LeishMANIAdb
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Inositol phosphorylceramide synthase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Inositol phosphorylceramide synthase
Gene product:
sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional
Species:
Leishmania braziliensis
UniProt:
A4HNG1_LEIBR
TriTrypDb:
LbrM.34.4930 , LBRM2903_340059800 *
Length:
385

Annotations

LeishMANIAdb annotations

Publication identifier(s): 20457606
Bidirectional lipid inositolphosphotransferase (experimentally validated). Homologous to animal phosphatidylcholine:ceramide cholinephosphotransferases. Expanded on the Trypanosoma lineage.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 15
NetGPI no yes: 0, no: 15
Cellular components
Term Name Level Count
GO:0016020 membrane 2 16
GO:0110165 cellular anatomical entity 1 16
GO:0005768 endosome 7 1
GO:0005794 Golgi apparatus 5 1
GO:0005886 plasma membrane 3 1
GO:0020016 ciliary pocket 2 1
GO:0031410 cytoplasmic vesicle 6 1
GO:0031982 vesicle 4 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0097708 intracellular vesicle 5 1

Expansion

Sequence features

A4HNG1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNG1

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 16
GO:0006643 membrane lipid metabolic process 4 16
GO:0006665 sphingolipid metabolic process 4 16
GO:0006793 phosphorus metabolic process 3 16
GO:0006796 phosphate-containing compound metabolic process 4 16
GO:0006807 nitrogen compound metabolic process 2 16
GO:0008152 metabolic process 1 16
GO:0009987 cellular process 1 16
GO:0016310 phosphorylation 5 16
GO:0044237 cellular metabolic process 2 16
GO:0044238 primary metabolic process 2 16
GO:0044255 cellular lipid metabolic process 3 16
GO:0071704 organic substance metabolic process 2 16
GO:1901564 organonitrogen compound metabolic process 3 16
GO:0006066 alcohol metabolic process 3 1
GO:0006576 biogenic amine metabolic process 5 1
GO:0006580 ethanolamine metabolic process 5 1
GO:0006672 ceramide metabolic process 4 1
GO:0008610 lipid biosynthetic process 4 1
GO:0009058 biosynthetic process 2 1
GO:0009308 amine metabolic process 4 1
GO:0009309 amine biosynthetic process 5 1
GO:0030148 sphingolipid biosynthetic process 5 1
GO:0034308 primary alcohol metabolic process 4 1
GO:0034309 primary alcohol biosynthetic process 5 1
GO:0034641 cellular nitrogen compound metabolic process 3 1
GO:0042401 biogenic amine biosynthetic process 6 1
GO:0042439 ethanolamine-containing compound metabolic process 4 1
GO:0043603 amide metabolic process 3 1
GO:0043604 amide biosynthetic process 4 1
GO:0044249 cellular biosynthetic process 3 1
GO:0044271 cellular nitrogen compound biosynthetic process 4 1
GO:0044281 small molecule metabolic process 2 1
GO:0044283 small molecule biosynthetic process 3 1
GO:0046165 alcohol biosynthetic process 4 1
GO:0046335 ethanolamine biosynthetic process 6 1
GO:0046467 membrane lipid biosynthetic process 4 1
GO:0046513 ceramide biosynthetic process 5 1
GO:1901160 primary amino compound metabolic process 4 1
GO:1901162 primary amino compound biosynthetic process 5 1
GO:1901566 organonitrogen compound biosynthetic process 4 1
GO:1901576 organic substance biosynthetic process 3 1
GO:1901615 organic hydroxy compound metabolic process 3 1
GO:1901617 organic hydroxy compound biosynthetic process 4 1
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 16
GO:0016301 kinase activity 4 16
GO:0016740 transferase activity 2 16
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 16
GO:0016780 phosphotransferase activity, for other substituted phosphate groups 4 16
GO:0033188 sphingomyelin synthase activity 5 6
GO:0047493 ceramide cholinephosphotransferase activity 5 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 11 13 PF00675 0.454
CLV_NRD_NRD_1 142 144 PF00675 0.391
CLV_PCSK_KEX2_1 142 144 PF00082 0.387
CLV_PCSK_KEX2_1 148 150 PF00082 0.364
CLV_PCSK_PC1ET2_1 148 150 PF00082 0.355
CLV_PCSK_SKI1_1 132 136 PF00082 0.304
CLV_PCSK_SKI1_1 157 161 PF00082 0.261
CLV_PCSK_SKI1_1 36 40 PF00082 0.401
DEG_APCC_KENBOX_2 12 16 PF00400 0.565
DOC_ANK_TNKS_1 5 12 PF00023 0.578
DOC_CDC14_PxL_1 65 73 PF14671 0.390
DOC_CYCLIN_yCln2_LP_2 39 45 PF00134 0.354
DOC_MAPK_DCC_7 63 73 PF00069 0.318
DOC_MAPK_FxFP_2 237 240 PF00069 0.365
DOC_MAPK_gen_1 148 156 PF00069 0.585
DOC_MAPK_MEF2A_6 149 158 PF00069 0.365
DOC_MAPK_MEF2A_6 192 200 PF00069 0.344
DOC_MAPK_MEF2A_6 36 43 PF00069 0.296
DOC_MAPK_NFAT4_5 36 44 PF00069 0.401
DOC_PP1_RVXF_1 130 136 PF00149 0.592
DOC_PP1_RVXF_1 76 82 PF00149 0.277
DOC_PP2B_LxvP_1 39 42 PF13499 0.187
DOC_PP4_FxxP_1 237 240 PF00568 0.545
DOC_USP7_MATH_1 260 264 PF00917 0.290
DOC_USP7_MATH_1 348 352 PF00917 0.677
DOC_USP7_MATH_1 354 358 PF00917 0.643
DOC_WW_Pin1_4 232 237 PF00397 0.428
DOC_WW_Pin1_4 331 336 PF00397 0.725
LIG_14-3-3_CanoR_1 125 131 PF00244 0.501
LIG_14-3-3_CanoR_1 157 163 PF00244 0.296
LIG_14-3-3_CanoR_1 244 250 PF00244 0.315
LIG_14-3-3_CanoR_1 262 271 PF00244 0.164
LIG_BIR_II_1 1 5 PF00653 0.611
LIG_deltaCOP1_diTrp_1 74 81 PF00928 0.351
LIG_eIF4E_1 162 168 PF01652 0.189
LIG_eIF4E_1 265 271 PF01652 0.243
LIG_FHA_1 219 225 PF00498 0.296
LIG_FHA_1 264 270 PF00498 0.236
LIG_FHA_1 277 283 PF00498 0.287
LIG_FHA_1 29 35 PF00498 0.429
LIG_FHA_1 313 319 PF00498 0.740
LIG_FHA_1 344 350 PF00498 0.732
LIG_FHA_1 359 365 PF00498 0.757
LIG_FHA_1 84 90 PF00498 0.368
LIG_FHA_1 94 100 PF00498 0.397
LIG_FHA_2 116 122 PF00498 0.583
LIG_Integrin_isoDGR_2 56 58 PF01839 0.569
LIG_LIR_Apic_2 235 240 PF02991 0.537
LIG_LIR_Gen_1 160 170 PF02991 0.324
LIG_LIR_Gen_1 254 260 PF02991 0.296
LIG_LIR_Nem_3 160 165 PF02991 0.331
LIG_LIR_Nem_3 233 237 PF02991 0.471
LIG_LIR_Nem_3 254 259 PF02991 0.325
LIG_LIR_Nem_3 279 283 PF02991 0.288
LIG_LIR_Nem_3 338 342 PF02991 0.577
LIG_LIR_Nem_3 44 50 PF02991 0.356
LIG_MYND_1 236 240 PF01753 0.537
LIG_PCNA_PIPBox_1 152 161 PF02747 0.365
LIG_PCNA_yPIPBox_3 148 159 PF02747 0.365
LIG_Pex14_2 228 232 PF04695 0.402
LIG_Pex14_2 237 241 PF04695 0.519
LIG_Pex14_2 43 47 PF04695 0.238
LIG_PTB_Apo_2 113 120 PF02174 0.562
LIG_SH2_CRK 162 166 PF00017 0.298
LIG_SH2_CRK 24 28 PF00017 0.593
LIG_SH2_CRK 256 260 PF00017 0.306
LIG_SH2_CRK 280 284 PF00017 0.331
LIG_SH2_PTP2 274 277 PF00017 0.439
LIG_SH2_STAP1 162 166 PF00017 0.302
LIG_SH2_STAP1 265 269 PF00017 0.236
LIG_SH2_STAT5 105 108 PF00017 0.389
LIG_SH2_STAT5 256 259 PF00017 0.303
LIG_SH2_STAT5 265 268 PF00017 0.223
LIG_SH2_STAT5 274 277 PF00017 0.287
LIG_SH3_1 63 69 PF00018 0.256
LIG_SH3_3 246 252 PF00018 0.449
LIG_SH3_3 319 325 PF00018 0.714
LIG_SH3_3 4 10 PF00018 0.698
LIG_SH3_3 63 69 PF00018 0.270
LIG_Sin3_3 168 175 PF02671 0.357
LIG_SUMO_SIM_anti_2 163 168 PF11976 0.216
LIG_SUMO_SIM_anti_2 315 323 PF11976 0.717
LIG_SUMO_SIM_anti_2 86 92 PF11976 0.347
LIG_SUMO_SIM_par_1 170 177 PF11976 0.291
LIG_SUMO_SIM_par_1 198 204 PF11976 0.303
LIG_TYR_ITSM 158 165 PF00017 0.402
LIG_UBA3_1 363 367 PF00899 0.584
LIG_UBA3_1 72 78 PF00899 0.392
LIG_WW_2 66 69 PF00397 0.249
MOD_CK1_1 218 224 PF00069 0.287
MOD_CK1_1 263 269 PF00069 0.279
MOD_CK1_1 330 336 PF00069 0.573
MOD_CK1_1 369 375 PF00069 0.719
MOD_CK2_1 115 121 PF00069 0.578
MOD_CK2_1 281 287 PF00069 0.187
MOD_CMANNOS 300 303 PF00535 0.418
MOD_Cter_Amidation 10 13 PF01082 0.375
MOD_Cter_Amidation 140 143 PF01082 0.399
MOD_GlcNHglycan 139 142 PF01048 0.386
MOD_GlcNHglycan 206 209 PF01048 0.540
MOD_GlcNHglycan 217 220 PF01048 0.234
MOD_GlcNHglycan 328 332 PF01048 0.521
MOD_GlcNHglycan 350 353 PF01048 0.480
MOD_GlcNHglycan 356 359 PF01048 0.511
MOD_GSK3_1 174 181 PF00069 0.330
MOD_GSK3_1 281 288 PF00069 0.410
MOD_GSK3_1 327 334 PF00069 0.732
MOD_GSK3_1 350 357 PF00069 0.726
MOD_N-GLC_1 115 120 PF02516 0.377
MOD_N-GLC_1 306 311 PF02516 0.285
MOD_N-GLC_1 93 98 PF02516 0.397
MOD_N-GLC_2 183 185 PF02516 0.554
MOD_NEK2_1 158 163 PF00069 0.286
MOD_NEK2_1 215 220 PF00069 0.287
MOD_NEK2_1 276 281 PF00069 0.370
MOD_NEK2_1 93 98 PF00069 0.415
MOD_PIKK_1 29 35 PF00454 0.468
MOD_PKA_2 354 360 PF00069 0.757
MOD_Plk_1 115 121 PF00069 0.602
MOD_Plk_1 16 22 PF00069 0.692
MOD_Plk_1 93 99 PF00069 0.428
MOD_Plk_4 115 121 PF00069 0.621
MOD_Plk_4 160 166 PF00069 0.269
MOD_Plk_4 198 204 PF00069 0.304
MOD_Plk_4 218 224 PF00069 0.109
MOD_Plk_4 245 251 PF00069 0.259
MOD_Plk_4 93 99 PF00069 0.275
MOD_ProDKin_1 232 238 PF00069 0.428
MOD_ProDKin_1 331 337 PF00069 0.725
TRG_ENDOCYTIC_2 162 165 PF00928 0.292
TRG_ENDOCYTIC_2 234 237 PF00928 0.443
TRG_ENDOCYTIC_2 256 259 PF00928 0.296
TRG_ENDOCYTIC_2 274 277 PF00928 0.296
TRG_ENDOCYTIC_2 280 283 PF00928 0.296
TRG_ENDOCYTIC_2 339 342 PF00928 0.576
TRG_ER_diArg_1 142 144 PF00400 0.609
TRG_NES_CRM1_1 74 87 PF08389 0.343

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HRL7 Leptomonas seymouri 69% 100%
A0A0S4J1W3 Bodo saltans 46% 100%
A0A1X0P4U9 Trypanosomatidae 48% 100%
A0A3S7XA07 Leishmania donovani 68% 100%
A0A422NCN9 Trypanosoma rangeli 44% 100%
A4IC70 Leishmania infantum 68% 100%
B3A0L9 Trypanosoma brucei brucei 45% 100%
B3A0M0 Trypanosoma brucei brucei 44% 100%
B3A0M1 Trypanosoma brucei brucei 44% 100%
B3A0M2 Trypanosoma brucei brucei 45% 100%
C9ZYF5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
C9ZYF7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 44% 100%
C9ZYF8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
C9ZYF9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
C9ZYG0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
C9ZYG2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
E9AFX2 Leishmania major 71% 100%
E9B725 Leishmania mexicana (strain MHOM/GT/2001/U1103) 67% 100%
Q38E53 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 45% 100%
Q38E54 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 45% 100%
Q38E55 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 45% 100%
Q38E56 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) 45% 100%
Q4E4I4 Trypanosoma cruzi (strain CL Brener) 49% 100%
Q4JM44 Rattus norvegicus 25% 100%
Q96LT4 Homo sapiens 25% 93%
Q9D4B1 Mus musculus 25% 100%
Q9DA37 Mus musculus 24% 81%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS