9 Leishmania braziliensis 26% 100%
A4HAS1 Leishmania braziliensis 26% 100%
A4HCE6 Leishmania braziliensis 39% 100%
A4HFA1 Leishmania braziliensis 27% 100%
A4HH03 Leishmania braziliensis 28% 100%
A4HJT5 Leishmania braziliensis 34% 100%
A4HJW2 Leishmania braziliensis 36% 100%
A4HKG9 Leishmania braziliensis 29% 100%
A4HLR0 Leishmania braziliensis 35% 100%
A4HP12 Leishmania braziliensis 34% 94%
A4HP13 Leishmania braziliensis 35% 95%
A4HZV1 Leishmania infantum 32% 100%
A4HZW8 Leishmania infantum 36% 100%
A4I1T4 Leishmania infantum 32% 100%
A4I7A1 Leishmania infantum 33% 100%
A4I7C4 Leishmania infantum 36% 100%
A4I7Z6 Leishmania infantum 29% 73%
A4I960 Leishmania infantum 35% 100%
A4I9Y5 Leishmania infantum 28% 100%
A4IC37 Leishmania infantum 90% 100%
A4IDC1 Leishmania infantum 34% 94%
A4IDC2 Leishmania infantum 35% 95%
C9ZMH9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
C9ZWI1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 100%
C9ZWK2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 36% 100%
D0A2Z1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 98%
D0A2Z6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 97%
D0AA64 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 83%
E9AEB9 Leishmania major 34% 95%
E9AFZ2 Leishmania major 90% 100%
E9AG71 Leishmania infantum 26% 100%
E9AKZ7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9ASS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 94%
E9ASS3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 95%
E9AVR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9AVS7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 38% 100%
E9AXW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 32% 100%
E9B296 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9B2B7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9B2V8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 73%
E9B436 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9B4G9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B4Z4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B745 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
O61267 Drosophila melanogaster 30% 100%
O95747 Homo sapiens 28% 91%
P22209 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 28% 100%
P51956 Homo sapiens 30% 94%
Q03428 Trypanosoma brucei brucei 37% 100%
Q08942 Trypanosoma brucei brucei 38% 100%
Q4Q1S3 Leishmania major 36% 100%
Q4Q1S4 Leishmania major 35% 100%
Q4Q2Z2 Leishmania major 27% 100%
Q4Q3Y9 Leishmania major 35% 100%
Q4Q598 Leishmania major 29% 100%
Q4Q5T9 Leishmania major 36% 100%
Q4Q5W2 Leishmania major 33% 100%
Q4Q9K2 Leishmania major 32% 100%
Q4QBQ2 Leishmania major 36% 100%
Q4QBR6 Leishmania major 32% 100%
Q4QCK0 Leishmania major 25% 100%
Q5R495 Pongo abelii 28% 91%
Q6P9R2 Mus musculus 28% 91%
Q863I2 Sus scrofa 28% 90%
Q91YA2 Mus musculus 28% 100%
V5BHW8 Trypanosoma cruzi 31% 75%
V5BPJ0 Trypanosoma cruzi 35% 97%
V5D579 Trypanosoma cruzi 37% 100%
V5DFW9 Trypanosoma cruzi 31% 82%
V5DKY9 Trypanosoma cruzi 29% 77%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS