Archaic_translocase_outer_membrane_12_kDa_subunit_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial import receptor subunit ATOM40, putative

Species:

Leishmania braziliensis

UniProt:

A4HNF0_LEIBR

TriTrypDb:

LbrM.34.4820 , LBRM2903_340058600

Length:

348

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0005742	mitochondrial outer membrane translocase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098799	outer mitochondrial membrane protein complex	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNF0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006839	mitochondrial transport	4	1
GO:0006886	intracellular protein transport	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0030150	protein import into mitochondrial matrix	4	1
GO:0033036	macromolecule localization	2	1
GO:0033365	protein localization to organelle	5	1
GO:0044743	protein transmembrane import into intracellular organelle	4	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0055085	transmembrane transport	2	1
GO:0065002	intracellular protein transmembrane transport	4	1
GO:0070585	protein localization to mitochondrion	6	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071806	protein transmembrane transport	3	1
GO:0072594	establishment of protein localization to organelle	4	1
GO:0072655	establishment of protein localization to mitochondrion	5	1
GO:1990542	mitochondrial transmembrane transport	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	287	289	PF00675	0.442
CLV_NRD_NRD_1	43	45	PF00675	0.571
CLV_NRD_NRD_1	72	74	PF00675	0.548
CLV_PCSK_KEX2_1	235	237	PF00082	0.601
CLV_PCSK_KEX2_1	42	44	PF00082	0.592
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.601
CLV_PCSK_PC1ET2_1	42	44	PF00082	0.658
CLV_PCSK_SKI1_1	107	111	PF00082	0.333
CLV_PCSK_SKI1_1	280	284	PF00082	0.550
CLV_PCSK_SKI1_1	64	68	PF00082	0.567
DEG_Nend_Nbox_1	1	3	PF02207	0.592
DEG_SCF_SKP2-CKS1_1	241	248	PF00560	0.477
DOC_MAPK_gen_1	19	27	PF00069	0.619
DOC_MAPK_gen_1	73	80	PF00069	0.536
DOC_MAPK_MEF2A_6	308	315	PF00069	0.437
DOC_MAPK_NFAT4_5	308	316	PF00069	0.532
DOC_PP1_RVXF_1	324	330	PF00149	0.559
DOC_PP2B_LxvP_1	311	314	PF13499	0.551
DOC_USP7_MATH_1	113	117	PF00917	0.458
DOC_USP7_MATH_1	219	223	PF00917	0.481
DOC_USP7_UBL2_3	15	19	PF12436	0.655
DOC_USP7_UBL2_3	248	252	PF12436	0.422
DOC_WW_Pin1_4	242	247	PF00397	0.486
LIG_14-3-3_CanoR_1	147	156	PF00244	0.466
LIG_14-3-3_CanoR_1	288	292	PF00244	0.543
LIG_14-3-3_CanoR_1	326	330	PF00244	0.550
LIG_14-3-3_CanoR_1	7	17	PF00244	0.615
LIG_14-3-3_CanoR_1	73	80	PF00244	0.445
LIG_Actin_WH2_2	312	328	PF00022	0.619
LIG_FHA_1	248	254	PF00498	0.489
LIG_FHA_1	296	302	PF00498	0.464
LIG_FHA_1	320	326	PF00498	0.572
LIG_FHA_1	73	79	PF00498	0.511
LIG_FHA_1	90	96	PF00498	0.464
LIG_FHA_2	254	260	PF00498	0.391
LIG_LIR_Gen_1	105	115	PF02991	0.595
LIG_LIR_Gen_1	134	143	PF02991	0.404
LIG_LIR_Gen_1	171	179	PF02991	0.475
LIG_LIR_Nem_3	105	111	PF02991	0.576
LIG_LIR_Nem_3	134	138	PF02991	0.391
LIG_LIR_Nem_3	65	71	PF02991	0.488
LIG_PCNA_yPIPBox_3	163	176	PF02747	0.438
LIG_PDZ_Class_2	343	348	PF00595	0.397
LIG_SH2_CRK	145	149	PF00017	0.445
LIG_SH2_CRK	68	72	PF00017	0.474
LIG_SH2_SRC	333	336	PF00017	0.449
LIG_SH2_STAP1	47	51	PF00017	0.680
LIG_SH2_STAT5	190	193	PF00017	0.420
LIG_SH2_STAT5	224	227	PF00017	0.501
LIG_SH3_1	56	62	PF00018	0.569
LIG_SH3_2	59	64	PF14604	0.566
LIG_SH3_3	56	62	PF00018	0.569
LIG_SH3_4	15	22	PF00018	0.513
LIG_TYR_ITIM	143	148	PF00017	0.402
LIG_TYR_ITIM	66	71	PF00017	0.488
MOD_CDK_SPxK_1	242	248	PF00069	0.488
MOD_CK1_1	134	140	PF00069	0.407
MOD_CK1_1	168	174	PF00069	0.558
MOD_CK1_1	223	229	PF00069	0.446
MOD_CK1_1	230	236	PF00069	0.484
MOD_CK1_1	247	253	PF00069	0.479
MOD_CK1_1	278	284	PF00069	0.358
MOD_CK1_1	38	44	PF00069	0.643
MOD_CK2_1	113	119	PF00069	0.446
MOD_CK2_1	51	57	PF00069	0.608
MOD_CK2_1	6	12	PF00069	0.731
MOD_GlcNHglycan	280	283	PF01048	0.500
MOD_GlcNHglycan	336	339	PF01048	0.411
MOD_GlcNHglycan	37	40	PF01048	0.607
MOD_GlcNHglycan	53	56	PF01048	0.449
MOD_GSK3_1	192	199	PF00069	0.411
MOD_GSK3_1	219	226	PF00069	0.420
MOD_GSK3_1	60	67	PF00069	0.605
MOD_GSK3_1	99	106	PF00069	0.477
MOD_N-GLC_1	212	217	PF02516	0.488
MOD_NEK2_1	103	108	PF00069	0.452
MOD_NEK2_1	154	159	PF00069	0.493
MOD_NEK2_1	196	201	PF00069	0.404
MOD_NEK2_1	297	302	PF00069	0.470
MOD_NEK2_1	325	330	PF00069	0.529
MOD_NEK2_1	51	56	PF00069	0.563
MOD_NEK2_1	6	11	PF00069	0.727
MOD_NEK2_1	72	77	PF00069	0.407
MOD_NEK2_2	275	280	PF00069	0.396
MOD_PIKK_1	154	160	PF00454	0.442
MOD_PIKK_1	165	171	PF00454	0.405
MOD_PIKK_1	183	189	PF00454	0.407
MOD_PIKK_1	72	78	PF00454	0.521
MOD_PKA_2	275	281	PF00069	0.630
MOD_PKA_2	287	293	PF00069	0.540
MOD_PKA_2	325	331	PF00069	0.553
MOD_PKA_2	6	12	PF00069	0.715
MOD_PKA_2	72	78	PF00069	0.311
MOD_Plk_1	192	198	PF00069	0.434
MOD_Plk_1	212	218	PF00069	0.222
MOD_Plk_4	168	174	PF00069	0.411
MOD_Plk_4	220	226	PF00069	0.540
MOD_Plk_4	287	293	PF00069	0.509
MOD_Plk_4	297	303	PF00069	0.491
MOD_Plk_4	99	105	PF00069	0.398
MOD_ProDKin_1	242	248	PF00069	0.488
MOD_SUMO_rev_2	12	22	PF00179	0.710
MOD_SUMO_rev_2	45	52	PF00179	0.600
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.473
TRG_ENDOCYTIC_2	141	144	PF00928	0.431
TRG_ENDOCYTIC_2	145	148	PF00928	0.420
TRG_ENDOCYTIC_2	68	71	PF00928	0.439
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.613
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.670

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE17	Leptomonas seymouri	82%	100%
A0A0S4J3Y4	Bodo saltans	47%	100%
A0A1X0P556	Trypanosomatidae	54%	99%
A0A3R7KX50	Trypanosoma rangeli	54%	99%
A0A3S7XA15	Leishmania donovani	93%	100%
A4IC22	Leishmania infantum	93%	100%
C9ZYH7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	99%
E9AFW1	Leishmania major	92%	100%
E9B714	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5D7G9	Trypanosoma cruzi	53%	99%