G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNH9_LEIBR

TriTrypDb:

LbrM.34.5120 , LBRM2903_340061700

Length:

370

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNH9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNH9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0005488	binding	1	2
GO:0005525	GTP binding	5	2
GO:0017076	purine nucleotide binding	4	2
GO:0019001	guanyl nucleotide binding	5	2
GO:0032553	ribonucleotide binding	3	2
GO:0032555	purine ribonucleotide binding	4	2
GO:0032561	guanyl ribonucleotide binding	5	2
GO:0035639	purine ribonucleoside triphosphate binding	4	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	167	171	PF00656	0.533
CLV_C14_Caspase3-7	350	354	PF00656	0.443
CLV_PCSK_KEX2_1	326	328	PF00082	0.491
CLV_PCSK_PC1ET2_1	326	328	PF00082	0.282
CLV_PCSK_SKI1_1	111	115	PF00082	0.442
CLV_PCSK_SKI1_1	251	255	PF00082	0.270
CLV_PCSK_SKI1_1	26	30	PF00082	0.689
CLV_PCSK_SKI1_1	310	314	PF00082	0.552
CLV_PCSK_SKI1_1	34	38	PF00082	0.634
DEG_SPOP_SBC_1	38	42	PF00917	0.463
DOC_CKS1_1	159	164	PF01111	0.330
DOC_CKS1_1	70	75	PF01111	0.639
DOC_CYCLIN_RxL_1	108	117	PF00134	0.469
DOC_MAPK_gen_1	186	195	PF00069	0.470
DOC_MAPK_gen_1	323	332	PF00069	0.361
DOC_MAPK_gen_1	94	101	PF00069	0.373
DOC_MAPK_MEF2A_6	331	340	PF00069	0.402
DOC_MAPK_MEF2A_6	94	103	PF00069	0.497
DOC_PP1_RVXF_1	298	304	PF00149	0.306
DOC_PP2B_LxvP_1	104	107	PF13499	0.478
DOC_PP4_FxxP_1	7	10	PF00568	0.532
DOC_USP7_MATH_1	10	14	PF00917	0.741
DOC_USP7_MATH_1	361	365	PF00917	0.693
DOC_USP7_MATH_1	78	82	PF00917	0.459
DOC_USP7_MATH_1	87	91	PF00917	0.420
DOC_WW_Pin1_4	158	163	PF00397	0.362
DOC_WW_Pin1_4	262	267	PF00397	0.370
DOC_WW_Pin1_4	39	44	PF00397	0.676
DOC_WW_Pin1_4	69	74	PF00397	0.708
LIG_14-3-3_CanoR_1	236	244	PF00244	0.274
LIG_14-3-3_CanoR_1	26	33	PF00244	0.657
LIG_14-3-3_CanoR_1	53	62	PF00244	0.727
LIG_14-3-3_CanoR_1	82	87	PF00244	0.571
LIG_APCC_ABBA_1	330	335	PF00400	0.352
LIG_BIR_III_2	263	267	PF00653	0.384
LIG_BRCT_BRCA1_1	264	268	PF00533	0.225
LIG_deltaCOP1_diTrp_1	223	233	PF00928	0.372
LIG_FHA_1	139	145	PF00498	0.402
LIG_FHA_1	217	223	PF00498	0.349
LIG_FHA_1	252	258	PF00498	0.503
LIG_FHA_1	302	308	PF00498	0.451
LIG_FHA_1	316	322	PF00498	0.526
LIG_FHA_1	355	361	PF00498	0.432
LIG_FHA_1	44	50	PF00498	0.620
LIG_FHA_1	96	102	PF00498	0.406
LIG_FHA_2	140	146	PF00498	0.374
LIG_FHA_2	165	171	PF00498	0.441
LIG_FHA_2	269	275	PF00498	0.375
LIG_LIR_Apic_2	4	10	PF02991	0.618
LIG_LIR_Gen_1	153	162	PF02991	0.367
LIG_LIR_Nem_3	153	159	PF02991	0.379
LIG_LIR_Nem_3	265	270	PF02991	0.307
LIG_MLH1_MIPbox_1	264	268	PF16413	0.225
LIG_Pex14_1	233	237	PF04695	0.447
LIG_SH2_STAP1	88	92	PF00017	0.432
LIG_SH2_STAT3	88	91	PF00017	0.438
LIG_SH2_STAT5	166	169	PF00017	0.531
LIG_SH2_STAT5	249	252	PF00017	0.408
LIG_SH2_STAT5	302	305	PF00017	0.318
LIG_SH3_3	126	132	PF00018	0.448
LIG_SH3_3	145	151	PF00018	0.394
LIG_SH3_3	199	205	PF00018	0.390
LIG_SUMO_SIM_par_1	287	293	PF11976	0.239
LIG_SUMO_SIM_par_1	315	322	PF11976	0.511
LIG_TRAF2_1	56	59	PF00917	0.621
MOD_CDK_SPK_2	69	74	PF00069	0.641
MOD_CK1_1	13	19	PF00069	0.580
MOD_CK1_1	164	170	PF00069	0.520
MOD_CK1_1	252	258	PF00069	0.406
MOD_CK1_1	290	296	PF00069	0.295
MOD_CK1_1	364	370	PF00069	0.462
MOD_CK1_1	42	48	PF00069	0.656
MOD_CK1_1	77	83	PF00069	0.700
MOD_CK2_1	139	145	PF00069	0.528
MOD_CK2_1	53	59	PF00069	0.707
MOD_GlcNHglycan	135	138	PF01048	0.638
MOD_GlcNHglycan	238	241	PF01048	0.358
MOD_GlcNHglycan	55	58	PF01048	0.671
MOD_GlcNHglycan	63	66	PF01048	0.721
MOD_GlcNHglycan	67	70	PF01048	0.759
MOD_GlcNHglycan	76	79	PF01048	0.481
MOD_GSK3_1	13	20	PF00069	0.571
MOD_GSK3_1	249	256	PF00069	0.537
MOD_GSK3_1	361	368	PF00069	0.687
MOD_GSK3_1	38	45	PF00069	0.709
MOD_GSK3_1	61	68	PF00069	0.725
MOD_GSK3_1	74	81	PF00069	0.550
MOD_LATS_1	51	57	PF00433	0.648
MOD_N-GLC_1	123	128	PF02516	0.561
MOD_N-GLC_1	354	359	PF02516	0.424
MOD_NEK2_1	114	119	PF00069	0.377
MOD_NEK2_1	138	143	PF00069	0.459
MOD_NEK2_1	193	198	PF00069	0.452
MOD_NEK2_1	253	258	PF00069	0.350
MOD_NEK2_1	268	273	PF00069	0.376
MOD_NEK2_1	321	326	PF00069	0.479
MOD_NEK2_1	37	42	PF00069	0.553
MOD_NEK2_2	10	15	PF00069	0.493
MOD_PIKK_1	193	199	PF00454	0.447
MOD_PIKK_1	21	27	PF00454	0.656
MOD_PIKK_1	290	296	PF00454	0.323
MOD_PIKK_1	87	93	PF00454	0.701
MOD_PKA_2	17	23	PF00069	0.601
MOD_PKA_2	322	328	PF00069	0.359
MOD_PKA_2	78	84	PF00069	0.624
MOD_PKB_1	234	242	PF00069	0.293
MOD_Plk_1	123	129	PF00069	0.607
MOD_Plk_1	315	321	PF00069	0.407
MOD_Plk_4	109	115	PF00069	0.342
MOD_Plk_4	161	167	PF00069	0.414
MOD_Plk_4	227	233	PF00069	0.496
MOD_Plk_4	243	249	PF00069	0.432
MOD_ProDKin_1	158	164	PF00069	0.362
MOD_ProDKin_1	262	268	PF00069	0.364
MOD_ProDKin_1	39	45	PF00069	0.677
MOD_ProDKin_1	69	75	PF00069	0.706
TRG_ER_diArg_1	233	236	PF00400	0.561
TRG_ER_diArg_1	60	63	PF00400	0.639
TRG_Pf-PMV_PEXEL_1	258	263	PF00026	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5M5	Leptomonas seymouri	61%	90%
A0A0S4JLN7	Bodo saltans	36%	92%
A0A1X0P4S5	Trypanosomatidae	55%	92%
A0A3Q8IFN6	Leishmania donovani	78%	89%
A0A422NCK5	Trypanosoma rangeli	50%	100%
A4IC35	Leishmania infantum	81%	100%
C9ZYD6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	98%
E9AFZ0	Leishmania major	79%	100%
E9B743	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	89%
V5B8T8	Trypanosoma cruzi	53%	95%