Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNH5_LEIBR

TriTrypDb:

LbrM.34.5070 , LBRM2903_340061200

Length:

368

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNH5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	189	191	PF00675	0.669
CLV_NRD_NRD_1	245	247	PF00675	0.704
CLV_NRD_NRD_1	357	359	PF00675	0.517
CLV_NRD_NRD_1	46	48	PF00675	0.604
CLV_PCSK_KEX2_1	189	191	PF00082	0.502
CLV_PCSK_KEX2_1	245	247	PF00082	0.704
CLV_PCSK_KEX2_1	357	359	PF00082	0.517
CLV_PCSK_KEX2_1	46	48	PF00082	0.604
CLV_PCSK_SKI1_1	20	24	PF00082	0.602
DOC_CKS1_1	204	209	PF01111	0.503
DOC_CYCLIN_RxL_1	308	319	PF00134	0.480
DOC_CYCLIN_yCln2_LP_2	5	11	PF00134	0.504
DOC_MAPK_gen_1	20	29	PF00069	0.486
DOC_MAPK_gen_1	64	73	PF00069	0.528
DOC_MAPK_MEF2A_6	66	75	PF00069	0.525
DOC_PP1_RVXF_1	309	316	PF00149	0.473
DOC_USP7_MATH_1	119	123	PF00917	0.753
DOC_USP7_MATH_1	133	137	PF00917	0.529
DOC_USP7_MATH_1	160	164	PF00917	0.524
DOC_USP7_MATH_1	222	226	PF00917	0.503
DOC_USP7_MATH_1	292	296	PF00917	0.610
DOC_USP7_MATH_1	346	350	PF00917	0.567
DOC_USP7_MATH_1	40	44	PF00917	0.522
DOC_WW_Pin1_4	127	132	PF00397	0.668
DOC_WW_Pin1_4	164	169	PF00397	0.545
DOC_WW_Pin1_4	203	208	PF00397	0.507
DOC_WW_Pin1_4	265	270	PF00397	0.531
DOC_WW_Pin1_4	290	295	PF00397	0.619
DOC_WW_Pin1_4	342	347	PF00397	0.617
DOC_WW_Pin1_4	4	9	PF00397	0.501
DOC_WW_Pin1_4	75	80	PF00397	0.515
LIG_14-3-3_CanoR_1	103	111	PF00244	0.609
LIG_14-3-3_CanoR_1	223	227	PF00244	0.512
LIG_14-3-3_CanoR_1	34	41	PF00244	0.511
LIG_14-3-3_CanoR_1	347	353	PF00244	0.531
LIG_14-3-3_CanoR_1	357	361	PF00244	0.467
LIG_14-3-3_CterR_2	363	368	PF00244	0.521
LIG_BIR_II_1	1	5	PF00653	0.504
LIG_BRCT_BRCA1_1	267	271	PF00533	0.558
LIG_BRCT_BRCA1_1	77	81	PF00533	0.504
LIG_FHA_1	10	16	PF00498	0.631
LIG_FHA_1	135	141	PF00498	0.569
LIG_Integrin_RGD_1	354	356	PF01839	0.563
LIG_LIR_Apic_2	201	207	PF02991	0.502
LIG_LIR_Apic_2	288	294	PF02991	0.620
LIG_LIR_Gen_1	21	31	PF02991	0.639
LIG_LIR_Gen_1	274	284	PF02991	0.539
LIG_LIR_Nem_3	21	27	PF02991	0.639
LIG_LIR_Nem_3	274	279	PF02991	0.539
LIG_LRP6_Inhibitor_1	305	311	PF00058	0.389
LIG_MYND_1	257	261	PF01753	0.597
LIG_Pex14_2	271	275	PF04695	0.527
LIG_SH2_CRK	204	208	PF00017	0.508
LIG_SH2_CRK	291	295	PF00017	0.490
LIG_SH2_NCK_1	204	208	PF00017	0.508
LIG_SH2_NCK_1	291	295	PF00017	0.528
LIG_SH2_STAT5	301	304	PF00017	0.634
LIG_SH2_STAT5	314	317	PF00017	0.433
LIG_SH3_3	109	115	PF00018	0.549
LIG_SH3_3	165	171	PF00018	0.545
LIG_SH3_3	251	257	PF00018	0.568
LIG_SH3_3	91	97	PF00018	0.527
LIG_SUMO_SIM_par_1	321	327	PF11976	0.462
LIG_UBA3_1	5	14	PF00899	0.503
LIG_WRC_WIRS_1	239	244	PF05994	0.451
MOD_CDK_SPK_2	265	270	PF00069	0.531
MOD_CDK_SPK_2	342	347	PF00069	0.511
MOD_CDK_SPxxK_3	75	82	PF00069	0.509
MOD_CK1_1	136	142	PF00069	0.630
MOD_CK1_1	167	173	PF00069	0.552
MOD_CK1_1	290	296	PF00069	0.612
MOD_CK1_1	324	330	PF00069	0.555
MOD_CK1_1	333	339	PF00069	0.579
MOD_CK1_1	350	356	PF00069	0.509
MOD_GlcNHglycan	155	158	PF01048	0.575
MOD_GlcNHglycan	180	183	PF01048	0.513
MOD_GlcNHglycan	200	203	PF01048	0.524
MOD_GlcNHglycan	254	257	PF01048	0.602
MOD_GlcNHglycan	330	333	PF01048	0.555
MOD_GSK3_1	119	126	PF00069	0.656
MOD_GSK3_1	129	136	PF00069	0.727
MOD_GSK3_1	160	167	PF00069	0.604
MOD_GSK3_1	178	185	PF00069	0.470
MOD_GSK3_1	271	278	PF00069	0.640
MOD_GSK3_1	283	290	PF00069	0.560
MOD_GSK3_1	292	299	PF00069	0.597
MOD_GSK3_1	323	330	PF00069	0.559
MOD_GSK3_1	342	349	PF00069	0.594
MOD_GSK3_1	358	365	PF00069	0.666
MOD_GSK3_1	60	67	PF00069	0.776
MOD_NEK2_1	198	203	PF00069	0.586
MOD_NEK2_1	231	236	PF00069	0.506
MOD_NEK2_1	271	276	PF00069	0.585
MOD_NEK2_1	287	292	PF00069	0.553
MOD_NEK2_1	9	14	PF00069	0.631
MOD_PIKK_1	134	140	PF00454	0.530
MOD_PIKK_1	358	364	PF00454	0.515
MOD_PK_1	162	168	PF00069	0.536
MOD_PKA_2	102	108	PF00069	0.620
MOD_PKA_2	222	228	PF00069	0.509
MOD_PKA_2	33	39	PF00069	0.501
MOD_PKA_2	346	352	PF00069	0.677
MOD_PKA_2	356	362	PF00069	0.469
MOD_PKB_1	62	70	PF00069	0.685
MOD_Plk_1	287	293	PF00069	0.730
MOD_Plk_1	333	339	PF00069	0.651
MOD_Plk_4	136	142	PF00069	0.625
MOD_Plk_4	143	149	PF00069	0.688
MOD_Plk_4	222	228	PF00069	0.501
MOD_Plk_4	271	277	PF00069	0.636
MOD_Plk_4	333	339	PF00069	0.745
MOD_ProDKin_1	127	133	PF00069	0.666
MOD_ProDKin_1	164	170	PF00069	0.544
MOD_ProDKin_1	203	209	PF00069	0.503
MOD_ProDKin_1	265	271	PF00069	0.533
MOD_ProDKin_1	290	296	PF00069	0.618
MOD_ProDKin_1	342	348	PF00069	0.616
MOD_ProDKin_1	4	10	PF00069	0.502
MOD_ProDKin_1	75	81	PF00069	0.518
MOD_SUMO_for_1	41	44	PF00179	0.523
MOD_SUMO_rev_2	84	92	PF00179	0.680
TRG_DiLeu_BaLyEn_6	255	260	PF01217	0.507
TRG_ER_diArg_1	188	190	PF00400	0.509
TRG_ER_diArg_1	245	247	PF00400	0.578
TRG_ER_diArg_1	95	98	PF00400	0.664

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I004	Leptomonas seymouri	33%	96%
A0A3S7XA50	Leishmania donovani	60%	99%
A4IC31	Leishmania infantum	60%	99%
E9AFY6	Leishmania major	58%	100%
E9B739	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	100%