Conserved oligomeric Golgi complex subunit 4

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNH4_LEIBR

TriTrypDb:

LbrM.34.5060 , LBRM2903_340061100

Length:

719

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 8

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNH4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNH4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	387	391	PF00656	0.421
CLV_C14_Caspase3-7	398	402	PF00656	0.428
CLV_C14_Caspase3-7	515	519	PF00656	0.592
CLV_C14_Caspase3-7	572	576	PF00656	0.510
CLV_MEL_PAP_1	564	570	PF00089	0.495
CLV_NRD_NRD_1	210	212	PF00675	0.548
CLV_NRD_NRD_1	215	217	PF00675	0.494
CLV_NRD_NRD_1	313	315	PF00675	0.522
CLV_NRD_NRD_1	423	425	PF00675	0.537
CLV_NRD_NRD_1	547	549	PF00675	0.429
CLV_NRD_NRD_1	572	574	PF00675	0.673
CLV_NRD_NRD_1	632	634	PF00675	0.490
CLV_NRD_NRD_1	645	647	PF00675	0.274
CLV_PCSK_KEX2_1	215	217	PF00082	0.443
CLV_PCSK_KEX2_1	313	315	PF00082	0.522
CLV_PCSK_KEX2_1	423	425	PF00082	0.597
CLV_PCSK_KEX2_1	510	512	PF00082	0.627
CLV_PCSK_KEX2_1	547	549	PF00082	0.469
CLV_PCSK_KEX2_1	645	647	PF00082	0.436
CLV_PCSK_PC1ET2_1	510	512	PF00082	0.645
CLV_PCSK_PC7_1	211	217	PF00082	0.318
CLV_PCSK_SKI1_1	136	140	PF00082	0.443
CLV_PCSK_SKI1_1	215	219	PF00082	0.405
CLV_PCSK_SKI1_1	241	245	PF00082	0.709
CLV_PCSK_SKI1_1	284	288	PF00082	0.453
CLV_PCSK_SKI1_1	397	401	PF00082	0.386
CLV_PCSK_SKI1_1	412	416	PF00082	0.365
CLV_PCSK_SKI1_1	44	48	PF00082	0.592
CLV_PCSK_SKI1_1	447	451	PF00082	0.364
CLV_PCSK_SKI1_1	458	462	PF00082	0.362
CLV_PCSK_SKI1_1	645	649	PF00082	0.375
DEG_APCC_DBOX_1	283	291	PF00400	0.473
DEG_APCC_DBOX_1	668	676	PF00400	0.508
DEG_SPOP_SBC_1	29	33	PF00917	0.626
DOC_CDC14_PxL_1	166	174	PF14671	0.519
DOC_CKS1_1	344	349	PF01111	0.569
DOC_CYCLIN_RxL_1	394	401	PF00134	0.421
DOC_CYCLIN_RxL_1	444	452	PF00134	0.367
DOC_CYCLIN_yClb1_LxF_4	536	542	PF00134	0.464
DOC_MAPK_gen_1	313	321	PF00069	0.473
DOC_MAPK_gen_1	348	358	PF00069	0.412
DOC_MAPK_gen_1	514	522	PF00069	0.560
DOC_MAPK_gen_1	630	640	PF00069	0.521
DOC_MAPK_gen_1	667	675	PF00069	0.452
DOC_MAPK_JIP1_4	516	522	PF00069	0.592
DOC_MAPK_MEF2A_6	351	360	PF00069	0.377
DOC_MAPK_MEF2A_6	528	535	PF00069	0.453
DOC_MAPK_MEF2A_6	669	677	PF00069	0.430
DOC_PP4_FxxP_1	326	329	PF00568	0.491
DOC_PP4_FxxP_1	344	347	PF00568	0.518
DOC_SPAK_OSR1_1	528	532	PF12202	0.288
DOC_USP7_MATH_1	24	28	PF00917	0.523
DOC_USP7_MATH_1	243	247	PF00917	0.690
DOC_USP7_MATH_1	29	33	PF00917	0.472
DOC_USP7_MATH_1	563	567	PF00917	0.699
DOC_USP7_UBL2_3	368	372	PF12436	0.506
DOC_USP7_UBL2_3	412	416	PF12436	0.483
DOC_USP7_UBL2_3	630	634	PF12436	0.524
DOC_USP7_UBL2_3	667	671	PF12436	0.324
DOC_WW_Pin1_4	343	348	PF00397	0.565
LIG_14-3-3_CanoR_1	129	135	PF00244	0.512
LIG_14-3-3_CanoR_1	145	151	PF00244	0.601
LIG_14-3-3_CanoR_1	19	25	PF00244	0.588
LIG_14-3-3_CanoR_1	247	251	PF00244	0.600
LIG_14-3-3_CanoR_1	266	274	PF00244	0.457
LIG_14-3-3_CanoR_1	423	431	PF00244	0.512
LIG_14-3-3_CanoR_1	528	532	PF00244	0.494
LIG_14-3-3_CanoR_1	633	640	PF00244	0.481
LIG_14-3-3_CanoR_1	694	700	PF00244	0.466
LIG_14-3-3_CterR_2	716	719	PF00244	0.329
LIG_Actin_WH2_2	162	179	PF00022	0.514
LIG_Actin_WH2_2	442	460	PF00022	0.481
LIG_Actin_WH2_2	617	635	PF00022	0.509
LIG_APCC_ABBA_1	615	620	PF00400	0.340
LIG_BIR_II_1	1	5	PF00653	0.486
LIG_BRCT_BRCA1_1	130	134	PF00533	0.533
LIG_BRCT_BRCA1_1	586	590	PF00533	0.530
LIG_BRCT_BRCA1_2	130	136	PF00533	0.530
LIG_Clathr_ClatBox_1	621	625	PF01394	0.574
LIG_deltaCOP1_diTrp_1	362	367	PF00928	0.372
LIG_EH1_1	393	401	PF00400	0.404
LIG_eIF4E_1	394	400	PF01652	0.492
LIG_eIF4E_1	444	450	PF01652	0.389
LIG_FHA_1	135	141	PF00498	0.431
LIG_FHA_1	205	211	PF00498	0.451
LIG_FHA_1	438	444	PF00498	0.314
LIG_FHA_1	481	487	PF00498	0.510
LIG_FHA_1	55	61	PF00498	0.590
LIG_FHA_1	551	557	PF00498	0.509
LIG_FHA_1	627	633	PF00498	0.596
LIG_FHA_1	646	652	PF00498	0.327
LIG_FHA_1	668	674	PF00498	0.410
LIG_FHA_1	89	95	PF00498	0.403
LIG_FHA_2	231	237	PF00498	0.561
LIG_FHA_2	432	438	PF00498	0.475
LIG_FHA_2	493	499	PF00498	0.313
LIG_FHA_2	513	519	PF00498	0.685
LIG_FHA_2	57	63	PF00498	0.498
LIG_FHA_2	705	711	PF00498	0.566
LIG_Integrin_isoDGR_2	692	694	PF01839	0.506
LIG_LIR_Apic_2	323	329	PF02991	0.498
LIG_LIR_Gen_1	305	316	PF02991	0.436
LIG_LIR_Gen_1	352	361	PF02991	0.437
LIG_LIR_Gen_1	587	598	PF02991	0.513
LIG_LIR_Gen_1	682	691	PF02991	0.412
LIG_LIR_Nem_3	305	311	PF02991	0.430
LIG_LIR_Nem_3	352	358	PF02991	0.363
LIG_LIR_Nem_3	425	431	PF02991	0.469
LIG_LIR_Nem_3	451	457	PF02991	0.446
LIG_LIR_Nem_3	587	593	PF02991	0.520
LIG_LIR_Nem_3	610	615	PF02991	0.351
LIG_LIR_Nem_3	95	99	PF02991	0.354
LIG_Pex14_1	608	612	PF04695	0.382
LIG_Pex14_2	604	608	PF04695	0.388
LIG_PTB_Apo_2	388	395	PF02174	0.493
LIG_PTB_Apo_2	535	542	PF02174	0.358
LIG_PTB_Phospho_1	388	394	PF10480	0.489
LIG_Rb_pABgroove_1	584	592	PF01858	0.542
LIG_SH2_CRK	454	458	PF00017	0.448
LIG_SH2_CRK	462	466	PF00017	0.527
LIG_SH2_CRK	70	74	PF00017	0.463
LIG_SH2_GRB2like	403	406	PF00017	0.484
LIG_SH2_NCK_1	294	298	PF00017	0.522
LIG_SH2_PTP2	353	356	PF00017	0.463
LIG_SH2_SRC	257	260	PF00017	0.558
LIG_SH2_SRC	403	406	PF00017	0.491
LIG_SH2_STAP1	418	422	PF00017	0.435
LIG_SH2_STAP1	99	103	PF00017	0.458
LIG_SH2_STAT5	103	106	PF00017	0.415
LIG_SH2_STAT5	285	288	PF00017	0.387
LIG_SH2_STAT5	349	352	PF00017	0.483
LIG_SH2_STAT5	353	356	PF00017	0.463
LIG_SH2_STAT5	403	406	PF00017	0.439
LIG_SH2_STAT5	444	447	PF00017	0.397
LIG_SH2_STAT5	481	484	PF00017	0.496
LIG_SH2_STAT5	657	660	PF00017	0.492
LIG_SH2_STAT5	96	99	PF00017	0.380
LIG_SH3_3	145	151	PF00018	0.697
LIG_SH3_3	152	158	PF00018	0.619
LIG_SH3_3	283	289	PF00018	0.383
LIG_SH3_3	576	582	PF00018	0.582
LIG_SH3_3	71	77	PF00018	0.538
LIG_SUMO_SIM_anti_2	518	526	PF11976	0.418
LIG_SUMO_SIM_par_1	56	62	PF11976	0.619
LIG_SUMO_SIM_par_1	670	676	PF11976	0.362
LIG_TRAF2_1	474	477	PF00917	0.416
LIG_TRAF2_1	59	62	PF00917	0.506
LIG_TRFH_1	285	289	PF08558	0.387
LIG_TYR_ITIM	460	465	PF00017	0.541
LIG_TYR_ITIM	655	660	PF00017	0.303
LIG_WRC_WIRS_1	25	30	PF05994	0.542
LIG_WRC_WIRS_1	450	455	PF05994	0.474
MOD_CDK_SPK_2	343	348	PF00069	0.565
MOD_CK1_1	146	152	PF00069	0.684
MOD_CK1_1	242	248	PF00069	0.660
MOD_CK1_1	324	330	PF00069	0.337
MOD_CK1_1	33	39	PF00069	0.596
MOD_CK1_1	521	527	PF00069	0.466
MOD_CK1_1	616	622	PF00069	0.473
MOD_CK2_1	431	437	PF00069	0.384
MOD_CK2_1	471	477	PF00069	0.435
MOD_CK2_1	492	498	PF00069	0.402
MOD_CK2_1	56	62	PF00069	0.493
MOD_CK2_1	604	610	PF00069	0.477
MOD_CK2_1	625	631	PF00069	0.560
MOD_CK2_1	704	710	PF00069	0.547
MOD_CK2_1	78	84	PF00069	0.559
MOD_GlcNHglycan	1	4	PF01048	0.454
MOD_GlcNHglycan	151	154	PF01048	0.598
MOD_GlcNHglycan	166	169	PF01048	0.665
MOD_GlcNHglycan	20	23	PF01048	0.547
MOD_GlcNHglycan	241	244	PF01048	0.586
MOD_GlcNHglycan	269	272	PF01048	0.407
MOD_GlcNHglycan	32	35	PF01048	0.521
MOD_GlcNHglycan	437	440	PF01048	0.315
MOD_GlcNHglycan	80	83	PF01048	0.511
MOD_GSK3_1	172	179	PF00069	0.668
MOD_GSK3_1	239	246	PF00069	0.700
MOD_GSK3_1	24	31	PF00069	0.521
MOD_GSK3_1	298	305	PF00069	0.479
MOD_GSK3_1	320	327	PF00069	0.480
MOD_GSK3_1	366	373	PF00069	0.297
MOD_GSK3_1	418	425	PF00069	0.458
MOD_GSK3_1	427	434	PF00069	0.376
MOD_GSK3_1	449	456	PF00069	0.468
MOD_GSK3_1	512	519	PF00069	0.625
MOD_GSK3_1	616	623	PF00069	0.566
MOD_GSK3_1	78	85	PF00069	0.561
MOD_N-GLC_1	204	209	PF02516	0.486
MOD_N-GLC_1	54	59	PF02516	0.626
MOD_N-GLC_2	538	540	PF02516	0.459
MOD_NEK2_1	134	139	PF00069	0.448
MOD_NEK2_1	143	148	PF00069	0.525
MOD_NEK2_1	172	177	PF00069	0.644
MOD_NEK2_1	230	235	PF00069	0.421
MOD_NEK2_1	28	33	PF00069	0.516
MOD_NEK2_1	333	338	PF00069	0.350
MOD_NEK2_1	370	375	PF00069	0.485
MOD_NEK2_1	449	454	PF00069	0.401
MOD_NEK2_1	461	466	PF00069	0.288
MOD_NEK2_1	604	609	PF00069	0.431
MOD_NEK2_1	632	637	PF00069	0.469
MOD_NEK2_2	418	423	PF00069	0.513
MOD_NEK2_2	613	618	PF00069	0.494
MOD_PIKK_1	146	152	PF00454	0.595
MOD_PIKK_1	584	590	PF00454	0.547
MOD_PIKK_1	632	638	PF00454	0.487
MOD_PIKK_1	695	701	PF00454	0.558
MOD_PKA_1	645	651	PF00069	0.297
MOD_PKA_2	128	134	PF00069	0.515
MOD_PKA_2	164	170	PF00069	0.634
MOD_PKA_2	18	24	PF00069	0.585
MOD_PKA_2	246	252	PF00069	0.635
MOD_PKA_2	265	271	PF00069	0.478
MOD_PKA_2	422	428	PF00069	0.519
MOD_PKA_2	527	533	PF00069	0.496
MOD_PKA_2	626	632	PF00069	0.551
MOD_PKA_2	645	651	PF00069	0.381
MOD_Plk_1	292	298	PF00069	0.346
MOD_Plk_1	321	327	PF00069	0.480
MOD_Plk_1	385	391	PF00069	0.514
MOD_Plk_1	431	437	PF00069	0.483
MOD_Plk_1	54	60	PF00069	0.616
MOD_Plk_1	673	679	PF00069	0.391
MOD_Plk_1	83	89	PF00069	0.577
MOD_Plk_2-3	292	298	PF00069	0.320
MOD_Plk_2-3	492	498	PF00069	0.283
MOD_Plk_2-3	620	626	PF00069	0.557
MOD_Plk_4	246	252	PF00069	0.671
MOD_Plk_4	302	308	PF00069	0.410
MOD_Plk_4	321	327	PF00069	0.330
MOD_Plk_4	449	455	PF00069	0.421
MOD_Plk_4	461	467	PF00069	0.283
MOD_Plk_4	518	524	PF00069	0.557
MOD_ProDKin_1	343	349	PF00069	0.562
MOD_SUMO_rev_2	213	223	PF00179	0.497
MOD_SUMO_rev_2	41	48	PF00179	0.640
MOD_SUMO_rev_2	566	576	PF00179	0.658
MOD_SUMO_rev_2	661	668	PF00179	0.509
TRG_DiLeu_BaEn_2	376	382	PF01217	0.475
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.565
TRG_ENDOCYTIC_2	353	356	PF00928	0.434
TRG_ENDOCYTIC_2	454	457	PF00928	0.418
TRG_ENDOCYTIC_2	462	465	PF00928	0.483
TRG_ENDOCYTIC_2	657	660	PF00928	0.390
TRG_ER_diArg_1	214	216	PF00400	0.440
TRG_ER_diArg_1	312	314	PF00400	0.525
TRG_ER_diArg_1	394	397	PF00400	0.527
TRG_ER_diArg_1	422	424	PF00400	0.545
TRG_ER_diArg_1	546	548	PF00400	0.466
TRG_ER_diArg_1	645	647	PF00400	0.472
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.445
TRG_Pf-PMV_PEXEL_1	272	277	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	397	401	PF00026	0.391
TRG_Pf-PMV_PEXEL_1	494	498	PF00026	0.467

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2N5	Leptomonas seymouri	66%	100%
A0A0S4JQA4	Bodo saltans	36%	98%
A0A1X0P526	Trypanosomatidae	42%	100%
A0A3Q8IIV4	Leishmania donovani	82%	100%
A0A422NCN3	Trypanosoma rangeli	43%	100%
C9ZYD8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AFY5	Leishmania major	82%	100%
E9B738	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
V5BYQ9	Trypanosoma cruzi	43%	100%