Histidine phosphatase family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histidine phosphatase superfamily (branch 1), putative

Species:

Leishmania braziliensis

UniProt:

A4HNE6_LEIBR

TriTrypDb:

LbrM.34.4780 , LBRM2903_340058200

Length:

335

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 7, no: 4
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HNE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNE6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	58	62	PF00656	0.734
CLV_NRD_NRD_1	158	160	PF00675	0.301
CLV_NRD_NRD_1	285	287	PF00675	0.370
CLV_PCSK_FUR_1	64	68	PF00082	0.280
CLV_PCSK_KEX2_1	158	160	PF00082	0.301
CLV_PCSK_KEX2_1	285	287	PF00082	0.334
CLV_PCSK_KEX2_1	66	68	PF00082	0.336
CLV_PCSK_PC1ET2_1	66	68	PF00082	0.361
CLV_PCSK_PC7_1	281	287	PF00082	0.327
CLV_PCSK_SKI1_1	137	141	PF00082	0.386
CLV_PCSK_SKI1_1	281	285	PF00082	0.305
CLV_PCSK_SKI1_1	70	74	PF00082	0.292
CLV_PCSK_SKI1_1	95	99	PF00082	0.336
DEG_Kelch_Keap1_1	314	319	PF01344	0.542
DEG_Nend_Nbox_1	1	3	PF02207	0.287
DOC_CKS1_1	16	21	PF01111	0.449
DOC_CYCLIN_yCln2_LP_2	90	96	PF00134	0.634
DOC_MAPK_gen_1	137	145	PF00069	0.582
DOC_MAPK_gen_1	64	74	PF00069	0.532
DOC_MAPK_MEF2A_6	64	73	PF00069	0.547
DOC_PP1_RVXF_1	140	146	PF00149	0.581
DOC_PP1_RVXF_1	68	74	PF00149	0.498
DOC_PP2B_LxvP_1	90	93	PF13499	0.640
DOC_PP4_FxxP_1	287	290	PF00568	0.583
DOC_USP7_MATH_1	111	115	PF00917	0.520
DOC_USP7_MATH_1	120	124	PF00917	0.538
DOC_USP7_MATH_1	147	151	PF00917	0.560
DOC_USP7_MATH_1	261	265	PF00917	0.611
DOC_USP7_UBL2_3	328	332	PF12436	0.603
DOC_USP7_UBL2_3	42	46	PF12436	0.522
DOC_WW_Pin1_4	116	121	PF00397	0.516
DOC_WW_Pin1_4	15	20	PF00397	0.413
DOC_WW_Pin1_4	166	171	PF00397	0.595
LIG_14-3-3_CanoR_1	171	181	PF00244	0.534
LIG_14-3-3_CanoR_1	75	81	PF00244	0.491
LIG_AP2alpha_2	110	112	PF02296	0.540
LIG_BRCT_BRCA1_1	276	280	PF00533	0.487
LIG_CtBP_PxDLS_1	215	219	PF00389	0.620
LIG_FHA_1	103	109	PF00498	0.523
LIG_FHA_1	147	153	PF00498	0.517
LIG_FHA_1	161	167	PF00498	0.460
LIG_FHA_1	211	217	PF00498	0.593
LIG_FHA_1	324	330	PF00498	0.577
LIG_FHA_1	49	55	PF00498	0.641
LIG_FHA_2	56	62	PF00498	0.731
LIG_LIR_Gen_1	103	112	PF02991	0.544
LIG_LIR_Gen_1	236	246	PF02991	0.580
LIG_LIR_Gen_1	51	59	PF02991	0.613
LIG_LIR_Gen_1	79	88	PF02991	0.525
LIG_LIR_Nem_3	103	107	PF02991	0.555
LIG_LIR_Nem_3	277	283	PF02991	0.493
LIG_LIR_Nem_3	79	84	PF02991	0.501
LIG_MLH1_MIPbox_1	276	280	PF16413	0.498
LIG_Pex14_1	81	85	PF04695	0.515
LIG_Pex14_2	280	284	PF04695	0.497
LIG_PTB_Apo_2	79	86	PF02174	0.516
LIG_REV1ctd_RIR_1	281	288	PF16727	0.518
LIG_SH2_GRB2like	225	228	PF00017	0.596
LIG_SH2_SRC	225	228	PF00017	0.596
LIG_SH2_SRC	31	34	PF00017	0.585
LIG_SH2_STAT5	225	228	PF00017	0.586
LIG_SH2_STAT5	279	282	PF00017	0.535
LIG_SH2_STAT5	53	56	PF00017	0.640
LIG_SH3_3	13	19	PF00018	0.449
LIG_SH3_3	218	224	PF00018	0.601
LIG_SUMO_SIM_anti_2	217	223	PF11976	0.601
LIG_SUMO_SIM_anti_2	270	275	PF11976	0.491
LIG_TRAF2_1	184	187	PF00917	0.514
LIG_WRC_WIRS_1	132	137	PF05994	0.568
MOD_CDK_SPK_2	166	171	PF00069	0.595
MOD_CDK_SPxxK_3	15	22	PF00069	0.449
MOD_CK1_1	119	125	PF00069	0.529
MOD_CK1_1	196	202	PF00069	0.611
MOD_CK2_1	313	319	PF00069	0.540
MOD_Cter_Amidation	124	127	PF01082	0.427
MOD_Cter_Amidation	64	67	PF01082	0.420
MOD_GlcNHglycan	182	185	PF01048	0.331
MOD_GlcNHglycan	251	254	PF01048	0.395
MOD_GlcNHglycan	276	279	PF01048	0.312
MOD_GlcNHglycan	314	319	PF01048	0.371
MOD_GSK3_1	102	109	PF00069	0.601
MOD_GSK3_1	116	123	PF00069	0.486
MOD_GSK3_1	131	138	PF00069	0.586
MOD_GSK3_1	147	154	PF00069	0.593
MOD_GSK3_1	249	256	PF00069	0.483
MOD_GSK3_1	289	296	PF00069	0.599
MOD_GSK3_1	76	83	PF00069	0.497
MOD_N-GLC_1	210	215	PF02516	0.364
MOD_NEK2_1	135	140	PF00069	0.538
MOD_NEK2_1	84	89	PF00069	0.566
MOD_PIKK_1	172	178	PF00454	0.640
MOD_PIKK_1	186	192	PF00454	0.626
MOD_PKA_2	48	54	PF00069	0.583
MOD_Plk_1	253	259	PF00069	0.514
MOD_Plk_1	322	328	PF00069	0.528
MOD_Plk_4	131	137	PF00069	0.558
MOD_Plk_4	147	153	PF00069	0.477
MOD_Plk_4	253	259	PF00069	0.514
MOD_Plk_4	76	82	PF00069	0.493
MOD_ProDKin_1	116	122	PF00069	0.516
MOD_ProDKin_1	15	21	PF00069	0.413
MOD_ProDKin_1	166	172	PF00069	0.595
TRG_DiLeu_BaEn_2	102	108	PF01217	0.556
TRG_DiLeu_BaLyEn_6	168	173	PF01217	0.440
TRG_ENDOCYTIC_2	238	241	PF00928	0.504
TRG_ENDOCYTIC_2	331	334	PF00928	0.534
TRG_ENDOCYTIC_2	53	56	PF00928	0.591
TRG_ER_diArg_1	157	159	PF00400	0.502
TRG_ER_diArg_1	284	286	PF00400	0.569
TRG_NLS_Bipartite_1	285	302	PF00514	0.593
TRG_NLS_MonoCore_2	296	301	PF00514	0.559
TRG_NLS_MonoExtN_4	297	302	PF00514	0.520
TRG_Pf-PMV_PEXEL_1	171	176	PF00026	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P956	Leptomonas seymouri	76%	100%
A0A0S4J7E1	Bodo saltans	57%	100%
A0A1X0P4X0	Trypanosomatidae	60%	100%
A0A3Q8IVL2	Leishmania donovani	89%	100%
A0A422P1A4	Trypanosoma rangeli	59%	99%
A4IC18	Leishmania infantum	89%	100%
C9ZYI2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AFV7	Leishmania major	89%	100%
E9B710	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5BG29	Trypanosoma cruzi	57%	100%