LeishMANIAdb
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PseudoU_synth_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
PseudoU_synth_2 domain-containing protein
Gene product:
RNA pseudouridylate synthase, putative
Species:
Leishmania braziliensis
UniProt:
A4HNH3_LEIBR
TriTrypDb:
LbrM.34.5050 , LBRM2903_340061000 *
Length:
754

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNH3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNH3

Function

Biological processes
Term Name Level Count
GO:0001522 pseudouridine synthesis 6 12
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009451 RNA modification 5 12
GO:0009987 cellular process 1 12
GO:0016070 RNA metabolic process 5 12
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0046483 heterocycle metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
GO:0000154 rRNA modification 6 1
GO:0000455 enzyme-directed rRNA pseudouridine synthesis 8 1
GO:0006364 rRNA processing 8 1
GO:0006396 RNA processing 6 1
GO:0016072 rRNA metabolic process 7 1
GO:0031118 rRNA pseudouridine synthesis 7 1
GO:0034470 ncRNA processing 7 1
GO:0034660 ncRNA metabolic process 6 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003723 RNA binding 4 12
GO:0003824 catalytic activity 1 12
GO:0005488 binding 1 12
GO:0009982 pseudouridine synthase activity 4 12
GO:0016853 isomerase activity 2 12
GO:0016866 intramolecular transferase activity 3 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12
GO:0009055 electron transfer activity 3 1
GO:0016491 oxidoreductase activity 2 1
GO:0020037 heme binding 4 1
GO:0043167 ion binding 2 1
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1
GO:0046906 tetrapyrrole binding 3 1
GO:0106029 tRNA pseudouridine synthase activity 5 1
GO:0140098 catalytic activity, acting on RNA 3 1
GO:0140101 catalytic activity, acting on a tRNA 4 1
GO:0140640 catalytic activity, acting on a nucleic acid 2 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 631 635 PF00656 0.441
CLV_MEL_PAP_1 266 272 PF00089 0.459
CLV_NRD_NRD_1 128 130 PF00675 0.401
CLV_NRD_NRD_1 249 251 PF00675 0.627
CLV_NRD_NRD_1 331 333 PF00675 0.454
CLV_NRD_NRD_1 336 338 PF00675 0.482
CLV_NRD_NRD_1 44 46 PF00675 0.332
CLV_NRD_NRD_1 442 444 PF00675 0.431
CLV_NRD_NRD_1 671 673 PF00675 0.231
CLV_NRD_NRD_1 750 752 PF00675 0.596
CLV_PCSK_FUR_1 247 251 PF00082 0.501
CLV_PCSK_FUR_1 329 333 PF00082 0.495
CLV_PCSK_KEX2_1 128 130 PF00082 0.393
CLV_PCSK_KEX2_1 249 251 PF00082 0.513
CLV_PCSK_KEX2_1 331 333 PF00082 0.451
CLV_PCSK_KEX2_1 336 338 PF00082 0.478
CLV_PCSK_KEX2_1 387 389 PF00082 0.397
CLV_PCSK_KEX2_1 44 46 PF00082 0.332
CLV_PCSK_KEX2_1 442 444 PF00082 0.421
CLV_PCSK_KEX2_1 671 673 PF00082 0.236
CLV_PCSK_PC1ET2_1 387 389 PF00082 0.397
CLV_PCSK_PC7_1 332 338 PF00082 0.474
CLV_PCSK_PC7_1 438 444 PF00082 0.393
CLV_PCSK_SKI1_1 13 17 PF00082 0.503
CLV_PCSK_SKI1_1 357 361 PF00082 0.435
CLV_PCSK_SKI1_1 384 388 PF00082 0.445
CLV_PCSK_SKI1_1 45 49 PF00082 0.333
CLV_PCSK_SKI1_1 465 469 PF00082 0.328
CLV_PCSK_SKI1_1 564 568 PF00082 0.236
CLV_PCSK_SKI1_1 57 61 PF00082 0.552
CLV_PCSK_SKI1_1 699 703 PF00082 0.268
DEG_APCC_DBOX_1 12 20 PF00400 0.478
DEG_APCC_DBOX_1 33 41 PF00400 0.453
DEG_APCC_DBOX_1 437 445 PF00400 0.385
DEG_APCC_DBOX_1 464 472 PF00400 0.356
DEG_APCC_DBOX_1 728 736 PF00400 0.456
DEG_SPOP_SBC_1 97 101 PF00917 0.649
DOC_ANK_TNKS_1 441 448 PF00023 0.317
DOC_CDC14_PxL_1 509 517 PF14671 0.483
DOC_CKS1_1 213 218 PF01111 0.483
DOC_CKS1_1 23 28 PF01111 0.371
DOC_CYCLIN_RxL_1 460 469 PF00134 0.332
DOC_CYCLIN_yCln2_LP_2 213 219 PF00134 0.460
DOC_MAPK_gen_1 258 266 PF00069 0.446
DOC_MAPK_gen_1 442 450 PF00069 0.317
DOC_MAPK_gen_1 641 649 PF00069 0.466
DOC_MAPK_MEF2A_6 610 619 PF00069 0.519
DOC_MAPK_RevD_3 323 337 PF00069 0.578
DOC_PP1_RVXF_1 643 650 PF00149 0.424
DOC_PP1_RVXF_1 652 658 PF00149 0.424
DOC_PP2B_LxvP_1 78 81 PF13499 0.363
DOC_PP4_FxxP_1 709 712 PF00568 0.358
DOC_USP7_MATH_1 201 205 PF00917 0.547
DOC_USP7_MATH_1 236 240 PF00917 0.473
DOC_USP7_MATH_1 339 343 PF00917 0.623
DOC_USP7_MATH_1 359 363 PF00917 0.390
DOC_USP7_MATH_1 459 463 PF00917 0.342
DOC_USP7_MATH_1 591 595 PF00917 0.394
DOC_USP7_MATH_1 89 93 PF00917 0.743
DOC_USP7_MATH_1 97 101 PF00917 0.582
DOC_USP7_UBL2_3 158 162 PF12436 0.359
DOC_USP7_UBL2_3 254 258 PF12436 0.525
DOC_WW_Pin1_4 157 162 PF00397 0.510
DOC_WW_Pin1_4 212 217 PF00397 0.484
DOC_WW_Pin1_4 22 27 PF00397 0.477
DOC_WW_Pin1_4 406 411 PF00397 0.497
DOC_WW_Pin1_4 60 65 PF00397 0.530
DOC_WW_Pin1_4 87 92 PF00397 0.645
LIG_14-3-3_CanoR_1 140 146 PF00244 0.385
LIG_14-3-3_CanoR_1 261 267 PF00244 0.556
LIG_14-3-3_CanoR_1 394 400 PF00244 0.561
LIG_14-3-3_CanoR_1 438 442 PF00244 0.533
LIG_14-3-3_CanoR_1 44 50 PF00244 0.557
LIG_14-3-3_CanoR_1 534 542 PF00244 0.424
LIG_Actin_RPEL_3 37 56 PF02755 0.388
LIG_Actin_WH2_2 341 359 PF00022 0.549
LIG_Actin_WH2_2 608 626 PF00022 0.462
LIG_APCC_ABBA_1 38 43 PF00400 0.300
LIG_APCC_ABBA_1 626 631 PF00400 0.441
LIG_BRCT_BRCA1_1 601 605 PF00533 0.519
LIG_BRCT_BRCA1_1 675 679 PF00533 0.480
LIG_BRCT_BRCA1_1 705 709 PF00533 0.442
LIG_deltaCOP1_diTrp_1 352 358 PF00928 0.542
LIG_EH1_1 1 9 PF00400 0.411
LIG_EH1_1 275 283 PF00400 0.521
LIG_FHA_1 183 189 PF00498 0.510
LIG_FHA_1 44 50 PF00498 0.378
LIG_FHA_1 509 515 PF00498 0.506
LIG_FHA_1 544 550 PF00498 0.428
LIG_FHA_1 719 725 PF00498 0.269
LIG_FHA_2 120 126 PF00498 0.407
LIG_FHA_2 345 351 PF00498 0.440
LIG_FHA_2 464 470 PF00498 0.444
LIG_FHA_2 61 67 PF00498 0.375
LIG_Integrin_RGD_1 405 407 PF01839 0.524
LIG_LIR_Apic_2 706 712 PF02991 0.360
LIG_LIR_Gen_1 352 360 PF02991 0.536
LIG_LIR_Gen_1 609 619 PF02991 0.436
LIG_LIR_Nem_3 352 358 PF02991 0.542
LIG_LIR_Nem_3 412 418 PF02991 0.327
LIG_LIR_Nem_3 462 467 PF02991 0.322
LIG_LIR_Nem_3 609 615 PF02991 0.428
LIG_LIR_Nem_3 642 647 PF02991 0.416
LIG_LIR_Nem_3 676 682 PF02991 0.312
LIG_Pex14_1 306 310 PF04695 0.387
LIG_Pex14_2 222 226 PF04695 0.440
LIG_SH2_CRK 612 616 PF00017 0.453
LIG_SH2_CRK 644 648 PF00017 0.424
LIG_SH2_STAP1 399 403 PF00017 0.313
LIG_SH2_STAT5 114 117 PF00017 0.521
LIG_SH2_STAT5 418 421 PF00017 0.490
LIG_SH3_3 191 197 PF00018 0.521
LIG_SH3_3 291 297 PF00018 0.509
LIG_SH3_3 487 493 PF00018 0.343
LIG_SH3_3 507 513 PF00018 0.394
LIG_SH3_3 615 621 PF00018 0.453
LIG_SUMO_SIM_anti_2 46 51 PF11976 0.293
LIG_SUMO_SIM_anti_2 517 525 PF11976 0.279
LIG_SUMO_SIM_anti_2 546 554 PF11976 0.439
LIG_SUMO_SIM_par_1 517 525 PF11976 0.400
LIG_TYR_ITSM 640 647 PF00017 0.273
LIG_UBA3_1 55 60 PF00899 0.413
LIG_WRC_WIRS_1 223 228 PF05994 0.509
MOD_CDK_SPK_2 157 162 PF00069 0.354
MOD_CK1_1 195 201 PF00069 0.407
MOD_CK1_1 234 240 PF00069 0.515
MOD_CK1_1 257 263 PF00069 0.586
MOD_CK1_1 265 271 PF00069 0.573
MOD_CK1_1 283 289 PF00069 0.528
MOD_CK1_1 344 350 PF00069 0.540
MOD_CK1_1 606 612 PF00069 0.268
MOD_CK1_1 695 701 PF00069 0.438
MOD_CK1_1 92 98 PF00069 0.537
MOD_CK2_1 119 125 PF00069 0.380
MOD_CK2_1 346 352 PF00069 0.426
MOD_CK2_1 60 66 PF00069 0.511
MOD_Cter_Amidation 664 667 PF01082 0.242
MOD_Cter_Amidation 749 752 PF01082 0.477
MOD_GlcNHglycan 171 175 PF01048 0.524
MOD_GlcNHglycan 199 202 PF01048 0.411
MOD_GlcNHglycan 203 206 PF01048 0.391
MOD_GlcNHglycan 230 234 PF01048 0.523
MOD_GlcNHglycan 361 365 PF01048 0.501
MOD_GlcNHglycan 367 370 PF01048 0.530
MOD_GlcNHglycan 375 378 PF01048 0.403
MOD_GlcNHglycan 400 403 PF01048 0.516
MOD_GlcNHglycan 578 582 PF01048 0.252
MOD_GlcNHglycan 601 604 PF01048 0.242
MOD_GSK3_1 175 182 PF00069 0.460
MOD_GSK3_1 18 25 PF00069 0.419
MOD_GSK3_1 197 204 PF00069 0.398
MOD_GSK3_1 428 435 PF00069 0.506
MOD_GSK3_1 459 466 PF00069 0.334
MOD_GSK3_1 537 544 PF00069 0.303
MOD_GSK3_1 599 606 PF00069 0.266
MOD_GSK3_1 83 90 PF00069 0.566
MOD_GSK3_1 92 99 PF00069 0.541
MOD_NEK2_1 175 180 PF00069 0.423
MOD_NEK2_1 222 227 PF00069 0.522
MOD_NEK2_1 262 267 PF00069 0.458
MOD_NEK2_1 360 365 PF00069 0.530
MOD_NEK2_1 395 400 PF00069 0.348
MOD_NEK2_1 411 416 PF00069 0.485
MOD_NEK2_1 471 476 PF00069 0.381
MOD_NEK2_1 530 535 PF00069 0.256
MOD_NEK2_1 537 542 PF00069 0.226
MOD_NEK2_1 697 702 PF00069 0.254
MOD_NEK2_2 591 596 PF00069 0.242
MOD_PIKK_1 18 24 PF00454 0.358
MOD_PIKK_1 239 245 PF00454 0.447
MOD_PIKK_1 268 274 PF00454 0.455
MOD_PIKK_1 537 543 PF00454 0.242
MOD_PKA_1 128 134 PF00069 0.380
MOD_PKA_2 128 134 PF00069 0.319
MOD_PKA_2 268 274 PF00069 0.562
MOD_PKA_2 43 49 PF00069 0.316
MOD_PKA_2 432 438 PF00069 0.490
MOD_PKB_1 138 146 PF00069 0.352
MOD_Plk_1 283 289 PF00069 0.513
MOD_Plk_1 370 376 PF00069 0.471
MOD_Plk_1 411 417 PF00069 0.482
MOD_Plk_4 341 347 PF00069 0.536
MOD_Plk_4 432 438 PF00069 0.418
MOD_Plk_4 45 51 PF00069 0.509
MOD_Plk_4 459 465 PF00069 0.340
MOD_Plk_4 692 698 PF00069 0.470
MOD_Plk_4 705 711 PF00069 0.272
MOD_ProDKin_1 157 163 PF00069 0.512
MOD_ProDKin_1 212 218 PF00069 0.483
MOD_ProDKin_1 22 28 PF00069 0.472
MOD_ProDKin_1 406 412 PF00069 0.496
MOD_ProDKin_1 60 66 PF00069 0.529
MOD_ProDKin_1 87 93 PF00069 0.642
MOD_SUMO_for_1 115 118 PF00179 0.390
MOD_SUMO_for_1 486 489 PF00179 0.367
MOD_SUMO_rev_2 479 488 PF00179 0.544
MOD_SUMO_rev_2 631 640 PF00179 0.268
TRG_DiLeu_BaLyEn_6 391 396 PF01217 0.366
TRG_DiLeu_BaLyEn_6 446 451 PF01217 0.514
TRG_ENDOCYTIC_2 172 175 PF00928 0.316
TRG_ENDOCYTIC_2 612 615 PF00928 0.242
TRG_ENDOCYTIC_2 644 647 PF00928 0.251
TRG_ER_diArg_1 137 140 PF00400 0.407
TRG_ER_diArg_1 246 249 PF00400 0.470
TRG_ER_diArg_1 328 331 PF00400 0.476
TRG_ER_diArg_1 335 337 PF00400 0.471
TRG_ER_diArg_1 441 443 PF00400 0.419
TRG_ER_diArg_1 670 672 PF00400 0.265
TRG_Pf-PMV_PEXEL_1 140 145 PF00026 0.387
TRG_Pf-PMV_PEXEL_1 17 22 PF00026 0.535
TRG_Pf-PMV_PEXEL_1 388 392 PF00026 0.373
TRG_Pf-PMV_PEXEL_1 452 456 PF00026 0.420
TRG_Pf-PMV_PEXEL_1 465 469 PF00026 0.307

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1F5 Leptomonas seymouri 60% 100%
A0A0S4JPK1 Bodo saltans 37% 100%
A0A1X0NY31 Trypanosomatidae 43% 99%
A0A3Q8IN41 Leishmania donovani 82% 100%
A0A422P4N9 Trypanosoma rangeli 46% 100%
A4IC64 Leishmania infantum 82% 100%
C9ZKA6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 91%
E9AFY4 Leishmania major 83% 100%
E9B737 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
V5B2G2 Trypanosoma cruzi 45% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS