ATPase_AAA_core domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNH8_LEIBR

TriTrypDb:

LbrM.34.5110 , LBRM2903_340061600

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNH8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNH8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	300	302	PF00675	0.502
CLV_PCSK_KEX2_1	299	301	PF00082	0.395
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.395
CLV_PCSK_SKI1_1	24	28	PF00082	0.340
CLV_Separin_Metazoa	131	135	PF03568	0.434
DEG_APCC_DBOX_1	23	31	PF00400	0.326
DEG_SPOP_SBC_1	155	159	PF00917	0.422
DOC_CYCLIN_RxL_1	18	28	PF00134	0.456
DOC_MAPK_DCC_7	260	270	PF00069	0.484
DOC_MAPK_gen_1	176	186	PF00069	0.458
DOC_MAPK_MEF2A_6	234	243	PF00069	0.335
DOC_MAPK_MEF2A_6	4	12	PF00069	0.353
DOC_MAPK_MEF2A_6	96	103	PF00069	0.374
DOC_PP1_RVXF_1	27	34	PF00149	0.327
DOC_PP4_FxxP_1	199	202	PF00568	0.457
DOC_USP7_UBL2_3	299	303	PF12436	0.322
DOC_WW_Pin1_4	151	156	PF00397	0.578
DOC_WW_Pin1_4	226	231	PF00397	0.579
LIG_14-3-3_CanoR_1	108	118	PF00244	0.491
LIG_14-3-3_CanoR_1	247	251	PF00244	0.432
LIG_14-3-3_CanoR_1	272	277	PF00244	0.555
LIG_14-3-3_CanoR_1	43	47	PF00244	0.450
LIG_14-3-3_CanoR_1	57	65	PF00244	0.474
LIG_14-3-3_CanoR_1	70	74	PF00244	0.275
LIG_BIR_II_1	1	5	PF00653	0.448
LIG_BIR_III_2	227	231	PF00653	0.418
LIG_FHA_1	265	271	PF00498	0.453
LIG_FHA_1	92	98	PF00498	0.324
LIG_FHA_2	273	279	PF00498	0.479
LIG_FHA_2	59	65	PF00498	0.467
LIG_GBD_Chelix_1	114	122	PF00786	0.267
LIG_GBD_Chelix_1	290	298	PF00786	0.447
LIG_LIR_Gen_1	135	145	PF02991	0.492
LIG_LIR_Gen_1	2	12	PF02991	0.365
LIG_LIR_Gen_1	84	92	PF02991	0.409
LIG_LIR_Nem_3	135	140	PF02991	0.392
LIG_LIR_Nem_3	16	22	PF02991	0.359
LIG_LIR_Nem_3	2	8	PF02991	0.384
LIG_LIR_Nem_3	84	89	PF02991	0.354
LIG_PCNA_yPIPBox_3	57	69	PF02747	0.422
LIG_SH2_CRK	5	9	PF00017	0.395
LIG_SH2_STAT5	20	23	PF00017	0.334
LIG_SH2_STAT5	269	272	PF00017	0.473
LIG_SH2_STAT5	68	71	PF00017	0.459
LIG_SxIP_EBH_1	258	271	PF03271	0.412
LIG_TYR_ITIM	17	22	PF00017	0.424
LIG_WRC_WIRS_1	282	287	PF05994	0.232
MOD_CK1_1	143	149	PF00069	0.582
MOD_CK1_1	154	160	PF00069	0.521
MOD_CK1_1	87	93	PF00069	0.532
MOD_CK2_1	272	278	PF00069	0.289
MOD_CK2_1	58	64	PF00069	0.386
MOD_GlcNHglycan	118	121	PF01048	0.335
MOD_GlcNHglycan	170	173	PF01048	0.352
MOD_GlcNHglycan	206	209	PF01048	0.462
MOD_GlcNHglycan	220	223	PF01048	0.591
MOD_GlcNHglycan	262	265	PF01048	0.587
MOD_GSK3_1	143	150	PF00069	0.530
MOD_GSK3_1	151	158	PF00069	0.474
MOD_GSK3_1	200	207	PF00069	0.480
MOD_GSK3_1	242	249	PF00069	0.467
MOD_GSK3_1	260	267	PF00069	0.563
MOD_GSK3_1	52	59	PF00069	0.530
MOD_GSK3_1	87	94	PF00069	0.543
MOD_N-GLC_1	122	127	PF02516	0.464
MOD_N-GLC_1	189	194	PF02516	0.450
MOD_NEK2_1	122	127	PF00069	0.393
MOD_NEK2_1	147	152	PF00069	0.457
MOD_NEK2_1	204	209	PF00069	0.467
MOD_NEK2_1	241	246	PF00069	0.457
MOD_NEK2_1	25	30	PF00069	0.327
MOD_PIKK_1	58	64	PF00454	0.386
MOD_PIKK_1	87	93	PF00454	0.453
MOD_PKA_2	246	252	PF00069	0.442
MOD_PKA_2	271	277	PF00069	0.508
MOD_PKA_2	42	48	PF00069	0.449
MOD_PKA_2	56	62	PF00069	0.486
MOD_PKA_2	69	75	PF00069	0.279
MOD_Plk_1	122	128	PF00069	0.461
MOD_Plk_1	140	146	PF00069	0.561
MOD_Plk_1	189	195	PF00069	0.506
MOD_Plk_1	37	43	PF00069	0.559
MOD_Plk_1	55	61	PF00069	0.296
MOD_Plk_2-3	189	195	PF00069	0.302
MOD_Plk_4	123	129	PF00069	0.481
MOD_Plk_4	246	252	PF00069	0.559
MOD_Plk_4	264	270	PF00069	0.506
MOD_Plk_4	281	287	PF00069	0.512
MOD_Plk_4	69	75	PF00069	0.409
MOD_Plk_4	81	87	PF00069	0.449
MOD_ProDKin_1	151	157	PF00069	0.573
MOD_ProDKin_1	226	232	PF00069	0.574
TRG_ENDOCYTIC_2	19	22	PF00928	0.338
TRG_ENDOCYTIC_2	5	8	PF00928	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P619	Leptomonas seymouri	53%	94%
A0A3S7XA31	Leishmania donovani	79%	100%
A0A422P2U5	Trypanosoma rangeli	42%	77%
A4IC34	Leishmania infantum	79%	100%
C9ZZ55	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	74%
E9AFY9	Leishmania major	77%	100%
E9B742	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
V5BTH5	Trypanosoma cruzi	40%	76%