HAUS-augmin3 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNH0_LEIBR

TriTrypDb:

LbrM.34.5020 , LBRM2903_340060700

Length:

171

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005930	axoneme	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNH0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	89	93	PF00656	0.330
CLV_NRD_NRD_1	122	124	PF00675	0.426
CLV_PCSK_KEX2_1	126	128	PF00082	0.395
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.409
CLV_PCSK_SKI1_1	130	134	PF00082	0.477
CLV_PCSK_SKI1_1	85	89	PF00082	0.511
DOC_MAPK_gen_1	130	139	PF00069	0.533
DOC_MAPK_gen_1	162	170	PF00069	0.363
DOC_MAPK_MEF2A_6	162	170	PF00069	0.481
DOC_PP4_FxxP_1	4	7	PF00568	0.442
DOC_USP7_UBL2_3	120	124	PF12436	0.462
LIG_14-3-3_CanoR_1	167	171	PF00244	0.502
LIG_14-3-3_CanoR_1	72	78	PF00244	0.500
LIG_14-3-3_CanoR_1	9	14	PF00244	0.545
LIG_Actin_WH2_2	10	28	PF00022	0.544
LIG_BIR_II_1	1	5	PF00653	0.524
LIG_BRCT_BRCA1_1	157	161	PF00533	0.303
LIG_FHA_1	93	99	PF00498	0.527
LIG_FHA_2	22	28	PF00498	0.530
LIG_LIR_Apic_2	2	7	PF02991	0.483
LIG_LIR_Nem_3	83	87	PF02991	0.451
LIG_PDZ_Class_1	166	171	PF00595	0.495
LIG_SH2_CRK	84	88	PF00017	0.550
LIG_SH2_STAP1	31	35	PF00017	0.525
LIG_SH2_STAT3	46	49	PF00017	0.564
LIG_UBA3_1	77	85	PF00899	0.499
MOD_CK1_1	113	119	PF00069	0.641
MOD_CK1_1	12	18	PF00069	0.503
MOD_CK1_1	56	62	PF00069	0.554
MOD_CK1_1	67	73	PF00069	0.509
MOD_CK2_1	21	27	PF00069	0.541
MOD_GSK3_1	151	158	PF00069	0.516
MOD_GSK3_1	56	63	PF00069	0.461
MOD_GSK3_1	64	71	PF00069	0.480
MOD_GSK3_1	8	15	PF00069	0.353
MOD_NEK2_1	107	112	PF00069	0.609
MOD_NEK2_1	77	82	PF00069	0.530
MOD_NEK2_2	118	123	PF00069	0.540
MOD_PIKK_1	110	116	PF00454	0.606
MOD_PIKK_1	151	157	PF00454	0.519
MOD_PIKK_1	71	77	PF00454	0.567
MOD_PIKK_1	93	99	PF00454	0.488
MOD_PK_1	9	15	PF00069	0.610
MOD_PKA_2	67	73	PF00069	0.481
MOD_PKA_2	8	14	PF00069	0.507
MOD_Plk_1	56	62	PF00069	0.530
MOD_Plk_1	99	105	PF00069	0.542
MOD_Plk_4	12	18	PF00069	0.510
MOD_SUMO_rev_2	79	87	PF00179	0.310
TRG_ENDOCYTIC_2	84	87	PF00928	0.514
TRG_NLS_MonoExtC_3	122	127	PF00514	0.558
TRG_NLS_MonoExtN_4	120	127	PF00514	0.526
TRG_Pf-PMV_PEXEL_1	105	109	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	26	30	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.423

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHH3	Leptomonas seymouri	47%	100%
A0A0S4JTH6	Bodo saltans	23%	97%
A0A1X0P528	Trypanosomatidae	30%	100%
A0A422NCM8	Trypanosoma rangeli	25%	100%
C9ZYE2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	20%	100%
E9AFY1	Leishmania major	71%	100%
E9B734	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q25302	Leishmania infantum	70%	100%