LeishMANIAdb
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ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HNE8_LEIBR
TriTrypDb:
LbrM.34.4800 , LBRM2903_340058400
Length:
140

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 2
NetGPI no yes: 0, no: 2
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNE8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNE8

Putative motif mimicry

Leishmania From To Domain/Motif Score
DOC_MAPK_gen_1 97 106 PF00069 0.425
DOC_PP4_FxxP_1 105 108 PF00568 0.409
DOC_WW_Pin1_4 122 127 PF00397 0.447
DOC_WW_Pin1_4 53 58 PF00397 0.451
LIG_BRCT_BRCA1_1 124 128 PF00533 0.457
LIG_FHA_2 131 137 PF00498 0.598
LIG_FHA_2 60 66 PF00498 0.391
LIG_LIR_Apic_2 103 108 PF02991 0.414
LIG_LIR_Nem_3 62 67 PF02991 0.380
LIG_PTB_Apo_2 99 106 PF02174 0.434
LIG_SH2_STAT5 43 46 PF00017 0.454
LIG_SH3_3 105 111 PF00018 0.413
LIG_TRAF2_1 133 136 PF00917 0.498
MOD_CDK_SPK_2 53 58 PF00069 0.451
MOD_CK1_1 124 130 PF00069 0.537
MOD_CK1_1 20 26 PF00069 0.592
MOD_CK2_1 130 136 PF00069 0.722
MOD_CK2_1 59 65 PF00069 0.399
MOD_GSK3_1 122 129 PF00069 0.569
MOD_GSK3_1 13 20 PF00069 0.497
MOD_GSK3_1 24 31 PF00069 0.482
MOD_GSK3_1 53 60 PF00069 0.463
MOD_N-GLC_2 17 19 PF02516 0.503
MOD_NEK2_1 70 75 PF00069 0.475
MOD_NMyristoyl 1 7 PF02799 0.469
MOD_PIKK_1 25 31 PF00454 0.520
MOD_PKA_2 130 136 PF00069 0.546
MOD_Plk_1 70 76 PF00069 0.668
MOD_Plk_2-3 130 136 PF00069 0.495
MOD_ProDKin_1 122 128 PF00069 0.452
MOD_ProDKin_1 53 59 PF00069 0.449
TRG_ENDOCYTIC_2 67 70 PF00928 0.412
TRG_ER_diArg_1 97 100 PF00400 0.394

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IMM7 Leptomonas seymouri 46% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS