BRCT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

BRCA1 C Terminus (BRCT) domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HNE5_LEIBR

TriTrypDb:

LbrM.34.4770 , LBRM2903_340058100

Length:

352

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HNE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNE5

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0006470	protein dephosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0016311	dephosphorylation	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0070940	obsolete dephosphorylation of RNA polymerase II C-terminal domain	6	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0004722	protein serine/threonine phosphatase activity	4	1
GO:0008420	RNA polymerase II CTD heptapeptide repeat phosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:0005488	binding	1	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	289	293	PF00656	0.314
CLV_NRD_NRD_1	213	215	PF00675	0.638
CLV_PCSK_KEX2_1	131	133	PF00082	0.452
CLV_PCSK_PC1ET2_1	131	133	PF00082	0.452
CLV_PCSK_SKI1_1	146	150	PF00082	0.647
CLV_PCSK_SKI1_1	214	218	PF00082	0.449
CLV_PCSK_SKI1_1	234	238	PF00082	0.444
CLV_PCSK_SKI1_1	252	256	PF00082	0.344
CLV_PCSK_SKI1_1	346	350	PF00082	0.362
DEG_Nend_UBRbox_2	1	3	PF02207	0.428
DOC_CKS1_1	332	337	PF01111	0.529
DOC_CYCLIN_RxL_1	231	238	PF00134	0.513
DOC_MAPK_gen_1	214	222	PF00069	0.526
DOC_MAPK_gen_1	290	296	PF00069	0.422
DOC_MAPK_gen_1	64	72	PF00069	0.465
DOC_PP4_FxxP_1	140	143	PF00568	0.493
DOC_USP7_MATH_1	28	32	PF00917	0.499
DOC_USP7_UBL2_3	345	349	PF12436	0.546
DOC_WW_Pin1_4	242	247	PF00397	0.416
DOC_WW_Pin1_4	303	308	PF00397	0.380
DOC_WW_Pin1_4	331	336	PF00397	0.526
LIG_14-3-3_CanoR_1	102	107	PF00244	0.418
LIG_14-3-3_CanoR_1	39	48	PF00244	0.469
LIG_14-3-3_CanoR_1	74	82	PF00244	0.441
LIG_APCC_ABBA_1	172	177	PF00400	0.660
LIG_BRCT_BRCA1_1	10	14	PF00533	0.292
LIG_Clathr_ClatBox_1	255	259	PF01394	0.317
LIG_FHA_1	279	285	PF00498	0.425
LIG_FHA_1	304	310	PF00498	0.361
LIG_FHA_1	334	340	PF00498	0.484
LIG_FHA_2	158	164	PF00498	0.627
LIG_FHA_2	182	188	PF00498	0.519
LIG_FHA_2	44	50	PF00498	0.516
LIG_LIR_Apic_2	133	137	PF02991	0.599
LIG_LIR_Apic_2	138	143	PF02991	0.651
LIG_LIR_Apic_2	2	7	PF02991	0.487
LIG_LIR_Gen_1	11	22	PF02991	0.293
LIG_LIR_Gen_1	187	196	PF02991	0.366
LIG_LIR_Gen_1	228	237	PF02991	0.345
LIG_LIR_Gen_1	73	83	PF02991	0.352
LIG_LIR_Nem_3	11	17	PF02991	0.381
LIG_LIR_Nem_3	187	192	PF02991	0.357
LIG_LIR_Nem_3	228	232	PF02991	0.363
LIG_LIR_Nem_3	73	78	PF02991	0.383
LIG_MLH1_MIPbox_1	10	14	PF16413	0.292
LIG_NRBOX	86	92	PF00104	0.417
LIG_PCNA_yPIPBox_3	277	291	PF02747	0.339
LIG_Pex14_2	10	14	PF04695	0.427
LIG_SH2_CRK	134	138	PF00017	0.592
LIG_SH2_CRK	189	193	PF00017	0.372
LIG_SH2_CRK	229	233	PF00017	0.352
LIG_SH2_CRK	4	8	PF00017	0.509
LIG_SH2_CRK	75	79	PF00017	0.449
LIG_SH2_NCK_1	183	187	PF00017	0.400
LIG_SH2_NCK_1	229	233	PF00017	0.487
LIG_SH2_NCK_1	347	351	PF00017	0.371
LIG_SH2_NCK_1	75	79	PF00017	0.389
LIG_SH2_STAP1	189	193	PF00017	0.436
LIG_SH2_STAT5	13	16	PF00017	0.399
LIG_SH2_STAT5	183	186	PF00017	0.411
LIG_SH2_STAT5	333	336	PF00017	0.462
LIG_SH3_3	153	159	PF00018	0.690
LIG_SH3_3	240	246	PF00018	0.440
LIG_SUMO_SIM_par_1	184	190	PF11976	0.358
LIG_TRAF2_1	271	274	PF00917	0.377
LIG_UBA3_1	339	346	PF00899	0.478
MOD_CDK_SPK_2	333	338	PF00069	0.483
MOD_CDK_SPxxK_3	331	338	PF00069	0.571
MOD_CK1_1	225	231	PF00069	0.421
MOD_CK1_1	278	284	PF00069	0.484
MOD_CK1_1	76	82	PF00069	0.292
MOD_CK2_1	157	163	PF00069	0.595
MOD_CK2_1	244	250	PF00069	0.439
MOD_CK2_1	268	274	PF00069	0.486
MOD_GlcNHglycan	10	13	PF01048	0.527
MOD_GlcNHglycan	199	202	PF01048	0.622
MOD_GlcNHglycan	277	280	PF01048	0.602
MOD_GSK3_1	110	117	PF00069	0.660
MOD_GSK3_1	242	249	PF00069	0.467
MOD_GSK3_1	268	275	PF00069	0.550
MOD_GSK3_1	40	47	PF00069	0.524
MOD_GSK3_1	86	93	PF00069	0.508
MOD_N-GLC_1	110	115	PF02516	0.450
MOD_NEK2_1	222	227	PF00069	0.503
MOD_NEK2_1	272	277	PF00069	0.537
MOD_NEK2_1	301	306	PF00069	0.567
MOD_NEK2_1	311	316	PF00069	0.458
MOD_NEK2_1	339	344	PF00069	0.455
MOD_NEK2_1	86	91	PF00069	0.440
MOD_NEK2_2	110	115	PF00069	0.450
MOD_PIKK_1	222	228	PF00454	0.529
MOD_PK_1	102	108	PF00069	0.419
MOD_PK_1	74	80	PF00069	0.315
MOD_PKA_2	101	107	PF00069	0.548
MOD_PKA_2	114	120	PF00069	0.667
MOD_PKA_2	268	274	PF00069	0.609
MOD_PKA_2	73	79	PF00069	0.406
MOD_Plk_1	110	116	PF00069	0.454
MOD_Plk_1	272	278	PF00069	0.537
MOD_Plk_2-3	157	163	PF00069	0.661
MOD_Plk_4	181	187	PF00069	0.661
MOD_Plk_4	48	54	PF00069	0.515
MOD_Plk_4	86	92	PF00069	0.464
MOD_Plk_4	96	102	PF00069	0.447
MOD_ProDKin_1	242	248	PF00069	0.414
MOD_ProDKin_1	303	309	PF00069	0.367
MOD_ProDKin_1	331	337	PF00069	0.534
MOD_SUMO_rev_2	139	148	PF00179	0.497
MOD_SUMO_rev_2	245	254	PF00179	0.329
TRG_DiLeu_BaEn_1	297	302	PF01217	0.353
TRG_DiLeu_LyEn_5	250	255	PF01217	0.336
TRG_ENDOCYTIC_2	183	186	PF00928	0.421
TRG_ENDOCYTIC_2	189	192	PF00928	0.306
TRG_ENDOCYTIC_2	229	232	PF00928	0.488
TRG_ENDOCYTIC_2	75	78	PF00928	0.366

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P9H3	Leptomonas seymouri	66%	90%
A0A0S4J3S6	Bodo saltans	46%	90%
A0A1X0P4V1	Trypanosomatidae	51%	92%
A0A3R7RRN6	Trypanosoma rangeli	51%	92%
A0A3S7XA18	Leishmania donovani	66%	96%
C9ZYI4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	88%
E9AFV6	Leishmania major	64%	100%
E9AHW9	Leishmania infantum	66%	96%
E9B709	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	92%
V5B718	Trypanosoma cruzi	51%	91%