FAM184 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNF1_LEIBR

TriTrypDb:

LbrM.34.4830 , LBRM2903_340058700

Length:

1014

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0097542	ciliary tip	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNF1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNF1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.565
CLV_C14_Caspase3-7	366	370	PF00656	0.523
CLV_C14_Caspase3-7	501	505	PF00656	0.474
CLV_NRD_NRD_1	1008	1010	PF00675	0.531
CLV_NRD_NRD_1	249	251	PF00675	0.633
CLV_NRD_NRD_1	260	262	PF00675	0.597
CLV_NRD_NRD_1	275	277	PF00675	0.558
CLV_NRD_NRD_1	392	394	PF00675	0.499
CLV_NRD_NRD_1	466	468	PF00675	0.544
CLV_NRD_NRD_1	483	485	PF00675	0.469
CLV_NRD_NRD_1	710	712	PF00675	0.593
CLV_NRD_NRD_1	717	719	PF00675	0.633
CLV_NRD_NRD_1	868	870	PF00675	0.667
CLV_NRD_NRD_1	906	908	PF00675	0.682
CLV_PCSK_KEX2_1	141	143	PF00082	0.566
CLV_PCSK_KEX2_1	249	251	PF00082	0.576
CLV_PCSK_KEX2_1	259	261	PF00082	0.673
CLV_PCSK_KEX2_1	275	277	PF00082	0.424
CLV_PCSK_KEX2_1	458	460	PF00082	0.613
CLV_PCSK_KEX2_1	466	468	PF00082	0.606
CLV_PCSK_KEX2_1	710	712	PF00082	0.593
CLV_PCSK_KEX2_1	717	719	PF00082	0.633
CLV_PCSK_KEX2_1	81	83	PF00082	0.455
CLV_PCSK_KEX2_1	855	857	PF00082	0.609
CLV_PCSK_KEX2_1	868	870	PF00082	0.600
CLV_PCSK_KEX2_1	906	908	PF00082	0.682
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.566
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.691
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.475
CLV_PCSK_PC1ET2_1	855	857	PF00082	0.711
CLV_PCSK_SKI1_1	163	167	PF00082	0.552
CLV_PCSK_SKI1_1	173	177	PF00082	0.559
CLV_PCSK_SKI1_1	219	223	PF00082	0.674
CLV_PCSK_SKI1_1	276	280	PF00082	0.596
CLV_PCSK_SKI1_1	283	287	PF00082	0.654
CLV_PCSK_SKI1_1	336	340	PF00082	0.670
CLV_PCSK_SKI1_1	380	384	PF00082	0.726
CLV_PCSK_SKI1_1	799	803	PF00082	0.701
CLV_PCSK_SKI1_1	90	94	PF00082	0.394
CLV_PCSK_SKI1_1	942	946	PF00082	0.400
CLV_Separin_Metazoa	725	729	PF03568	0.563
DOC_ANK_TNKS_1	345	352	PF00023	0.429
DOC_CYCLIN_RxL_1	939	949	PF00134	0.530
DOC_MAPK_gen_1	141	151	PF00069	0.658
DOC_MAPK_gen_1	585	594	PF00069	0.459
DOC_MAPK_gen_1	736	743	PF00069	0.442
DOC_MAPK_gen_1	930	939	PF00069	0.572
DOC_PP1_RVXF_1	378	384	PF00149	0.479
DOC_USP7_MATH_1	1001	1005	PF00917	0.515
DOC_USP7_MATH_1	278	282	PF00917	0.485
DOC_USP7_MATH_1	362	366	PF00917	0.546
DOC_USP7_MATH_1	407	411	PF00917	0.460
DOC_USP7_MATH_1	417	421	PF00917	0.648
DOC_USP7_MATH_1	431	435	PF00917	0.589
DOC_USP7_MATH_1	491	495	PF00917	0.465
DOC_USP7_MATH_1	511	515	PF00917	0.651
DOC_USP7_MATH_1	617	621	PF00917	0.518
DOC_USP7_MATH_1	675	679	PF00917	0.496
DOC_USP7_MATH_1	702	706	PF00917	0.459
DOC_USP7_UBL2_3	19	23	PF12436	0.530
LIG_14-3-3_CanoR_1	219	224	PF00244	0.776
LIG_14-3-3_CanoR_1	249	255	PF00244	0.566
LIG_14-3-3_CanoR_1	655	663	PF00244	0.548
LIG_14-3-3_CanoR_1	664	668	PF00244	0.659
LIG_14-3-3_CanoR_1	760	768	PF00244	0.435
LIG_14-3-3_CanoR_1	82	92	PF00244	0.602
LIG_14-3-3_CanoR_1	917	925	PF00244	0.629
LIG_14-3-3_CterR_2	1009	1014	PF00244	0.644
LIG_Actin_WH2_2	649	666	PF00022	0.715
LIG_Actin_WH2_2	940	957	PF00022	0.407
LIG_FHA_1	138	144	PF00498	0.636
LIG_FHA_1	26	32	PF00498	0.535
LIG_FHA_1	272	278	PF00498	0.503
LIG_FHA_1	327	333	PF00498	0.497
LIG_FHA_1	369	375	PF00498	0.521
LIG_FHA_1	43	49	PF00498	0.566
LIG_FHA_1	449	455	PF00498	0.464
LIG_FHA_1	487	493	PF00498	0.543
LIG_FHA_1	918	924	PF00498	0.413
LIG_FHA_2	249	255	PF00498	0.607
LIG_FHA_2	321	327	PF00498	0.682
LIG_FHA_2	551	557	PF00498	0.544
LIG_FHA_2	619	625	PF00498	0.467
LIG_FHA_2	664	670	PF00498	0.484
LIG_FHA_2	805	811	PF00498	0.441
LIG_FHA_2	84	90	PF00498	0.425
LIG_FHA_2	888	894	PF00498	0.633
LIG_FHA_2	917	923	PF00498	0.634
LIG_FHA_2	982	988	PF00498	0.655
LIG_GBD_Chelix_1	84	92	PF00786	0.395
LIG_LIR_Gen_1	972	983	PF02991	0.631
LIG_LIR_Nem_3	972	978	PF02991	0.624
LIG_LIR_Nem_3	987	991	PF02991	0.617
LIG_NRBOX	836	842	PF00104	0.667
LIG_PCNA_yPIPBox_3	820	833	PF02747	0.400
LIG_SH2_CRK	975	979	PF00017	0.635
LIG_SH2_CRK	988	992	PF00017	0.676
LIG_SH2_NCK_1	975	979	PF00017	0.635
LIG_SH2_STAP1	121	125	PF00017	0.569
LIG_SH2_STAP1	63	67	PF00017	0.521
LIG_SH2_STAP1	634	638	PF00017	0.707
LIG_SH2_STAP1	739	743	PF00017	0.590
LIG_SH2_STAT5	32	35	PF00017	0.556
LIG_SUMO_SIM_anti_2	635	643	PF11976	0.460
LIG_SUMO_SIM_anti_2	723	728	PF11976	0.446
LIG_SUMO_SIM_anti_2	935	941	PF11976	0.561
LIG_SUMO_SIM_par_1	943	949	PF11976	0.397
LIG_TRAF2_1	115	118	PF00917	0.325
LIG_TRAF2_1	251	254	PF00917	0.642
LIG_TRAF2_1	413	416	PF00917	0.469
LIG_TRAF2_1	474	477	PF00917	0.627
LIG_TRAF2_1	596	599	PF00917	0.459
LIG_TRAF2_1	836	839	PF00917	0.617
LIG_TRAF2_1	919	922	PF00917	0.663
LIG_TRAF2_1	98	101	PF00917	0.644
LIG_UBA3_1	826	833	PF00899	0.651
LIG_UBA3_1	847	855	PF00899	0.429
LIG_UBA3_1	939	948	PF00899	0.553
MOD_CK1_1	120	126	PF00069	0.446
MOD_CK1_1	230	236	PF00069	0.730
MOD_CK1_1	281	287	PF00069	0.624
MOD_CK1_1	320	326	PF00069	0.664
MOD_CK1_1	365	371	PF00069	0.629
MOD_CK1_1	4	10	PF00069	0.556
MOD_CK1_1	494	500	PF00069	0.519
MOD_CK1_1	618	624	PF00069	0.466
MOD_CK1_1	705	711	PF00069	0.463
MOD_CK1_1	829	835	PF00069	0.548
MOD_CK2_1	112	118	PF00069	0.652
MOD_CK2_1	121	127	PF00069	0.630
MOD_CK2_1	230	236	PF00069	0.702
MOD_CK2_1	248	254	PF00069	0.421
MOD_CK2_1	320	326	PF00069	0.685
MOD_CK2_1	506	512	PF00069	0.733
MOD_CK2_1	550	556	PF00069	0.689
MOD_CK2_1	618	624	PF00069	0.466
MOD_CK2_1	62	68	PF00069	0.624
MOD_CK2_1	663	669	PF00069	0.481
MOD_CK2_1	673	679	PF00069	0.556
MOD_CK2_1	829	835	PF00069	0.651
MOD_CK2_1	83	89	PF00069	0.467
MOD_CK2_1	887	893	PF00069	0.633
MOD_CK2_1	916	922	PF00069	0.631
MOD_CK2_1	929	935	PF00069	0.486
MOD_GlcNHglycan	228	232	PF01048	0.748
MOD_GlcNHglycan	359	362	PF01048	0.590
MOD_GlcNHglycan	493	496	PF01048	0.477
MOD_GlcNHglycan	512	516	PF01048	0.653
MOD_GlcNHglycan	531	535	PF01048	0.504
MOD_GlcNHglycan	576	581	PF01048	0.721
MOD_GlcNHglycan	692	695	PF01048	0.639
MOD_GlcNHglycan	707	710	PF01048	0.403
MOD_GlcNHglycan	887	890	PF01048	0.415
MOD_GlcNHglycan	987	991	PF01048	0.629
MOD_GlcNHglycan	999	1002	PF01048	0.635
MOD_GSK3_1	108	115	PF00069	0.609
MOD_GSK3_1	117	124	PF00069	0.566
MOD_GSK3_1	317	324	PF00069	0.681
MOD_GSK3_1	365	372	PF00069	0.671
MOD_GSK3_1	615	622	PF00069	0.511
MOD_GSK3_1	640	647	PF00069	0.443
MOD_GSK3_1	669	676	PF00069	0.531
MOD_GSK3_1	825	832	PF00069	0.584
MOD_GSK3_1	84	91	PF00069	0.557
MOD_GSK3_1	993	1000	PF00069	0.695
MOD_N-GLC_1	35	40	PF02516	0.433
MOD_N-GLC_1	437	442	PF02516	0.685
MOD_N-GLC_2	35	37	PF02516	0.641
MOD_NEK2_1	213	218	PF00069	0.718
MOD_NEK2_1	446	451	PF00069	0.436
MOD_NEK2_1	506	511	PF00069	0.718
MOD_NEK2_1	530	535	PF00069	0.536
MOD_NEK2_1	550	555	PF00069	0.462
MOD_NEK2_1	663	668	PF00069	0.676
MOD_NEK2_1	673	678	PF00069	0.692
MOD_NEK2_1	768	773	PF00069	0.690
MOD_NEK2_1	812	817	PF00069	0.642
MOD_NEK2_1	826	831	PF00069	0.408
MOD_NEK2_1	887	892	PF00069	0.556
MOD_NEK2_2	121	126	PF00069	0.417
MOD_PIKK_1	108	114	PF00454	0.524
MOD_PIKK_1	326	332	PF00454	0.520
MOD_PIKK_1	369	375	PF00454	0.744
MOD_PIKK_1	472	478	PF00454	0.546
MOD_PIKK_1	550	556	PF00454	0.542
MOD_PKA_2	143	149	PF00069	0.482
MOD_PKA_2	248	254	PF00069	0.567
MOD_PKA_2	271	277	PF00069	0.521
MOD_PKA_2	417	423	PF00069	0.731
MOD_PKA_2	431	437	PF00069	0.473
MOD_PKA_2	480	486	PF00069	0.490
MOD_PKA_2	654	660	PF00069	0.588
MOD_PKA_2	663	669	PF00069	0.486
MOD_PKA_2	916	922	PF00069	0.626
MOD_PKA_2	929	935	PF00069	0.496
MOD_Plk_1	117	123	PF00069	0.537
MOD_Plk_1	281	287	PF00069	0.655
MOD_Plk_1	668	674	PF00069	0.496
MOD_Plk_1	88	94	PF00069	0.396
MOD_Plk_2-3	720	726	PF00069	0.477
MOD_Plk_4	150	156	PF00069	0.396
MOD_SUMO_for_1	180	183	PF00179	0.665
MOD_SUMO_for_1	422	425	PF00179	0.685
MOD_SUMO_rev_2	135	143	PF00179	0.569
MOD_SUMO_rev_2	333	338	PF00179	0.444
MOD_SUMO_rev_2	574	580	PF00179	0.637
MOD_SUMO_rev_2	765	774	PF00179	0.493
TRG_DiLeu_BaEn_1	150	155	PF01217	0.546
TRG_DiLeu_BaEn_1	442	447	PF01217	0.593
TRG_DiLeu_BaEn_1	502	507	PF01217	0.727
TRG_DiLeu_BaEn_1	935	940	PF01217	0.561
TRG_DiLeu_LyEn_5	442	447	PF01217	0.558
TRG_ENDOCYTIC_2	162	165	PF00928	0.555
TRG_ENDOCYTIC_2	958	961	PF00928	0.574
TRG_ENDOCYTIC_2	975	978	PF00928	0.632
TRG_ENDOCYTIC_2	988	991	PF00928	0.676
TRG_ER_diArg_1	248	250	PF00400	0.566
TRG_ER_diArg_1	259	261	PF00400	0.669
TRG_ER_diArg_1	275	277	PF00400	0.424
TRG_ER_diArg_1	465	467	PF00400	0.472
TRG_ER_diArg_1	507	510	PF00400	0.584
TRG_ER_diArg_1	585	588	PF00400	0.467
TRG_ER_diArg_1	681	684	PF00400	0.473
TRG_ER_diArg_1	736	739	PF00400	0.584
TRG_NES_CRM1_1	520	531	PF08389	0.497
TRG_NES_CRM1_1	810	825	PF08389	0.508
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.634
TRG_Pf-PMV_PEXEL_1	452	456	PF00026	0.452
TRG_Pf-PMV_PEXEL_1	466	471	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	570	574	PF00026	0.656
TRG_Pf-PMV_PEXEL_1	799	803	PF00026	0.448
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I973	Leptomonas seymouri	48%	100%
A0A3S7XA02	Leishmania donovani	70%	100%
A4IC23	Leishmania infantum	70%	100%
E9AFW2	Leishmania major	68%	98%
E9B715	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%