CUE domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNF7_LEIBR

TriTrypDb:

LbrM.34.4890 , LBRM2903_340059300

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HNF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNF7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.365
CLV_NRD_NRD_1	169	171	PF00675	0.399
CLV_NRD_NRD_1	38	40	PF00675	0.537
CLV_NRD_NRD_1	95	97	PF00675	0.415
CLV_PCSK_FUR_1	42	46	PF00082	0.467
CLV_PCSK_FUR_1	93	97	PF00082	0.494
CLV_PCSK_KEX2_1	44	46	PF00082	0.522
CLV_PCSK_KEX2_1	95	97	PF00082	0.466
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.466
CLV_PCSK_SKI1_1	170	174	PF00082	0.497
CLV_PCSK_SKI1_1	82	86	PF00082	0.456
CLV_PCSK_SKI1_1	96	100	PF00082	0.418
DEG_Nend_Nbox_1	1	3	PF02207	0.361
DOC_MAPK_gen_1	158	164	PF00069	0.601
DOC_MAPK_gen_1	170	177	PF00069	0.638
DOC_USP7_MATH_1	109	113	PF00917	0.744
DOC_USP7_MATH_1	182	186	PF00917	0.640
DOC_USP7_UBL2_3	116	120	PF12436	0.660
DOC_USP7_UBL2_3	131	135	PF12436	0.647
DOC_USP7_UBL2_3	40	44	PF12436	0.696
DOC_WW_Pin1_4	82	87	PF00397	0.545
LIG_14-3-3_CanoR_1	104	111	PF00244	0.652
LIG_14-3-3_CanoR_1	114	124	PF00244	0.738
LIG_14-3-3_CanoR_1	158	163	PF00244	0.704
LIG_BRCT_BRCA1_1	160	164	PF00533	0.641
LIG_FHA_1	25	31	PF00498	0.585
LIG_FHA_1	52	58	PF00498	0.678
LIG_FHA_1	60	66	PF00498	0.609
LIG_FHA_2	149	155	PF00498	0.645
LIG_LIR_Apic_2	3	7	PF02991	0.340
LIG_LIR_Nem_3	121	127	PF02991	0.605
LIG_MLH1_MIPbox_1	160	164	PF16413	0.655
LIG_Pex14_2	16	20	PF04695	0.281
LIG_REV1ctd_RIR_1	161	169	PF16727	0.637
LIG_SH2_SRC	4	7	PF00017	0.404
LIG_SH2_STAP1	53	57	PF00017	0.674
LIG_SH2_STAT5	4	7	PF00017	0.307
LIG_SH2_STAT5	53	56	PF00017	0.622
LIG_SH3_4	40	47	PF00018	0.729
LIG_SUMO_SIM_par_1	54	63	PF11976	0.654
LIG_TRAF2_1	98	101	PF00917	0.706
MOD_CK1_1	149	155	PF00069	0.545
MOD_CK1_1	43	49	PF00069	0.737
MOD_CK2_1	148	154	PF00069	0.624
MOD_CK2_1	23	29	PF00069	0.648
MOD_Cter_Amidation	93	96	PF01082	0.342
MOD_GlcNHglycan	117	120	PF01048	0.524
MOD_GlcNHglycan	148	151	PF01048	0.493
MOD_GlcNHglycan	184	187	PF01048	0.516
MOD_GlcNHglycan	74	77	PF01048	0.457
MOD_GSK3_1	144	151	PF00069	0.751
MOD_GSK3_1	25	32	PF00069	0.639
MOD_GSK3_1	43	50	PF00069	0.742
MOD_GSK3_1	72	79	PF00069	0.655
MOD_N-GLC_1	166	171	PF02516	0.354
MOD_N-GLC_1	23	28	PF02516	0.291
MOD_NEK2_1	163	168	PF00069	0.627
MOD_PIKK_1	102	108	PF00454	0.654
MOD_PIKK_1	43	49	PF00454	0.678
MOD_PKA_1	158	164	PF00069	0.654
MOD_PKA_2	47	53	PF00069	0.693
MOD_Plk_4	158	164	PF00069	0.666
MOD_Plk_4	31	37	PF00069	0.569
MOD_ProDKin_1	82	88	PF00069	0.541
MOD_SUMO_for_1	177	180	PF00179	0.718
MOD_SUMO_for_1	98	101	PF00179	0.620
MOD_SUMO_rev_2	152	161	PF00179	0.569
MOD_SUMO_rev_2	75	84	PF00179	0.704
TRG_ER_diArg_1	92	95	PF00400	0.653
TRG_ER_diLys_1	200	204	PF00400	0.630
TRG_NLS_MonoCore_2	38	43	PF00514	0.730
TRG_NLS_MonoExtN_4	37	43	PF00514	0.681

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ICF1	Leptomonas seymouri	57%	93%
A0A0S4J7Q9	Bodo saltans	28%	100%
A0A1X0P5X3	Trypanosomatidae	33%	100%
A0A3Q8IN24	Leishmania donovani	77%	100%
A0A3R7KQ70	Trypanosoma rangeli	37%	100%
A4IC29	Leishmania infantum	77%	100%
C9ZYH0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	96%
E9AFW8	Leishmania major	76%	100%
E9B721	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	98%