Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNF4_LEIBR

TriTrypDb:

LbrM.34.4860 , LBRM2903_340059000

Length:

153

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNF4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	45	47	PF00675	0.652
CLV_PCSK_KEX2_1	45	47	PF00082	0.619
DEG_SPOP_SBC_1	72	76	PF00917	0.768
LIG_14-3-3_CanoR_1	3	11	PF00244	0.692
LIG_Clathr_ClatBox_1	120	124	PF01394	0.422
LIG_deltaCOP1_diTrp_1	143	148	PF00928	0.630
LIG_deltaCOP1_diTrp_1	99	107	PF00928	0.446
LIG_FHA_1	92	98	PF00498	0.470
LIG_LIR_Gen_1	99	107	PF02991	0.446
LIG_LIR_Nem_3	130	136	PF02991	0.477
LIG_LIR_Nem_3	141	147	PF02991	0.513
LIG_LIR_Nem_3	99	103	PF02991	0.444
LIG_Pex14_1	144	148	PF04695	0.491
LIG_SH2_STAT5	119	122	PF00017	0.595
LIG_SH2_STAT5	147	150	PF00017	0.614
MOD_CK1_1	49	55	PF00069	0.570
MOD_CK1_1	74	80	PF00069	0.576
MOD_CK2_1	67	73	PF00069	0.553
MOD_GlcNHglycan	48	51	PF01048	0.593
MOD_GlcNHglycan	94	97	PF01048	0.478
MOD_GSK3_1	46	53	PF00069	0.570
MOD_GSK3_1	67	74	PF00069	0.539
MOD_NEK2_1	92	97	PF00069	0.445
MOD_PKA_2	2	8	PF00069	0.722
MOD_PKA_2	36	42	PF00069	0.527
MOD_Plk_1	80	86	PF00069	0.504
TRG_ER_diArg_1	33	36	PF00400	0.662
TRG_ER_diArg_1	44	46	PF00400	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I444	Leptomonas seymouri	55%	98%
A0A3S5H809	Leishmania donovani	74%	100%
A4IC26	Leishmania infantum	74%	100%
E9AFW5	Leishmania major	76%	100%
E9B718	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%