Putative DNA replication factor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA replication licensing factor MCM9, putative

Species:

Leishmania braziliensis

UniProt:

A4HNF5_LEIBR

TriTrypDb:

LbrM.34.4870 , LBRM2903_340059100

Length:

916

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0042555	MCM complex	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNF5

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0032392	DNA geometric change	7	11
GO:0032508	DNA duplex unwinding	8	11
GO:0051276	chromosome organization	5	11
GO:0071103	DNA conformation change	6	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003697	single-stranded DNA binding	5	1
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	2	6	PF00656	0.431
CLV_C14_Caspase3-7	26	30	PF00656	0.462
CLV_C14_Caspase3-7	80	84	PF00656	0.285
CLV_NRD_NRD_1	286	288	PF00675	0.584
CLV_NRD_NRD_1	309	311	PF00675	0.404
CLV_NRD_NRD_1	472	474	PF00675	0.272
CLV_NRD_NRD_1	733	735	PF00675	0.662
CLV_NRD_NRD_1	900	902	PF00675	0.618
CLV_PCSK_KEX2_1	143	145	PF00082	0.227
CLV_PCSK_KEX2_1	285	287	PF00082	0.587
CLV_PCSK_KEX2_1	309	311	PF00082	0.404
CLV_PCSK_KEX2_1	472	474	PF00082	0.246
CLV_PCSK_KEX2_1	843	845	PF00082	0.577
CLV_PCSK_KEX2_1	902	904	PF00082	0.562
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.227
CLV_PCSK_PC1ET2_1	309	311	PF00082	0.486
CLV_PCSK_PC1ET2_1	843	845	PF00082	0.577
CLV_PCSK_PC1ET2_1	902	904	PF00082	0.620
CLV_PCSK_PC7_1	139	145	PF00082	0.227
CLV_PCSK_SKI1_1	12	16	PF00082	0.410
CLV_PCSK_SKI1_1	215	219	PF00082	0.214
CLV_PCSK_SKI1_1	246	250	PF00082	0.499
CLV_PCSK_SKI1_1	312	316	PF00082	0.379
CLV_PCSK_SKI1_1	51	55	PF00082	0.474
CLV_PCSK_SKI1_1	734	738	PF00082	0.414
DEG_APCC_DBOX_1	126	134	PF00400	0.211
DEG_APCC_DBOX_1	214	222	PF00400	0.414
DEG_Nend_UBRbox_2	1	3	PF02207	0.594
DEG_SCF_FBW7_2	495	502	PF00400	0.445
DEG_SPOP_SBC_1	274	278	PF00917	0.653
DEG_SPOP_SBC_1	380	384	PF00917	0.414
DEG_SPOP_SBC_1	635	639	PF00917	0.389
DEG_SPOP_SBC_1	886	890	PF00917	0.492
DOC_CKS1_1	496	501	PF01111	0.445
DOC_CYCLIN_yCln2_LP_2	624	630	PF00134	0.490
DOC_CYCLIN_yCln2_LP_2	869	875	PF00134	0.649
DOC_MAPK_gen_1	156	163	PF00069	0.375
DOC_MAPK_gen_1	212	221	PF00069	0.352
DOC_MAPK_gen_1	307	316	PF00069	0.486
DOC_MAPK_gen_1	472	481	PF00069	0.508
DOC_MAPK_MEF2A_6	109	117	PF00069	0.527
DOC_MAPK_MEF2A_6	212	221	PF00069	0.352
DOC_MAPK_MEF2A_6	876	885	PF00069	0.560
DOC_PP1_RVXF_1	532	539	PF00149	0.316
DOC_PP1_RVXF_1	908	915	PF00149	0.578
DOC_PP2B_LxvP_1	327	330	PF13499	0.427
DOC_PP2B_LxvP_1	883	886	PF13499	0.679
DOC_PP4_FxxP_1	164	167	PF00568	0.451
DOC_USP7_MATH_1	147	151	PF00917	0.508
DOC_USP7_MATH_1	31	35	PF00917	0.632
DOC_USP7_MATH_1	37	41	PF00917	0.625
DOC_USP7_MATH_1	518	522	PF00917	0.409
DOC_USP7_MATH_1	571	575	PF00917	0.424
DOC_USP7_MATH_1	726	730	PF00917	0.617
DOC_USP7_MATH_1	748	752	PF00917	0.523
DOC_USP7_MATH_1	773	777	PF00917	0.569
DOC_USP7_MATH_1	818	822	PF00917	0.595
DOC_USP7_MATH_1	879	883	PF00917	0.740
DOC_USP7_MATH_1	886	890	PF00917	0.491
DOC_USP7_UBL2_3	307	311	PF12436	0.517
DOC_WW_Pin1_4	427	432	PF00397	0.508
DOC_WW_Pin1_4	495	500	PF00397	0.445
DOC_WW_Pin1_4	569	574	PF00397	0.445
DOC_WW_Pin1_4	781	786	PF00397	0.584
DOC_WW_Pin1_4	877	882	PF00397	0.704
DOC_WW_Pin1_4	887	892	PF00397	0.552
LIG_14-3-3_CanoR_1	109	117	PF00244	0.377
LIG_14-3-3_CanoR_1	139	147	PF00244	0.527
LIG_14-3-3_CanoR_1	212	218	PF00244	0.357
LIG_14-3-3_CanoR_1	272	282	PF00244	0.683
LIG_14-3-3_CanoR_1	287	296	PF00244	0.465
LIG_14-3-3_CanoR_1	312	317	PF00244	0.332
LIG_14-3-3_CanoR_1	381	388	PF00244	0.414
LIG_14-3-3_CanoR_1	434	438	PF00244	0.428
LIG_14-3-3_CanoR_1	458	464	PF00244	0.379
LIG_14-3-3_CanoR_1	473	481	PF00244	0.461
LIG_14-3-3_CanoR_1	619	625	PF00244	0.501
LIG_14-3-3_CanoR_1	702	709	PF00244	0.533
LIG_14-3-3_CanoR_1	710	715	PF00244	0.569
LIG_14-3-3_CanoR_1	798	804	PF00244	0.679
LIG_14-3-3_CanoR_1	901	909	PF00244	0.635
LIG_BIR_III_2	577	581	PF00653	0.470
LIG_BRCT_BRCA1_1	324	328	PF00533	0.445
LIG_BRCT_BRCA1_1	910	914	PF00533	0.581
LIG_Clathr_ClatBox_1	218	222	PF01394	0.414
LIG_EH_1	165	169	PF12763	0.462
LIG_FHA_1	140	146	PF00498	0.464
LIG_FHA_1	158	164	PF00498	0.351
LIG_FHA_1	367	373	PF00498	0.508
LIG_FHA_1	443	449	PF00498	0.425
LIG_FHA_1	714	720	PF00498	0.566
LIG_FHA_1	76	82	PF00498	0.364
LIG_FHA_1	97	103	PF00498	0.330
LIG_FHA_2	218	224	PF00498	0.427
LIG_FHA_2	518	524	PF00498	0.614
LIG_FHA_2	526	532	PF00498	0.509
LIG_FHA_2	604	610	PF00498	0.414
LIG_FHA_2	682	688	PF00498	0.674
LIG_FHA_2	78	84	PF00498	0.416
LIG_FHA_2	854	860	PF00498	0.738
LIG_LIR_Apic_2	162	167	PF02991	0.446
LIG_LIR_Gen_1	487	495	PF02991	0.420
LIG_LIR_Nem_3	299	305	PF02991	0.437
LIG_LIR_Nem_3	487	492	PF02991	0.420
LIG_LIR_Nem_3	835	839	PF02991	0.564
LIG_NRBOX	331	337	PF00104	0.386
LIG_Pex14_1	245	249	PF04695	0.429
LIG_Pex14_2	164	168	PF04695	0.468
LIG_Pex14_2	301	305	PF04695	0.438
LIG_Pex14_2	489	493	PF04695	0.414
LIG_SH2_CRK	671	675	PF00017	0.565
LIG_SH2_NCK_1	543	547	PF00017	0.374
LIG_SH2_STAP1	148	152	PF00017	0.508
LIG_SH2_STAP1	836	840	PF00017	0.508
LIG_SH2_STAT3	563	566	PF00017	0.427
LIG_SH2_STAT5	13	16	PF00017	0.460
LIG_SH2_STAT5	360	363	PF00017	0.468
LIG_SH2_STAT5	535	538	PF00017	0.316
LIG_SH2_STAT5	836	839	PF00017	0.566
LIG_SH3_3	118	124	PF00018	0.470
LIG_SH3_3	18	24	PF00018	0.556
LIG_SH3_3	358	364	PF00018	0.427
LIG_SH3_3	404	410	PF00018	0.414
LIG_SH3_3	478	484	PF00018	0.416
LIG_SH3_3	804	810	PF00018	0.604
LIG_SH3_3	871	877	PF00018	0.731
LIG_SH3_3	878	884	PF00018	0.627
LIG_SUMO_SIM_anti_2	800	805	PF11976	0.465
LIG_SUMO_SIM_par_1	159	165	PF11976	0.368
LIG_SUMO_SIM_par_1	216	224	PF11976	0.416
LIG_SUMO_SIM_par_1	745	751	PF11976	0.549
LIG_TRAF2_1	521	524	PF00917	0.420
LIG_TRAF2_1	528	531	PF00917	0.273
LIG_TRAF2_1	845	848	PF00917	0.582
LIG_TRFH_1	893	897	PF08558	0.655
LIG_TYR_ITIM	11	16	PF00017	0.503
LIG_UBA3_1	137	143	PF00899	0.382
LIG_WRC_WIRS_1	302	307	PF05994	0.451
MOD_CDK_SPxxK_3	427	434	PF00069	0.382
MOD_CK1_1	104	110	PF00069	0.427
MOD_CK1_1	207	213	PF00069	0.295
MOD_CK1_1	252	258	PF00069	0.570
MOD_CK1_1	288	294	PF00069	0.490
MOD_CK1_1	382	388	PF00069	0.257
MOD_CK1_1	40	46	PF00069	0.603
MOD_CK1_1	675	681	PF00069	0.450
MOD_CK1_1	713	719	PF00069	0.637
MOD_CK1_1	729	735	PF00069	0.499
MOD_CK1_1	783	789	PF00069	0.688
MOD_CK1_1	862	868	PF00069	0.704
MOD_CK2_1	433	439	PF00069	0.251
MOD_CK2_1	517	523	PF00069	0.606
MOD_CK2_1	525	531	PF00069	0.534
MOD_CK2_1	635	641	PF00069	0.578
MOD_CK2_1	681	687	PF00069	0.495
MOD_CK2_1	747	753	PF00069	0.528
MOD_CK2_1	772	778	PF00069	0.732
MOD_Cter_Amidation	841	844	PF01082	0.589
MOD_GlcNHglycan	209	212	PF01048	0.269
MOD_GlcNHglycan	278	281	PF01048	0.594
MOD_GlcNHglycan	287	290	PF01048	0.559
MOD_GlcNHglycan	31	34	PF01048	0.592
MOD_GlcNHglycan	324	327	PF01048	0.282
MOD_GlcNHglycan	336	339	PF01048	0.295
MOD_GlcNHglycan	39	42	PF01048	0.571
MOD_GlcNHglycan	391	394	PF01048	0.260
MOD_GlcNHglycan	464	467	PF01048	0.251
MOD_GlcNHglycan	553	556	PF01048	0.170
MOD_GlcNHglycan	661	664	PF01048	0.415
MOD_GlcNHglycan	674	677	PF01048	0.506
MOD_GlcNHglycan	737	740	PF01048	0.554
MOD_GlcNHglycan	750	753	PF01048	0.521
MOD_GlcNHglycan	762	765	PF01048	0.597
MOD_GlcNHglycan	813	816	PF01048	0.654
MOD_GlcNHglycan	865	868	PF01048	0.608
MOD_GlcNHglycan	903	906	PF01048	0.735
MOD_GSK3_1	104	111	PF00069	0.342
MOD_GSK3_1	115	122	PF00069	0.390
MOD_GSK3_1	169	176	PF00069	0.320
MOD_GSK3_1	213	220	PF00069	0.260
MOD_GSK3_1	223	230	PF00069	0.236
MOD_GSK3_1	248	255	PF00069	0.505
MOD_GSK3_1	341	348	PF00069	0.274
MOD_GSK3_1	36	43	PF00069	0.542
MOD_GSK3_1	362	369	PF00069	0.251
MOD_GSK3_1	379	386	PF00069	0.276
MOD_GSK3_1	389	396	PF00069	0.310
MOD_GSK3_1	413	420	PF00069	0.314
MOD_GSK3_1	452	459	PF00069	0.251
MOD_GSK3_1	513	520	PF00069	0.517
MOD_GSK3_1	709	716	PF00069	0.642
MOD_GSK3_1	773	780	PF00069	0.598
MOD_GSK3_1	834	841	PF00069	0.541
MOD_GSK3_1	855	862	PF00069	0.697
MOD_GSK3_1	863	870	PF00069	0.709
MOD_GSK3_1	887	894	PF00069	0.638
MOD_GSK3_1	897	904	PF00069	0.614
MOD_GSK3_1	96	103	PF00069	0.418
MOD_LATS_1	670	676	PF00433	0.354
MOD_N-GLC_1	207	212	PF02516	0.382
MOD_N-GLC_1	710	715	PF02516	0.607
MOD_N-GLC_1	726	731	PF02516	0.451
MOD_N-GLC_1	897	902	PF02516	0.732
MOD_N-GLC_2	65	67	PF02516	0.256
MOD_NEK2_1	102	107	PF00069	0.518
MOD_NEK2_1	133	138	PF00069	0.319
MOD_NEK2_1	227	232	PF00069	0.330
MOD_NEK2_1	301	306	PF00069	0.430
MOD_NEK2_1	339	344	PF00069	0.219
MOD_NEK2_1	388	393	PF00069	0.330
MOD_NEK2_1	457	462	PF00069	0.211
MOD_NEK2_1	551	556	PF00069	0.243
MOD_NEK2_1	585	590	PF00069	0.251
MOD_NEK2_1	617	622	PF00069	0.331
MOD_NEK2_1	737	742	PF00069	0.492
MOD_NEK2_1	75	80	PF00069	0.384
MOD_NEK2_1	791	796	PF00069	0.616
MOD_NEK2_1	797	802	PF00069	0.634
MOD_NEK2_2	346	351	PF00069	0.327
MOD_NEK2_2	49	54	PF00069	0.405
MOD_PIKK_1	173	179	PF00454	0.374
MOD_PIKK_1	366	372	PF00454	0.251
MOD_PIKK_1	538	544	PF00454	0.371
MOD_PIKK_1	704	710	PF00454	0.604
MOD_PIKK_1	729	735	PF00454	0.505
MOD_PIKK_1	791	797	PF00454	0.623
MOD_PIKK_1	816	822	PF00454	0.697
MOD_PIKK_1	867	873	PF00454	0.702
MOD_PKA_1	285	291	PF00069	0.570
MOD_PKA_1	901	907	PF00069	0.627
MOD_PKA_2	108	114	PF00069	0.344
MOD_PKA_2	138	144	PF00069	0.365
MOD_PKA_2	157	163	PF00069	0.160
MOD_PKA_2	169	175	PF00069	0.267
MOD_PKA_2	252	258	PF00069	0.457
MOD_PKA_2	285	291	PF00069	0.570
MOD_PKA_2	352	358	PF00069	0.251
MOD_PKA_2	37	43	PF00069	0.475
MOD_PKA_2	380	386	PF00069	0.281
MOD_PKA_2	433	439	PF00069	0.251
MOD_PKA_2	457	463	PF00069	0.211
MOD_PKA_2	701	707	PF00069	0.660
MOD_PKA_2	709	715	PF00069	0.596
MOD_PKA_2	760	766	PF00069	0.648
MOD_PKA_2	797	803	PF00069	0.673
MOD_PKB_1	310	318	PF00069	0.332
MOD_Plk_1	223	229	PF00069	0.330
MOD_Plk_1	525	531	PF00069	0.493
MOD_Plk_1	617	623	PF00069	0.387
MOD_Plk_1	704	710	PF00069	0.447
MOD_Plk_2-3	433	439	PF00069	0.251
MOD_Plk_2-3	525	531	PF00069	0.526
MOD_Plk_4	133	139	PF00069	0.251
MOD_Plk_4	31	37	PF00069	0.567
MOD_Plk_4	585	591	PF00069	0.251
MOD_Plk_4	726	732	PF00069	0.571
MOD_Plk_4	742	748	PF00069	0.520
MOD_Plk_4	77	83	PF00069	0.383
MOD_Plk_4	799	805	PF00069	0.537
MOD_ProDKin_1	427	433	PF00069	0.382
MOD_ProDKin_1	495	501	PF00069	0.295
MOD_ProDKin_1	569	575	PF00069	0.295
MOD_ProDKin_1	781	787	PF00069	0.582
MOD_ProDKin_1	877	883	PF00069	0.706
MOD_ProDKin_1	887	893	PF00069	0.555
MOD_SUMO_rev_2	169	176	PF00179	0.382
TRG_DiLeu_BaEn_1	409	414	PF01217	0.251
TRG_DiLeu_BaEn_1	850	855	PF01217	0.690
TRG_DiLeu_BaLyEn_6	481	486	PF01217	0.251
TRG_DiLeu_BaLyEn_6	546	551	PF01217	0.167
TRG_ENDOCYTIC_2	13	16	PF00928	0.511
TRG_ENDOCYTIC_2	562	565	PF00928	0.269
TRG_ENDOCYTIC_2	836	839	PF00928	0.566
TRG_ER_diArg_1	10	13	PF00400	0.481
TRG_ER_diArg_1	155	158	PF00400	0.330
TRG_ER_diArg_1	284	287	PF00400	0.614
TRG_NES_CRM1_1	186	200	PF08389	0.270
TRG_NES_CRM1_1	5	20	PF08389	0.346
TRG_NES_CRM1_1	694	705	PF08389	0.414
TRG_NLS_MonoCore_2	308	313	PF00514	0.431
TRG_NLS_MonoExtC_3	900	906	PF00514	0.679
TRG_NLS_MonoExtN_4	307	314	PF00514	0.494
TRG_Pf-PMV_PEXEL_1	640	644	PF00026	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P860	Leptomonas seymouri	28%	92%
A0A0N0P9H0	Leptomonas seymouri	74%	99%
A0A0S4J4D4	Bodo saltans	44%	98%
A0A1X0P4W1	Trypanosomatidae	60%	100%
A0A3Q8IQ79	Leishmania donovani	85%	100%
A0A3R7MUG3	Trypanosoma rangeli	57%	100%
A0A3S7WY81	Leishmania donovani	27%	100%
A4HDE7	Leishmania braziliensis	26%	100%
A4HGC9	Leishmania braziliensis	28%	94%
A4I0T0	Leishmania infantum	27%	100%
A4IC27	Leishmania infantum	85%	100%
B8B406	Oryza sativa subsp. indica	33%	100%
C9ZYH2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AFW6	Leishmania major	85%	99%
E9AWT2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AZQ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	94%
E9B719	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QAP2	Leishmania major	27%	100%
Q69QA6	Oryza sativa subsp. japonica	33%	100%
Q9SF37	Arabidopsis thaliana	28%	100%