PSP1 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PSP1 C-terminal conserved region, putative

Species:

Leishmania braziliensis

UniProt:

A4HNG2_LEIBR

TriTrypDb:

LbrM.34.4940 , LBRM2903_340059900

Length:

279

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNG2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.531
CLV_NRD_NRD_1	153	155	PF00675	0.358
CLV_NRD_NRD_1	165	167	PF00675	0.290
CLV_NRD_NRD_1	217	219	PF00675	0.304
CLV_NRD_NRD_1	252	254	PF00675	0.571
CLV_NRD_NRD_1	256	258	PF00675	0.562
CLV_PCSK_KEX2_1	153	155	PF00082	0.358
CLV_PCSK_KEX2_1	165	167	PF00082	0.329
CLV_PCSK_KEX2_1	217	219	PF00082	0.296
CLV_PCSK_KEX2_1	252	254	PF00082	0.571
CLV_PCSK_KEX2_1	256	258	PF00082	0.552
CLV_PCSK_PC7_1	252	258	PF00082	0.680
CLV_PCSK_SKI1_1	153	157	PF00082	0.249
CLV_PCSK_SKI1_1	166	170	PF00082	0.185
CLV_PCSK_SKI1_1	200	204	PF00082	0.321
CLV_PCSK_SKI1_1	221	225	PF00082	0.296
CLV_PCSK_SKI1_1	267	271	PF00082	0.535
CLV_PCSK_SKI1_1	62	66	PF00082	0.743
DOC_CKS1_1	29	34	PF01111	0.687
DOC_CYCLIN_RxL_1	217	225	PF00134	0.410
DOC_CYCLIN_RxL_1	264	274	PF00134	0.429
DOC_CYCLIN_yCln2_LP_2	29	35	PF00134	0.703
DOC_MAPK_gen_1	12	19	PF00069	0.633
DOC_MAPK_gen_1	200	206	PF00069	0.288
DOC_MAPK_gen_1	208	216	PF00069	0.272
DOC_PP1_RVXF_1	228	234	PF00149	0.397
DOC_PP4_FxxP_1	86	89	PF00568	0.424
DOC_USP7_MATH_1	3	7	PF00917	0.649
DOC_USP7_MATH_1	51	55	PF00917	0.748
DOC_USP7_MATH_1	60	64	PF00917	0.612
DOC_USP7_MATH_1	68	72	PF00917	0.652
DOC_USP7_MATH_1	82	86	PF00917	0.658
DOC_USP7_UBL2_3	105	109	PF12436	0.406
DOC_USP7_UBL2_3	14	18	PF12436	0.656
DOC_WW_Pin1_4	139	144	PF00397	0.548
DOC_WW_Pin1_4	28	33	PF00397	0.657
DOC_WW_Pin1_4	44	49	PF00397	0.629
DOC_WW_Pin1_4	56	61	PF00397	0.649
DOC_WW_Pin1_4	87	92	PF00397	0.535
DOC_WW_Pin1_4	95	100	PF00397	0.397
LIG_14-3-3_CanoR_1	208	214	PF00244	0.339
LIG_14-3-3_CanoR_1	256	264	PF00244	0.535
LIG_Actin_WH2_2	236	254	PF00022	0.477
LIG_BIR_II_1	1	5	PF00653	0.558
LIG_BRCT_BRCA1_1	209	213	PF00533	0.430
LIG_FHA_1	112	118	PF00498	0.334
LIG_FHA_1	139	145	PF00498	0.561
LIG_FHA_1	201	207	PF00498	0.290
LIG_FHA_1	246	252	PF00498	0.621
LIG_FHA_2	154	160	PF00498	0.298
LIG_FHA_2	186	192	PF00498	0.289
LIG_FHA_2	210	216	PF00498	0.291
LIG_LIR_Apic_2	83	89	PF02991	0.417
LIG_LIR_Gen_1	210	219	PF02991	0.317
LIG_LIR_Gen_1	98	106	PF02991	0.428
LIG_LIR_Nem_3	210	216	PF02991	0.326
LIG_LIR_Nem_3	79	84	PF02991	0.638
LIG_LIR_Nem_3	98	104	PF02991	0.397
LIG_LYPXL_yS_3	81	84	PF13949	0.405
LIG_PALB2_WD40_1	228	236	PF16756	0.356
LIG_PCNA_yPIPBox_3	109	123	PF02747	0.355
LIG_PCNA_yPIPBox_3	217	227	PF02747	0.410
LIG_PDZ_Class_2	274	279	PF00595	0.422
LIG_Pex14_2	111	115	PF04695	0.371
LIG_PTAP_UEV_1	69	74	PF05743	0.458
LIG_SH2_STAP1	25	29	PF00017	0.572
LIG_SH2_STAT5	235	238	PF00017	0.353
LIG_SH3_3	181	187	PF00018	0.296
LIG_SH3_3	244	250	PF00018	0.654
LIG_SH3_3	29	35	PF00018	0.574
LIG_SH3_3	45	51	PF00018	0.533
LIG_SH3_3	67	73	PF00018	0.579
LIG_SUMO_SIM_par_1	121	126	PF11976	0.449
LIG_SUMO_SIM_par_1	202	207	PF11976	0.397
LIG_UBA3_1	194	201	PF00899	0.358
LIG_WRC_WIRS_1	112	117	PF05994	0.248
MOD_CDC14_SPxK_1	59	62	PF00782	0.672
MOD_CDK_SPK_2	44	49	PF00069	0.678
MOD_CDK_SPxK_1	56	62	PF00069	0.679
MOD_CK1_1	2	8	PF00069	0.645
MOD_CK1_1	207	213	PF00069	0.380
MOD_CK1_1	28	34	PF00069	0.635
MOD_CK1_1	47	53	PF00069	0.485
MOD_CK1_1	54	60	PF00069	0.620
MOD_CK2_1	115	121	PF00069	0.265
MOD_CK2_1	185	191	PF00069	0.289
MOD_CK2_1	257	263	PF00069	0.670
MOD_CK2_1	31	37	PF00069	0.728
MOD_CK2_1	60	66	PF00069	0.583
MOD_Cter_Amidation	106	109	PF01082	0.492
MOD_Cter_Amidation	198	201	PF01082	0.345
MOD_GlcNHglycan	1	4	PF01048	0.714
MOD_GlcNHglycan	70	73	PF01048	0.632
MOD_GSK3_1	111	118	PF00069	0.463
MOD_GSK3_1	138	145	PF00069	0.447
MOD_GSK3_1	153	160	PF00069	0.424
MOD_GSK3_1	200	207	PF00069	0.298
MOD_GSK3_1	241	248	PF00069	0.513
MOD_GSK3_1	269	276	PF00069	0.526
MOD_GSK3_1	47	54	PF00069	0.633
MOD_GSK3_1	56	63	PF00069	0.606
MOD_GSK3_1	76	83	PF00069	0.453
MOD_GSK3_1	8	15	PF00069	0.595
MOD_NEK2_1	111	116	PF00069	0.279
MOD_NEK2_1	269	274	PF00069	0.440
MOD_NEK2_2	173	178	PF00069	0.445
MOD_PIKK_1	3	9	PF00454	0.547
MOD_PKA_1	153	159	PF00069	0.410
MOD_PKA_1	200	206	PF00069	0.339
MOD_PKA_2	153	159	PF00069	0.410
MOD_PKA_2	207	213	PF00069	0.299
MOD_Plk_4	25	31	PF00069	0.613
MOD_Plk_4	76	82	PF00069	0.405
MOD_ProDKin_1	139	145	PF00069	0.553
MOD_ProDKin_1	28	34	PF00069	0.654
MOD_ProDKin_1	44	50	PF00069	0.628
MOD_ProDKin_1	56	62	PF00069	0.650
MOD_ProDKin_1	87	93	PF00069	0.521
MOD_ProDKin_1	95	101	PF00069	0.392
MOD_SUMO_rev_2	192	202	PF00179	0.372
TRG_ENDOCYTIC_2	81	84	PF00928	0.408
TRG_ER_diArg_1	152	154	PF00400	0.360
TRG_ER_diArg_1	216	218	PF00400	0.302
TRG_ER_diArg_1	227	230	PF00400	0.451
TRG_ER_diArg_1	251	253	PF00400	0.643
TRG_Pf-PMV_PEXEL_1	221	225	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	62	66	PF00026	0.612

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYT9	Leptomonas seymouri	27%	73%
A0A0N1PC14	Leptomonas seymouri	62%	96%
A0A1X0P536	Trypanosomatidae	43%	100%
A0A3Q8I8Y8	Leishmania donovani	27%	96%
A0A3Q8IJZ1	Leishmania donovani	82%	100%
A0A3R7NIU7	Trypanosoma rangeli	41%	100%
A4HMC6	Leishmania braziliensis	23%	68%
A4HUS6	Leishmania infantum	27%	96%
A4IC69	Leishmania infantum	82%	100%
C9ZYF4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D0A3S8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AFX3	Leishmania major	82%	100%
E9B726	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%