LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

TPT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
TPT domain-containing protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania braziliensis
UniProt:
A4HNE2_LEIBR
TriTrypDb:
LbrM.34.4740
Length:
103

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 3
NetGPI no yes: 0, no: 3
Cellular components
Term Name Level Count
GO:0016020 membrane 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

A4HNE2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HNE2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 16 18 PF00082 0.437
CLV_PCSK_PC1ET2_1 16 18 PF00082 0.446
CLV_PCSK_SKI1_1 21 25 PF00082 0.262
CLV_PCSK_SKI1_1 67 71 PF00082 0.327
DOC_MAPK_MEF2A_6 59 68 PF00069 0.316
DOC_PP1_RVXF_1 65 71 PF00149 0.390
DOC_PP1_RVXF_1 75 81 PF00149 0.293
DOC_PP4_FxxP_1 92 95 PF00568 0.626
DOC_USP7_MATH_1 11 15 PF00917 0.720
DOC_USP7_MATH_1 84 88 PF00917 0.631
DOC_WW_Pin1_4 26 31 PF00397 0.549
DOC_WW_Pin1_4 49 54 PF00397 0.521
LIG_BIR_II_1 1 5 PF00653 0.635
LIG_FHA_1 52 58 PF00498 0.465
LIG_FHA_1 69 75 PF00498 0.355
LIG_LIR_Apic_2 89 95 PF02991 0.625
LIG_LIR_Gen_1 35 44 PF02991 0.526
LIG_LIR_Nem_3 35 39 PF02991 0.526
LIG_PDZ_Class_2 98 103 PF00595 0.644
LIG_SH2_CRK 41 45 PF00017 0.316
LIG_SH2_CRK 61 65 PF00017 0.390
LIG_SH2_STAP1 41 45 PF00017 0.316
LIG_SH2_STAP1 61 65 PF00017 0.390
LIG_WRC_WIRS_1 33 38 PF05994 0.316
MOD_GlcNHglycan 9 12 PF01048 0.576
MOD_GSK3_1 28 35 PF00069 0.392
MOD_GSK3_1 7 14 PF00069 0.693
MOD_N-GLC_1 25 30 PF02516 0.316
MOD_NEK2_1 32 37 PF00069 0.341
MOD_Plk_4 28 34 PF00069 0.316
MOD_Plk_4 35 41 PF00069 0.275
MOD_ProDKin_1 26 32 PF00069 0.549
MOD_ProDKin_1 49 55 PF00069 0.517
TRG_DiLeu_BaLyEn_6 92 97 PF01217 0.623
TRG_ENDOCYTIC_2 41 44 PF00928 0.316
TRG_ENDOCYTIC_2 61 64 PF00928 0.390

Homologs

Protein Taxonomy Sequence identity Coverage
E9AFV3 Leishmania major 51% 100%
E9B706 Leishmania mexicana (strain MHOM/GT/2001/U1103) 47% 68%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS