C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNF8_LEIBR

TriTrypDb:

LbrM.34.4900 , LBRM2903_340059400

Length:

1012

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNF8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.611
CLV_C14_Caspase3-7	721	725	PF00656	0.567
CLV_MEL_PAP_1	754	760	PF00089	0.537
CLV_NRD_NRD_1	511	513	PF00675	0.717
CLV_NRD_NRD_1	66	68	PF00675	0.486
CLV_NRD_NRD_1	825	827	PF00675	0.740
CLV_NRD_NRD_1	846	848	PF00675	0.737
CLV_NRD_NRD_1	967	969	PF00675	0.758
CLV_NRD_NRD_1	972	974	PF00675	0.673
CLV_PCSK_KEX2_1	511	513	PF00082	0.717
CLV_PCSK_KEX2_1	846	848	PF00082	0.813
CLV_PCSK_KEX2_1	915	917	PF00082	0.725
CLV_PCSK_KEX2_1	967	969	PF00082	0.720
CLV_PCSK_KEX2_1	972	974	PF00082	0.666
CLV_PCSK_KEX2_1	976	978	PF00082	0.618
CLV_PCSK_PC1ET2_1	915	917	PF00082	0.725
CLV_PCSK_PC1ET2_1	976	978	PF00082	0.705
CLV_PCSK_PC7_1	968	974	PF00082	0.716
CLV_PCSK_SKI1_1	161	165	PF00082	0.462
CLV_PCSK_SKI1_1	294	298	PF00082	0.725
CLV_PCSK_SKI1_1	718	722	PF00082	0.725
CLV_PCSK_SKI1_1	750	754	PF00082	0.527
CLV_PCSK_SKI1_1	776	780	PF00082	0.547
CLV_PCSK_SKI1_1	801	805	PF00082	0.560
DEG_SCF_FBW7_1	30	36	PF00400	0.551
DEG_SCF_FBW7_1	470	475	PF00400	0.576
DEG_SCF_FBW7_1	858	864	PF00400	0.562
DEG_SCF_FBW7_1	939	944	PF00400	0.694
DEG_SPOP_SBC_1	19	23	PF00917	0.552
DEG_SPOP_SBC_1	532	536	PF00917	0.672
DEG_SPOP_SBC_1	623	627	PF00917	0.585
DEG_SPOP_SBC_1	849	853	PF00917	0.576
DOC_CDC14_PxL_1	703	711	PF14671	0.566
DOC_CKS1_1	30	35	PF01111	0.577
DOC_CKS1_1	398	403	PF01111	0.691
DOC_CKS1_1	858	863	PF01111	0.559
DOC_MAPK_DCC_7	499	509	PF00069	0.730
DOC_MAPK_gen_1	511	519	PF00069	0.579
DOC_MAPK_gen_1	785	795	PF00069	0.591
DOC_MAPK_gen_1	797	805	PF00069	0.444
DOC_MAPK_MEF2A_6	420	427	PF00069	0.691
DOC_MAPK_MEF2A_6	786	795	PF00069	0.594
DOC_MAPK_NFAT4_5	788	796	PF00069	0.579
DOC_PP1_RVXF_1	109	116	PF00149	0.467
DOC_PP1_RVXF_1	777	784	PF00149	0.536
DOC_PP1_RVXF_1	799	806	PF00149	0.419
DOC_PP2B_LxvP_1	384	387	PF13499	0.713
DOC_PP2B_LxvP_1	470	473	PF13499	0.718
DOC_PP4_FxxP_1	591	594	PF00568	0.605
DOC_PP4_FxxP_1	906	909	PF00568	0.692
DOC_USP7_MATH_1	19	23	PF00917	0.552
DOC_USP7_MATH_1	202	206	PF00917	0.579
DOC_USP7_MATH_1	248	252	PF00917	0.698
DOC_USP7_MATH_1	256	260	PF00917	0.638
DOC_USP7_MATH_1	316	320	PF00917	0.562
DOC_USP7_MATH_1	359	363	PF00917	0.609
DOC_USP7_MATH_1	440	444	PF00917	0.711
DOC_USP7_MATH_1	455	459	PF00917	0.582
DOC_USP7_MATH_1	526	530	PF00917	0.721
DOC_USP7_MATH_1	531	535	PF00917	0.676
DOC_USP7_MATH_1	619	623	PF00917	0.657
DOC_USP7_MATH_1	631	635	PF00917	0.610
DOC_USP7_MATH_1	756	760	PF00917	0.529
DOC_USP7_MATH_1	811	815	PF00917	0.684
DOC_USP7_MATH_1	849	853	PF00917	0.594
DOC_USP7_MATH_1	861	865	PF00917	0.794
DOC_USP7_MATH_1	902	906	PF00917	0.729
DOC_USP7_MATH_1	945	949	PF00917	0.727
DOC_USP7_UBL2_3	911	915	PF12436	0.717
DOC_WW_Pin1_4	221	226	PF00397	0.628
DOC_WW_Pin1_4	234	239	PF00397	0.684
DOC_WW_Pin1_4	26	31	PF00397	0.682
DOC_WW_Pin1_4	365	370	PF00397	0.571
DOC_WW_Pin1_4	387	392	PF00397	0.722
DOC_WW_Pin1_4	397	402	PF00397	0.621
DOC_WW_Pin1_4	410	415	PF00397	0.581
DOC_WW_Pin1_4	46	51	PF00397	0.520
DOC_WW_Pin1_4	468	473	PF00397	0.690
DOC_WW_Pin1_4	607	612	PF00397	0.626
DOC_WW_Pin1_4	625	630	PF00397	0.599
DOC_WW_Pin1_4	641	646	PF00397	0.552
DOC_WW_Pin1_4	854	859	PF00397	0.714
DOC_WW_Pin1_4	897	902	PF00397	0.720
DOC_WW_Pin1_4	905	910	PF00397	0.641
DOC_WW_Pin1_4	931	936	PF00397	0.643
DOC_WW_Pin1_4	937	942	PF00397	0.591
DOC_WW_Pin1_4	947	952	PF00397	0.568
LIG_14-3-3_CanoR_1	18	25	PF00244	0.675
LIG_14-3-3_CanoR_1	229	234	PF00244	0.734
LIG_14-3-3_CanoR_1	271	278	PF00244	0.689
LIG_14-3-3_CanoR_1	294	302	PF00244	0.727
LIG_14-3-3_CanoR_1	511	519	PF00244	0.579
LIG_14-3-3_CanoR_1	567	573	PF00244	0.620
LIG_14-3-3_CanoR_1	624	629	PF00244	0.578
LIG_14-3-3_CanoR_1	639	645	PF00244	0.528
LIG_14-3-3_CanoR_1	718	723	PF00244	0.723
LIG_14-3-3_CanoR_1	757	763	PF00244	0.525
LIG_14-3-3_CanoR_1	826	833	PF00244	0.726
LIG_Actin_WH2_2	763	781	PF00022	0.534
LIG_BIR_II_1	1	5	PF00653	0.680
LIG_BIR_III_4	5	9	PF00653	0.550
LIG_BRCT_BRCA1_1	130	134	PF00533	0.488
LIG_EH1_1	139	147	PF00400	0.465
LIG_EH1_1	679	687	PF00400	0.692
LIG_FHA_1	125	131	PF00498	0.469
LIG_FHA_1	136	142	PF00498	0.376
LIG_FHA_1	151	157	PF00498	0.294
LIG_FHA_1	457	463	PF00498	0.708
LIG_FHA_1	483	489	PF00498	0.578
LIG_FHA_1	498	504	PF00498	0.686
LIG_FHA_1	597	603	PF00498	0.717
LIG_FHA_1	753	759	PF00498	0.531
LIG_FHA_1	762	768	PF00498	0.428
LIG_FHA_1	828	834	PF00498	0.790
LIG_FHA_1	931	937	PF00498	0.656
LIG_FHA_2	147	153	PF00498	0.467
LIG_FHA_2	34	40	PF00498	0.560
LIG_FHA_2	719	725	PF00498	0.713
LIG_FHA_2	827	833	PF00498	0.581
LIG_FHA_2	951	957	PF00498	0.723
LIG_Integrin_isoDGR_2	739	741	PF01839	0.683
LIG_LIR_Apic_2	903	909	PF02991	0.696
LIG_LIR_Gen_1	152	163	PF02991	0.449
LIG_LIR_Gen_1	860	870	PF02991	0.571
LIG_LIR_Gen_1	93	103	PF02991	0.458
LIG_LIR_Nem_3	152	158	PF02991	0.439
LIG_LIR_Nem_3	860	865	PF02991	0.639
LIG_LIR_Nem_3	93	98	PF02991	0.446
LIG_LIR_Nem_3	99	105	PF02991	0.406
LIG_MYND_1	707	711	PF01753	0.566
LIG_PCNA_yPIPBox_3	83	95	PF02747	0.468
LIG_SH2_CRK	216	220	PF00017	0.667
LIG_SH2_CRK	862	866	PF00017	0.572
LIG_SH2_CRK	95	99	PF00017	0.444
LIG_SH2_PTP2	102	105	PF00017	0.458
LIG_SH2_SRC	1008	1011	PF00017	0.371
LIG_SH2_STAP1	170	174	PF00017	0.458
LIG_SH2_STAT3	184	187	PF00017	0.659
LIG_SH2_STAT5	1008	1011	PF00017	0.371
LIG_SH2_STAT5	102	105	PF00017	0.458
LIG_SH2_STAT5	140	143	PF00017	0.464
LIG_SH2_STAT5	148	151	PF00017	0.379
LIG_SH2_STAT5	780	783	PF00017	0.461
LIG_SH3_1	420	426	PF00018	0.691
LIG_SH3_2	258	263	PF14604	0.625
LIG_SH3_2	842	847	PF14604	0.590
LIG_SH3_2	932	937	PF14604	0.577
LIG_SH3_3	222	228	PF00018	0.567
LIG_SH3_3	255	261	PF00018	0.623
LIG_SH3_3	27	33	PF00018	0.561
LIG_SH3_3	393	399	PF00018	0.712
LIG_SH3_3	401	407	PF00018	0.637
LIG_SH3_3	420	426	PF00018	0.641
LIG_SH3_3	560	566	PF00018	0.715
LIG_SH3_3	599	605	PF00018	0.647
LIG_SH3_3	69	75	PF00018	0.453
LIG_SH3_3	701	707	PF00018	0.609
LIG_SH3_3	805	811	PF00018	0.508
LIG_SH3_3	839	845	PF00018	0.691
LIG_SH3_3	855	861	PF00018	0.686
LIG_SH3_3	869	875	PF00018	0.833
LIG_SH3_3	929	935	PF00018	0.717
LIG_SUMO_SIM_par_1	791	796	PF11976	0.607
LIG_TRAF2_1	613	616	PF00917	0.709
LIG_TRAF2_1	835	838	PF00917	0.720
LIG_TRAF2_2	811	816	PF00917	0.566
LIG_UBA3_1	154	161	PF00899	0.437
MOD_CDC14_SPxK_1	908	911	PF00782	0.708
MOD_CDC14_SPxK_1	934	937	PF00782	0.581
MOD_CDK_SPxK_1	905	911	PF00069	0.717
MOD_CDK_SPxK_1	931	937	PF00069	0.578
MOD_CDK_SPxxK_3	947	954	PF00069	0.726
MOD_CK1_1	157	163	PF00069	0.452
MOD_CK1_1	173	179	PF00069	0.348
MOD_CK1_1	21	27	PF00069	0.711
MOD_CK1_1	29	35	PF00069	0.617
MOD_CK1_1	362	368	PF00069	0.631
MOD_CK1_1	390	396	PF00069	0.720
MOD_CK1_1	456	462	PF00069	0.668
MOD_CK1_1	474	480	PF00069	0.550
MOD_CK1_1	534	540	PF00069	0.604
MOD_CK1_1	622	628	PF00069	0.720
MOD_CK1_1	647	653	PF00069	0.674
MOD_CK1_1	761	767	PF00069	0.518
MOD_CK1_1	814	820	PF00069	0.754
MOD_CK1_1	857	863	PF00069	0.705
MOD_CK1_1	905	911	PF00069	0.705
MOD_CK1_1	924	930	PF00069	0.544
MOD_CK1_1	944	950	PF00069	0.609
MOD_CK2_1	215	221	PF00069	0.573
MOD_CK2_1	826	832	PF00069	0.583
MOD_CK2_1	904	910	PF00069	0.830
MOD_CK2_1	950	956	PF00069	0.721
MOD_Cter_Amidation	970	973	PF01082	0.710
MOD_Cter_Amidation	974	977	PF01082	0.674
MOD_DYRK1A_RPxSP_1	397	401	PF00069	0.687
MOD_GlcNHglycan	1	4	PF01048	0.679
MOD_GlcNHglycan	175	178	PF01048	0.510
MOD_GlcNHglycan	251	254	PF01048	0.731
MOD_GlcNHglycan	289	292	PF01048	0.582
MOD_GlcNHglycan	305	308	PF01048	0.595
MOD_GlcNHglycan	318	321	PF01048	0.654
MOD_GlcNHglycan	341	344	PF01048	0.721
MOD_GlcNHglycan	357	360	PF01048	0.569
MOD_GlcNHglycan	361	364	PF01048	0.527
MOD_GlcNHglycan	442	445	PF01048	0.702
MOD_GlcNHglycan	455	458	PF01048	0.602
MOD_GlcNHglycan	476	479	PF01048	0.690
MOD_GlcNHglycan	528	531	PF01048	0.714
MOD_GlcNHglycan	540	543	PF01048	0.601
MOD_GlcNHglycan	553	556	PF01048	0.549
MOD_GlcNHglycan	605	608	PF01048	0.725
MOD_GlcNHglycan	621	624	PF01048	0.585
MOD_GlcNHglycan	649	652	PF01048	0.648
MOD_GlcNHglycan	760	763	PF01048	0.520
MOD_GlcNHglycan	83	86	PF01048	0.468
MOD_GlcNHglycan	852	855	PF01048	0.592
MOD_GlcNHglycan	917	920	PF01048	0.683
MOD_GlcNHglycan	928	931	PF01048	0.664
MOD_GlcNHglycan	969	972	PF01048	0.800
MOD_GSK3_1	124	131	PF00069	0.470
MOD_GSK3_1	146	153	PF00069	0.464
MOD_GSK3_1	166	173	PF00069	0.268
MOD_GSK3_1	19	26	PF00069	0.676
MOD_GSK3_1	229	236	PF00069	0.733
MOD_GSK3_1	29	36	PF00069	0.585
MOD_GSK3_1	329	336	PF00069	0.710
MOD_GSK3_1	355	362	PF00069	0.580
MOD_GSK3_1	363	370	PF00069	0.537
MOD_GSK3_1	410	417	PF00069	0.669
MOD_GSK3_1	440	447	PF00069	0.708
MOD_GSK3_1	449	456	PF00069	0.636
MOD_GSK3_1	462	469	PF00069	0.589
MOD_GSK3_1	472	479	PF00069	0.585
MOD_GSK3_1	532	539	PF00069	0.722
MOD_GSK3_1	549	556	PF00069	0.532
MOD_GSK3_1	603	610	PF00069	0.674
MOD_GSK3_1	619	626	PF00069	0.631
MOD_GSK3_1	637	644	PF00069	0.561
MOD_GSK3_1	652	659	PF00069	0.608
MOD_GSK3_1	752	759	PF00069	0.528
MOD_GSK3_1	761	768	PF00069	0.434
MOD_GSK3_1	850	857	PF00069	0.728
MOD_GSK3_1	861	868	PF00069	0.691
MOD_GSK3_1	915	922	PF00069	0.734
MOD_GSK3_1	926	933	PF00069	0.623
MOD_GSK3_1	937	944	PF00069	0.596
MOD_GSK3_1	945	952	PF00069	0.562
MOD_LATS_1	825	831	PF00433	0.582
MOD_N-GLC_1	221	226	PF02516	0.714
MOD_N-GLC_1	333	338	PF02516	0.572
MOD_N-GLC_1	52	57	PF02516	0.498
MOD_N-GLC_1	526	531	PF02516	0.715
MOD_N-GLC_1	532	537	PF02516	0.671
MOD_N-GLC_1	827	832	PF02516	0.580
MOD_N-GLC_1	87	92	PF02516	0.479
MOD_N-GLC_1	945	950	PF02516	0.726
MOD_N-GLC_1	96	101	PF02516	0.372
MOD_NEK2_1	141	146	PF00069	0.443
MOD_NEK2_1	154	159	PF00069	0.300
MOD_NEK2_1	175	180	PF00069	0.395
MOD_NEK2_1	337	342	PF00069	0.661
MOD_NEK2_1	355	360	PF00069	0.594
MOD_NEK2_1	752	757	PF00069	0.532
MOD_NEK2_1	804	809	PF00069	0.592
MOD_NEK2_1	87	92	PF00069	0.479
MOD_NEK2_2	150	155	PF00069	0.450
MOD_PIKK_1	124	130	PF00454	0.467
MOD_PIKK_1	472	478	PF00454	0.606
MOD_PIKK_1	482	488	PF00454	0.650
MOD_PIKK_1	489	495	PF00454	0.674
MOD_PIKK_1	605	611	PF00454	0.580
MOD_PK_1	229	235	PF00069	0.734
MOD_PKA_1	826	832	PF00069	0.583
MOD_PKA_1	915	921	PF00069	0.780
MOD_PKA_1	967	973	PF00069	0.688
MOD_PKA_2	249	255	PF00069	0.729
MOD_PKA_2	264	270	PF00069	0.572
MOD_PKA_2	510	516	PF00069	0.720
MOD_PKA_2	623	629	PF00069	0.579
MOD_PKA_2	756	762	PF00069	0.530
MOD_PKA_2	915	921	PF00069	0.663
MOD_PKA_2	967	973	PF00069	0.692
MOD_Plk_1	116	122	PF00069	0.457
MOD_Plk_1	329	335	PF00069	0.723
MOD_Plk_1	631	637	PF00069	0.575
MOD_Plk_1	87	93	PF00069	0.479
MOD_Plk_1	902	908	PF00069	0.727
MOD_Plk_1	945	951	PF00069	0.721
MOD_Plk_2-3	264	270	PF00069	0.718
MOD_Plk_2-3	52	58	PF00069	0.489
MOD_Plk_4	141	147	PF00069	0.451
MOD_Plk_4	150	156	PF00069	0.361
MOD_Plk_4	159	165	PF00069	0.281
MOD_Plk_4	170	176	PF00069	0.273
MOD_Plk_4	202	208	PF00069	0.696
MOD_Plk_4	718	724	PF00069	0.577
MOD_Plk_4	87	93	PF00069	0.479
MOD_ProDKin_1	221	227	PF00069	0.630
MOD_ProDKin_1	234	240	PF00069	0.684
MOD_ProDKin_1	26	32	PF00069	0.679
MOD_ProDKin_1	365	371	PF00069	0.572
MOD_ProDKin_1	387	393	PF00069	0.722
MOD_ProDKin_1	397	403	PF00069	0.623
MOD_ProDKin_1	410	416	PF00069	0.577
MOD_ProDKin_1	46	52	PF00069	0.518
MOD_ProDKin_1	468	474	PF00069	0.691
MOD_ProDKin_1	607	613	PF00069	0.628
MOD_ProDKin_1	625	631	PF00069	0.598
MOD_ProDKin_1	641	647	PF00069	0.553
MOD_ProDKin_1	854	860	PF00069	0.712
MOD_ProDKin_1	897	903	PF00069	0.723
MOD_ProDKin_1	905	911	PF00069	0.639
MOD_ProDKin_1	931	937	PF00069	0.649
MOD_ProDKin_1	941	947	PF00069	0.546
MOD_SUMO_rev_2	782	787	PF00179	0.527
TRG_DiLeu_BaEn_3	747	753	PF01217	0.532
TRG_DiLeu_BaEn_4	773	779	PF01217	0.539
TRG_ENDOCYTIC_2	102	105	PF00928	0.390
TRG_ENDOCYTIC_2	216	219	PF00928	0.667
TRG_ENDOCYTIC_2	780	783	PF00928	0.535
TRG_ENDOCYTIC_2	862	865	PF00928	0.575
TRG_ENDOCYTIC_2	95	98	PF00928	0.444
TRG_ER_diArg_1	797	800	PF00400	0.562
TRG_ER_diArg_1	845	847	PF00400	0.743

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IIU2	Leishmania donovani	76%	98%
E9AFW9	Leishmania major	76%	99%
E9AHX0	Leishmania infantum	77%	99%
E9B722	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	98%