Putative biopterin transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

biopterin transporter, putative

Species:

Leishmania braziliensis

UniProt:

A4HNH7_LEIBR

TriTrypDb:

LbrM.34.5090 , LBRM2903_340061400

Length:

628

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 9
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 52

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 6

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 71
NetGPI	no	yes: 0, no: 71

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	72
GO:0110165	cellular anatomical entity	1	72
GO:0005737	cytoplasm	2	6
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

A4HNH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNH7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0015877	biopterin transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	1
GO:0015224	biopterin transmembrane transporter activity	3	1
GO:0022857	transmembrane transporter activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	264	268	PF00656	0.489
CLV_C14_Caspase3-7	9	13	PF00656	0.627
CLV_NRD_NRD_1	243	245	PF00675	0.303
CLV_NRD_NRD_1	600	602	PF00675	0.279
CLV_PCSK_KEX2_1	122	124	PF00082	0.292
CLV_PCSK_KEX2_1	243	245	PF00082	0.252
CLV_PCSK_KEX2_1	278	280	PF00082	0.311
CLV_PCSK_KEX2_1	475	477	PF00082	0.521
CLV_PCSK_PC1ET2_1	122	124	PF00082	0.292
CLV_PCSK_PC1ET2_1	278	280	PF00082	0.406
CLV_PCSK_PC1ET2_1	475	477	PF00082	0.521
CLV_PCSK_SKI1_1	279	283	PF00082	0.262
CLV_PCSK_SKI1_1	331	335	PF00082	0.278
CLV_PCSK_SKI1_1	52	56	PF00082	0.251
DEG_APCC_DBOX_1	330	338	PF00400	0.398
DEG_ODPH_VHL_1	515	527	PF01847	0.520
DOC_CDC14_PxL_1	30	38	PF14671	0.531
DOC_CDC14_PxL_1	561	569	PF14671	0.331
DOC_CKS1_1	573	578	PF01111	0.432
DOC_CYCLIN_yClb5_NLxxxL_5	393	402	PF00134	0.264
DOC_CYCLIN_yCln2_LP_2	462	468	PF00134	0.206
DOC_CYCLIN_yCln2_LP_2	504	510	PF00134	0.397
DOC_CYCLIN_yCln2_LP_2	578	584	PF00134	0.369
DOC_MAPK_gen_1	475	483	PF00069	0.323
DOC_MAPK_gen_1	601	608	PF00069	0.563
DOC_MAPK_MEF2A_6	475	483	PF00069	0.357
DOC_MAPK_MEF2A_6	52	59	PF00069	0.535
DOC_PP1_RVXF_1	252	258	PF00149	0.381
DOC_PP1_RVXF_1	381	388	PF00149	0.477
DOC_PP2B_LxvP_1	504	507	PF13499	0.337
DOC_PP4_FxxP_1	306	309	PF00568	0.458
DOC_PP4_FxxP_1	375	378	PF00568	0.316
DOC_USP7_MATH_1	145	149	PF00917	0.264
DOC_USP7_MATH_1	188	192	PF00917	0.323
DOC_USP7_MATH_1	448	452	PF00917	0.524
DOC_USP7_MATH_1	464	468	PF00917	0.322
DOC_USP7_UBL2_3	278	282	PF12436	0.585
DOC_WW_Pin1_4	11	16	PF00397	0.756
DOC_WW_Pin1_4	272	277	PF00397	0.502
DOC_WW_Pin1_4	572	577	PF00397	0.414
LIG_14-3-3_CanoR_1	453	459	PF00244	0.491
LIG_14-3-3_CanoR_1	93	98	PF00244	0.491
LIG_14-3-3_CterR_2	625	628	PF00244	0.604
LIG_APCC_ABBA_1	172	177	PF00400	0.520
LIG_APCC_ABBA_1	237	242	PF00400	0.406
LIG_APCC_ABBA_1	307	312	PF00400	0.381
LIG_APCC_ABBA_1	488	493	PF00400	0.246
LIG_BIR_II_1	1	5	PF00653	0.700
LIG_BIR_III_4	302	306	PF00653	0.545
LIG_BRCT_BRCA1_1	371	375	PF00533	0.257
LIG_BRCT_BRCA1_1	419	423	PF00533	0.317
LIG_BRCT_BRCA1_1	450	454	PF00533	0.460
LIG_BRCT_BRCA1_1	521	525	PF00533	0.492
LIG_eIF4E_1	329	335	PF01652	0.381
LIG_FHA_1	112	118	PF00498	0.548
LIG_FHA_1	194	200	PF00498	0.327
LIG_FHA_1	222	228	PF00498	0.433
LIG_FHA_1	267	273	PF00498	0.425
LIG_FHA_1	338	344	PF00498	0.349
LIG_FHA_1	362	368	PF00498	0.332
LIG_FHA_1	374	380	PF00498	0.354
LIG_FHA_1	402	408	PF00498	0.378
LIG_FHA_1	568	574	PF00498	0.416
LIG_FHA_1	85	91	PF00498	0.412
LIG_FHA_2	262	268	PF00498	0.563
LIG_FHA_2	352	358	PF00498	0.208
LIG_LIR_Apic_2	372	378	PF02991	0.401
LIG_LIR_Gen_1	113	120	PF02991	0.522
LIG_LIR_Gen_1	354	363	PF02991	0.295
LIG_LIR_Gen_1	422	431	PF02991	0.324
LIG_LIR_Gen_1	440	448	PF02991	0.383
LIG_LIR_Gen_1	467	474	PF02991	0.334
LIG_LIR_Gen_1	522	532	PF02991	0.511
LIG_LIR_Nem_3	113	118	PF02991	0.497
LIG_LIR_Nem_3	121	127	PF02991	0.501
LIG_LIR_Nem_3	217	222	PF02991	0.305
LIG_LIR_Nem_3	357	363	PF02991	0.286
LIG_LIR_Nem_3	372	377	PF02991	0.367
LIG_LIR_Nem_3	420	424	PF02991	0.296
LIG_LIR_Nem_3	440	446	PF02991	0.257
LIG_LIR_Nem_3	451	455	PF02991	0.466
LIG_LIR_Nem_3	467	472	PF02991	0.335
LIG_LIR_Nem_3	522	528	PF02991	0.472
LIG_LIR_Nem_3	548	554	PF02991	0.291
LIG_MLH1_MIPbox_1	371	375	PF16413	0.399
LIG_NRBOX	229	235	PF00104	0.378
LIG_Pex14_1	356	360	PF04695	0.285
LIG_Pex14_2	352	356	PF04695	0.226
LIG_Pex14_2	419	423	PF04695	0.306
LIG_Pex14_2	443	447	PF04695	0.365
LIG_Pex14_2	49	53	PF04695	0.492
LIG_PTB_Apo_2	400	407	PF02174	0.391
LIG_PTB_Apo_2	446	453	PF02174	0.553
LIG_PTB_Phospho_1	400	406	PF10480	0.402
LIG_PTB_Phospho_1	446	452	PF10480	0.454
LIG_SH2_CRK	125	129	PF00017	0.367
LIG_SH2_CRK	140	144	PF00017	0.321
LIG_SH2_CRK	360	364	PF00017	0.355
LIG_SH2_CRK	452	456	PF00017	0.495
LIG_SH2_CRK	91	95	PF00017	0.512
LIG_SH2_GRB2like	389	392	PF00017	0.381
LIG_SH2_GRB2like	395	398	PF00017	0.405
LIG_SH2_GRB2like	561	564	PF00017	0.351
LIG_SH2_NCK_1	360	364	PF00017	0.416
LIG_SH2_NCK_1	561	565	PF00017	0.295
LIG_SH2_PTP2	21	24	PF00017	0.615
LIG_SH2_PTP2	38	41	PF00017	0.643
LIG_SH2_PTP2	395	398	PF00017	0.350
LIG_SH2_PTP2	584	587	PF00017	0.206
LIG_SH2_SRC	21	24	PF00017	0.621
LIG_SH2_SRC	38	41	PF00017	0.566
LIG_SH2_STAP1	120	124	PF00017	0.501
LIG_SH2_STAP1	175	179	PF00017	0.487
LIG_SH2_STAT3	175	178	PF00017	0.495
LIG_SH2_STAT5	120	123	PF00017	0.498
LIG_SH2_STAT5	21	24	PF00017	0.613
LIG_SH2_STAT5	314	317	PF00017	0.548
LIG_SH2_STAT5	38	41	PF00017	0.602
LIG_SH2_STAT5	389	392	PF00017	0.353
LIG_SH2_STAT5	395	398	PF00017	0.342
LIG_SH2_STAT5	406	409	PF00017	0.281
LIG_SH2_STAT5	421	424	PF00017	0.261
LIG_SH2_STAT5	489	492	PF00017	0.294
LIG_SH2_STAT5	544	547	PF00017	0.256
LIG_SH2_STAT5	584	587	PF00017	0.505
LIG_SH2_STAT5	98	101	PF00017	0.545
LIG_SH3_2	273	278	PF14604	0.394
LIG_SH3_3	270	276	PF00018	0.544
LIG_SH3_3	393	399	PF00018	0.380
LIG_SH3_3	404	410	PF00018	0.333
LIG_SH3_3	411	417	PF00018	0.280
LIG_SH3_3	458	464	PF00018	0.206
LIG_SH3_3	582	588	PF00018	0.390
LIG_SH3_3	617	623	PF00018	0.730
LIG_SUMO_SIM_anti_2	364	369	PF11976	0.435
LIG_SUMO_SIM_anti_2	470	475	PF11976	0.315
LIG_SUMO_SIM_par_1	226	231	PF11976	0.206
LIG_SUMO_SIM_par_1	617	624	PF11976	0.597
LIG_TRAF2_1	615	618	PF00917	0.614
LIG_TRFH_1	140	144	PF08558	0.361
LIG_TRFH_1	584	588	PF08558	0.291
LIG_TYR_ITIM	138	143	PF00017	0.377
LIG_TYR_ITIM	358	363	PF00017	0.374
LIG_TYR_ITIM	36	41	PF00017	0.585
LIG_TYR_ITIM	393	398	PF00017	0.333
LIG_TYR_ITIM	582	587	PF00017	0.505
LIG_UBA3_1	138	146	PF00899	0.348
LIG_UBA3_1	468	475	PF00899	0.323
LIG_WRC_WIRS_1	371	376	PF05994	0.287
LIG_WRC_WIRS_1	402	407	PF05994	0.335
LIG_WRC_WIRS_1	46	51	PF05994	0.556
MOD_CDC14_SPxK_1	275	278	PF00782	0.398
MOD_CDK_SPxK_1	272	278	PF00069	0.398
MOD_CDK_SPxxK_3	272	279	PF00069	0.381
MOD_CK1_1	373	379	PF00069	0.206
MOD_CK1_1	537	543	PF00069	0.358
MOD_CK1_1	609	615	PF00069	0.680
MOD_CK1_1	621	627	PF00069	0.698
MOD_CK2_1	11	17	PF00069	0.613
MOD_Cter_Amidation	599	602	PF01082	0.320
MOD_GlcNHglycan	128	131	PF01048	0.390
MOD_GlcNHglycan	147	151	PF01048	0.502
MOD_GlcNHglycan	230	233	PF01048	0.387
MOD_GlcNHglycan	25	28	PF01048	0.285
MOD_GlcNHglycan	437	440	PF01048	0.336
MOD_GlcNHglycan	458	461	PF01048	0.378
MOD_GlcNHglycan	539	542	PF01048	0.391
MOD_GlcNHglycan	588	591	PF01048	0.400
MOD_GlcNHglycan	610	614	PF01048	0.524
MOD_GlcNHglycan	8	11	PF01048	0.460
MOD_GSK3_1	262	269	PF00069	0.486
MOD_GSK3_1	369	376	PF00069	0.293
MOD_GSK3_1	533	540	PF00069	0.375
MOD_GSK3_1	555	562	PF00069	0.400
MOD_GSK3_1	586	593	PF00069	0.514
MOD_GSK3_1	6	13	PF00069	0.610
MOD_GSK3_1	621	628	PF00069	0.759
MOD_GSK3_1	92	99	PF00069	0.541
MOD_N-GLC_1	262	267	PF02516	0.395
MOD_N-GLC_1	448	453	PF02516	0.254
MOD_NEK2_1	111	116	PF00069	0.495
MOD_NEK2_1	118	123	PF00069	0.453
MOD_NEK2_1	157	162	PF00069	0.342
MOD_NEK2_1	193	198	PF00069	0.335
MOD_NEK2_1	202	207	PF00069	0.332
MOD_NEK2_1	228	233	PF00069	0.286
MOD_NEK2_1	337	342	PF00069	0.357
MOD_NEK2_1	419	424	PF00069	0.309
MOD_NEK2_1	42	47	PF00069	0.545
MOD_NEK2_1	454	459	PF00069	0.362
MOD_NEK2_1	527	532	PF00069	0.346
MOD_NEK2_1	534	539	PF00069	0.353
MOD_NEK2_1	546	551	PF00069	0.301
MOD_NEK2_1	567	572	PF00069	0.457
MOD_NEK2_1	72	77	PF00069	0.479
MOD_NEK2_2	370	375	PF00069	0.462
MOD_NEK2_2	464	469	PF00069	0.369
MOD_PK_1	262	268	PF00069	0.381
MOD_PKA_2	590	596	PF00069	0.400
MOD_PKA_2	72	78	PF00069	0.407
MOD_PKA_2	92	98	PF00069	0.519
MOD_Plk_1	262	268	PF00069	0.460
MOD_Plk_1	448	454	PF00069	0.454
MOD_Plk_4	188	194	PF00069	0.347
MOD_Plk_4	202	208	PF00069	0.337
MOD_Plk_4	310	316	PF00069	0.502
MOD_Plk_4	370	376	PF00069	0.391
MOD_Plk_4	401	407	PF00069	0.338
MOD_Plk_4	419	425	PF00069	0.363
MOD_Plk_4	437	443	PF00069	0.231
MOD_Plk_4	464	470	PF00069	0.320
MOD_Plk_4	519	525	PF00069	0.516
MOD_Plk_4	527	533	PF00069	0.358
MOD_Plk_4	546	552	PF00069	0.299
MOD_Plk_4	93	99	PF00069	0.444
MOD_ProDKin_1	11	17	PF00069	0.755
MOD_ProDKin_1	272	278	PF00069	0.502
MOD_ProDKin_1	572	578	PF00069	0.414
MOD_SUMO_for_1	253	256	PF00179	0.560
MOD_SUMO_rev_2	251	255	PF00179	0.411
MOD_SUMO_rev_2	275	284	PF00179	0.547
TRG_ENDOCYTIC_2	125	128	PF00928	0.346
TRG_ENDOCYTIC_2	140	143	PF00928	0.336
TRG_ENDOCYTIC_2	329	332	PF00928	0.496
TRG_ENDOCYTIC_2	360	363	PF00928	0.358
TRG_ENDOCYTIC_2	38	41	PF00928	0.594
TRG_ENDOCYTIC_2	395	398	PF00928	0.352
TRG_ENDOCYTIC_2	424	427	PF00928	0.301
TRG_ENDOCYTIC_2	452	455	PF00928	0.495
TRG_ENDOCYTIC_2	544	547	PF00928	0.323
TRG_ENDOCYTIC_2	584	587	PF00928	0.495
TRG_ENDOCYTIC_2	91	94	PF00928	0.480
TRG_ER_diArg_1	179	182	PF00400	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2U2	Leptomonas seymouri	42%	89%
A0A0N1HY49	Leptomonas seymouri	39%	93%
A0A0N1HZ06	Leptomonas seymouri	59%	100%
A0A0N1IHL1	Leptomonas seymouri	37%	88%
A0A0N1PAY4	Leptomonas seymouri	38%	71%
A0A0N1PB77	Leptomonas seymouri	69%	97%
A0A0N1PBZ2	Leptomonas seymouri	36%	93%
A0A0N1PCC1	Leptomonas seymouri	37%	94%
A0A0S4INN8	Bodo saltans	28%	97%
A0A381MBI0	Leishmania infantum	39%	95%
A0A3Q8I8X7	Leishmania donovani	39%	95%
A0A3Q8IAZ0	Leishmania donovani	36%	90%
A0A3Q8IH50	Leishmania donovani	37%	87%
A0A3Q8IVN0	Leishmania donovani	85%	100%
A0A3R7M4J1	Trypanosoma rangeli	39%	98%
A0A3S5H5P4	Leishmania donovani	39%	93%
A0A3S5H5V2	Leishmania donovani	44%	96%
A0A3S5H6F6	Leishmania donovani	36%	90%
A0A3S5H763	Leishmania donovani	40%	93%
A0A3S7WR10	Leishmania donovani	39%	84%
A0A3S7WR14	Leishmania donovani	36%	92%
A0A3S7WR15	Leishmania donovani	35%	74%
A0A3S7WR24	Leishmania donovani	37%	89%
A4H4T8	Leishmania braziliensis	43%	100%
A4H5Y4	Leishmania braziliensis	39%	100%
A4H617	Leishmania braziliensis	36%	100%
A4H618	Leishmania braziliensis	36%	100%
A4H619	Leishmania braziliensis	36%	100%
A4H620	Leishmania braziliensis	38%	100%
A4H6C3	Leishmania braziliensis	39%	100%
A4HSS2	Leishmania infantum	39%	93%
A4HUE4	Leishmania infantum	39%	84%
A4HUE5	Leishmania infantum	35%	91%
A4HUE6	Leishmania infantum	36%	92%
A4HUE7	Leishmania infantum	36%	90%
A4HUE8	Leishmania infantum	37%	89%
A4HUF4	Leishmania infantum	36%	90%
A4HUF5	Leishmania infantum	37%	95%
A4HYA9	Leishmania infantum	41%	93%
A4IC33	Leishmania infantum	84%	99%
C9ZIK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	96%
C9ZIK3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	96%
C9ZVE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	99%
C9ZVE9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	99%
C9ZVF1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	99%
D0A423	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	98%
E8NHQ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	90%
E9AG72	Leishmania infantum	44%	96%
E9AI40	Leishmania braziliensis	35%	92%
E9AJY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AKQ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	93%
E9AL06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	96%
E9AN44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	84%
E9AN45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	96%
E9AN46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
E9AN47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	88%
E9ANE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	95%
E9AS42	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	93%
E9B741	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QDC4	Leishmania major	40%	100%
Q4QH81	Leishmania major	38%	100%
Q4QHH7	Leishmania major	37%	100%
Q4QHH8	Leishmania major	36%	100%
Q4QHH9	Leishmania major	36%	100%
Q4QHI0	Leishmania major	35%	100%
Q4QHI1	Leishmania major	37%	100%
Q4QHI2	Leishmania major	35%	100%
Q4QIU9	Leishmania major	44%	100%
Q4QJ48	Leishmania major	39%	100%
Q7KIP2	Leishmania major	82%	100%