PRORP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNH1_LEIBR

TriTrypDb:

LbrM.34.5030 , LBRM2903_340060800

Length:

581

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	12
GO:0043226	organelle	2	16
GO:0043227	membrane-bounded organelle	3	16
GO:0043229	intracellular organelle	3	16
GO:0043231	intracellular membrane-bounded organelle	4	16
GO:0110165	cellular anatomical entity	1	16

Expansion

Sequence features

A4HNH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNH1

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	16
GO:0006396	RNA processing	6	16
GO:0006399	tRNA metabolic process	7	16
GO:0006725	cellular aromatic compound metabolic process	3	16
GO:0006807	nitrogen compound metabolic process	2	16
GO:0008033	tRNA processing	8	16
GO:0008152	metabolic process	1	16
GO:0009987	cellular process	1	16
GO:0016070	RNA metabolic process	5	16
GO:0034470	ncRNA processing	7	16
GO:0034641	cellular nitrogen compound metabolic process	3	16
GO:0034660	ncRNA metabolic process	6	16
GO:0043170	macromolecule metabolic process	3	16
GO:0044237	cellular metabolic process	2	16
GO:0044238	primary metabolic process	2	16
GO:0046483	heterocycle metabolic process	3	16
GO:0071704	organic substance metabolic process	2	16
GO:0090304	nucleic acid metabolic process	4	16
GO:1901360	organic cyclic compound metabolic process	3	16
GO:0000966	RNA 5'-end processing	7	1
GO:0001682	tRNA 5'-leader removal	9	1
GO:0099116	tRNA 5'-end processing	8	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	16
GO:0016787	hydrolase activity	2	16
GO:0004518	nuclease activity	4	6
GO:0004519	endonuclease activity	5	5
GO:0004521	RNA endonuclease activity	5	5
GO:0004526	ribonuclease P activity	6	5
GO:0004540	RNA nuclease activity	4	5
GO:0004549	tRNA-specific ribonuclease activity	5	5
GO:0016788	hydrolase activity, acting on ester bonds	3	6
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	5
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	5
GO:0140098	catalytic activity, acting on RNA	3	5
GO:0140101	catalytic activity, acting on a tRNA	4	5
GO:0140640	catalytic activity, acting on a nucleic acid	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	347	351	PF00656	0.476
CLV_C14_Caspase3-7	365	369	PF00656	0.494
CLV_C14_Caspase3-7	464	468	PF00656	0.450
CLV_NRD_NRD_1	161	163	PF00675	0.440
CLV_NRD_NRD_1	174	176	PF00675	0.300
CLV_NRD_NRD_1	51	53	PF00675	0.377
CLV_PCSK_KEX2_1	15	17	PF00082	0.677
CLV_PCSK_KEX2_1	161	163	PF00082	0.432
CLV_PCSK_KEX2_1	173	175	PF00082	0.331
CLV_PCSK_KEX2_1	51	53	PF00082	0.396
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.768
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.408
CLV_PCSK_PC7_1	47	53	PF00082	0.513
CLV_PCSK_SKI1_1	12	16	PF00082	0.544
CLV_PCSK_SKI1_1	161	165	PF00082	0.425
CLV_PCSK_SKI1_1	174	178	PF00082	0.272
CLV_PCSK_SKI1_1	213	217	PF00082	0.412
CLV_PCSK_SKI1_1	260	264	PF00082	0.496
CLV_PCSK_SKI1_1	293	297	PF00082	0.489
CLV_PCSK_SKI1_1	303	307	PF00082	0.456
CLV_PCSK_SKI1_1	487	491	PF00082	0.314
CLV_PCSK_SKI1_1	55	59	PF00082	0.466
CLV_Separin_Metazoa	92	96	PF03568	0.518
DEG_APCC_DBOX_1	160	168	PF00400	0.354
DOC_CKS1_1	106	111	PF01111	0.368
DOC_CKS1_1	427	432	PF01111	0.260
DOC_CYCLIN_RxL_1	257	266	PF00134	0.488
DOC_MAPK_DCC_7	386	395	PF00069	0.566
DOC_MAPK_gen_1	173	182	PF00069	0.423
DOC_MAPK_gen_1	411	420	PF00069	0.304
DOC_MAPK_gen_1	506	515	PF00069	0.438
DOC_MAPK_MEF2A_6	140	148	PF00069	0.342
DOC_MAPK_MEF2A_6	509	517	PF00069	0.459
DOC_MAPK_MEF2A_6	75	82	PF00069	0.531
DOC_PP4_FxxP_1	387	390	PF00568	0.591
DOC_SPAK_OSR1_1	386	390	PF12202	0.587
DOC_USP7_MATH_1	118	122	PF00917	0.339
DOC_USP7_MATH_1	149	153	PF00917	0.375
DOC_USP7_MATH_1	188	192	PF00917	0.256
DOC_USP7_MATH_1	366	370	PF00917	0.297
DOC_USP7_MATH_1	94	98	PF00917	0.292
DOC_WW_Pin1_4	1	6	PF00397	0.535
DOC_WW_Pin1_4	105	110	PF00397	0.485
DOC_WW_Pin1_4	265	270	PF00397	0.497
DOC_WW_Pin1_4	286	291	PF00397	0.628
DOC_WW_Pin1_4	426	431	PF00397	0.353
DOC_WW_Pin1_4	445	450	PF00397	0.366
LIG_14-3-3_CanoR_1	236	240	PF00244	0.571
LIG_14-3-3_CanoR_1	495	501	PF00244	0.375
LIG_14-3-3_CanoR_1	509	514	PF00244	0.330
LIG_14-3-3_CanoR_1	519	524	PF00244	0.317
LIG_14-3-3_CterR_2	579	581	PF00244	0.380
LIG_Actin_WH2_2	134	149	PF00022	0.445
LIG_BIR_II_1	1	5	PF00653	0.664
LIG_BIR_III_2	165	169	PF00653	0.481
LIG_BIR_III_2	20	24	PF00653	0.421
LIG_BIR_III_4	63	67	PF00653	0.384
LIG_BRCT_BRCA1_1	190	194	PF00533	0.381
LIG_BRCT_BRCA1_1	383	387	PF00533	0.651
LIG_BRCT_BRCA1_1	447	451	PF00533	0.409
LIG_Clathr_ClatBox_1	37	41	PF01394	0.321
LIG_CtBP_PxDLS_1	22	26	PF00389	0.380
LIG_deltaCOP1_diTrp_1	573	578	PF00928	0.401
LIG_EVH1_1	446	450	PF00568	0.220
LIG_FHA_1	106	112	PF00498	0.571
LIG_FHA_1	200	206	PF00498	0.407
LIG_FHA_1	235	241	PF00498	0.509
LIG_FHA_1	414	420	PF00498	0.350
LIG_FHA_1	570	576	PF00498	0.493
LIG_FHA_2	227	233	PF00498	0.398
LIG_FHA_2	345	351	PF00498	0.405
LIG_FHA_2	462	468	PF00498	0.359
LIG_GBD_Chelix_1	296	304	PF00786	0.385
LIG_LIR_Apic_2	384	390	PF02991	0.595
LIG_LIR_Gen_1	191	200	PF02991	0.552
LIG_LIR_Gen_1	332	340	PF02991	0.405
LIG_LIR_Gen_1	342	352	PF02991	0.381
LIG_LIR_Gen_1	454	463	PF02991	0.315
LIG_LIR_Nem_3	191	197	PF02991	0.473
LIG_LIR_Nem_3	209	215	PF02991	0.396
LIG_LIR_Nem_3	332	336	PF02991	0.436
LIG_LIR_Nem_3	342	348	PF02991	0.431
LIG_LIR_Nem_3	454	459	PF02991	0.361
LIG_LIR_Nem_3	478	484	PF02991	0.355
LIG_LIR_Nem_3	499	503	PF02991	0.352
LIG_MAD2	101	109	PF02301	0.354
LIG_Pex14_1	208	212	PF04695	0.361
LIG_Pex14_1	536	540	PF04695	0.452
LIG_Pex14_2	133	137	PF04695	0.510
LIG_Pex14_2	177	181	PF04695	0.344
LIG_Pex14_2	387	391	PF04695	0.615
LIG_Pex14_2	488	492	PF04695	0.350
LIG_PTB_Apo_2	175	182	PF02174	0.252
LIG_PTB_Apo_2	450	457	PF02174	0.338
LIG_PTB_Apo_2	56	63	PF02174	0.374
LIG_PTB_Phospho_1	450	456	PF10480	0.338
LIG_REV1ctd_RIR_1	486	495	PF16727	0.350
LIG_SH2_CRK	345	349	PF00017	0.397
LIG_SH2_CRK	460	464	PF00017	0.348
LIG_SH2_SRC	363	366	PF00017	0.344
LIG_SH2_STAP1	345	349	PF00017	0.377
LIG_SH2_STAP1	435	439	PF00017	0.293
LIG_SH2_STAP1	521	525	PF00017	0.352
LIG_SH2_STAT5	183	186	PF00017	0.391
LIG_SH2_STAT5	456	459	PF00017	0.336
LIG_SH2_STAT5	480	483	PF00017	0.410
LIG_SH2_STAT5	516	519	PF00017	0.226
LIG_SH2_STAT5	540	543	PF00017	0.459
LIG_SH3_1	16	22	PF00018	0.516
LIG_SH3_3	16	22	PF00018	0.513
LIG_SH3_3	173	179	PF00018	0.458
LIG_SH3_3	386	392	PF00018	0.457
LIG_SH3_3	444	450	PF00018	0.220
LIG_SH3_3	480	486	PF00018	0.505
LIG_SH3_4	306	313	PF00018	0.431
LIG_SUMO_SIM_anti_2	416	421	PF11976	0.220
LIG_SUMO_SIM_anti_2	542	548	PF11976	0.537
LIG_SUMO_SIM_par_1	36	41	PF11976	0.321
LIG_TRFH_1	286	290	PF08558	0.361
LIG_TYR_ITIM	354	359	PF00017	0.378
LIG_WRC_WIRS_1	283	288	PF05994	0.423
MOD_CDC14_SPxK_1	4	7	PF00782	0.533
MOD_CDK_SPxK_1	1	7	PF00069	0.535
MOD_CDK_SPxxK_3	286	293	PF00069	0.361
MOD_CK1_1	268	274	PF00069	0.434
MOD_CK1_1	344	350	PF00069	0.578
MOD_CK1_1	380	386	PF00069	0.625
MOD_CK1_1	97	103	PF00069	0.354
MOD_CK2_1	226	232	PF00069	0.409
MOD_CK2_1	28	34	PF00069	0.395
MOD_CK2_1	310	316	PF00069	0.502
MOD_CK2_1	397	403	PF00069	0.456
MOD_CK2_1	71	77	PF00069	0.529
MOD_Cter_Amidation	412	415	PF01082	0.350
MOD_GlcNHglycan	113	116	PF01048	0.497
MOD_GlcNHglycan	169	172	PF01048	0.571
MOD_GlcNHglycan	24	28	PF01048	0.572
MOD_GlcNHglycan	441	445	PF01048	0.306
MOD_GSK3_1	23	30	PF00069	0.586
MOD_GSK3_1	282	289	PF00069	0.439
MOD_GSK3_1	366	373	PF00069	0.561
MOD_GSK3_1	376	383	PF00069	0.660
MOD_GSK3_1	461	468	PF00069	0.372
MOD_GSK3_1	504	511	PF00069	0.250
MOD_GSK3_1	553	560	PF00069	0.621
MOD_GSK3_1	574	581	PF00069	0.391
MOD_GSK3_1	93	100	PF00069	0.382
MOD_N-GLC_1	124	129	PF02516	0.291
MOD_N-GLC_1	431	436	PF02516	0.360
MOD_N-GLC_1	504	509	PF02516	0.440
MOD_N-GLC_1	551	556	PF02516	0.693
MOD_N-GLC_1	557	562	PF02516	0.691
MOD_NEK2_1	111	116	PF00069	0.507
MOD_NEK2_1	199	204	PF00069	0.387
MOD_NEK2_1	263	268	PF00069	0.560
MOD_NEK2_1	370	375	PF00069	0.500
MOD_PIKK_1	529	535	PF00454	0.491
MOD_PK_1	519	525	PF00069	0.375
MOD_PKA_2	235	241	PF00069	0.292
MOD_PKA_2	496	502	PF00069	0.399
MOD_PKA_2	508	514	PF00069	0.357
MOD_PKA_2	94	100	PF00069	0.342
MOD_PKB_1	438	446	PF00069	0.220
MOD_Plk_1	188	194	PF00069	0.287
MOD_Plk_1	234	240	PF00069	0.443
MOD_Plk_1	27	33	PF00069	0.348
MOD_Plk_1	431	437	PF00069	0.429
MOD_Plk_1	440	446	PF00069	0.326
MOD_Plk_1	551	557	PF00069	0.721
MOD_Plk_2-3	28	34	PF00069	0.484
MOD_Plk_2-3	341	347	PF00069	0.399
MOD_Plk_4	118	124	PF00069	0.476
MOD_Plk_4	150	156	PF00069	0.520
MOD_Plk_4	235	241	PF00069	0.375
MOD_Plk_4	344	350	PF00069	0.434
MOD_Plk_4	358	364	PF00069	0.374
MOD_Plk_4	366	372	PF00069	0.424
MOD_Plk_4	413	419	PF00069	0.355
MOD_Plk_4	519	525	PF00069	0.343
MOD_Plk_4	78	84	PF00069	0.377
MOD_Plk_4	94	100	PF00069	0.298
MOD_ProDKin_1	1	7	PF00069	0.535
MOD_ProDKin_1	105	111	PF00069	0.478
MOD_ProDKin_1	265	271	PF00069	0.497
MOD_ProDKin_1	286	292	PF00069	0.626
MOD_ProDKin_1	426	432	PF00069	0.353
MOD_ProDKin_1	445	451	PF00069	0.366
MOD_SUMO_rev_2	206	215	PF00179	0.403
MOD_SUMO_rev_2	28	38	PF00179	0.363
MOD_SUMO_rev_2	332	339	PF00179	0.440
MOD_SUMO_rev_2	360	369	PF00179	0.445
TRG_DiLeu_BaEn_1	235	240	PF01217	0.385
TRG_DiLeu_BaEn_1	34	39	PF01217	0.539
TRG_ENDOCYTIC_2	212	215	PF00928	0.364
TRG_ENDOCYTIC_2	345	348	PF00928	0.391
TRG_ENDOCYTIC_2	356	359	PF00928	0.384
TRG_ENDOCYTIC_2	456	459	PF00928	0.346
TRG_ENDOCYTIC_2	460	463	PF00928	0.355
TRG_ENDOCYTIC_2	480	483	PF00928	0.410
TRG_ENDOCYTIC_2	500	503	PF00928	0.197
TRG_ER_diArg_1	16	19	PF00400	0.626
TRG_ER_diArg_1	160	162	PF00400	0.435
TRG_ER_diArg_1	174	176	PF00400	0.348
TRG_ER_diArg_1	371	374	PF00400	0.503
TRG_ER_diArg_1	492	495	PF00400	0.326
TRG_NLS_Bipartite_1	161	177	PF00514	0.518
TRG_NLS_MonoCore_2	14	19	PF00514	0.620
TRG_NLS_MonoExtC_3	14	19	PF00514	0.759
TRG_NLS_MonoExtN_4	12	19	PF00514	0.765
TRG_Pf-PMV_PEXEL_1	161	165	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	423	427	PF00026	0.260

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I198	Leptomonas seymouri	65%	98%
A0A0S4JLM5	Bodo saltans	39%	100%
A0A1X0P3X4	Trypanosomatidae	32%	100%
A0A1X0P680	Trypanosomatidae	41%	100%
A0A3Q8IIJ5	Leishmania donovani	80%	99%
A0A3R7LTW4	Trypanosoma rangeli	45%	100%
A0A422MWI6	Trypanosoma rangeli	31%	100%
A4HLQ7	Leishmania braziliensis	30%	82%
A4IC62	Leishmania infantum	81%	99%
C9ZYE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
D0A6B5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AFY2	Leishmania major	82%	100%
E9B735	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	99%
V5B8T9	Trypanosoma cruzi	44%	100%
V5BPA7	Trypanosoma cruzi	29%	100%