YcaO domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNE7_LEIBR

TriTrypDb:

LbrM.34.4790 , LBRM2903_340058300

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNE7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.429
CLV_NRD_NRD_1	365	367	PF00675	0.657
CLV_NRD_NRD_1	40	42	PF00675	0.475
CLV_PCSK_KEX2_1	365	367	PF00082	0.657
CLV_PCSK_KEX2_1	40	42	PF00082	0.449
CLV_PCSK_SKI1_1	275	279	PF00082	0.484
CLV_PCSK_SKI1_1	317	321	PF00082	0.617
CLV_PCSK_SKI1_1	4	8	PF00082	0.525
DEG_Nend_UBRbox_3	1	3	PF02207	0.464
DOC_CKS1_1	131	136	PF01111	0.500
DOC_CYCLIN_yCln2_LP_2	242	248	PF00134	0.504
DOC_MAPK_MEF2A_6	188	196	PF00069	0.536
DOC_MAPK_MEF2A_6	74	81	PF00069	0.574
DOC_PP1_RVXF_1	2	8	PF00149	0.588
DOC_PP2B_LxvP_1	169	172	PF13499	0.487
DOC_PP2B_LxvP_1	279	282	PF13499	0.462
DOC_PP2B_PxIxI_1	191	197	PF00149	0.537
DOC_PP4_FxxP_1	312	315	PF00568	0.603
DOC_PP4_FxxP_1	7	10	PF00568	0.466
DOC_SPAK_OSR1_1	214	218	PF12202	0.458
DOC_USP7_MATH_1	25	29	PF00917	0.471
DOC_USP7_MATH_1	267	271	PF00917	0.454
DOC_USP7_MATH_1	333	337	PF00917	0.681
DOC_WW_Pin1_4	130	135	PF00397	0.494
DOC_WW_Pin1_4	188	193	PF00397	0.497
LIG_14-3-3_CanoR_1	365	369	PF00244	0.685
LIG_14-3-3_CanoR_1	40	49	PF00244	0.398
LIG_Actin_WH2_2	350	367	PF00022	0.692
LIG_APCC_ABBA_1	170	175	PF00400	0.435
LIG_BIR_III_4	59	63	PF00653	0.561
LIG_BRCT_BRCA1_1	27	31	PF00533	0.575
LIG_Clathr_ClatBox_1	86	90	PF01394	0.374
LIG_EH1_1	226	234	PF00400	0.457
LIG_FHA_1	110	116	PF00498	0.456
LIG_FHA_1	189	195	PF00498	0.475
LIG_FHA_1	359	365	PF00498	0.702
LIG_FHA_1	66	72	PF00498	0.498
LIG_FHA_1	94	100	PF00498	0.438
LIG_FHA_2	108	114	PF00498	0.422
LIG_FHA_2	131	137	PF00498	0.575
LIG_FHA_2	145	151	PF00498	0.439
LIG_FHA_2	353	359	PF00498	0.677
LIG_LIR_Apic_2	101	105	PF02991	0.443
LIG_LIR_Apic_2	310	315	PF02991	0.603
LIG_LIR_Apic_2	43	49	PF02991	0.567
LIG_LIR_Gen_1	255	265	PF02991	0.437
LIG_LIR_Gen_1	273	284	PF02991	0.389
LIG_LIR_Gen_1	28	39	PF02991	0.315
LIG_LIR_Gen_1	306	315	PF02991	0.596
LIG_LIR_Gen_1	377	388	PF02991	0.625
LIG_LIR_Gen_1	95	105	PF02991	0.388
LIG_LIR_Nem_3	255	260	PF02991	0.418
LIG_LIR_Nem_3	273	279	PF02991	0.301
LIG_LIR_Nem_3	28	34	PF02991	0.331
LIG_LIR_Nem_3	306	312	PF02991	0.644
LIG_LIR_Nem_3	377	383	PF02991	0.617
LIG_LIR_Nem_3	78	84	PF02991	0.422
LIG_LIR_Nem_3	95	100	PF02991	0.320
LIG_Pex14_2	142	146	PF04695	0.463
LIG_PTB_Apo_2	378	385	PF02174	0.618
LIG_PTB_Phospho_1	378	384	PF10480	0.616
LIG_Rb_LxCxE_1	83	101	PF01857	0.533
LIG_SH2_CRK	102	106	PF00017	0.496
LIG_SH2_CRK	276	280	PF00017	0.392
LIG_SH2_CRK	284	288	PF00017	0.410
LIG_SH2_CRK	289	293	PF00017	0.458
LIG_SH2_CRK	46	50	PF00017	0.525
LIG_SH2_CRK	8	12	PF00017	0.494
LIG_SH2_CRK	84	88	PF00017	0.461
LIG_SH2_NCK_1	102	106	PF00017	0.529
LIG_SH2_STAP1	161	165	PF00017	0.376
LIG_SH2_STAP1	276	280	PF00017	0.367
LIG_SH2_STAP1	305	309	PF00017	0.584
LIG_SH2_STAT3	176	179	PF00017	0.441
LIG_SH3_3	180	186	PF00018	0.429
LIG_SH3_5	172	176	PF00018	0.481
LIG_TRAF2_1	253	256	PF00917	0.381
LIG_TYR_ITAM	273	292	PF00017	0.441
LIG_WRC_WIRS_1	104	109	PF05994	0.430
MOD_CDK_SPxxK_3	130	137	PF00069	0.572
MOD_CK1_1	109	115	PF00069	0.533
MOD_CK1_1	352	358	PF00069	0.738
MOD_CK2_1	122	128	PF00069	0.413
MOD_CK2_1	220	226	PF00069	0.386
MOD_CK2_1	250	256	PF00069	0.390
MOD_CK2_1	267	273	PF00069	0.433
MOD_CK2_1	352	358	PF00069	0.680
MOD_GlcNHglycan	124	127	PF01048	0.397
MOD_GlcNHglycan	16	19	PF01048	0.570
MOD_GlcNHglycan	267	270	PF01048	0.469
MOD_GlcNHglycan	331	334	PF01048	0.636
MOD_GlcNHglycan	59	63	PF01048	0.537
MOD_GSK3_1	103	110	PF00069	0.393
MOD_GSK3_1	25	32	PF00069	0.359
MOD_GSK3_1	325	332	PF00069	0.650
MOD_GSK3_1	352	359	PF00069	0.649
MOD_GSK3_1	364	371	PF00069	0.599
MOD_N-GLC_1	344	349	PF02516	0.721
MOD_NEK2_1	107	112	PF00069	0.487
MOD_NEK2_1	122	127	PF00069	0.278
MOD_NEK2_1	260	265	PF00069	0.488
MOD_NEK2_1	364	369	PF00069	0.631
MOD_NEK2_2	267	272	PF00069	0.354
MOD_PIKK_1	107	113	PF00454	0.525
MOD_PKA_1	40	46	PF00069	0.318
MOD_PKA_2	364	370	PF00069	0.684
MOD_PKA_2	40	46	PF00069	0.318
MOD_Plk_1	120	126	PF00069	0.400
MOD_Plk_1	161	167	PF00069	0.463
MOD_Plk_1	250	256	PF00069	0.395
MOD_Plk_4	260	266	PF00069	0.464
MOD_Plk_4	267	273	PF00069	0.418
MOD_ProDKin_1	130	136	PF00069	0.497
MOD_ProDKin_1	188	194	PF00069	0.484
TRG_DiLeu_BaEn_1	95	100	PF01217	0.422
TRG_DiLeu_BaLyEn_6	134	139	PF01217	0.337
TRG_ENDOCYTIC_2	276	279	PF00928	0.433
TRG_ENDOCYTIC_2	289	292	PF00928	0.469
TRG_ENDOCYTIC_2	309	312	PF00928	0.401
TRG_ENDOCYTIC_2	8	11	PF00928	0.490
TRG_ENDOCYTIC_2	84	87	PF00928	0.462
TRG_ER_diArg_1	364	366	PF00400	0.657
TRG_ER_diArg_1	39	41	PF00400	0.473
TRG_NES_CRM1_1	114	128	PF08389	0.404
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.465
TRG_Pf-PMV_PEXEL_1	366	370	PF00026	0.722

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDR1	Leptomonas seymouri	81%	82%
A0A0S4J7W9	Bodo saltans	50%	98%
A0A1X0P558	Trypanosomatidae	66%	84%
A0A3Q8IFL6	Leishmania donovani	92%	100%
A4IC19	Leishmania infantum	92%	100%
C9ZYI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	85%
E9AFV8	Leishmania major	91%	100%
E9B711	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5BBH8	Trypanosoma cruzi	63%	84%