Scamp family-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HNE3_LEIBR

TriTrypDb:

LbrM.34.4750 , LBRM2903_340057900

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0010008	endosome membrane	5	1
GO:0012506	vesicle membrane	4	1
GO:0030659	cytoplasmic vesicle membrane	5	1
GO:0031090	organelle membrane	3	1
GO:0032588	trans-Golgi network membrane	4	1
GO:0055038	recycling endosome membrane	6	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

A4HNE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNE3

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.369
CLV_PCSK_KEX2_1	19	21	PF00082	0.370
CLV_PCSK_KEX2_1	25	27	PF00082	0.385
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.466
CLV_PCSK_SKI1_1	135	139	PF00082	0.237
CLV_PCSK_SKI1_1	171	175	PF00082	0.444
CLV_PCSK_SKI1_1	20	24	PF00082	0.456
DEG_APCC_DBOX_1	132	140	PF00400	0.401
DOC_MAPK_gen_1	131	138	PF00069	0.466
DOC_MAPK_MEF2A_6	135	143	PF00069	0.233
DOC_PP2B_LxvP_1	109	112	PF13499	0.315
DOC_USP7_UBL2_3	25	29	PF12436	0.505
LIG_14-3-3_CanoR_1	171	177	PF00244	0.249
LIG_BRCT_BRCA1_1	103	107	PF00533	0.316
LIG_FHA_1	172	178	PF00498	0.280
LIG_FHA_1	74	80	PF00498	0.386
LIG_FHA_2	32	38	PF00498	0.514
LIG_GBD_Chelix_1	81	89	PF00786	0.304
LIG_LIR_Gen_1	104	112	PF02991	0.271
LIG_LIR_Gen_1	148	158	PF02991	0.285
LIG_LIR_Gen_1	174	184	PF02991	0.209
LIG_LIR_Nem_3	104	108	PF02991	0.271
LIG_LIR_Nem_3	148	153	PF02991	0.311
LIG_LIR_Nem_3	174	179	PF02991	0.209
LIG_PCNA_PIPBox_1	67	76	PF02747	0.487
LIG_PDZ_Class_1	215	220	PF00595	0.615
LIG_Pex14_1	115	119	PF04695	0.397
LIG_Pex14_1	163	167	PF04695	0.201
LIG_Pex14_2	101	105	PF04695	0.271
LIG_SH2_CRK	123	127	PF00017	0.462
LIG_SH2_CRK	52	56	PF00017	0.454
LIG_SH2_CRK	83	87	PF00017	0.299
LIG_SH2_GRB2like	119	122	PF00017	0.444
LIG_SH2_GRB2like	52	55	PF00017	0.444
LIG_SH2_NCK_1	83	87	PF00017	0.455
LIG_SH2_PTP2	74	77	PF00017	0.350
LIG_SH2_STAP1	165	169	PF00017	0.299
LIG_SH2_STAT5	123	126	PF00017	0.487
LIG_SH2_STAT5	68	71	PF00017	0.434
LIG_SH2_STAT5	74	77	PF00017	0.264
LIG_SH3_3	30	36	PF00018	0.593
LIG_SH3_3	56	62	PF00018	0.382
LIG_SUMO_SIM_anti_2	174	182	PF11976	0.244
LIG_SUMO_SIM_anti_2	76	81	PF11976	0.337
LIG_SUMO_SIM_par_1	177	182	PF11976	0.348
LIG_TYR_ITIM	117	122	PF00017	0.239
LIG_TYR_ITIM	198	203	PF00017	0.499
LIG_TYR_ITIM	50	55	PF00017	0.529
LIG_TYR_ITIM	81	86	PF00017	0.285
LIG_WRC_WIRS_1	173	178	PF05994	0.220
MOD_CK1_1	31	37	PF00069	0.614
MOD_CMANNOS	115	118	PF00535	0.400
MOD_GlcNHglycan	181	184	PF01048	0.373
MOD_GlcNHglycan	203	206	PF01048	0.307
MOD_GSK3_1	165	172	PF00069	0.289
MOD_GSK3_1	24	31	PF00069	0.638
MOD_N-GLC_1	96	101	PF02516	0.369
MOD_NEK2_1	101	106	PF00069	0.280
MOD_NEK2_1	169	174	PF00069	0.288
MOD_NEK2_1	73	78	PF00069	0.340
MOD_PIKK_1	24	30	PF00454	0.658
MOD_PKA_2	201	207	PF00069	0.611
MOD_Plk_1	96	102	PF00069	0.169
MOD_Plk_4	101	107	PF00069	0.277
MOD_Plk_4	172	178	PF00069	0.212
MOD_Plk_4	203	209	PF00069	0.507
TRG_ENDOCYTIC_2	119	122	PF00928	0.457
TRG_ENDOCYTIC_2	123	126	PF00928	0.446
TRG_ENDOCYTIC_2	200	203	PF00928	0.496
TRG_ENDOCYTIC_2	52	55	PF00928	0.454
TRG_ENDOCYTIC_2	74	77	PF00928	0.279
TRG_ENDOCYTIC_2	83	86	PF00928	0.258
TRG_ER_diArg_1	208	211	PF00400	0.572
TRG_NES_CRM1_1	134	148	PF08389	0.367

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P960	Leptomonas seymouri	63%	99%
A0A0S4J7Y6	Bodo saltans	41%	88%
A0A1X0P4W4	Trypanosomatidae	56%	97%
A0A3Q8IN09	Leishmania donovani	75%	100%
A0A3R7KQ76	Trypanosoma rangeli	60%	97%
A2YMP7	Oryza sativa subsp. indica	27%	72%
A4HE02	Leishmania braziliensis	30%	100%
A4IC16	Leishmania infantum	75%	100%
C9ZYI6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	97%
E9AFV4	Leishmania major	76%	100%
E9B707	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
O15127	Homo sapiens	26%	67%
Q17QF8	Bos taurus	28%	94%
Q28F21	Xenopus tropicalis	25%	95%
Q58DF6	Bos taurus	28%	96%
Q5R5Z8	Pongo abelii	28%	94%
Q5RCY9	Pongo abelii	28%	96%
Q60EA5	Oryza sativa subsp. japonica	30%	78%
Q6GM42	Xenopus laevis	27%	94%
Q6GPA8	Xenopus laevis	28%	94%
Q6P0C7	Danio rerio	27%	96%
Q75IC7	Oryza sativa subsp. japonica	28%	70%
Q7F613	Oryza sativa subsp. japonica	28%	77%
Q8H5X5	Oryza sativa subsp. japonica	27%	72%
Q8TAC9	Homo sapiens	27%	94%
Q969E2	Homo sapiens	28%	96%
Q9ERN0	Mus musculus	25%	67%
Q9ET20	Rattus norvegicus	28%	96%
Q9JKD3	Mus musculus	28%	94%
Q9JKE3	Rattus norvegicus	28%	94%
Q9JKV5	Mus musculus	28%	96%
Q9LR68	Arabidopsis thaliana	28%	78%
Q9M5P2	Arabidopsis thaliana	30%	76%
Q9SKT3	Arabidopsis thaliana	27%	78%