bVLRF1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNG8_LEIBR

TriTrypDb:

LbrM.34.5000 , LBRM2903_340060500

Length:

514

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HNG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNG8

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010033	response to organic substance	3	1
GO:0010243	response to organonitrogen compound	4	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0030163	protein catabolic process	4	1
GO:0030433	ubiquitin-dependent ERAD pathway	6	1
GO:0033554	cellular response to stress	3	1
GO:0034976	response to endoplasmic reticulum stress	4	1
GO:0036503	ERAD pathway	5	1
GO:0042221	response to chemical	2	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0050896	response to stimulus	1	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901698	response to nitrogen compound	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	290	294	PF00656	0.656
CLV_C14_Caspase3-7	297	301	PF00656	0.594
CLV_NRD_NRD_1	114	116	PF00675	0.643
CLV_NRD_NRD_1	315	317	PF00675	0.515
CLV_NRD_NRD_1	384	386	PF00675	0.260
CLV_NRD_NRD_1	465	467	PF00675	0.275
CLV_NRD_NRD_1	495	497	PF00675	0.323
CLV_PCSK_FUR_1	138	142	PF00082	0.515
CLV_PCSK_KEX2_1	114	116	PF00082	0.690
CLV_PCSK_KEX2_1	137	139	PF00082	0.655
CLV_PCSK_KEX2_1	140	142	PF00082	0.668
CLV_PCSK_KEX2_1	253	255	PF00082	0.294
CLV_PCSK_KEX2_1	315	317	PF00082	0.515
CLV_PCSK_KEX2_1	495	497	PF00082	0.323
CLV_PCSK_KEX2_1	70	72	PF00082	0.502
CLV_PCSK_PC1ET2_1	137	139	PF00082	0.655
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.668
CLV_PCSK_PC1ET2_1	253	255	PF00082	0.294
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.502
CLV_PCSK_SKI1_1	211	215	PF00082	0.451
CLV_PCSK_SKI1_1	253	257	PF00082	0.301
CLV_PCSK_SKI1_1	346	350	PF00082	0.332
CLV_PCSK_SKI1_1	37	41	PF00082	0.485
CLV_PCSK_SKI1_1	42	46	PF00082	0.525
CLV_PCSK_SKI1_1	422	426	PF00082	0.240
CLV_PCSK_SKI1_1	448	452	PF00082	0.240
CLV_PCSK_SKI1_1	8	12	PF00082	0.474
DEG_APCC_DBOX_1	41	49	PF00400	0.525
DEG_Nend_Nbox_1	1	3	PF02207	0.536
DEG_SPOP_SBC_1	192	196	PF00917	0.553
DOC_CKS1_1	21	26	PF01111	0.569
DOC_MAPK_gen_1	466	474	PF00069	0.557
DOC_MAPK_gen_1	475	484	PF00069	0.508
DOC_MAPK_RevD_3	454	467	PF00069	0.475
DOC_PP2B_LxvP_1	331	334	PF13499	0.550
DOC_USP7_MATH_1	110	114	PF00917	0.736
DOC_USP7_MATH_1	116	120	PF00917	0.780
DOC_USP7_MATH_1	167	171	PF00917	0.601
DOC_USP7_MATH_1	192	196	PF00917	0.350
DOC_USP7_MATH_1	205	209	PF00917	0.326
DOC_USP7_MATH_1	260	264	PF00917	0.563
DOC_USP7_MATH_1	459	463	PF00917	0.503
DOC_USP7_MATH_1	46	50	PF00917	0.530
DOC_USP7_MATH_1	477	481	PF00917	0.546
DOC_USP7_UBL2_3	118	122	PF12436	0.645
DOC_USP7_UBL2_3	136	140	PF12436	0.544
DOC_USP7_UBL2_3	387	391	PF12436	0.440
DOC_WW_Pin1_4	139	144	PF00397	0.596
DOC_WW_Pin1_4	17	22	PF00397	0.534
DOC_WW_Pin1_4	282	287	PF00397	0.657
DOC_WW_Pin1_4	298	303	PF00397	0.573
DOC_WW_Pin1_4	426	431	PF00397	0.382
DOC_WW_Pin1_4	467	472	PF00397	0.465
LIG_14-3-3_CanoR_1	211	220	PF00244	0.538
LIG_14-3-3_CanoR_1	254	261	PF00244	0.307
LIG_14-3-3_CanoR_1	346	355	PF00244	0.294
LIG_14-3-3_CanoR_1	37	45	PF00244	0.454
LIG_14-3-3_CanoR_1	448	458	PF00244	0.440
LIG_14-3-3_CanoR_1	481	491	PF00244	0.494
LIG_Actin_WH2_2	3	20	PF00022	0.289
LIG_BRCT_BRCA1_1	337	341	PF00533	0.534
LIG_BRCT_BRCA1_1	85	89	PF00533	0.671
LIG_FHA_1	171	177	PF00498	0.523
LIG_FHA_1	328	334	PF00498	0.486
LIG_FHA_1	427	433	PF00498	0.376
LIG_FHA_1	9	15	PF00498	0.513
LIG_FHA_2	140	146	PF00498	0.761
LIG_FHA_2	21	27	PF00498	0.508
LIG_FHA_2	238	244	PF00498	0.432
LIG_FHA_2	295	301	PF00498	0.806
LIG_FHA_2	488	494	PF00498	0.471
LIG_LIR_Apic_2	240	244	PF02991	0.314
LIG_LIR_Gen_1	173	181	PF02991	0.430
LIG_LIR_Gen_1	350	357	PF02991	0.346
LIG_LIR_Gen_1	401	409	PF02991	0.534
LIG_LIR_Gen_1	452	461	PF02991	0.472
LIG_LIR_Gen_1	490	498	PF02991	0.453
LIG_LIR_Nem_3	173	178	PF02991	0.435
LIG_LIR_Nem_3	217	223	PF02991	0.385
LIG_LIR_Nem_3	230	235	PF02991	0.357
LIG_LIR_Nem_3	350	356	PF02991	0.363
LIG_LIR_Nem_3	401	405	PF02991	0.441
LIG_LIR_Nem_3	427	431	PF02991	0.471
LIG_LIR_Nem_3	436	440	PF02991	0.458
LIG_LIR_Nem_3	452	457	PF02991	0.377
LIG_LIR_Nem_3	490	494	PF02991	0.453
LIG_PDZ_Class_3	509	514	PF00595	0.320
LIG_Pex14_2	85	89	PF04695	0.671
LIG_SH2_CRK	232	236	PF00017	0.357
LIG_SH2_CRK	402	406	PF00017	0.440
LIG_SH2_CRK	440	444	PF00017	0.535
LIG_SH2_NCK_1	402	406	PF00017	0.535
LIG_SH2_NCK_1	440	444	PF00017	0.535
LIG_SH2_STAT5	362	365	PF00017	0.440
LIG_SH2_STAT5	382	385	PF00017	0.440
LIG_SH2_STAT5	431	434	PF00017	0.440
LIG_SH2_STAT5	508	511	PF00017	0.358
LIG_SH2_STAT5	52	55	PF00017	0.390
LIG_SH3_1	18	24	PF00018	0.356
LIG_SH3_3	18	24	PF00018	0.369
LIG_SUMO_SIM_par_1	235	240	PF11976	0.246
LIG_TRAF2_1	411	414	PF00917	0.535
LIG_TRAF2_1	490	493	PF00917	0.453
LIG_TRAF2_1	90	93	PF00917	0.638
LIG_TRAF2_2	471	476	PF00917	0.492
LIG_TRFH_1	454	458	PF08558	0.409
MOD_CDC14_SPxK_1	285	288	PF00782	0.470
MOD_CDK_SPK_2	17	22	PF00069	0.573
MOD_CDK_SPxK_1	282	288	PF00069	0.469
MOD_CK1_1	170	176	PF00069	0.641
MOD_CK1_1	191	197	PF00069	0.440
MOD_CK1_1	274	280	PF00069	0.721
MOD_CK1_1	320	326	PF00069	0.687
MOD_CK1_1	401	407	PF00069	0.285
MOD_CK1_1	502	508	PF00069	0.338
MOD_CK2_1	1	7	PF00069	0.454
MOD_CK2_1	101	107	PF00069	0.659
MOD_CK2_1	20	26	PF00069	0.388
MOD_CK2_1	237	243	PF00069	0.489
MOD_CK2_1	244	250	PF00069	0.390
MOD_CK2_1	300	306	PF00069	0.749
MOD_CK2_1	487	493	PF00069	0.295
MOD_Cter_Amidation	138	141	PF01082	0.807
MOD_Cter_Amidation	464	467	PF01082	0.324
MOD_GlcNHglycan	103	106	PF01048	0.743
MOD_GlcNHglycan	157	160	PF01048	0.650
MOD_GlcNHglycan	190	193	PF01048	0.445
MOD_GlcNHglycan	195	198	PF01048	0.488
MOD_GlcNHglycan	3	6	PF01048	0.290
MOD_GlcNHglycan	302	305	PF01048	0.595
MOD_GlcNHglycan	319	322	PF01048	0.579
MOD_GlcNHglycan	47	51	PF01048	0.436
MOD_GSK3_1	13	20	PF00069	0.541
MOD_GSK3_1	163	170	PF00069	0.642
MOD_GSK3_1	184	191	PF00069	0.478
MOD_GSK3_1	212	219	PF00069	0.395
MOD_GSK3_1	294	301	PF00069	0.684
MOD_GSK3_1	316	323	PF00069	0.621
MOD_GSK3_1	483	490	PF00069	0.295
MOD_N-GLC_1	205	210	PF02516	0.321
MOD_NEK2_1	1	6	PF00069	0.479
MOD_NEK2_1	148	153	PF00069	0.700
MOD_NEK2_1	193	198	PF00069	0.520
MOD_PIKK_1	254	260	PF00454	0.392
MOD_PIKK_1	404	410	PF00454	0.297
MOD_PKA_1	8	14	PF00069	0.272
MOD_PKA_2	477	483	PF00069	0.432
MOD_PKA_2	487	493	PF00069	0.185
MOD_PKB_1	344	352	PF00069	0.440
MOD_Plk_1	205	211	PF00069	0.320
MOD_Plk_1	216	222	PF00069	0.293
MOD_Plk_1	306	312	PF00069	0.684
MOD_Plk_1	452	458	PF00069	0.330
MOD_Plk_2-3	216	222	PF00069	0.317
MOD_Plk_4	433	439	PF00069	0.356
MOD_Plk_4	502	508	PF00069	0.447
MOD_ProDKin_1	139	145	PF00069	0.595
MOD_ProDKin_1	17	23	PF00069	0.529
MOD_ProDKin_1	282	288	PF00069	0.662
MOD_ProDKin_1	298	304	PF00069	0.573
MOD_ProDKin_1	426	432	PF00069	0.194
MOD_ProDKin_1	467	473	PF00069	0.312
MOD_SUMO_for_1	278	281	PF00179	0.607
MOD_SUMO_rev_2	4	11	PF00179	0.427
TRG_ENDOCYTIC_2	232	235	PF00928	0.382
TRG_ENDOCYTIC_2	402	405	PF00928	0.277
TRG_ER_diArg_1	114	116	PF00400	0.671
TRG_ER_diArg_1	315	317	PF00400	0.515
TRG_ER_diArg_1	494	496	PF00400	0.298
TRG_ER_diArg_1	56	59	PF00400	0.293
TRG_NLS_Bipartite_1	126	141	PF00514	0.776
TRG_NLS_MonoExtC_3	135	140	PF00514	0.589
TRG_NLS_MonoExtN_4	136	141	PF00514	0.754

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGL8	Leptomonas seymouri	59%	99%
A0A1X0P4S2	Trypanosomatidae	39%	100%
A0A3Q8IQ93	Leishmania donovani	73%	100%
A0A3S5IQY8	Trypanosoma rangeli	38%	99%
A4IC59	Leishmania infantum	74%	100%
C9ZYE4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AFX9	Leishmania major	74%	100%
E9B732	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
V5DQH4	Trypanosoma cruzi	41%	100%