Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNG5_LEIBR

TriTrypDb:

LbrM.34.4970 , LBRM2903_340060200

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNG5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	465	469	PF00656	0.359
CLV_NRD_NRD_1	225	227	PF00675	0.434
CLV_NRD_NRD_1	24	26	PF00675	0.528
CLV_NRD_NRD_1	303	305	PF00675	0.423
CLV_NRD_NRD_1	355	357	PF00675	0.409
CLV_NRD_NRD_1	40	42	PF00675	0.424
CLV_NRD_NRD_1	417	419	PF00675	0.603
CLV_NRD_NRD_1	492	494	PF00675	0.592
CLV_PCSK_KEX2_1	225	227	PF00082	0.435
CLV_PCSK_KEX2_1	303	305	PF00082	0.423
CLV_PCSK_KEX2_1	355	357	PF00082	0.409
CLV_PCSK_KEX2_1	40	42	PF00082	0.453
CLV_PCSK_KEX2_1	417	419	PF00082	0.615
CLV_PCSK_KEX2_1	492	494	PF00082	0.592
CLV_PCSK_SKI1_1	298	302	PF00082	0.542
CLV_PCSK_SKI1_1	40	44	PF00082	0.433
DOC_CKS1_1	244	249	PF01111	0.607
DOC_MAPK_gen_1	54	62	PF00069	0.677
DOC_PP1_RVXF_1	288	294	PF00149	0.661
DOC_PP2B_LxvP_1	105	108	PF13499	0.639
DOC_PP2B_LxvP_1	11	14	PF13499	0.649
DOC_PP2B_LxvP_1	165	168	PF13499	0.703
DOC_PP4_FxxP_1	197	200	PF00568	0.619
DOC_USP7_MATH_1	198	202	PF00917	0.763
DOC_USP7_MATH_1	216	220	PF00917	0.738
DOC_USP7_MATH_1	233	237	PF00917	0.604
DOC_USP7_MATH_1	250	254	PF00917	0.741
DOC_USP7_MATH_1	366	370	PF00917	0.570
DOC_USP7_MATH_1	469	473	PF00917	0.354
DOC_USP7_MATH_1	474	478	PF00917	0.340
DOC_USP7_MATH_1	89	93	PF00917	0.760
DOC_USP7_UBL2_3	137	141	PF12436	0.712
DOC_USP7_UBL2_3	142	146	PF12436	0.657
DOC_WW_Pin1_4	126	131	PF00397	0.666
DOC_WW_Pin1_4	243	248	PF00397	0.667
DOC_WW_Pin1_4	315	320	PF00397	0.739
DOC_WW_Pin1_4	80	85	PF00397	0.727
LIG_14-3-3_CanoR_1	118	124	PF00244	0.750
LIG_14-3-3_CanoR_1	193	198	PF00244	0.727
LIG_14-3-3_CanoR_1	49	54	PF00244	0.692
LIG_14-3-3_CanoR_1	95	102	PF00244	0.747
LIG_BIR_II_1	1	5	PF00653	0.600
LIG_BIR_III_2	468	472	PF00653	0.355
LIG_CSL_BTD_1	419	422	PF09270	0.424
LIG_eIF4E_1	159	165	PF01652	0.606
LIG_FHA_1	243	249	PF00498	0.607
LIG_FHA_1	321	327	PF00498	0.672
LIG_FHA_1	406	412	PF00498	0.471
LIG_FHA_1	429	435	PF00498	0.397
LIG_FHA_1	449	455	PF00498	0.513
LIG_FHA_1	462	468	PF00498	0.349
LIG_FHA_2	5	11	PF00498	0.658
LIG_LIR_Apic_2	196	200	PF02991	0.619
LIG_LIR_Gen_1	169	177	PF02991	0.641
LIG_LIR_Gen_1	437	447	PF02991	0.359
LIG_LIR_Nem_3	169	173	PF02991	0.639
LIG_LIR_Nem_3	437	442	PF02991	0.360
LIG_LIR_Nem_3	475	481	PF02991	0.362
LIG_NRBOX	386	392	PF00104	0.315
LIG_Pex14_2	339	343	PF04695	0.580
LIG_SH2_CRK	3	7	PF00017	0.678
LIG_SH2_STAP1	481	485	PF00017	0.363
LIG_SH2_STAT3	214	217	PF00017	0.640
LIG_SH2_STAT5	159	162	PF00017	0.612
LIG_SH2_STAT5	170	173	PF00017	0.597
LIG_SH2_STAT5	67	70	PF00017	0.734
LIG_SH3_2	247	252	PF14604	0.614
LIG_SH3_3	105	111	PF00018	0.700
LIG_SH3_3	244	250	PF00018	0.706
LIG_SH3_3	416	422	PF00018	0.414
LIG_SH3_3	81	87	PF00018	0.631
LIG_SUMO_SIM_par_1	160	169	PF11976	0.608
LIG_SUMO_SIM_par_1	386	393	PF11976	0.233
LIG_TRAF2_1	407	410	PF00917	0.348
LIG_WRC_WIRS_1	170	175	PF05994	0.490
LIG_WRC_WIRS_1	194	199	PF05994	0.516
LIG_WRC_WIRS_1	362	367	PF05994	0.457
LIG_WRC_WIRS_1	391	396	PF05994	0.395
LIG_WW_3	222	226	PF00397	0.503
MOD_CK1_1	100	106	PF00069	0.548
MOD_CK1_1	122	128	PF00069	0.798
MOD_CK1_1	152	158	PF00069	0.521
MOD_CK1_1	181	187	PF00069	0.534
MOD_CK1_1	203	209	PF00069	0.624
MOD_CK1_1	254	260	PF00069	0.594
MOD_CK1_1	315	321	PF00069	0.593
MOD_CK1_1	369	375	PF00069	0.686
MOD_CK1_1	428	434	PF00069	0.514
MOD_CK1_1	48	54	PF00069	0.593
MOD_CK1_1	83	89	PF00069	0.702
MOD_CK2_1	282	288	PF00069	0.406
MOD_CK2_1	4	10	PF00069	0.495
MOD_CK2_1	469	475	PF00069	0.417
MOD_CK2_1	485	491	PF00069	0.455
MOD_CK2_1	58	64	PF00069	0.502
MOD_GlcNHglycan	200	203	PF01048	0.669
MOD_GlcNHglycan	206	209	PF01048	0.633
MOD_GlcNHglycan	260	263	PF01048	0.645
MOD_GlcNHglycan	298	301	PF01048	0.574
MOD_GlcNHglycan	320	323	PF01048	0.671
MOD_GlcNHglycan	344	347	PF01048	0.556
MOD_GlcNHglycan	398	401	PF01048	0.491
MOD_GlcNHglycan	97	100	PF01048	0.625
MOD_GSK3_1	119	126	PF00069	0.769
MOD_GSK3_1	149	156	PF00069	0.551
MOD_GSK3_1	177	184	PF00069	0.577
MOD_GSK3_1	200	207	PF00069	0.547
MOD_GSK3_1	250	257	PF00069	0.507
MOD_GSK3_1	309	316	PF00069	0.592
MOD_GSK3_1	318	325	PF00069	0.691
MOD_GSK3_1	390	397	PF00069	0.454
MOD_GSK3_1	401	408	PF00069	0.303
MOD_GSK3_1	41	48	PF00069	0.564
MOD_GSK3_1	425	432	PF00069	0.440
MOD_GSK3_1	97	104	PF00069	0.558
MOD_N-GLC_1	203	208	PF02516	0.512
MOD_N-GLC_1	254	259	PF02516	0.501
MOD_N-GLC_1	429	434	PF02516	0.403
MOD_N-GLC_2	183	185	PF02516	0.499
MOD_N-GLC_2	295	297	PF02516	0.592
MOD_N-GLC_2	76	78	PF02516	0.570
MOD_NEK2_1	101	106	PF00069	0.552
MOD_NEK2_1	123	128	PF00069	0.615
MOD_NEK2_1	149	154	PF00069	0.548
MOD_NEK2_1	258	263	PF00069	0.518
MOD_NEK2_1	390	395	PF00069	0.395
MOD_NEK2_1	43	48	PF00069	0.544
MOD_NEK2_1	449	454	PF00069	0.454
MOD_NEK2_2	119	124	PF00069	0.537
MOD_NEK2_2	322	327	PF00069	0.537
MOD_NEK2_2	330	335	PF00069	0.494
MOD_NEK2_2	347	352	PF00069	0.430
MOD_PIKK_1	369	375	PF00454	0.528
MOD_PIKK_1	41	47	PF00454	0.629
MOD_PIKK_1	449	455	PF00454	0.387
MOD_PIKK_1	469	475	PF00454	0.497
MOD_PK_1	49	55	PF00069	0.534
MOD_PK_1	58	64	PF00069	0.480
MOD_PKA_2	119	125	PF00069	0.647
MOD_PKA_2	251	257	PF00069	0.503
MOD_PKA_2	354	360	PF00069	0.482
MOD_PKA_2	425	431	PF00069	0.439
MOD_PKA_2	48	54	PF00069	0.607
MOD_PKB_1	191	199	PF00069	0.515
MOD_PKB_1	263	271	PF00069	0.439
MOD_PKB_1	294	302	PF00069	0.591
MOD_PKB_1	56	64	PF00069	0.671
MOD_PKB_1	95	103	PF00069	0.542
MOD_Plk_1	160	166	PF00069	0.642
MOD_Plk_1	254	260	PF00069	0.498
MOD_Plk_1	429	435	PF00069	0.392
MOD_Plk_1	474	480	PF00069	0.483
MOD_Plk_1	58	64	PF00069	0.640
MOD_Plk_2-3	157	163	PF00069	0.511
MOD_Plk_4	12	18	PF00069	0.481
MOD_Plk_4	160	166	PF00069	0.667
MOD_Plk_4	234	240	PF00069	0.521
MOD_Plk_4	254	260	PF00069	0.644
MOD_Plk_4	366	372	PF00069	0.589
MOD_Plk_4	390	396	PF00069	0.384
MOD_Plk_4	429	435	PF00069	0.392
MOD_Plk_4	97	103	PF00069	0.542
MOD_ProDKin_1	126	132	PF00069	0.576
MOD_ProDKin_1	243	249	PF00069	0.583
MOD_ProDKin_1	315	321	PF00069	0.683
MOD_ProDKin_1	80	86	PF00069	0.665
MOD_SUMO_rev_2	138	148	PF00179	0.626
MOD_SUMO_rev_2	285	291	PF00179	0.561
TRG_AP2beta_CARGO_1	437	446	PF09066	0.403
TRG_DiLeu_BaEn_1	383	388	PF01217	0.529
TRG_DiLeu_BaLyEn_6	225	230	PF01217	0.582
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.537
TRG_ENDOCYTIC_2	170	173	PF00928	0.504
TRG_ENDOCYTIC_2	3	6	PF00928	0.599
TRG_ENDOCYTIC_2	483	486	PF00928	0.467
TRG_ER_diArg_1	117	120	PF00400	0.637
TRG_ER_diArg_1	191	194	PF00400	0.519
TRG_ER_diArg_1	224	226	PF00400	0.593
TRG_ER_diArg_1	293	296	PF00400	0.645
TRG_ER_diArg_1	302	304	PF00400	0.572
TRG_ER_diArg_1	416	418	PF00400	0.504
TRG_ER_diArg_1	492	494	PF00400	0.475
TRG_ER_diArg_1	53	56	PF00400	0.723
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.688

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3L4	Leptomonas seymouri	30%	85%
A0A3S7XA13	Leishmania donovani	58%	93%
A4IC56	Leishmania infantum	58%	93%
E9AFX6	Leishmania major	56%	100%
E9B729	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	93%