HECT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNG4_LEIBR

TriTrypDb:

LbrM.34.4960 , LBRM2903_340060100

Length:

903

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNG4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	108	112	PF00656	0.639
CLV_C14_Caspase3-7	155	159	PF00656	0.498
CLV_C14_Caspase3-7	292	296	PF00656	0.582
CLV_C14_Caspase3-7	612	616	PF00656	0.530
CLV_C14_Caspase3-7	676	680	PF00656	0.397
CLV_NRD_NRD_1	148	150	PF00675	0.442
CLV_NRD_NRD_1	369	371	PF00675	0.587
CLV_NRD_NRD_1	384	386	PF00675	0.319
CLV_NRD_NRD_1	69	71	PF00675	0.461
CLV_NRD_NRD_1	75	77	PF00675	0.406
CLV_NRD_NRD_1	750	752	PF00675	0.389
CLV_PCSK_FUR_1	382	386	PF00082	0.492
CLV_PCSK_FUR_1	73	77	PF00082	0.426
CLV_PCSK_KEX2_1	369	371	PF00082	0.587
CLV_PCSK_KEX2_1	384	386	PF00082	0.425
CLV_PCSK_KEX2_1	73	75	PF00082	0.428
CLV_PCSK_KEX2_1	750	752	PF00082	0.389
CLV_PCSK_PC7_1	70	76	PF00082	0.435
CLV_PCSK_SKI1_1	300	304	PF00082	0.510
CLV_PCSK_SKI1_1	369	373	PF00082	0.462
CLV_PCSK_SKI1_1	384	388	PF00082	0.322
CLV_PCSK_SKI1_1	480	484	PF00082	0.572
CLV_PCSK_SKI1_1	510	514	PF00082	0.542
CLV_PCSK_SKI1_1	518	522	PF00082	0.519
CLV_PCSK_SKI1_1	580	584	PF00082	0.412
CLV_PCSK_SKI1_1	605	609	PF00082	0.322
CLV_PCSK_SKI1_1	843	847	PF00082	0.526
CLV_PCSK_SKI1_1	89	93	PF00082	0.520
CLV_Separin_Metazoa	287	291	PF03568	0.515
DEG_SPOP_SBC_1	181	185	PF00917	0.351
DEG_SPOP_SBC_1	229	233	PF00917	0.557
DEG_SPOP_SBC_1	238	242	PF00917	0.643
DOC_CDC14_PxL_1	254	262	PF14671	0.518
DOC_CDC14_PxL_1	704	712	PF14671	0.499
DOC_CKS1_1	755	760	PF01111	0.541
DOC_CYCLIN_RxL_1	492	502	PF00134	0.406
DOC_CYCLIN_RxL_1	623	634	PF00134	0.336
DOC_MAPK_gen_1	262	269	PF00069	0.497
DOC_MAPK_gen_1	660	667	PF00069	0.502
DOC_MAPK_gen_1	70	81	PF00069	0.413
DOC_MAPK_MEF2A_6	518	527	PF00069	0.304
DOC_MAPK_MEF2A_6	558	567	PF00069	0.461
DOC_MAPK_MEF2A_6	691	698	PF00069	0.546
DOC_MAPK_NFAT4_5	691	699	PF00069	0.543
DOC_PP1_RVXF_1	624	631	PF00149	0.379
DOC_PP1_RVXF_1	87	94	PF00149	0.423
DOC_USP7_MATH_1	121	125	PF00917	0.701
DOC_USP7_MATH_1	142	146	PF00917	0.300
DOC_USP7_MATH_1	180	184	PF00917	0.391
DOC_USP7_MATH_1	227	231	PF00917	0.516
DOC_USP7_MATH_1	238	242	PF00917	0.656
DOC_USP7_MATH_1	677	681	PF00917	0.574
DOC_USP7_MATH_1	734	738	PF00917	0.421
DOC_USP7_UBL2_3	506	510	PF12436	0.379
DOC_WW_Pin1_4	115	120	PF00397	0.548
DOC_WW_Pin1_4	354	359	PF00397	0.622
DOC_WW_Pin1_4	390	395	PF00397	0.518
DOC_WW_Pin1_4	550	555	PF00397	0.513
DOC_WW_Pin1_4	643	648	PF00397	0.553
DOC_WW_Pin1_4	696	701	PF00397	0.587
DOC_WW_Pin1_4	708	713	PF00397	0.709
DOC_WW_Pin1_4	732	737	PF00397	0.502
DOC_WW_Pin1_4	754	759	PF00397	0.509
DOC_WW_Pin1_4	855	860	PF00397	0.719
LIG_14-3-3_CanoR_1	209	214	PF00244	0.444
LIG_14-3-3_CanoR_1	362	372	PF00244	0.623
LIG_14-3-3_CanoR_1	439	448	PF00244	0.448
LIG_14-3-3_CanoR_1	518	527	PF00244	0.478
LIG_14-3-3_CanoR_1	580	589	PF00244	0.452
LIG_14-3-3_CanoR_1	629	636	PF00244	0.464
LIG_14-3-3_CanoR_1	750	756	PF00244	0.540
LIG_14-3-3_CanoR_1	777	786	PF00244	0.550
LIG_14-3-3_CanoR_1	843	852	PF00244	0.471
LIG_Actin_WH2_2	164	181	PF00022	0.303
LIG_Actin_WH2_2	276	292	PF00022	0.343
LIG_Actin_WH2_2	420	438	PF00022	0.515
LIG_Actin_WH2_2	560	578	PF00022	0.302
LIG_Actin_WH2_2	614	631	PF00022	0.312
LIG_BRCT_BRCA1_1	182	186	PF00533	0.342
LIG_BRCT_BRCA1_1	224	228	PF00533	0.429
LIG_CtBP_PxDLS_1	164	168	PF00389	0.516
LIG_DLG_GKlike_1	209	216	PF00625	0.489
LIG_FHA_1	374	380	PF00498	0.553
LIG_FHA_1	492	498	PF00498	0.466
LIG_FHA_1	524	530	PF00498	0.522
LIG_FHA_1	581	587	PF00498	0.461
LIG_FHA_1	638	644	PF00498	0.544
LIG_FHA_1	699	705	PF00498	0.446
LIG_FHA_1	733	739	PF00498	0.450
LIG_FHA_1	755	761	PF00498	0.487
LIG_FHA_2	13	19	PF00498	0.641
LIG_FHA_2	136	142	PF00498	0.510
LIG_FHA_2	232	238	PF00498	0.675
LIG_FHA_2	445	451	PF00498	0.508
LIG_FHA_2	487	493	PF00498	0.454
LIG_FHA_2	572	578	PF00498	0.550
LIG_FHA_2	606	612	PF00498	0.480
LIG_FHA_2	615	621	PF00498	0.559
LIG_FHA_2	674	680	PF00498	0.485
LIG_FHA_2	687	693	PF00498	0.552
LIG_FHA_2	870	876	PF00498	0.389
LIG_Integrin_RGD_1	795	797	PF01839	0.431
LIG_LIR_Gen_1	41	50	PF02991	0.458
LIG_LIR_Gen_1	514	523	PF02991	0.417
LIG_LIR_Gen_1	53	63	PF02991	0.569
LIG_LIR_Gen_1	631	639	PF02991	0.481
LIG_LIR_Gen_1	64	69	PF02991	0.440
LIG_LIR_Nem_3	161	165	PF02991	0.462
LIG_LIR_Nem_3	514	519	PF02991	0.455
LIG_LIR_Nem_3	53	59	PF02991	0.573
LIG_LIR_Nem_3	555	560	PF02991	0.466
LIG_LIR_Nem_3	631	636	PF02991	0.449
LIG_LIR_Nem_3	64	68	PF02991	0.426
LIG_LIR_Nem_3	776	782	PF02991	0.506
LIG_MYND_1	708	712	PF01753	0.504
LIG_MYND_3	803	807	PF01753	0.423
LIG_NRBOX	447	453	PF00104	0.414
LIG_Pex14_1	778	782	PF04695	0.501
LIG_SH2_CRK	516	520	PF00017	0.433
LIG_SH2_CRK	663	667	PF00017	0.383
LIG_SH2_SRC	85	88	PF00017	0.544
LIG_SH2_STAP1	516	520	PF00017	0.569
LIG_SH2_STAP1	633	637	PF00017	0.537
LIG_SH2_STAP1	663	667	PF00017	0.383
LIG_SH2_STAP1	782	786	PF00017	0.462
LIG_SH2_STAT5	42	45	PF00017	0.404
LIG_SH2_STAT5	552	555	PF00017	0.541
LIG_SH2_STAT5	785	788	PF00017	0.505
LIG_SH2_STAT5	818	821	PF00017	0.518
LIG_SH2_STAT5	884	887	PF00017	0.432
LIG_SH3_3	123	129	PF00018	0.658
LIG_SH3_3	531	537	PF00018	0.580
LIG_SH3_3	585	591	PF00018	0.559
LIG_SH3_3	697	703	PF00018	0.653
LIG_SUMO_SIM_anti_2	393	399	PF11976	0.363
LIG_SUMO_SIM_anti_2	619	626	PF11976	0.490
LIG_SUMO_SIM_par_1	163	168	PF11976	0.520
LIG_SUMO_SIM_par_1	393	399	PF11976	0.363
LIG_SUMO_SIM_par_1	406	412	PF11976	0.302
LIG_SUMO_SIM_par_1	539	545	PF11976	0.394
LIG_SUMO_SIM_par_1	783	791	PF11976	0.315
LIG_SxIP_EBH_1	250	264	PF03271	0.551
LIG_TRAF2_1	719	722	PF00917	0.505
LIG_TYR_ITIM	661	666	PF00017	0.491
LIG_UBA3_1	473	480	PF00899	0.350
LIG_UBA3_1	499	506	PF00899	0.471
LIG_WRC_WIRS_1	410	415	PF05994	0.374
LIG_WRC_WIRS_1	633	638	PF05994	0.499
LIG_WRC_WIRS_1	860	865	PF05994	0.621
MOD_CDK_SPK_2	754	759	PF00069	0.346
MOD_CK1_1	105	111	PF00069	0.651
MOD_CK1_1	230	236	PF00069	0.637
MOD_CK1_1	241	247	PF00069	0.550
MOD_CK1_1	314	320	PF00069	0.566
MOD_CK1_1	393	399	PF00069	0.483
MOD_CK1_1	442	448	PF00069	0.514
MOD_CK1_1	486	492	PF00069	0.503
MOD_CK1_1	614	620	PF00069	0.586
MOD_CK1_1	631	637	PF00069	0.491
MOD_CK1_1	651	657	PF00069	0.293
MOD_CK1_1	754	760	PF00069	0.460
MOD_CK1_1	780	786	PF00069	0.506
MOD_CK1_1	897	903	PF00069	0.719
MOD_CK2_1	12	18	PF00069	0.535
MOD_CK2_1	135	141	PF00069	0.440
MOD_CK2_1	444	450	PF00069	0.488
MOD_CK2_1	571	577	PF00069	0.420
MOD_CK2_1	675	681	PF00069	0.509
MOD_CK2_1	686	692	PF00069	0.553
MOD_CK2_1	760	766	PF00069	0.463
MOD_CK2_1	870	876	PF00069	0.574
MOD_Cter_Amidation	367	370	PF01082	0.606
MOD_GlcNHglycan	241	244	PF01048	0.658
MOD_GlcNHglycan	398	401	PF01048	0.564
MOD_GlcNHglycan	456	459	PF01048	0.517
MOD_GlcNHglycan	46	50	PF01048	0.530
MOD_GlcNHglycan	463	466	PF01048	0.611
MOD_GlcNHglycan	779	782	PF01048	0.541
MOD_GlcNHglycan	830	833	PF01048	0.477
MOD_GlcNHglycan	846	849	PF01048	0.483
MOD_GlcNHglycan	891	894	PF01048	0.523
MOD_GlcNHglycan	899	902	PF01048	0.703
MOD_GSK3_1	105	112	PF00069	0.758
MOD_GSK3_1	196	203	PF00069	0.585
MOD_GSK3_1	227	234	PF00069	0.522
MOD_GSK3_1	237	244	PF00069	0.525
MOD_GSK3_1	439	446	PF00069	0.574
MOD_GSK3_1	450	457	PF00069	0.429
MOD_GSK3_1	50	57	PF00069	0.586
MOD_GSK3_1	521	528	PF00069	0.503
MOD_GSK3_1	571	578	PF00069	0.368
MOD_GSK3_1	628	635	PF00069	0.496
MOD_GSK3_1	637	644	PF00069	0.450
MOD_GSK3_1	651	658	PF00069	0.352
MOD_GSK3_1	673	680	PF00069	0.637
MOD_GSK3_1	698	705	PF00069	0.656
MOD_GSK3_1	773	780	PF00069	0.483
MOD_GSK3_1	855	862	PF00069	0.615
MOD_LATS_1	437	443	PF00433	0.352
MOD_N-GLC_1	102	107	PF02516	0.527
MOD_N-GLC_1	390	395	PF02516	0.406
MOD_N-GLC_1	592	597	PF02516	0.483
MOD_NEK2_1	228	233	PF00069	0.506
MOD_NEK2_1	289	294	PF00069	0.317
MOD_NEK2_1	348	353	PF00069	0.420
MOD_NEK2_1	378	383	PF00069	0.387
MOD_NEK2_1	44	49	PF00069	0.441
MOD_NEK2_1	440	445	PF00069	0.471
MOD_NEK2_1	483	488	PF00069	0.549
MOD_NEK2_1	50	55	PF00069	0.474
MOD_NEK2_1	523	528	PF00069	0.501
MOD_NEK2_1	569	574	PF00069	0.386
MOD_NEK2_1	575	580	PF00069	0.353
MOD_NEK2_1	628	633	PF00069	0.493
MOD_NEK2_1	648	653	PF00069	0.292
MOD_NEK2_1	686	691	PF00069	0.395
MOD_NEK2_1	760	765	PF00069	0.447
MOD_NEK2_2	571	576	PF00069	0.316
MOD_NEK2_2	637	642	PF00069	0.363
MOD_PIKK_1	373	379	PF00454	0.293
MOD_PIKK_1	592	598	PF00454	0.462
MOD_PKA_2	289	295	PF00069	0.532
MOD_PKA_2	575	581	PF00069	0.489
MOD_PKA_2	628	634	PF00069	0.500
MOD_PKA_2	69	75	PF00069	0.575
MOD_PKA_2	869	875	PF00069	0.596
MOD_Plk_1	102	108	PF00069	0.762
MOD_Plk_1	614	620	PF00069	0.484
MOD_Plk_1	649	655	PF00069	0.376
MOD_Plk_2-3	135	141	PF00069	0.486
MOD_Plk_2-3	409	415	PF00069	0.517
MOD_Plk_2-3	675	681	PF00069	0.398
MOD_Plk_4	135	141	PF00069	0.486
MOD_Plk_4	182	188	PF00069	0.505
MOD_Plk_4	311	317	PF00069	0.504
MOD_Plk_4	393	399	PF00069	0.569
MOD_Plk_4	50	56	PF00069	0.580
MOD_Plk_4	734	740	PF00069	0.475
MOD_Plk_4	822	828	PF00069	0.475
MOD_ProDKin_1	115	121	PF00069	0.546
MOD_ProDKin_1	354	360	PF00069	0.624
MOD_ProDKin_1	390	396	PF00069	0.506
MOD_ProDKin_1	550	556	PF00069	0.509
MOD_ProDKin_1	643	649	PF00069	0.550
MOD_ProDKin_1	696	702	PF00069	0.596
MOD_ProDKin_1	708	714	PF00069	0.704
MOD_ProDKin_1	732	738	PF00069	0.502
MOD_ProDKin_1	754	760	PF00069	0.505
MOD_ProDKin_1	855	861	PF00069	0.712
MOD_SUMO_rev_2	64	72	PF00179	0.566
TRG_DiLeu_BaLyEn_6	206	211	PF01217	0.297
TRG_DiLeu_BaLyEn_6	382	387	PF01217	0.494
TRG_DiLeu_BaLyEn_6	495	500	PF01217	0.432
TRG_DiLeu_BaLyEn_6	515	520	PF01217	0.536
TRG_DiLeu_BaLyEn_6	801	806	PF01217	0.568
TRG_DiLeu_BaLyEn_6	877	882	PF01217	0.566
TRG_ENDOCYTIC_2	42	45	PF00928	0.404
TRG_ENDOCYTIC_2	516	519	PF00928	0.597
TRG_ENDOCYTIC_2	557	560	PF00928	0.507
TRG_ENDOCYTIC_2	56	59	PF00928	0.466
TRG_ENDOCYTIC_2	633	636	PF00928	0.402
TRG_ENDOCYTIC_2	65	68	PF00928	0.540
TRG_ENDOCYTIC_2	663	666	PF00928	0.384
TRG_ENDOCYTIC_2	85	88	PF00928	0.215
TRG_ER_diArg_1	369	371	PF00400	0.587
TRG_ER_diArg_1	382	385	PF00400	0.337
TRG_ER_diArg_1	660	663	PF00400	0.416
TRG_ER_diArg_1	73	76	PF00400	0.439
TRG_ER_diArg_1	749	751	PF00400	0.425
TRG_ER_diArg_1	81	84	PF00400	0.425
TRG_NLS_MonoExtC_3	148	153	PF00514	0.547
TRG_Pf-PMV_PEXEL_1	384	388	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	815	820	PF00026	0.423
TRG_Pf-PMV_PEXEL_1	866	871	PF00026	0.653

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJ19	Leptomonas seymouri	53%	86%
A0A1X0P5W4	Trypanosomatidae	33%	91%
A0A3Q8IJL5	Leishmania donovani	77%	100%
A0A3R7KBK5	Trypanosoma rangeli	32%	97%
A4IC55	Leishmania infantum	77%	100%
C9ZYE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	93%
E9AFX5	Leishmania major	77%	99%
E9B728	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%